LOCUS AY756062 1733 bp mRNA linear HUM 18-OCT-2004 DEFINITION Homo sapiens 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 splice isoform 3 mRNA, complete cds, alternatively spliced. ACCESSION AY756062 VERSION AY756062.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1733) AUTHORS Minchenko,O., Opentanova,I., Minchenko,D., Ogura,T. and Esumi,H. TITLE Hypoxia induces transcription of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 gene via hypoxia-inducible factor-1alpha activation JOURNAL FEBS Lett. 576 (1-2), 14-20 (2004) PUBMED 15474002 REFERENCE 2 (bases 1 to 1733) AUTHORS Minchenko,D., Opentanova,I. and Minchenko,O. TITLE Direct Submission JOURNAL Submitted (20-SEP-2004) Molecular Biology, Palladin Institute of Biochemistry NAS, Leontovycha 9, Kyiv 01601, Ukraine FEATURES Location/Qualifiers source 1..1733 /db_xref="H-InvDB:HIT000257633" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="3" /map="3p22-p21" /cell_line="DB-1" /cell_type="melanoma" misc_difference 137..348 /replace="" CDS 353..1660 /EC_number="3.1.3.46" /EC_number="2.7.1.105" /function="catalyzes synthesis and degradation of fructose-2,6-biphosphate" /note="alternatively spliced; bifunctional enzyme with kinase and phosphatase activities; PFK-2; PFK-2/F-2,7BPase; PKFKB" /codon_start=1 /product="6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 4 splice isoform 3" /protein_id="AAV28717.1" /translation="MTNCPTLIVMVGLPARGKTYISKKLTRYLNWIGVPTREFNVGQY RRDVVKTYKSFEFFLPDNEEGLKIRKQCALAALRDVRRFLSEEGGHVAVFDATNTTRE RRATIFNFGEQNGYKTFFVESICVDPEVIAANIVQVKLGSPDYVNRDSDEATEDFMRR IECYENSYESLDEDLDRDLSYIKIMDVGQSYVVNRVADHIQSRIVYYLMNIHVTPRSI YLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQT AEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDNYPLEFALRDQDKYRYRYPKGESYED LVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKLTPV AYGCKVESIFLNVAAVNTHRDRPQNVDISRPPEEALVTVPAHQ" BASE COUNT 393 a 463 c 527 g 350 t ORIGIN 1 gggctgtcgc ggcttgagga ggggcggggc ccaaggggcg ggacctcggg tggcccgagg 61 tggcccggct gctgggttgg aagcggcgca gtccgactca tcccggcccc gggatggcgt 121 ccccacggga attgacacag aaccccctga agaagatctg gatgccatac agcaatgggc 181 ggcccgctct gcacgcttgc cagcgcggtg gtgggctagt tttccaacag gaggaagggt 241 gcctcttggc cttaaagcgt gctttgggca ggaacttcag cagagatgtg ctcaggatag 301 agacagaaaa gtatgccgtg tgggcctgtg tctgtgtccc gggacattgt gcatgaccaa 361 ctgcccaact ctcattgtca tggtgggcct gcccgccagg ggcaagacct acatctccaa 421 gaagctgact cgatacctga actggattgg tgtgcccact cgggagttca atgttggcca 481 gtatcgccgg gacgtggtca agacctacaa atcttttgaa ttttttctcc ccgacaatga 541 agagggcctg aaaatcagga agcagtgtgc cctggcagcc ctccgtgacg tccggcggtt 601 ccttagtgag gaggggggac atgtggcggt ttttgatgcc acaaacacca cccgagaacg 661 gagagcgacc atctttaatt ttggagaaca gaatggctac aagacctttt ttgtcgagtc 721 catctgtgtg gatcctgagg tcatagctgc caacatcgtg caagtgaaac tgggcagccc 781 tgactatgtc aaccgcgaca gtgatgaggc tacggaggac ttcatgaggc gcattgagtg 841 ctatgagaac tcctacgagt cgctagatga ggacctggat agggacctgt cctatatcaa 901 gatcatggat gtgggccaga gctacgtggt gaaccgtgtg gctgaccaca tccagagccg 961 catcgtatat tacctcatga acatccacgt gaccccccgc tccatctacc tctgccggca 1021 cggggagagc gagctcaacc tcaagggccg gattggcggg gacccaggac tgtcccctcg 1081 gggcagggag tttgccaaga gtctagccca gttcatcagt gaccaaaata tcaaggatct 1141 gaaggtctgg acaagccaga tgaagaggac aatccagacg gctgaggcac tgggtgtgcc 1201 ctatgaacag tggaaggtcc tcaacgagat cgatgcgggc gtctgtgagg aaatgaccta 1261 cgaggaaatt caggataatt atccactgga gttcgccctg cgggaccagg acaagtaccg 1321 gtaccggtac cctaaagggg agtcctacga ggacctggtc cagagactgg agcctgtcat 1381 catggagctg gagaggcaag agaatgtgct ggtcatctgc caccaggctg tgatgcgctg 1441 cctgctggcc tacttcctcg acaaggcagc agaacagctg ccctacctca agtgtccgct 1501 gcacacagtc ctgaagctga ctcctgtggc atatggttgt aaagtggagt ccatattcct 1561 gaacgtggct gctgtgaaca cgcaccggga caggcctcag aacgtggaca tctcaagacc 1621 tccagaggaa gcccttgtca cggtgcctgc tcaccagtga ccatgttcat ccactgtgac 1681 cactaggcag gcactgctct ctgcagaggg ggtcattcca ggccctccag tgt //