LOCUS AY894754 6581 bp mRNA linear HUM 11-DEC-2007
DEFINITION Homo sapiens proteasome activator 200 kDa ii (PSME4) mRNA, complete
cds, alternatively spliced.
ACCESSION AY894754
VERSION AY894754.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6581)
AUTHORS Blickwedehl,J., McEvoy,S., Wong,I., Kousis,P., Clements,J.,
Elliott,R., Cresswell,P., Liang,P. and Bangia,N.
TITLE Proteasomes and proteasome activator 200 kDa (PA200) accumulate on
chromatin in response to ionizing radiation
JOURNAL Radiat. Res. 167 (6), 663-674 (2007)
PUBMED 17523843
REFERENCE 2 (bases 1 to 6581)
AUTHORS Blickwedehl,J., McEvoy,S., Wong,I., Kousis,P., Cresswell,P.,
Liang,P. and Bangia,N.
TITLE Direct Submission
JOURNAL Submitted (17-JAN-2005) Immunology, Roswell Park Cancer Institute,
Elm and Carlton Streets, Buffalo, NY 14263, USA
FEATURES Location/Qualifiers
source 1..6581
/db_xref="H-InvDB:HIT000332526"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2p16.3"
/cell_line="KG1"
gene 1..6581
/gene="PSME4"
/gene_synonym="PA200"
CDS 1781..5437
/gene="PSME4"
/gene_synonym="PA200"
/note="PA200ii; lacks exon 14; alternatively spliced"
/codon_start=1
/product="proteasome activator 200 kDa ii"
/protein_id="AAX83869.1"
/translation="MVADMCRAAVKCCPEESLKLFVPHCCSVITQLTMNDDVLNDEEL
DKELLWNLQLLSEITRVDGRKLLLYREQLVKILQRTLHLTCKQGYTLSCNLLHHLLRS
TTLIYPTEYCSVPGGFDKPPSEYFPIKDWGKPGDLWNLGIQWHVPSSEEVSFAFYLLD
SFLQPELVKLQHCGDGKLEMSRDDILQSLTIVHNCLIGSGNLLPPLKGEPVTNLVPSM
VSLEETKLYTGLEYDLSRENHREVIATVIRKLLNHILDNSEDDTKSLFLIIKIIGDLL
QFQGSHKHEFDSRWKSFNLVKKSMENRLHGKKQHIRALLIDRVMLQHELRTLTVEGCE
YKKIHQDMIRDLLRLSTSSYSQVRNKAQQTFFAALGAYNFCCRDIIPLVLEFLRPDRQ
GVTQQQFKGALYCLLGNHSGVCLANLHDWDCIVQTWPAIVSSGLSQAMSLEKPSIVRL
FDDLAEKIHRQYETIGLDFTIPKSCVEIAELLQQSKNPSINQILLSPEKIKEGIKRQQ
EKNADALRNYENLVDTLLDGVEQRNLPWKFEHIGIGLLSLLLRDDRVLPLRAIRFFVE
NLNHDAIVVRKMAISAVAGILKQLKRTHKKLTINPCEISGCPKPTQIIAGDRPDNHWL
HYDSKTIPRTKKEWESSCFVEKTHWGYYTWPKNMVVYAGVEEQPKLGRSREDMTEAEQ
IIFDHFSDPKFVEQLITFLSLEDRKGKDKFNPRRFCLFKGIFRNFDDAFLPVLKPHLE
HLVADSHESTQRCVAEIIAGLIRGSKHWTFEKVEKLWELLCPLLRTALSNITVETYND
WGACIATSCESRDPRKLHWLFELLLESPLSGEGGSFVDACRLYVLQGGLAQQEWRVPE
LLHRLLKYLEPKLTQVYKNVRERIGSVLTYIFMIDVSLPNTTPTISPHVPEFTARILE
KLKPLMDVDEEIQNHVMEENGIGEEDERTQGIKLLKTILKWLMASAGRSFSTAVTEQL
QLLPLFFKIAPVENDNSYDELKRDAKLCLSLMSQGLLYPHQVPLVLQVLKQTARSSSW
HARYTVLTYLQTMVFYNLFIFLNNEDAVKDIRWLVISLLEDEQLEVREMAATTLSGLL
QCNFLTMDSPMQIHFEQLCKTKLPKKRKRDPGSVGDTIPSAELVKRHAGVLGLGACVL
SSPYDVPTWMPQLLMNLSAHLNDPQPIEMTVKKTLSNFRRTHHDNWQEHKQQFTDDQL
LVLTDLLVSPCYYA"
BASE COUNT 1911 a 1316 c 1439 g 1915 t
ORIGIN
1 ggtgggggcc ggggagggtt cgggtgggag ggggtggggg gggtgtccct gggctcatgg
