LOCUS       AY707863                1575 bp    mRNA    linear   HUM 04-FEB-2005
DEFINITION  Homo sapiens 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
            isoform 1 (PFKFB4) mRNA, complete cds, alternatively spliced.
ACCESSION   AY707863
VERSION     AY707863.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1575)
  AUTHORS   Minchenko,O.H., Opentanova,I.L., Minchenko,D.O., Ogura,T. and
            Esumi,H.
  TITLE     Hypoxia induces transcription of
            6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 gene via
            hypoxia-inducible factor-1alpha activation
  JOURNAL   FEBS Lett. (2004) In press
REFERENCE   2  (bases 1 to 1575)
  AUTHORS   Minchenko,O.H., Opentanova,I.L., Minchenko,D.O., Kurashima,Y. and
            Esumi,H.
  TITLE     Alternative splicing of human
            6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 in melanoma
            cells
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 1575)
  AUTHORS   Minchenko,O.H., Minchenko,D.O. and Opentanova,I.L.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-AUG-2004) Molecular Biology, Institute of
            Biochemistry, Leontovycha 9, Kyiv 01601, Ukraine
FEATURES             Location/Qualifiers
     source          1..1575
                     /db_xref="H-InvDB:HIT000257319"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /cell_line="DB-1"
                     /cell_type="melanoma"
     gene            1..1575
                     /gene="PFKFB4"
     CDS             114..1502
                     /gene="PFKFB4"
                     /EC_number="2.7.1.105"
                     /EC_number="3.1.3.46"
                     /function="catalyzes the synthesis and degradation of
                     fructose-2,6-biphosphate"
                     /note="alternatively spliced; contains deletion in
                     biphosphatase domain box I; bifunctional; contains both
                     kinase and biphosphatase activities;
                     fructose-6-phosphate-2-kinase/fructose-2,6-biphosphatase;
                     PFK-2; PFK-2/F-2,6-BPase; PFKFB"
                     /codon_start=1
                     /product="6-phosphofructo-2-kinase/fructose-2,
                     6-biphosphatase 4 isoform 1"
                     /protein_id="AAU11326.1"
                     /translation="MASPRELTQNPLKKIWMPYSNGRPALHACQRGVCMTNCPTLIVM
                     VGLPARGKTYISKKLTRYLNWIGVPTREFNVGQYRRDVVKTYKSFEFFLPDNEEGLKI
                     RKQCALAALRDVRRFLSEEGGHVAVFDATNTTRERRATIFNFGEQNGYKTFFVESICV
                     DPEVIAANIVQVKLGSPDYVNRDSDEATEDFMRRIECYENSYESLDEDLDRDLSYIKI
                     MDVGQSYVVNRVADHIQSRIVYYLMNIHVTPRSIYLCRHGESELNLKGRIGGDPGLSP
                     RGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEALGVPYEQWKGVCEEMTYEEIQ
                     DNYPLEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLL
                     AYFLDKAAEQLPYLKCPLHTVLKLTPVAYGCKVESIFLNVAAVNTHRDRPQNVDISRP
                     PEEALVTVPAHQ"
BASE COUNT          358 a          430 c          474 g          313 t
ORIGIN      
        1 gggctgtcgc ggcttgagga ggggcggggc ccaaggggcg ggacctcggg tggcccgagg
       61 tggcccggct gctgggttgg aagcggcgca gtccgactca tcccggcccc gggatggcgt
      121 ccccacggga attgacacag aaccccctga agaagatctg gatgccatac agcaatgggc
      181 ggcccgctct gcacgcttgc cagcgcggtg tgtgcatgac caactgccca actctcattg
      241 tcatggtggg cctgcccgcc aggggcaaga cctacatctc caagaagctg actcgatacc
      301 tgaactggat tggtgtgccc actcgggagt tcaatgttgg ccagtatcgc cgggacgtgg
      361 tcaagaccta caaatctttt gaattttttc tccccgacaa tgaagagggc ctgaaaatca
      421 ggaagcagtg tgccctggca gccctccgtg acgtccggcg gttccttagt gaggaggggg
      481 gacatgtggc ggtttttgat gccacaaaca ccacccgaga acggagagcg accatcttta
      541 attttggaga acagaatggc tacaagacct tttttgtcga gtccatctgt gtggatcctg
      601 aggtcatagc tgccaacatc gtgcaagtga aactgggcag ccctgactat gtcaaccgcg
      661 acagtgatga ggctacggag gacttcatga ggcgcattga gtgctatgag aactcctacg
      721 agtcgctaga tgaggacctg gatagggacc tgtcctatat caagatcatg gatgtgggcc
      781 agagctacgt ggtgaaccgt gtggctgacc acatccagag ccgcatcgta tattacctca
      841 tgaacatcca cgtgaccccc cgctccatct acctctgccg gcacggggag agcgagctca
      901 acctcaaggg ccggattggc ggggacccag gactgtcccc tcggggcagg gagtttgcca
      961 agagtctagc ccagttcatc agtgaccaaa atatcaagga tctgaaggtc tggacaagcc
     1021 agatgaagag gacaatccag acggctgagg cactgggtgt gccctatgaa cagtggaagg
     1081 gcgtctgtga ggaaatgacc tacgaggaaa ttcaggataa ttatccactg gagttcgccc
     1141 tgcgggacca ggacaagtac cggtaccggt accctaaagg ggagtcctac gaggacctgg
     1201 tccagagact ggagcctgtc atcatggagc tggagaggca agagaatgtg ctggtcatct
     1261 gccaccaggc tgtgatgcgc tgcctgctgg cctacttcct cgacaaggca gcagaacagc
     1321 tgccctacct caagtgtccg ctgcacacag tcctgaagct gactcctgtg gcatatggtt
     1381 gtaaagtgga gtccatattc ctgaacgtgg ctgctgtgaa cacgcaccgg gacaggcctc
     1441 agaacgtgga catctcaaga cctccagagg aagcccttgt cacggtgcct gctcaccagt
     1501 gaccatgttc atccactgtg accactaggc aggcactgct ctctgcagag ggggtcattc
     1561 caggccctcc agtgt
//