LOCUS       AY714243                1744 bp    mRNA    linear   HUM 03-APR-2009
DEFINITION  Homo sapiens 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4
            isoform 2 (PFKFB4) mRNA, complete cds, alternatively spliced.
ACCESSION   AY714243
VERSION     AY714243.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1744)
  AUTHORS   Minchenko,O.H., Opentanova,I.L., Minchenko,D.O., Ogura,T. and
            Esumi,H.
  TITLE     Hypoxia induces transcription of
            6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 gene via
            hypoxia-inducible factor-1alpha activation
  JOURNAL   FEBS Lett. (2004) In press
REFERENCE   2  (bases 1 to 1744)
  AUTHORS   Minchenko,O.H., Opentanova,I.L., Minchenko,D.O., Kurashima,Y. and
            Esumi,H.
  TITLE     Alternative splicing of human
            6-phosphofructo-2-kinase/fructose-2,6-phosphatase 4 in melanoma
            cells
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 1744)
  AUTHORS   Kurashima,Y. and Esumi,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2004) National Cancer Center Research Institute
            East, Investigative Treatment Division, Kashiwa, Chiba 2778577,
            Japan
REFERENCE   4  (bases 1 to 1744)
  AUTHORS   Minchenko,O.H., Opentanova,I.L. and Minchenko,D.O.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2004) Molecular Biology, Institute of
            Biochemistry, Leontovycha 9, Kyiv 01601, Ukraine
FEATURES             Location/Qualifiers
     source          1..1744
                     /db_xref="H-InvDB:HIT000257329"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /cell_line="DB-1"
                     /cell_type="melanoma"
     gene            1..1744
                     /gene="PFKFB4"
     CDS             364..1671
                     /gene="PFKFB4"
                     /EC_number="2.7.1.105"
                     /EC_number="3.1.3.46"
                     /function="catalyzes the synthesis and degradation of
                     fructose-2,6-biphosphate"
                     /note="bifunctional enzyme with kinase and biphosphatase
                     activities; alternatively spliced,
                     fructose-6-phosphate-2-kinase/fructose-2,6-biphosphatase;
                     PFK-2; PFK-2/F-2,6-BPase; PFKFB"
                     /codon_start=1
                     /product="6-phosphofructo-2-kinase/fructose-2,
                     6-biphosphatase-4 isoform 2"
                     /protein_id="AAU14998.1"
                     /translation="MTNCPTLIVMVGLPARGKTYISKKLTRYLNWIGVPTREFNVGQY
                     RRDVVKTYKSFEFFLPDNEEGLKIRKQCALAALRDVRRFLSEEGGHVAVFDATNTTRE
                     RRATIFNFGEQNGYKTFFVESICVDPEVIAANIVQVKLGSPDYVNRDSDEATEDFMRR
                     IECYENSYESLDEDLDRDLSYIKIMDVGQSYVVNRVADHIQSRIVYYLMNIHVTPRSI
                     YLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQT
                     AEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDNYPLEFALRDQDKYRYRYPKGESYED
                     LVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKLTPV
                     AYGCKVESIFLNVAAVNTHRDRPQNVDISRPPEEALVTVPAHQ"
BASE COUNT          398 a          465 c          528 g          353 t
ORIGIN      
        1 gggctgtcgc ggcttgagga ggggcggggc ccaaggggcg ggacctcggg tggcccgagg
       61 tggcccggct gctgggttgg aagcggcgca gtccgactca tcccggcccc gggatggcgt
      121 ccccacggga attgacacag aaccccctga agaagatctg gatgccatac agcaatgggc
      181 ggcccgctct gcacgcttgc cagcgcggtg aactttcaaa ggtgggctag ttttccaaca
      241 ggaggaaggg tgcctcttgg ccttaaagcg tgctttgggc aggaacttca gcagagatgt
      301 gctcaggata gagacagaaa agtatgccgt gtgggcctgt gtctgtgtcc cgggacattg
      361 tgcatgacca actgcccaac tctcattgtc atggtgggcc tgcccgccag gggcaagacc
      421 tacatctcca agaagctgac tcgatacctg aactggattg gtgtgcccac tcgggagttc
      481 aatgttggcc agtatcgccg ggacgtggtc aagacctaca aatcttttga attttttctc
      541 cccgacaatg aagagggcct gaaaatcagg aagcagtgtg ccctggcagc cctccgtgac
      601 gtccggcggt tccttagtga ggagggggga catgtggcgg tttttgatgc cacaaacacc
      661 acccgagaac ggagagcgac catctttaat tttggagaac agaatggcta caagaccttt
      721 tttgtcgagt ccatctgtgt ggatcctgag gtcatagctg ccaacatcgt gcaagtgaaa
      781 ctgggcagcc ctgactatgt caaccgcgac agtgatgagg ctacggagga cttcatgagg
      841 cgcattgagt gctatgagaa ctcctacgag tcgctagatg aggacctgga tagggacctg
      901 tcctatatca agatcatgga tgtgggccag agctacgtgg tgaaccgtgt ggctgaccac
      961 atccagagcc gcatcgtata ttacctcatg aacatccacg tgaccccccg ctccatctac
     1021 ctctgccggc acggggagag cgagctcaac ctcaagggcc ggattggcgg ggacccagga
     1081 ctgtcccctc ggggcaggga gtttgccaag agtctagccc agttcatcag tgaccaaaat
     1141 atcaaggatc tgaaggtctg gacaagccag atgaagagga caatccagac ggctgaggca
     1201 ctgggtgtgc cctatgaaca gtggaaggtc ctcaacgaga tcgatgcggg cgtctgtgag
     1261 gaaatgacct acgaggaaat tcaggataat tatccactgg agttcgccct gcgggaccag
     1321 gacaagtacc ggtaccggta ccctaaaggg gagtcctacg aggacctggt ccagagactg
     1381 gagcctgtca tcatggagct ggagaggcaa gagaatgtgc tggtcatctg ccaccaggct
     1441 gtgatgcgct gcctgctggc ctacttcctc gacaaggcag cagaacagct gccctacctc
     1501 aagtgtccgc tgcacacagt cctgaagctg actcctgtgg catatggttg taaagtggag
     1561 tccatattcc tgaacgtggc tgctgtgaac acgcaccggg acaggcctca gaacgtggac
     1621 atctcaagac ctccagagga agcccttgtc acggtgcctg ctcaccagtg accatgttca
     1681 tccactgtga ccactaggca ggcactgctc tctgcagagg gggtcattcc aggccctcca
     1741 gtgt
//