LOCUS       AY756062                1733 bp    mRNA    linear   HUM 18-OCT-2004
DEFINITION  Homo sapiens 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
            splice isoform 3 mRNA, complete cds, alternatively spliced.
ACCESSION   AY756062
VERSION     AY756062.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1733)
  AUTHORS   Minchenko,O., Opentanova,I., Minchenko,D., Ogura,T. and Esumi,H.
  TITLE     Hypoxia induces transcription of
            6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 gene via
            hypoxia-inducible factor-1alpha activation
  JOURNAL   FEBS Lett. 576 (1-2), 14-20 (2004)
   PUBMED   15474002
REFERENCE   2  (bases 1 to 1733)
  AUTHORS   Minchenko,D., Opentanova,I. and Minchenko,O.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-SEP-2004) Molecular Biology, Palladin Institute of
            Biochemistry NAS, Leontovycha 9, Kyiv 01601, Ukraine
FEATURES             Location/Qualifiers
     source          1..1733
                     /db_xref="H-InvDB:HIT000257633"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22-p21"
                     /cell_line="DB-1"
                     /cell_type="melanoma"
     misc_difference 137..348
                     /replace=""
     CDS             353..1660
                     /EC_number="3.1.3.46"
                     /EC_number="2.7.1.105"
                     /function="catalyzes synthesis and degradation of
                     fructose-2,6-biphosphate"
                     /note="alternatively spliced; bifunctional enzyme with
                     kinase and phosphatase activities; PFK-2;
                     PFK-2/F-2,7BPase; PKFKB"
                     /codon_start=1
                     /product="6-phosphofructo-2-kinase/fructose-2,
                     6-biphosphatase 4 splice isoform 3"
                     /protein_id="AAV28717.1"
                     /translation="MTNCPTLIVMVGLPARGKTYISKKLTRYLNWIGVPTREFNVGQY
                     RRDVVKTYKSFEFFLPDNEEGLKIRKQCALAALRDVRRFLSEEGGHVAVFDATNTTRE
                     RRATIFNFGEQNGYKTFFVESICVDPEVIAANIVQVKLGSPDYVNRDSDEATEDFMRR
                     IECYENSYESLDEDLDRDLSYIKIMDVGQSYVVNRVADHIQSRIVYYLMNIHVTPRSI
                     YLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQT
                     AEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDNYPLEFALRDQDKYRYRYPKGESYED
                     LVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKLTPV
                     AYGCKVESIFLNVAAVNTHRDRPQNVDISRPPEEALVTVPAHQ"
BASE COUNT          393 a          463 c          527 g          350 t
ORIGIN      
        1 gggctgtcgc ggcttgagga ggggcggggc ccaaggggcg ggacctcggg tggcccgagg
       61 tggcccggct gctgggttgg aagcggcgca gtccgactca tcccggcccc gggatggcgt
      121 ccccacggga attgacacag aaccccctga agaagatctg gatgccatac agcaatgggc
      181 ggcccgctct gcacgcttgc cagcgcggtg gtgggctagt tttccaacag gaggaagggt
      241 gcctcttggc cttaaagcgt gctttgggca ggaacttcag cagagatgtg ctcaggatag
      301 agacagaaaa gtatgccgtg tgggcctgtg tctgtgtccc gggacattgt gcatgaccaa
      361 ctgcccaact ctcattgtca tggtgggcct gcccgccagg ggcaagacct acatctccaa
      421 gaagctgact cgatacctga actggattgg tgtgcccact cgggagttca atgttggcca
      481 gtatcgccgg gacgtggtca agacctacaa atcttttgaa ttttttctcc ccgacaatga
      541 agagggcctg aaaatcagga agcagtgtgc cctggcagcc ctccgtgacg tccggcggtt
      601 ccttagtgag gaggggggac atgtggcggt ttttgatgcc acaaacacca cccgagaacg
      661 gagagcgacc atctttaatt ttggagaaca gaatggctac aagacctttt ttgtcgagtc
      721 catctgtgtg gatcctgagg tcatagctgc caacatcgtg caagtgaaac tgggcagccc
      781 tgactatgtc aaccgcgaca gtgatgaggc tacggaggac ttcatgaggc gcattgagtg
      841 ctatgagaac tcctacgagt cgctagatga ggacctggat agggacctgt cctatatcaa
      901 gatcatggat gtgggccaga gctacgtggt gaaccgtgtg gctgaccaca tccagagccg
      961 catcgtatat tacctcatga acatccacgt gaccccccgc tccatctacc tctgccggca
     1021 cggggagagc gagctcaacc tcaagggccg gattggcggg gacccaggac tgtcccctcg
     1081 gggcagggag tttgccaaga gtctagccca gttcatcagt gaccaaaata tcaaggatct
     1141 gaaggtctgg acaagccaga tgaagaggac aatccagacg gctgaggcac tgggtgtgcc
     1201 ctatgaacag tggaaggtcc tcaacgagat cgatgcgggc gtctgtgagg aaatgaccta
     1261 cgaggaaatt caggataatt atccactgga gttcgccctg cgggaccagg acaagtaccg
     1321 gtaccggtac cctaaagggg agtcctacga ggacctggtc cagagactgg agcctgtcat
     1381 catggagctg gagaggcaag agaatgtgct ggtcatctgc caccaggctg tgatgcgctg
     1441 cctgctggcc tacttcctcg acaaggcagc agaacagctg ccctacctca agtgtccgct
     1501 gcacacagtc ctgaagctga ctcctgtggc atatggttgt aaagtggagt ccatattcct
     1561 gaacgtggct gctgtgaaca cgcaccggga caggcctcag aacgtggaca tctcaagacc
     1621 tccagaggaa gcccttgtca cggtgcctgc tcaccagtga ccatgttcat ccactgtgac
     1681 cactaggcag gcactgctct ctgcagaggg ggtcattcca ggccctccag tgt
//