LOCUS AY830713 6638 bp mRNA linear HUM 08-NOV-2006
DEFINITION Homo sapiens clone HLCC126 voltage-dependent L-type calcium channel
alpha-1C subunit splice variant mRNA, complete cds, alternatively
spliced.
ACCESSION AY830713
VERSION AY830713.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6638)
AUTHORS Tiwari,S., Zhang,Y., Heller,J., Abernethy,D.R. and Soldatov,N.M.
TITLE Atherosclerosis-related molecular alteration of the human CaV1.2
calcium channel alpha1C subunit
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 103 (45), 17024-17029 (2006)
PUBMED 17071743
REFERENCE 2 (bases 1 to 6638)
AUTHORS Tiwari,S.
TITLE Direct Submission
JOURNAL Submitted (18-NOV-2004) Laboratory of Clinical Investigations,
National Institute on Aging, NIH, 5600 Nathan Shock Drive,
Baltimore, MD 21224, USA
FEATURES Location/Qualifiers
source 1..6638
/db_xref="H-InvDB:HIT000332405"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="HLCC126"
/cell_type="smooth muscle"
CDS 1..6540
/note="Cav1.2; alternatively spliced"
/codon_start=1
/product="voltage-dependent L-type calcium channel
alpha-1C subunit splice variant"
/protein_id="AAX37356.1"
/translation="MVNENTRMYIPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIP
TPGAALSWQAAIDAARQAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR
ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLE
RVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA
DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVL
FVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP
GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIG
SFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPE
NEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR
WNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLAL
FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL
LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEM
QTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICG
NYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE
SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVG
PRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSS
ISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNIL
DLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIG
NIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQP
RSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFF
IIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIP
KNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLF
TVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMGPSCS
HPPLAVLTAPPVADGFQNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKS
FQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCAT
GEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFV
AVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGF
GKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAE
DPFRPAGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEY
FRKFKKRKEQGLVGKPSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKE
AVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTESP
SHEKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPA
IRVQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEML
SYQDDENRQLTLPEEDKRDIRQSPKRGFLRSASLGRRASFHLECLKRQKDRGGDISQK
TVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLE
GVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSA
SSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQSPN
GALLPFVNCRDAGQDRAGGEEDAGCVRARGAPSEEELQDSRVYVSSL"
BASE COUNT 1481 a 1971 c 1791 g 1395 t
ORIGIN
1 atggtcaatg agaatacgag gatgtacatt ccagaggaaa accaccaagg ttccaactat
61 gggagcccac gccccgccca tgccaacatg aatgccaatg cggcagcggg gctggcccct
121 gagcacatcc ccaccccggg ggctgccctg tcgtggcagg cggccatcga cgcagcccgg
181 caggctaagc tgatgggcag cgctggcaat gcgaccatct ccacagtcag ctccacgcag
