LOCUS AY714243 1744 bp mRNA linear HUM 03-APR-2009 DEFINITION Homo sapiens 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 isoform 2 (PFKFB4) mRNA, complete cds, alternatively spliced. ACCESSION AY714243 VERSION AY714243.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1744) AUTHORS Minchenko,O.H., Opentanova,I.L., Minchenko,D.O., Ogura,T. and Esumi,H. TITLE Hypoxia induces transcription of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 gene via hypoxia-inducible factor-1alpha activation JOURNAL FEBS Lett. (2004) In press REFERENCE 2 (bases 1 to 1744) AUTHORS Minchenko,O.H., Opentanova,I.L., Minchenko,D.O., Kurashima,Y. and Esumi,H. TITLE Alternative splicing of human 6-phosphofructo-2-kinase/fructose-2,6-phosphatase 4 in melanoma cells JOURNAL Unpublished REFERENCE 3 (bases 1 to 1744) AUTHORS Kurashima,Y. and Esumi,H. TITLE Direct Submission JOURNAL Submitted (10-AUG-2004) National Cancer Center Research Institute East, Investigative Treatment Division, Kashiwa, Chiba 2778577, Japan REFERENCE 4 (bases 1 to 1744) AUTHORS Minchenko,O.H., Opentanova,I.L. and Minchenko,D.O. TITLE Direct Submission JOURNAL Submitted (10-AUG-2004) Molecular Biology, Institute of Biochemistry, Leontovycha 9, Kyiv 01601, Ukraine FEATURES Location/Qualifiers source 1..1744 /db_xref="H-InvDB:HIT000257329" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /cell_line="DB-1" /cell_type="melanoma" gene 1..1744 /gene="PFKFB4" CDS 364..1671 /gene="PFKFB4" /EC_number="2.7.1.105" /EC_number="3.1.3.46" /function="catalyzes the synthesis and degradation of fructose-2,6-biphosphate" /note="bifunctional enzyme with kinase and biphosphatase activities; alternatively spliced, fructose-6-phosphate-2-kinase/fructose-2,6-biphosphatase; PFK-2; PFK-2/F-2,6-BPase; PFKFB" /codon_start=1 /product="6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase-4 isoform 2" /protein_id="AAU14998.1" /translation="MTNCPTLIVMVGLPARGKTYISKKLTRYLNWIGVPTREFNVGQY RRDVVKTYKSFEFFLPDNEEGLKIRKQCALAALRDVRRFLSEEGGHVAVFDATNTTRE RRATIFNFGEQNGYKTFFVESICVDPEVIAANIVQVKLGSPDYVNRDSDEATEDFMRR IECYENSYESLDEDLDRDLSYIKIMDVGQSYVVNRVADHIQSRIVYYLMNIHVTPRSI YLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQT AEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDNYPLEFALRDQDKYRYRYPKGESYED LVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKLTPV AYGCKVESIFLNVAAVNTHRDRPQNVDISRPPEEALVTVPAHQ" BASE COUNT 398 a 465 c 528 g 353 t ORIGIN 1 gggctgtcgc ggcttgagga ggggcggggc ccaaggggcg ggacctcggg tggcccgagg 61 tggcccggct gctgggttgg aagcggcgca gtccgactca tcccggcccc gggatggcgt 121 ccccacggga attgacacag aaccccctga agaagatctg gatgccatac agcaatgggc 181 ggcccgctct gcacgcttgc cagcgcggtg aactttcaaa ggtgggctag ttttccaaca 241 ggaggaaggg tgcctcttgg ccttaaagcg tgctttgggc aggaacttca gcagagatgt 301 gctcaggata gagacagaaa agtatgccgt gtgggcctgt gtctgtgtcc cgggacattg 361 tgcatgacca actgcccaac tctcattgtc atggtgggcc tgcccgccag gggcaagacc 421 tacatctcca agaagctgac tcgatacctg aactggattg gtgtgcccac tcgggagttc 481 aatgttggcc agtatcgccg ggacgtggtc aagacctaca aatcttttga attttttctc 541 cccgacaatg aagagggcct gaaaatcagg aagcagtgtg ccctggcagc cctccgtgac 601 gtccggcggt tccttagtga ggagggggga catgtggcgg tttttgatgc cacaaacacc 661 acccgagaac ggagagcgac catctttaat tttggagaac agaatggcta caagaccttt 721 tttgtcgagt ccatctgtgt ggatcctgag gtcatagctg ccaacatcgt gcaagtgaaa 781 ctgggcagcc ctgactatgt caaccgcgac agtgatgagg ctacggagga cttcatgagg 841 cgcattgagt gctatgagaa ctcctacgag tcgctagatg aggacctgga tagggacctg 901 tcctatatca agatcatgga tgtgggccag agctacgtgg tgaaccgtgt ggctgaccac 961 atccagagcc gcatcgtata ttacctcatg aacatccacg tgaccccccg ctccatctac 1021 ctctgccggc acggggagag cgagctcaac ctcaagggcc ggattggcgg ggacccagga 1081 ctgtcccctc ggggcaggga gtttgccaag agtctagccc agttcatcag tgaccaaaat 1141 atcaaggatc tgaaggtctg gacaagccag atgaagagga caatccagac ggctgaggca 1201 ctgggtgtgc cctatgaaca gtggaaggtc ctcaacgaga tcgatgcggg cgtctgtgag 1261 gaaatgacct acgaggaaat tcaggataat tatccactgg agttcgccct gcgggaccag 1321 gacaagtacc ggtaccggta ccctaaaggg gagtcctacg aggacctggt ccagagactg 1381 gagcctgtca tcatggagct ggagaggcaa gagaatgtgc tggtcatctg ccaccaggct 1441 gtgatgcgct gcctgctggc ctacttcctc gacaaggcag cagaacagct gccctacctc 1501 aagtgtccgc tgcacacagt cctgaagctg actcctgtgg catatggttg taaagtggag 1561 tccatattcc tgaacgtggc tgctgtgaac acgcaccggg acaggcctca gaacgtggac 1621 atctcaagac ctccagagga agcccttgtc acggtgcctg ctcaccagtg accatgttca 1681 tccactgtga ccactaggca ggcactgctc tctgcagagg gggtcattcc aggccctcca 1741 gtgt //