LOCUS AY707863 1575 bp mRNA linear HUM 04-FEB-2005 DEFINITION Homo sapiens 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 isoform 1 (PFKFB4) mRNA, complete cds, alternatively spliced. ACCESSION AY707863 VERSION AY707863.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1575) AUTHORS Minchenko,O.H., Opentanova,I.L., Minchenko,D.O., Ogura,T. and Esumi,H. TITLE Hypoxia induces transcription of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 gene via hypoxia-inducible factor-1alpha activation JOURNAL FEBS Lett. (2004) In press REFERENCE 2 (bases 1 to 1575) AUTHORS Minchenko,O.H., Opentanova,I.L., Minchenko,D.O., Kurashima,Y. and Esumi,H. TITLE Alternative splicing of human 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 in melanoma cells JOURNAL Unpublished REFERENCE 3 (bases 1 to 1575) AUTHORS Minchenko,O.H., Minchenko,D.O. and Opentanova,I.L. TITLE Direct Submission JOURNAL Submitted (08-AUG-2004) Molecular Biology, Institute of Biochemistry, Leontovycha 9, Kyiv 01601, Ukraine FEATURES Location/Qualifiers source 1..1575 /db_xref="H-InvDB:HIT000257319" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /cell_line="DB-1" /cell_type="melanoma" gene 1..1575 /gene="PFKFB4" CDS 114..1502 /gene="PFKFB4" /EC_number="2.7.1.105" /EC_number="3.1.3.46" /function="catalyzes the synthesis and degradation of fructose-2,6-biphosphate" /note="alternatively spliced; contains deletion in biphosphatase domain box I; bifunctional; contains both kinase and biphosphatase activities; fructose-6-phosphate-2-kinase/fructose-2,6-biphosphatase; PFK-2; PFK-2/F-2,6-BPase; PFKFB" /codon_start=1 /product="6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 4 isoform 1" /protein_id="AAU11326.1" /translation="MASPRELTQNPLKKIWMPYSNGRPALHACQRGVCMTNCPTLIVM VGLPARGKTYISKKLTRYLNWIGVPTREFNVGQYRRDVVKTYKSFEFFLPDNEEGLKI RKQCALAALRDVRRFLSEEGGHVAVFDATNTTRERRATIFNFGEQNGYKTFFVESICV DPEVIAANIVQVKLGSPDYVNRDSDEATEDFMRRIECYENSYESLDEDLDRDLSYIKI MDVGQSYVVNRVADHIQSRIVYYLMNIHVTPRSIYLCRHGESELNLKGRIGGDPGLSP RGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEALGVPYEQWKGVCEEMTYEEIQ DNYPLEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLL AYFLDKAAEQLPYLKCPLHTVLKLTPVAYGCKVESIFLNVAAVNTHRDRPQNVDISRP PEEALVTVPAHQ" BASE COUNT 358 a 430 c 474 g 313 t ORIGIN 1 gggctgtcgc ggcttgagga ggggcggggc ccaaggggcg ggacctcggg tggcccgagg 61 tggcccggct gctgggttgg aagcggcgca gtccgactca tcccggcccc gggatggcgt 121 ccccacggga attgacacag aaccccctga agaagatctg gatgccatac agcaatgggc 181 ggcccgctct gcacgcttgc cagcgcggtg tgtgcatgac caactgccca actctcattg 241 tcatggtggg cctgcccgcc aggggcaaga cctacatctc caagaagctg actcgatacc 301 tgaactggat tggtgtgccc actcgggagt tcaatgttgg ccagtatcgc cgggacgtgg 361 tcaagaccta caaatctttt gaattttttc tccccgacaa tgaagagggc ctgaaaatca 421 ggaagcagtg tgccctggca gccctccgtg acgtccggcg gttccttagt gaggaggggg 481 gacatgtggc ggtttttgat gccacaaaca ccacccgaga acggagagcg accatcttta 541 attttggaga acagaatggc tacaagacct tttttgtcga gtccatctgt gtggatcctg 601 aggtcatagc tgccaacatc gtgcaagtga aactgggcag ccctgactat gtcaaccgcg 661 acagtgatga ggctacggag gacttcatga ggcgcattga gtgctatgag aactcctacg 721 agtcgctaga tgaggacctg gatagggacc tgtcctatat caagatcatg gatgtgggcc 781 agagctacgt ggtgaaccgt gtggctgacc acatccagag ccgcatcgta tattacctca 841 tgaacatcca cgtgaccccc cgctccatct acctctgccg gcacggggag agcgagctca 901 acctcaaggg ccggattggc ggggacccag gactgtcccc tcggggcagg gagtttgcca 961 agagtctagc ccagttcatc agtgaccaaa atatcaagga tctgaaggtc tggacaagcc 1021 agatgaagag gacaatccag acggctgagg cactgggtgt gccctatgaa cagtggaagg 1081 gcgtctgtga ggaaatgacc tacgaggaaa ttcaggataa ttatccactg gagttcgccc 1141 tgcgggacca ggacaagtac cggtaccggt accctaaagg ggagtcctac gaggacctgg 1201 tccagagact ggagcctgtc atcatggagc tggagaggca agagaatgtg ctggtcatct 1261 gccaccaggc tgtgatgcgc tgcctgctgg cctacttcct cgacaaggca gcagaacagc 1321 tgccctacct caagtgtccg ctgcacacag tcctgaagct gactcctgtg gcatatggtt 1381 gtaaagtgga gtccatattc ctgaacgtgg ctgctgtgaa cacgcaccgg gacaggcctc 1441 agaacgtgga catctcaaga cctccagagg aagcccttgt cacggtgcct gctcaccagt 1501 gaccatgttc atccactgtg accactaggc aggcactgct ctctgcagag ggggtcattc 1561 caggccctcc agtgt //