241 cggaagcggc agcaatatgg gaaacccaag aagcagggca gcaccacggc cacacgcccg
301 ccccgagccc tgctctgcct gaccctgaag aaccccatcc ggagggcctg catcagcatt
361 gtcgaatgga aaccatttga aataattatt ttactgacta tttttgccaa ttgtgtggcc
421 ttagcgatct atattccctt tccagaagat gattccaacg ccaccaattc caacctggaa
481 cgagtggaat atctctttct cataattttt acggtggaag cgtttttaaa agtaatcgcc
541 tatggactcc tctttcaccc caatgcctac ctccgcaacg gctggaacct actagatttt
601 ataattgtgg ttgtggggct ttttagtgca attttagaac aagcaaccaa agcagatggg
661 gcaaacgctc tcggagggaa aggggccgga tttgatgtga aggcgctgag ggccttccgc
721 gtgctgcgcc ccctgcggct ggtgtccgga gtcccaagtc tccaggtggt cctgaattcc
781 atcatcaagg ccatggtccc cctgctgcac atcgccctgc ttgtgctgtt tgtcatcatc
841 atctacgcca tcatcggctt ggagctcttc atggggaaga tgcacaagac ctgctacaac
901 caggagggca tagcagatgt tccagcagaa gatgaccctt ccccttgtgc gctggaaacg
961 ggccacgggc ggcagtgcca gaacggcacg gtgtgcaagc ccggctggga tggtcccaag
1021 cacggcatca ccaactttga caactttgcc ttcgccatgc tcacggtgtt ccagtgcatc
1081 accatggagg gctggacgga cgtgctgtac tgggtcaatg atgccgtagg aagggactgg
1141 ccctggatct attttgttac actaatcatc atagggtcat tttttgtact taacttggtt
1201 ctcggtgtgc ttagcggaga gttttccaaa gagagggaga aggccaaggc ccggggagat
1261 ttccagaagc tgcgggagaa gcagcagcta gaagaggatc tcaaaggcta cctggattgg
1321 atcactcagg ccgaagacat cgatcctgag aatgaggacg aaggcatgga tgaggagaag
1381 ccccgaaaca tgagcatgcc caccagtgag accgagtccg tcaacaccga aaacgtggct
1441 ggaggtgaca tcgagggaga aaactgcggg gccaggctgg cccaccggat ctccaagtca
1501 aagttcagcc gctactggcg ccggtggaat cggttctgca gaaggaagtg ccgcgccgca
1561 gtcaagtcta atgtcttcta ctggctggtg attttcctgg tgttcctcaa cacgctcacc
1621 attgcctctg agcactacaa ccagcccaac tggctcacag aagtccaaga cacggcaaac
1681 aaggccctgc tggccctgtt cacggcagag atgctcctga agatgtacag cctgggcctg
1741 caggcctact tcgtgtccct cttcaaccgc tttgactgct tcgtcgtgtg tggcggcatc
1801 ctggagacca tcctggtgga gaccaagatc atgtccccac tgggcatctc cgtgctcaga
1861 tgcgtccggc tgctgaggat tttcaagatc acgaggtact ggaactcctt gagcaacctg
1921 gtggcatcct tgctgaactc tgtgcgctcc atcgcctccc tgctccttct cctcttcctc
1981 ttcatcatca tcttctccct cctggggatg cagctctttg gaggaaagtt caactttgat
2041 gagatgcaga cccggaggag cacattcgat aacttccccc agtccctcct cactgtgttt
2101 cagatcctga ccggggagga ctggaattcg gtgatgtatg atgggatcat ggcttatggc
2161 ggcccctctt ttccagggat gttagtctgt atttacttca tcatcctctt catctgtgga
2221 aactatatcc tactgaatgt gttcttggcc attgctgtgg acaacctggc tgatgctgag
2281 agcctcacat ctgcccaaaa ggaggaggaa gaggagaagg agagaaagaa gctggccagg
2341 actgccagcc cagagaagaa acaagagttg gtggagaagc cggcagtggg ggaatccaag
2401 gaggagaaga ttgagctgaa atccatcacg gctgacggag agtctccacc cgccaccaag
2461 atcaacatgg atgacctcca gcccaatgaa aatgaggata agagccccta ccccaaccca
2521 gaaactacag gagaagagga tgaggaggag ccagagatgc ctgtcggccc tcgcccacga
2581 ccactctctg agcttcacct taaggaaaag gcagtgccca tgccagaagc cagcgcgttt
2641 ttcatcttca gctctaacaa caggtttcgc ctccagtgcc accgcattgt caatgacacg
2701 atcttcacca acctgatcct cttcttcatt ctgctcagca gcatttccct ggctgctgag
2761 gacccggtcc agcacacctc cttcaggaac catattctgt tttattttga tattgttttt
2821 accaccattt tcaccattga aattgctctg aagatgactg cttatggggc tttcttgcac
2881 aagggttctt tctgccggaa ctacttcaac atcctggacc tgctggtggt cagcgtgtcc
2941 ctcatctcct ttggcatcca gtccagtgca atcaatgtcg tgaagatctt gcgagtcctg
3001 cgagtactca ggcccctgag ggccatcaac agggccaagg ggctaaagca tgtggttcag
3061 tgtgtgtttg tcgccatccg gaccatcggg aacatcgtga ttgtcaccac cctgctgcag
3121 ttcatgtttg cctgcatcgg ggtccagctc ttcaagggaa agctgtacac ctgttcagac
3181 agttccaagc agacagaggc ggaatgcaag ggcaactaca tcacgtacaa agacggggag
3241 gttgaccacc ccatcatcca accccgcagc tgggagaaca gcaagtttga ctttgacaat
3301 gttctggcag ccatgatggc cctcttcacc gtctccacct tcgaagggtg gccagagctg
3361 ctgtaccgct ccatcgactc ccacacggaa gacaagggcc ccatctacaa ctaccgtgtg
3421 gagatctcca tcttcttcat catctacatc atcatcatcg ccttcttcat gatgaacatc
