LOCUS AY830711 6533 bp mRNA linear HUM 08-NOV-2006
DEFINITION Homo sapiens clone HLCC125 voltage-dependent L-type calcium channel
alpha-1C subunit splice variant mRNA, complete cds, alternatively
spliced.
ACCESSION AY830711
VERSION AY830711.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6533)
AUTHORS Tiwari,S., Zhang,Y., Heller,J., Abernethy,D.R. and Soldatov,N.M.
TITLE Atherosclerosis-related molecular alteration of the human CaV1.2
calcium channel alpha1C subunit
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 103 (45), 17024-17029 (2006)
PUBMED 17071743
REFERENCE 2 (bases 1 to 6533)
AUTHORS Tiwari,S., Abernethy,D.R. and Soldatov,N.M.
TITLE Direct Submission
JOURNAL Submitted (17-NOV-2004) Laboratory of Clinical Investigations,
National Institute on Aging, NIH, 5600 Nathan Shock Drive,
Baltimore, MD 21224, USA
FEATURES Location/Qualifiers
source 1..6533
/db_xref="H-InvDB:HIT000332403"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="HLCC125"
/cell_type="smooth muscle"
CDS 1..6435
/note="Cav1.2; alternatively spliced"
/codon_start=1
/product="voltage-dependent L-type calcium channel
alpha-1C subunit splice variant"
/protein_id="AAX37354.1"
/translation="MVNENTRMYIPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIP
TPGAALSWQAAIDAARQAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR
ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLE
RVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA
DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVL
FVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP
GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIG
SFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPE
NEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR
WNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLAL
FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL
LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEM
QTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICG
NYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE
SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVG
PRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSS
ISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNIL
DLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIG
NIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQP
RSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFF
IIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIP
KNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLF
TVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITENAEENSRISITFFRLFRV
MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTT
EINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGS
SFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPE
AKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFAL
VRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWKRTSMKLLDQV
VPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTLHDIG
PEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQ
TFTTQRPLHINKAGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALGRL
PRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAMAGQEETSQDET
YEVKMNHDTEACSEPSLLSTEMLSYQDDENRQLTLPEEDKRDIRQSPKRGFLRSASLG
RRASFHLECLKRQKDRGGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPF
ATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARR
VRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACD
MTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAGQDRAGGEEDAGCVRARGAPSEE
ELQDSRVYVSSL"
BASE COUNT 1464 a 1930 c 1771 g 1368 t
ORIGIN
1 atggtcaatg agaatacgag gatgtacatt ccagaggaaa accaccaagg ttccaactat
61 gggagcccac gccccgccca tgccaacatg aatgccaatg cggcagcggg gctggcccct
121 gagcacatcc ccaccccggg ggctgccctg tcgtggcagg cggccatcga cgcagcccgg