61 agccggccga gcgggcggga gtcggagagc ccccggagcc gggcgggcgt cccgagccgg
121 gcccgcgggg cttcgtcccg cagaaggaga tcgtctacaa caagctgctg ccctacgcgg
181 agcggctaga cgccgagtcc gacttgcagc tggcccagat caaatgcaac ctgggccggg
241 ccgtgcagct ccaagagctg tggcccgggg gcctcttctg gaccaggaaa ctctccacat
301 atattcgact ttatgggaga aaatttagca aagaagatca tgttcttttt attaagttat
361 tgtatgagct ggtatcaatt ccaaaactgg aaatcagcat gatgcaggga tttgcccgcc
421 ttttgatcaa cttgttaaag aaaaaggaac ttctttcaag agctgatttg gagttaccct
481 ggagaccact ttatgacatg gtagaaagaa tattatattc caagacagag cacctaggat
541 taaattggtt tcctaattct gtagaaaata ttctcaaaac actcgtgaaa agctgccgac
601 catattttcc agcagatgcc accgctgaga tgctagaaga atggcgacct ttaatgtgcc
661 cttttgatgt aaccatgcaa aaggccatca cttattttga aatatttctt cctacctccc
721 ttcctccaga acttcatcat aaaggtttta aactttggtt tgatgaatta attggccttt
781 gggtttcagt gcaaaatctc ccacaatggg aggggcaact agtaaatctc tttgctcgat
841 tggctacaga taatataggg tacatagatt gggatccata tgtaccaaag atatttacaa
901 gaattctgag aagcttgaac ctcccagtgg gaagcagtca agtgttagtc ccaagatttt
961 taacaaatgc ttatgatata ggacatgctg taatatggat caccgccatg atgggtggac
1021 caagtaagct agtgcaaaaa cacttagctg gtttgtttaa cagcatcaca tctttttacc
1081 atccttcaaa taatgggcgc tggctgaaca agttaatgaa actacttcag cggttgccaa
1141 acagtgttgt tagaagattg catcgtgaaa gatacaagaa gccctcttgg ttaactcctg
1201 tgcctgatag ccacaagctt actgatcaag atgttacaga ctttgtacaa tgcattattc
1261 agcctgtcct cttggctatg tttagcaaaa ccggtagtct agaagcagcc caggctttgc
1321 agaatcttgc actcatgaga cctgaattgg taataccccc tgtacttgaa agaacatatc
1381 ctgcattaga gacattaaca gaacctcacc agctcacagc tactttaagt tgtgtaattg
1441 gagtagcccg cagtttggta tcaggaggca gatggtttcc tgaaggtcct acacatatgc
1501 tacctctgtt gatgagagca ttgcctgggg tggatccaaa tgactttagt aaatgcatga
1561 tcacattcca gttcatagca acattttcta ctctggtgcc tttagtagat tgttcatctg
1621 tactacaaga aagaaatgac ctcacagaag tggaacgaga actttgttca gccacagctg
1681 aatttgagga tttcgtctta cagtttatgg acaggtggcc cttcagaagg tttttaattt
1741 ttctacttca catatatttg aaacaagagt agcaggtcgc atggtggcag acatgtgccg
1801 cgctgctgta aagtgctgcc cagaagaatc tttgaagctc tttgttcccc actgctgcag
1861 tgttataact cagcttacaa tgaatgatga tgtattaaat gatgaagagc tagacaagga
1921 attactatgg aatcttcaac ttttgtctga gattactcga gtggatggaa ggaagttgct
1981 tctttatagg gagcagcttg taaagattct ccaaagaacc ctacatttaa cctgtaagca
2041 gggttacact ctgtcttgta accttttgca tcatcttctc cgttctacca cacttatcta
2101 ccctacagaa tactgcagtg tgccaggtgg ctttgacaag cctccttctg aatactttcc
2161 tatcaaggac tggggcaaac ccggggactt gtggaatctg ggaatccagt ggcatgttcc