3481 ttcgtgggct tcgtcatcgt cacctttcag gagcaggggg agcaggagta caagaactgt
3541 gagctggaca agaaccagcg acagtgcgtg gaatacgccc tcaaggcccg gcccctgcgg
3601 aggtacatcc ccaagaacca gcaccagtac aaagtgtggt acgtggtcaa ctccacctac
3661 ttcgagtacc tgatgttcgt cctcatcctg ctcaacacca tctgcctggc catgcagcac
3721 tacggccaga gctgcctgtt caaaatcgcc atgaacatcc tcaacatgct cttcactggc
3781 ctcttcaccg tggagatgat cctgaagctc attgccttca aacccaagca ctatttctgt
3841 gatgcatgga atacatttga cgccttgatt gttgtgggta gcattgttga tatagcaatc
3901 accgaggtaa acccagctga acatacccaa tgctctccct ctatggggcc ctcctgttct
3961 cacccccctc ttgctgtgct aactgcacct cctgttgccg acgggttcca gaacgcagag
4021 gaaaactccc gcatctccat caccttcttc cgcctgttcc gggtcatgcg tctggtgaag
4081 ctgctgagcc gtggggaggg catccggacg ctgctgtgga ccttcatcaa gtccttccag
4141 gccctgccct atgtggccct cctgatcgtg atgctgttct tcatctacgc ggtgatcggg
4201 atgcaggtgt ttgggaaaat tgccctgaat gataccacag agatcaaccg gaacaacaac
4261 tttcagacct tcccccaggc cgtgctgctc ctcttcaggt gtgccaccgg ggaggcctgg
4321 caggacatca tgctggcctg catgccaggc aagaagtgtg ccccagagtc cgagcccagc
4381 aacagcacgg agggtgaaac accctgtggt agcagctttg ctgtcttcta cttcatcagc
4441 ttctacatgc tctgtgcctt cctgatcatc aacctctttg tagctgtcat catggacaac
4501 tttgactacc tgacaaggga ctggtccatc cttggtcccc accacctgga tgagtttaaa
4561 agaatctggg cagagtatga ccctgaagcc aagggtcgta tcaaacacct ggatgtggtg
4621 accctcctcc ggcggattca gccgccacta ggttttggga agctgtgccc tcaccgcgtg
4681 gcttgcaaac gcctggtctc catgaacatg cctctgaaca gcgacgggac agtcatgttc
4741 aatgccaccc tgtttgccct ggtcaggacg gccctgagga tcaaaacaga agagggaccc
4801 agcccatcag aggcccacca aggggctgag gatcctttcc gccctgcagg gaacctagaa
4861 caagccaatg aggagctgcg ggcgatcatc aagaagatct ggaagcggac cagcatgaag
4921 ctgctggacc aggtggtgcc ccctgcaggt gatgatgagg tcaccgttgg caagttctac
4981 gccacgttcc tgatccagga gtacttccgg aagttcaaga agcgcaaaga gcagggcctt
5041 gtgggcaagc cctcccagag gaacgcgctg tctctgcagg ctggcttgcg cacactgcat
5101 gacatcgggc ctgagatccg acgggccatc tctggagatc tcaccgctga ggaggagctg
5161 gacaaggcca tgaaggaggc tgtgtccgct gcttctgaag atgacatctt caggagggcc
5221 ggtggcctgt tcggcaacca cgtcagctac taccaaagcg acggccggag cgccttcccc
5281 cagaccttca ccactcagcg cccgctgcac atcaacaagg cgggcagcag ccagggcgac
5341 actgagtcgc catcccacga gaagctggtg gactccacct tcaccccgag cagctactcg
5401 tccaccggct ccaacgccaa catcaacaac gccaacaaca ccgccctggg tcgcctccct
5461 cgccccgccg gctaccccag cacggtcagc actgtggagg gccacgggcc ccccttgtcc
5521 cctgccatcc gggtgcagga ggtggcgtgg aagctcagct ccaacaggtg ccactcccgg
5581 gagagccagg cagccatggc gggtcaggag gagacgtctc aggatgagac ctatgaagtg
5641 aagatgaacc atgacacgga ggcctgcagt gagcccagcc tgctctccac agagatgctc
5701 tcctaccagg atgacgaaaa tcggcaactg acgctcccag aggaggacaa gagggacatc
5761 cggcaatctc cgaagagggg tttcctccgc tctgcctcac taggtcgaag ggcctccttc
5821 cacctggaat gtctgaagcg acagaaggac cgagggggag acatctctca gaagacagtc
5881 ctgcccttgc atctggttca tcatcaggca ttggcagtgg caggcctgag ccccctcctc
5941 cagagaagcc attcccctgc ctcattccct aggccttttg ccaccccacc agccacacct
6001 ggcagccgag gctggccccc acagcccgtc cccaccctgc ggcttgaggg ggtcgagtcc
6061 agtgagaaac tcaacagcag cttcccatcc atccactgcg gctcctgggc tgagaccacc
6121 cccggtggcg ggggcagcag cgccgcccgg agagtccggc ccgtctccct catggtgccc
6181 agccaggctg gggccccagg gaggcagttc cacggcagtg ccagcagcct ggtggaagcg
6241 gtcttgattt cagaaggact ggggcagttt gctcaagatc ccaagttcat cgaggtcacc
6301 acccaggagc tggccgacgc ctgcgacatg accatagagg agatggagag cgcggccgac
6361 aacatcctca gcgggggcgc cccacagagc cccaatggcg ccctcttacc ctttgtgaac
6421 tgcagggacg cggggcagga ccgagccggg ggcgaggagg acgcgggctg tgtgcgcgcg
6481 cggggtgcac cgagtgagga ggagctccag gacagcaggg tctacgtcag cagcctgtag
6541 tgggcgctgc cagatgcggg cttttttttt tttatttgtt tcaatgttcc taatgggttc
6601 gtttcagaag tgcctcactg ttctcgtgac ctggagtt
//