181 caggctaagc tgatgggcag cgctggcaat gcgaccatct ccacagtcag ctccacgcag
241 cggaagcggc agcaatatgg gaaacccaag aagcagggca gcaccacggc cacacgcccg
301 ccccgagccc tgctctgcct gaccctgaag aaccccatcc ggagggcctg catcagcatt
361 gtcgaatgga aaccatttga aataattatt ttactgacta tttttgccaa ttgtgtggcc
421 ttagcgatct atattccctt tccagaagat gattccaacg ccaccaattc caacctggaa
481 cgagtggaat atctctttct cataattttt acggtggaag cgtttttaaa agtaatcgcc
541 tatggactcc tctttcaccc caatgcctac ctccgcaacg gctggaacct actagatttt
601 ataattgtgg ttgtggggct ttttagtgca attttagaac aagcaaccaa agcagatggg
661 gcaaacgctc tcggagggaa aggggccgga tttgatgtga aggcgctgag ggccttccgc
721 gtgctgcgcc ccctgcggct ggtgtccgga gtcccaagtc tccaggtggt cctgaattcc
781 atcatcaagg ccatggtccc cctgctgcac atcgccctgc ttgtgctgtt tgtcatcatc
841 atctacgcca tcatcggctt ggagctcttc atggggaaga tgcacaagac ctgctacaac
901 caggagggca tagcagatgt tccagcagaa gatgaccctt ccccttgtgc gctggaaacg
961 ggccacgggc ggcagtgcca gaacggcacg gtgtgcaagc ccggctggga tggtcccaag
1021 cacggcatca ccaactttga caactttgcc ttcgccatgc tcacggtgtt ccagtgcatc
1081 accatggagg gctggacgga cgtgctgtac tgggtcaatg atgccgtagg aagggactgg
1141 ccctggatct attttgttac actaatcatc atagggtcat tttttgtact taacttggtt
1201 ctcggtgtgc ttagcggaga gttttccaaa gagagggaga aggccaaggc ccggggagat
1261 ttccagaagc tgcgggagaa gcagcagcta gaagaggatc tcaaaggcta cctggattgg
1321 atcactcagg ccgaagacat cgatcctgag aatgaggacg aaggcatgga tgaggagaag
1381 ccccgaaaca tgagcatgcc caccagtgag accgagtccg tcaacaccga aaacgtggct
1441 ggaggtgaca tcgagggaga aaactgcggg gccaggctgg cccaccggat ctccaagtca
1501 aagttcagcc gctactggcg ccggtggaat cggttctgca gaaggaagtg ccgcgccgca
1561 gtcaagtcta atgtcttcta ctggctggtg attttcctgg tgttcctcaa cacgctcacc
1621 attgcctctg agcactacaa ccagcccaac tggctcacag aagtccaaga cacggcaaac
1681 aaggccctgc tggccctgtt cacggcagag atgctcctga agatgtacag cctgggcctg
1741 caggcctact tcgtgtccct cttcaaccgc tttgactgct tcgtcgtgtg tggcggcatc
1801 ctggagacca tcctggtgga gaccaagatc atgtccccac tgggcatctc cgtgctcaga
1861 tgcgtccggc tgctgaggat tttcaagatc acgaggtact ggaactcctt gagcaacctg
1921 gtggcatcct tgctgaactc tgtgcgctcc atcgcctccc tgctccttct cctcttcctc
1981 ttcatcatca tcttctccct cctggggatg cagctctttg gaggaaagtt caactttgat
2041 gagatgcaga cccggaggag cacattcgat aacttccccc agtccctcct cactgtgttt
2101 cagatcctga ccggggagga ctggaattcg gtgatgtatg atgggatcat ggcttatggc
2161 ggcccctctt ttccagggat gttagtctgt atttacttca tcatcctctt catctgtgga
2221 aactatatcc tactgaatgt gttcttggcc attgctgtgg acaacctggc tgatgctgag
2281 agcctcacat ctgcccaaaa ggaggaggaa gaggagaagg agagaaagaa gctggccagg
2341 actgccagcc cagagaagaa acaagagttg gtggagaagc cggcagtggg ggaatccaag
2401 gaggagaaga ttgagctgaa atccatcacg gctgacggag agtctccacc cgccaccaag
2461 atcaacatgg atgacctcca gcccaatgaa aatgaggata agagccccta ccccaaccca
2521 gaaactacag gagaagagga tgaggaggag ccagagatgc ctgtcggccc tcgcccacga
2581 ccactctctg agcttcacct taaggaaaag gcagtgccca tgccagaagc cagcgcgttt
2641 ttcatcttca gctctaacaa caggtttcgc ctccagtgcc accgcattgt caatgacacg
2701 atcttcacca acctgatcct cttcttcatt ctgctcagca gcatttccct ggctgctgag
2761 gacccggtcc agcacacctc cttcaggaac catattctgt tttattttga tattgttttt
2821 accaccattt tcaccattga aattgctctg aagatgactg cttatggggc tttcttgcac
2881 aagggttctt tctgccggaa ctacttcaac atcctggacc tgctggtggt cagcgtgtcc
2941 ctcatctcct ttggcatcca gtccagtgca atcaatgtcg tgaagatctt gcgagtcctg
3001 cgagtactca ggcccctgag ggccatcaac agggccaagg ggctaaagca tgtggttcag
3061 tgtgtgtttg tcgccatccg gaccatcggg aacatcgtga ttgtcaccac cctgctgcag
3121 ttcatgtttg cctgcatcgg ggtccagctc ttcaagggaa agctgtacac ctgttcagac
3181 agttccaagc agacagaggc ggaatgcaag ggcaactaca tcacgtacaa agacggggag
3241 gttgaccacc ccatcatcca accccgcagc tgggagaaca gcaagtttga ctttgacaat
3301 gttctggcag ccatgatggc cctcttcacc gtctccacct tcgaagggtg gccagagctg
