LOCUS       AY845858                1623 bp    mRNA    linear   HUM 04-JAN-2005
DEFINITION  Homo sapiens KCR1 (ALG10) mRNA, complete cds.
ACCESSION   AY845858
VERSION     AY845858.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1623)
  AUTHORS   Kupershmidt,S., Yang,I.C., Hayashi,K., Wei,J., Chanthaphaychith,S.,
            Petersen,C.I., Johns,D.C., George,A.L. Jr., Roden,D.M. and
            Balser,J.R.
  TITLE     The IKr drug response is modulated by KCR1 in transfected cardiac
            and noncardiac cell lines
  JOURNAL   FASEB J. 17 (15), 2263-2265 (2003)
   PUBMED   14525949
REFERENCE   2  (bases 1 to 1623)
  AUTHORS   Petersen,C.I., McFarland,T.R., Stepanovic,S.Z., Yang,P.,
            Reiner,D.J., Hayashi,K., George,A.L., Roden,D.M., Thomas,J.H. and
            Balser,J.R.
  TITLE     In vivo identification of genes that modify ether-a-go-go-related
            gene activity in Caenorhabditis elegans may also affect human
            cardiac arrhythmia
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (32), 11773-11778 (2004)
   PUBMED   15280551
REFERENCE   3  (bases 1 to 1623)
  AUTHORS   George,A.L. Jr.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-DEC-2004) Genetic Medicine, Vanderbilt University,
            2215 Garland Ave., Nashville, TN 37232-0275, USA
FEATURES             Location/Qualifiers
     source          1..1623
                     /db_xref="H-InvDB:HIT000257889"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     gene            1..1623
                     /gene="ALG10"
                     /gene_synonym="KCR1"
     CDS             1..1422
                     /gene="ALG10"
                     /gene_synonym="KCR1"
                     /note="modifier of the HERG potassium channel"
                     /codon_start=1
                     /product="KCR1"
                     /protein_id="AAW31756.1"
                     /translation="MAQLEGYCFSAALSCTFLVSCLLFSAFSRALREPYMDEIFHLPQ
                     AQRYCEGHFSLSQWDPMITTLPGLYLVSVGVVKPAIWIFGWSEHVVCSIGMLRFVNLL
                     FSVGNFYLLYLLFHKVQPRNKAASSIQRVLSTLTLAVFPTLYFFNFLYYTEAGSMFFT
                     LFAYLMCLYGNHKTSAFLGFCGFMFRQTNIIWAVFCAGNVIAQKLTEAWKTELQKKED
                     RLPPIKGPFAEFRKILQFLLAYSMSFKNLSMLFCLTWPYILLGFLFCAFVVVNGGIVI
                     GDRSSHEACLHFPQLFYFFSFTLFFSFPHLLSPSKIKTFLSLVWKHGILFLVVTLVSV
                     FLVWKFTYAHKYLLADNRHYTFYVWKRVFQRYAILKYLLVPAYIFAGWSIADSLKSKP
                     IFWNLMFFICLFIVIVPQKLLEFRYFILPYVIYRLNITLPPTSRLVCELSCYAIVNFI
                     TFYIFLNKTFQWPNSQDIQRFMW"
BASE COUNT          413 a          312 c          299 g          598 t
ORIGIN      
        1 atggcgcagc tagagggtta ctgtttctcg gccgccttga gctgtacctt tttagtgtcc
       61 tgcctcctct tctccgcctt cagccgggcg ctgcgagagc cctacatgga cgagatcttc
      121 cacctgcctc aggcgcagcg ctactgtgag ggccatttct ccctttccca gtgggatccc
      181 atgattacta cattacctgg cttgtacctg gtgtcagttg gagtggtcaa acctgccatt
      241 tggatctttg gatggtctga acatgttgtc tgctccattg ggatgctcag atttgttaat
      301 cttctcttca gtgttggcaa cttctattta ctatatttgc ttttccacaa ggtacaaccc
      361 agaaacaagg ctgcctcaag tatccagaga gtcttgtcaa cattaacact agcagtattt
      421 ccaacacttt atttttttaa cttcctttat tatacagaag caggatctat gttttttact
      481 ctttttgcat atttgatgtg tctttatgga aatcataaaa cttcagcctt ccttggattt
      541 tgtggcttca tgtttcggca aacaaatatc atctgggctg tcttctgtgc agggaatgtc
      601 attgcacaaa agttaactga ggcttggaaa actgagctac aaaagaagga agacagactt
      661 ccacctatta aaggaccatt tgcagaattc agaaaaattc ttcagtttct tttggcttat
      721 tccatgtcct ttaaaaactt gagtatgctt ttctgtttga cttggcccta catccttctg
      781 ggatttctgt tttgtgcttt tgtagtagtt aatggtggaa ttgttattgg cgatcggagt
      841 agtcatgaag cctgtcttca ttttcctcaa ctattctact ttttttcatt tactctcttt
      901 ttttcttttc ctcatctcct gtctcctagc aaaattaaga cttttctttc cttagtttgg
      961 aaacatggaa ttctgttttt ggtggttacc ttagtctctg tgtttttagt ttggaaattc
     1021 acttatgctc ataaatactt gctagcagac aatagacatt atactttcta tgtgtggaaa
     1081 agagtttttc aaagatatgc aattctgaaa tatttgttag ttccagccta tatatttgct
     1141 ggttggagta tagctgactc attgaaatca aagccaattt tttggaattt aatgtttttc
     1201 atatgcttgt tcattgttat agttcctcag aaactgctgg aatttcgtta cttcatttta
     1261 ccttatgtca tttataggct taacataact ctgcctccca catccagact tgtttgtgaa
     1321 ctgagttgct atgcaattgt taatttcata actttttaca tctttctgaa caagactttt
     1381 cagtggccaa atagtcagga cattcaaagg tttatgtggt aatatcagtg atattttgaa
     1441 ctgtaaaaat ggacttaata atagaccatt tctacaaaga acaactgaat aggnggaaaa
     1501 catggaattt cttttaggtg cagtggtggt cttcaaatta cattagtttt tttaatatat
     1561 attttaaaca tatgtaagaa attaagtggc aaagaactgg gaaagcttaa gacctgcttc
     1621 aaa
//