LOCUS AY648038 4680 bp mRNA linear HUM 07-JUL-2004
DEFINITION Homo sapiens myotonic dystrophy kinase-related CDC42-binding kinase
gamma mRNA, complete cds.
ACCESSION AY648038
VERSION AY648038.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4680)
AUTHORS Ng,Y., Tan,I., Lim,L. and Leung,T.
TITLE Expression of the Homo sapiens myotonic dystrophy kinase-related
CDC42-binding kinase gamma is regulated by promoter DNA methylation
and Sp1 binding
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 4680)
AUTHORS Leung,T., Ng,Y., Tan,I. and Lim,L.
TITLE Direct Submission
JOURNAL Submitted (08-JUN-2004) GSK-IMCB Lab, Institute of Molecular & Cell
Biology, 61 Biopolis Drive, Singapore 138673, Singapore
FEATURES Location/Qualifiers
source 1..4680
/db_xref="H-InvDB:HIT000255935"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 1..4656
/function="phosphorylation of myosin light chain-2 and
MBS85"
/note="protein kinase; serine/threonine kinase, contains
an autoinhibitory motif, GTPase-binding, phorbol
ester-binding"
/codon_start=1
/product="myotonic dystrophy kinase-related CDC42-binding
kinase gamma"
/protein_id="AAT67172.1"
/translation="MERRLRALEQLARGEAGGCPGLDGLLDLLLALHHELSSGPLRRE
RSVAQFLSWASPFVSKVKELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKML
HKWEMLKRAETACFREERDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLL
SRFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCL
RLNTNGMVDSSVAVGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPF
YAESLVETYGKIMNHEDHLQFPPDVPDVPASAQDLIRQLLCRQEERLGRGGLDDFRNH
PFFEGVDWERLASSTAPYIPELRGPMDTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLP
FVGFTYTSGSHSPESSSEAWAALERKLQCLEQEKVELSRKHQEALHAPTDHRELEQLR
KEVQTLRDRLPEMLRDKASLSQTDGPPAGSPGQDSDLRQELDRLHRELAEGRAGLQAQ
EQELCRAQGQQEELLQRLQEAQEREAATASQTRALSSQLEEARAAQRELEAQVSSLSR
QVTQLQGQWEQRLEESSQAKTIHTASETNGMGPPEGGPQEAQLRKEVAALREQLEQAH
SHRRSGKEEALCQLQEENRRLSREQERLEAELAQEQESKQRLEGERRETESNWEAQLA
DILSWVNDEKVSRGYLQALATKMAEELESLRNVGTQTLPARPLDHQWKARRLQKMEAS
ARLELQSALEAEIRAKQGLQERLTQVQEAQLQAERRLQEAEKQSQALQQELAMLREEL
RARGPVDTKPSNSLIPFLSFRSSEKDSAKDPGISGEATRHGGEPDLRPEGRRSLRMGA
VFPRAPTANTASTEGLPAKPGSHTLRPRSFPSPTKCLRCTSLMLGLGRQGLGCDACGY
FCHTTCAPQAPPCPVPPDLLRTALGVHPETGTGTAYEGFLSVPRPSGVRRGWQRVFAA
LSDSRLLLFDAPDLRLSPPSGALLQVLDLRDPQFSATPVLASDVIHAQSRDLPRIFRV
TTSQLAVPPTTCTVLLLAESEGERERWLQVLGELQRLLLDARPRPRPVYTLKEAYDNG
LPLLPHTLCAAILDQDRLALGTEEGLFVIHLRSNDIFQVGECRRVQQLTLSPSAGLLV
VLCGRGPSVRLFALAELENIEVAGAKIPESRGCQVLAAGSILQARTPVLCVAVKRQVL
CYQLGPGPGPWQRRIRELQAPATVQSLGLLGDRLCVGAAGGFALYPLLNEAAPLALGA
GLVPEELPPSRGGLGEALGAVELSLSEFLLLFTTAGIYVDGAGRKSRGHELLWPAAPM
GWGYAAPYLTVFSENSIDVFDVRRAEWVQTVPLKKVRPLNPEGSLFLYGTEKVRLTYL
RNQLAEKDEFDIPDLTDNSRRQLFRTKSKRRFFFRVSEEQQKQQRREMLKDPFVRSKL
ISPPTNFNHLVHVGPANGRPGARDKSPAPEEKGRVARGSGPQRPHSFSEALRRPASMG
SEGLGGDADPMKRKPWTSLSSESVSCPQGSLSPATSLMQVSERPRSLPLSPELESSP"