2221 ttcttcagaa gaagtgtctt ttgcctttta tcttttggac tcctttcttc agcctgagct
2281 cgtcaaactc cagcattgtg gggatggaaa acttgaaatg tctagagatg atattctaca
2341 gagtctgact atagtgcaca actgtttaat tggctctgga aacctcctac ctccgttgaa
2401 aggagagcca gttactaact tagtaccaag tatggtgtcc ttggaagaga caaagttgta
2461 tactggactt gaatatgatc tgtctcgaga gaaccaccga gaagtaattg ctacagttat
2521 aaggaaactt cttaaccaca tacttgataa ttcagaagat gatactaagt cattgtttct
2581 tattataaag attattggag accttttaca attccaagga tctcacaagc atgaatttga
2641 ctcccgatgg aaaagcttca acttagtaaa gaaatcaatg gaaaatcggc tccatgggaa
2701 aaaacaacat atcagagcac tgttgattga tagagtaatg ttacagcatg agctacggac
2761 actaactgtt gagggttgtg aatacaaaaa gatacatcaa gatatgatca gagatcttct
2821 tcgtttatct acaagttcat acagtcaggt gagaaataag gctcagcaaa cattttttgc
2881 tgccttggga gcatataact tctgttgcag agatatcatt cccttggttt tggagttctt
2941 aaggcctgat agacaaggtg ttacacagca acaattcaag ggtgccttgt actgtctcct
3001 tggaaatcac agtggtgtgt gcttggcaaa ccttcatgat tgggactgta ttgtacagac
3061 gtggccagcg attgtttctt cagggcttag ccaagcaatg tccctggaaa agccatcaat
3121 agtgagattg tttgatgatc ttgcagaaaa gattcatagg cagtatgaaa caattggctt
3181 ggacttcaca attccaaagt catgtgttga aatagcggaa ttacttcaac agtcaaaaaa
3241 cccctctatc aaccagatat tgcttagccc agaaaaaatt aaggaaggaa ttaaacgcca
3301 acaggaaaag aatgccgatg ccctaaggaa ctatgaaaat ttggtagaca ccttgctaga
3361 tggtgtggag caaagaaacc tgccctggaa atttgaacat ataggcattg ggcttctgtc
3421 tctactgctg agagatgacc gagtgttgcc tcttcgtgcc atacggtttt ttgttgagaa
3481 tctcaaccat gatgcaattg tagttcgaaa gatggctatc tcagctgttg ctggtatcct
3541 taaacagcta aaaagaaccc acaaaaagct gaccattaac ccctgtgaaa tcagtggatg
3601 ccctaaaccc acccaaatta ttgctggtga taggcctgat aatcattggt tgcattatga
3661 cagcaaaact ataccaagaa ctaaaaaaga atgggagtca agttgctttg tggaaaaaac
3721 tcactgggga tactacacct ggccaaagaa tatggttgtt tatgctggtg tggaagagca
3781 gcctaagctt ggcagaagca gggaggatat gacagaggca gaacagatta tatttgatca
3841 tttttctgat cctaaatttg ttgagcagtt aattactttt ctatcattag aagacagaaa
3901 aggaaaagat aagtttaatc cacgacgttt ttgcctcttt aagggtatat tcaggaattt
3961 tgatgatgcc ttcctgccag ttctgaagcc ccatttagaa catttggttg cagattcaca
4021 tgaaagcacc cagcgatgtg ttgcagaaat tatagctggt ttaatcagag gttctaagca
4081 ctggacattt gaaaaggtgg agaagctttg ggagcttctg tgccctctgc ttagaacagc
4141 actgtccaat attaccgtag aaacttataa tgactgggga gcttgtatag caacatcctg
4201 tgaaagcaga gatccccgga aacttcactg gctttttgaa ctgctgttgg aatcaccatt
4261 gagtggtgaa ggaggatcct ttgtagatgc atgtcgactt tatgtactac aaggtggcct
4321 tgcccagcaa gaatggagag tgcctgaact attgcacaga ctactgaagt acttggaacc
4381 caaactcacc caggtttaca aaaatgtcag agaaagaata ggaagtgtgc tgacctacat