3361 ctgtaccgct ccatcgactc ccacacggaa gacaagggcc ccatctacaa ctaccgtgtg
3421 gagatctcca tcttcttcat catctacatc atcatcatcg ccttcttcat gatgaacatc
3481 ttcgtgggct tcgtcatcgt cacctttcag gagcaggggg agcaggagta caagaactgt
3541 gagctggaca agaaccagcg acagtgcgtg gaatacgccc tcaaggcccg gcccctgcgg
3601 aggtacatcc ccaagaacca gcaccagtac aaagtgtggt acgtggtcaa ctccacctac
3661 ttcgagtacc tgatgttcgt cctcatcctg ctcaacacca tctgcctggc catgcagcac
3721 tacggccaga gctgcctgtt caaaatcgcc atgaacatcc tcaacatgct cttcactggc
3781 ctcttcaccg tggagatgat cctgaagctc attgccttca aacccaagca ctatttctgt
3841 gatgcatgga atacatttga cgccttgatt gttgtgggta gcattgttga tatagcaatc
3901 accgagaacg cagaggaaaa ctcccgcatc tccatcacct tcttccgcct gttccgggtc
3961 atgcgtctgg tgaagctgct gagccgtggg gagggcatcc ggacgctgct gtggaccttc
4021 atcaagtcct tccaggccct gccctatgtg gccctcctga tcgtgatgct gttcttcatc
4081 tacgcggtga tcgggatgca ggtgtttggg aaaattgccc tgaatgatac cacagagatc
4141 aaccggaaca acaactttca gaccttcccc caggccgtgc tgctcctctt caggtgtgcc
4201 accggggagg cctggcagga catcatgctg gcctgcatgc caggcaagaa gtgtgcccca
4261 gagtccgagc ccagcaacag cacggagggt gaaacaccct gtggtagcag ctttgctgtc
4321 ttctacttca tcagcttcta catgctctgt gccttcctga tcatcaacct ctttgtagct
4381 gtcatcatgg acaactttga ctacctgaca agggactggt ccatccttgg tccccaccac
4441 ctggatgagt ttaaaagaat ctgggcagag tatgaccctg aagccaaggg tcgtatcaaa
4501 cacctggatg tggtgaccct cctccggcgg attcagccgc cactaggttt tgggaagctg
4561 tgccctcacc gcgtggcttg caaacgcctg gtctccatga acatgcctct gaacagcgac
4621 gggacagtca tgttcaatgc caccctgttt gccctggtca ggacggccct gaggatcaaa
4681 acagaagagg gacccagccc atcagaggcc caccaagggg ctgaggatcc tttccgccct
4741 gcagggaacc tagaacaagc caatgaggag ctgcgggcga tcatcaagaa gatctggaag
4801 cggaccagca tgaagctgct ggaccaggtg gtgccccctg caggtgatga tgaggtcacc
4861 gttggcaagt tctacgccac gttcctgatc caggagtact tccggaagtt caagaagcgc
4921 aaagagcagg gccttgtggg caagccctcc cagaggaacg cgctgtctct gcaggctggc
4981 ttgcgcacac tgcatgacat cgggcctgag atccgacggg ccatctctgg agatctcacc
5041 gctgaggagg agctggacaa ggccatgaag gaggctgtgt ccgctgcttc tgaagatgac
5101 atcttcagga gggccggtgg cctgttcggc aaccacgtca gctactacca aagcgacggc
5161 cggagcgcct tcccccagac cttcaccact cagcgcccgc tgcacatcaa caaggcgggc
5221 agcagccagg gcgacactga gtcgccatcc cacgagaagc tggtggactc caccttcacc
5281 ccgagcagct actcgtccac cggctccaac gccaacatca acaacgccaa caacaccgcc
5341 ctgggtcgcc tccctcgccc cgccggctac cccagcacgg tcagcactgt ggagggccac
5401 gggcccccct tgtcccctgc catccgggtg caggaggtgg cgtggaagct cagctccaac
5461 aggtgccact cccgggagag ccaggcagcc atggcgggtc aggaggagac gtctcaggat
5521 gagacctatg aagtgaagat gaaccatgac acggaggcct gcagtgagcc cagcctgctc
5581 tccacagaga tgctctccta ccaggatgac gaaaatcggc aactgacgct cccagaggag
5641 gacaagaggg acatccggca atctccgaag aggggtttcc tccgctctgc ctcactaggt
5701 cgaagggcct ccttccacct ggaatgtctg aagcgacaga aggaccgagg gggagacatc
5761 tctcagaaga cagtcctgcc cttgcatctg gttcatcatc aggcattggc agtggcaggc
5821 ctgagccccc tcctccagag aagccattcc cctgcctcat tccctaggcc ttttgccacc
5881 ccaccagcca cacctggcag ccgaggctgg cccccacagc ccgtccccac cctgcggctt
5941 gagggggtcg agtccagtga gaaactcaac agcagcttcc catccatcca ctgcggctcc
6001 tgggctgaga ccacccccgg tggcgggggc agcagcgccg cccggagagt ccggcccgtc
6061 tccctcatgg tgcccagcca ggctggggcc ccagggaggc agttccacgg cagtgccagc
6121 agcctggtgg aagcggtctt gatttcagaa ggactggggc agtttgctca agatcccaag
6181 ttcatcgagg tcaccaccca ggagctggcc gacgcctgcg acatgaccat agaggagatg
6241 gagagcgcgg ccgacaacat cctcagcggg ggcgccccac agagccccaa tggcgccctc
6301 ttaccctttg tgaactgcag ggacgcgggg caggaccgag ccgggggcga ggaggacgcg
6361 ggctgtgtgc gcgcgcgggg tgcaccgagt gaggaggagc tccaggacag cagggtctac
6421 gtcagcagcc tgtagtgggc gctgccagat gcgggctttt ttttttttat ttgtttcaat
6481 gttcctaatg ggttcgtttc agaagtgcct cactgttctc gtgacctgga gtt
//