LOCUS BC000538 2000 bp mRNA linear HUM 04-NOV-2003
DEFINITION Homo sapiens golgi associated, gamma adaptin ear containing, ARF
binding protein 1, mRNA (cDNA clone IMAGE:3162847), partial cds.
ACCESSION BC000538
VERSION BC000538.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2000)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2000)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (15-NOV-2000) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Oct 28, 2003 this sequence version replaced BC000538.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 5 Row: a Column: 9.
FEATURES Location/Qualifiers
source 1..2000
/db_xref="H-InvDB:HIT000085839"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:3162847"
/tissue_type="Brain, neuroblastoma"
/clone_lib="NIH_MGC_19"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene <1..2000
/gene="GGA1"
/db_xref="GeneID:26088"
/db_xref="MIM:606004"
CDS <1..1100
/gene="GGA1"
/codon_start=3
/product="GGA1 protein"
/protein_id="AAH00538.2"
/db_xref="GeneID:26088"
/db_xref="MIM:606004"
/translation="EALAEILQANDNLTQVINLYKQLVRGEEVNGDATAGSIPGSTSA
LLDLSGLDLPPAGTTYPAMPTRPGEQASPEQPSASVSLLDDELMSLGLSDPTPPSGPS
LDGTGWNSFQSSDATEPPAPALAQAPSMESRPPAQTSLPASSGLDDLDLLGKTLLQQS
LPPESQQVRWEKQQPTPRLTLRDLQNKSSSCSSPSSSATSLLHTVSPEPPRPPQQPVP
TELSLASITVPLESIKPSNILPVTVYDQHGFRILFHFARDPLPGRSDVLVVVVSMLST
APQPIRNIVFQSAVPKVMKVKLQPPSGTELPAFNPIVHPSAITQVLLLANPQKEKVRL
RYKLTFTMGDQTYNEMGDVDQFPPPETWGSL"
misc_feature 3..104
/gene="GGA1"
/note="GAT; Region: GAT domain. The GAT domain is
responsible for binding of GGA proteins to several members
of the ARF family including ARF1 and ARF3. The GAT domain
stabilises membrane bound ARF1 in its GTP bound state, by
interfering with GAP proteins"
/db_xref="CDD:pfam03127"
misc_feature 699..1073
/gene="GGA1"
/note="Alpha_adaptinC2; Region: Adaptin C-terminal domain.
Alpha adaptin is a heterotetramer which regulates
clathrin-bud formation. The carboxyl-terminal appendage of
the alpha subunit regulates translocation of endocytic
accessory proteins to the bud site. This ig-fold domain is
found in alpha, beta and gamma adaptins"
/db_xref="CDD:pfam02883"
BASE COUNT 404 a 662 c 564 g 370 t
ORIGIN
1 atgaggcctt agcggagatc ctgcaggcca atgacaacct cacccaggtg atcaacctgt
61 ataagcagct ggtgcggggt gaggaggtca acggtgatgc cacagccggc tccatccctg
121 ggagcacctc ggccctgctg gatctctcag gcctggatct cccgcctgcg ggcaccacct
181 acccagctat gcccacccgc cctggcgagc aggccagccc tgagcagccc agtgcctcag
241 tttccctgct tgacgacgag ctcatgtctc tgggcctcag tgaccccaca cccccttcag
301 gcccaagcct ggatggtacc ggatggaaca gcttccagtc gtcggatgcc actgagcccc
361 cagcccctgc tctggcccag gcccccagta tggaaagccg acccccagcg cagacatccc
421 tgccagcaag cagcggtctg gacgacctag acctcctggg gaagaccctc ctgcagcagt
481 cgctgccccc ggaatcccag caagtgcggt gggagaagca gcagccaacc ccccggctca
541 cactccggga cctgcagaat aagagcagca gctgcagctc ccctagctcc agcgccacca
601 gccttctcca caccgtgtcc ccagagcccc ccaggcctcc gcagcagccc gtaccaaccg
661 agctctcact ggccagcatc actgtgcccc tggagtccat caaacccagc aacatcctgc
721 ccgtgactgt gtatgaccag cacggcttcc gcatcctctt ccattttgcc cgggacccac
781 tgccagggcg ctccgacgtg ctggtggtgg tggtttccat gctgagcacc gccccccagc
841 ccatccgcaa catcgtgttc cagtcagctg tccccaaggt tatgaaggtg aagctgcagc
901 caccctcggg cacggagctg ccagctttta accccatcgt ccacccctca gcaatcaccc
961 aggtcctgct gcttgccaac ccccagaagg agaaggttcg cctccgctac aagctcacct
1021 tcaccatggg tgaccagacc tacaacgaga tgggggatgt ggaccagttc cccccacctg
1081 aaacctgggg tagcctctag aacagagggg ctggggagag gaaggggcag agggaccggt
1141 cactgtccag cctggaggga ggcattggtg gccaaggaca ccctttgttg cccatggcca
1201 ttcaccccca ggcctggtgc ttctccccac acccctgtag gcctcaagtg actcttcccc
1261 ctcctgctcc ggccccgccc ctgctgagcc aaacccagta ggaggctggg cctgggtttg
1321 tgccgctggg gtctccatca ccgggacctg gagagggagg ggctgtgtag ccttggaaga
1381 acttgggtca tggggaggaa gcacagctgt tggggaaggg ccaggacctc aggcccagcc
1441 ccaaccccag ctggggtggg gtcttcccca cctgtctctt atgccttatg ggaaggccca
1501 gccataactc gggggccatg ctggagctgg ggaccagctt aggcctcctc cataggaacc
1561 cagtgactgg ggggtgacgc ctacaccccc agctatttgc actctggtgt gtggtttgac
1621 tctgcttttc ttccggattg gccctgtggt cacagcctca gggggccagg ctgggggaac
1681 ctcacctggc ccgtactcct gggggtttcc ctttgccatt gggccccctg agggactgtg
1741 ggggctcaag ggtaatgcca gaggcccatg gccccagcga ggggctgtgg ggcacctaga
1801 gttctcggtg tgtctccttc attcattggc ctctgctggg gcctcctatg ggtgtcttac
1861 gtctgtccat ccatctgtcc gtggtcagaa gtggggtcag tgtgtgagtg agagcaggag
1921 tatttatgaa aataaaacgt cgtttttcct ggaaaaaaaa aaaaaaaaaa aaaaaaaaaa
1981 aaaaaaaaaa aaaaaaaaaa
//