4441 attcatgata gatgtatctt tgccaaatac cacaccaacc atatcgcctc atgtccctga
4501 gtttactgct cgaattctgg agaaattgaa acctctcatg gatgtggatg aagaaattca
4561 gaaccatgtt atggaagaaa atggaattgg tgaagaagat gagcgaactc agggcattaa
4621 actcttgaaa accatattga aatggctgat ggcaagtgca ggaagatcct tttctacagc
4681 agttacagaa caacttcagc ttctaccttt gtttttcaag attgccccag tggaaaatga
4741 caatagctac gatgaactga aaagagatgc aaagttatgt ttatcattaa tgtctcaggg
4801 gttgctttac cctcatcaag tgcctttggt acttcaggtg ctaaaacaaa cagcaagaag
4861 cagttcttgg catgcacgat acacagtact gacctacctc cagaccatgg tattttataa
4921 cctctttatt ttcctaaaca atgaagatgc agttaaagat atcaggtggc tggttataag
4981 tcttttggag gacgaacaac tggaggttcg agaaatggct gctactacct taagcggtct
5041 gctacagtgt aactttctta ccatggacag tcctatgcag attcattttg agcaactttg
5101 caaaacaaaa ctacctaaga aaagaaagcg agaccctggt tctgtaggag ataccattcc
5161 ttctgcagag ttggtcaaac gccatgctgg ggtgctagga cttggtgcat gtgttctttc
5221 tagtccttac gatgttccca cctggatgcc ccagctcctc atgaatctca gtgcacatct
5281 aaatgatcct cagcctattg agatgactgt aaaaaaaacc ttatccaatt tccgaaggac
5341 tcaccatgac aactggcagg aacataaaca gcaattcact gatgaccaac tgcttgttct
5401 caccgatctt cttgtgtcac catgctatta tgcatagaaa gatgactagt cctcacttca
5461 ggctcttttc atcaaaaatt ccacaccctc aggtaccatc tgtggtggct ctctgcaagt
5521 tttaaaactg cctctgctga gctctcatca ttttggtggt ttctgtgtta gatctcgtta
5581 gtctgcattc cacagcttct cagttgccat ttgatttccc aacttgtccg gaagtgtttc
5641 cagaatactg atcacttttt ttttttgagg catctgacaa agtcacaaag tctcagacta
5701 gaaataatta cccagtatga tcatggcatc caagaccaga gtctcagaac tcattaagaa
5761 acagtttact tggaatggag aatacccatc tgtaatacag gtcctgtcat ttcattcatc
5821 tcaaattatt ttgaattctt cccaaatggc tgctggattt aggtggtaat aggggctgtg
5881 ggccataaat ctgaagcctt gagaaccttg ggtctggaga gccatgaaga gggaaggaaa
5941 agagggcaag tcctgaacct aaccaatgac ctgatggatt gctcgaccaa gacacagaag
6001 tgaagtctgt gtctgtgcac ttcccacaga ctggagtttt tggtgctgaa tagagccagt
6061 tgctaaaaaa ttgggggttt ggtgaagaaa tctgattgtt gtgtgtattc aatgtgtgat
6121 tttaaaaata aacagcaaca acaataaaaa ccctgactgg ctgttttttc cctgtattct
6181 ttacaactat tttttgaccc tctgaaaatt attatacttc acctaaatgg aagactgctg
6241 tgtttgtgga aattttgtaa ttttttaatt tattttattc tctctccctt tttattttgc
6301 ctgcagaatc gttgagagac taataaggct taatatttaa ttgatttgtt taatatgtta
6361 tataaatgta aaagagtgta taaactgtag agatagcatt ggcaagacat tgtacagatg
6421 caacctttta cacaacatca ttgtgtaatt tgtaaagatt cacgtgtagt tctttattat
6481 agtgattttg ggctttgtac ccactgaatg ccattttttg tgtttttaaa ttattttctt
6541 tatcttgtta caaaaactga gatgtggggt tttttttttt t
//