LOCUS       AY899304                 396 bp    mRNA    linear   HUM 15-FEB-2005
DEFINITION  Homo sapiens proinsulin mRNA, complete cds, alternatively spliced.
ACCESSION   AY899304
VERSION     AY899304.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 396)
  AUTHORS   Shalev,A., Blair,P.J., Hoffmann,S.C., Hirshberg,B., Peculis,B.A.
            and Harlan,D.M.
  TITLE     A proinsulin gene splice variant with increased translation
            efficiency is expressed in human pancreatic islets
  JOURNAL   Endocrinology 143 (7), 2541-2547 (2002)
   PUBMED   12072386
REFERENCE   2  (bases 1 to 396)
  AUTHORS   Minn,A.H., Kayton,M., Lorang,D., Hoffmann,S.C., Harlan,D.M.,
            Libutti,S.K. and Shalev,A.
  TITLE     Insulinomas and expression of an insulin splice variant
  JOURNAL   Lancet 363 (9406), 363-367 (2004)
   PUBMED   15070567
REFERENCE   3  (bases 1 to 396)
  AUTHORS   Shalev,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-JAN-2005) Medicine, University of Wisconsin, Madison,
            H4/526 Clinical Science Ctr., Madison, WI 53792, USA
FEATURES             Location/Qualifiers
     source          1..396
                     /db_xref="H-InvDB:HIT000258849"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     misc_feature    13..38
                     /note="retained partial intron"
     CDS             56..388
                     /note="alternatively spliced"
                     /codon_start=1
                     /product="proinsulin"
                     /protein_id="AAW83741.1"
                     /translation="MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCG
                     ERGFFYTPKTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSL
                     YQLENYCN"
BASE COUNT           68 a          128 c          124 g           76 t
ORIGIN      
        1 gccatcaagc aggtctgttc caagggcctt tgcgtcagat cactgtcctt ctgccatggc
       61 cctgtggatg cgcctcctgc ccctgctggc gctgctggcc ctctggggac ctgacccagc
      121 cgcagccttt gtgaaccaac acctgtgcgg ctcacacctg gtggaagctc tctacctagt
      181 gtgcggggaa cgaggcttct tctacacacc caagacccgc cgggaggcag aggacctgca
      241 ggtggggcag gtggagctgg gcgggggccc tggtgcaggc agcctgcagc ccttggccct
      301 ggaggggtcc ctgcagaagc gtggcattgt ggaacaatgc tgtaccagca tctgctccct
      361 ctaccagctg gagaactact gcaactagac gcagcc
//