BASE COUNT 865 a 1490 c 1564 g 761 t
ORIGIN
1 atggagcggc ggctgcgcgc gctggagcag ctggcgcggg gcgaggccgg cggctgcccg
61 gggctcgacg gcctcctaga tctgctgctg gcgctgcacc acgagctcag cagcggcccc
121 ctacggcggg agcgcagcgt ggcgcagttc ctgagctggg ccagcccctt cgtatcaaag
181 gtgaaagaac tgcgtctgca gagagatgac tttgagatct tgaaggtgat cggccgagga
241 gcctttgggg aggtcaccgt ggtgaggcag agggacactg ggcagatttt tgccatgaaa
301 atgctgcaca agtgggagat gctgaagagg gctgagacag cctgtttccg ggaggagcgg
361 gatgtgctcg tgaaagggga cagccgttgg gtgaccactc tgcactatgc cttccaagac
421 gaggagtacc tgtaccttgt gatggactac tatgctggtg gggacctcct gacgctgctg
481 agccgcttcg aggaccgtct cccgcccgag ctggcccagt tctacctggc tgagatggtg
541 ctggccatcc actcgctgca ccagctgggt tatgtccaca gggatgtcaa gccagacaac
601 gtcctgctgg atgtgaacgg gcacattcgc ctggctgact tcggctcctg cctgcgtctc
661 aacaccaacg gcatggtgga ttcatcagtg gcagtaggga cgccggacta tatctcccct
721 gagatcctgc aggccatgga ggagggcaag ggccactacg gcccacagtg tgactggtgg
781 tcgcttggag tctgcgccta tgagctgctc tttggggaga cgcccttcta tgctgagtcc
841 ttggtggaaa cctacggcaa gatcatgaac cacgaggacc acctgcagtt ccccccggac
901 gtgcctgacg tgccagccag cgcccaagac ctgatccgcc agctgctgtg tcgccaggaa
961 gagcggctag gccgtggtgg gctggatgac ttccggaacc atcctttctt cgaaggcgtg
1021 gactgggagc ggctggcgag cagcacggcc ccctatattc ctgagctgcg ggggcccatg
1081 gacacctcca actttgatgt ggatgacgac accctcaacc atccagggac cctgccaccg
1141 ccctcccacg gggccttctc cggccatcac ctgccattcg tgggcttcac ctacacctca
1201 ggcagtcaca gtcctgagag cagctctgag gcttgggctg ccctggagcg gaagctccag
1261 tgtctggagc aggagaaggt ggagctgagc aggaagcacc aagaggccct gcacgccccc
1321 acagaccatc gggagctgga gcagctacgg aaggaagtgc agactctgcg ggacaggctg
1381 ccagagatgc tgagggacaa ggcctcattg tcccagacgg atgggccccc agctggtagc
1441 ccaggtcagg acagtgacct acggcaggag cttgaccgac ttcaccggga gctggccgag
1501 ggtcgggcag ggctgcaggc tcaggagcag gagctctgca gggcccaggg gcagcaggag
1561 gagctgcttc agaggctaca ggaggcccag gagagagagg cggccacagc tagccagacc
1621 cgggccctga gctcccagct ggaggaagcc cgggctgccc agagggagct ggaggcccag
1681 gtgtcctccc tgagccggca ggtgacgcag ctgcagggac agtgggagca acgccttgag
1741 gagtcgtccc aggccaagac catccacacg gcctctgaga ccaacgggat gggaccccct
1801 gagggtgggc ctcaggaggc ccaactgagg aaggaggtgg ccgccctgcg agagcagctg
1861 gagcaggccc acagccacag gcggagtggt aaggaggagg ctctgtgcca gctgcaggag
1921 gaaaaccgga ggctgagccg ggagcaggag cggctagaag cagagctggc ccaggagcag
1981 gagagcaagc agcggctgga gggtgagcgg cgggagacgg agagcaactg ggaggcccag
2041 ctcgccgaca tcctcagctg ggtgaatgat gagaaggtct caagaggcta cctgcaggcc
2101 ctggccacca agatggcaga ggagctggag tccttgagga acgtaggcac ccagacgctc
2161 cctgcccggc cactggacca ccagtggaag gcgcggcgac tgcagaagat ggaggcctcg
2221 gccaggctgg agctgcagtc agcgctggag gccgagatcc gcgccaagca gggcctgcag
2281 gagcggctga cacaggtgca ggaggcccag ctgcaggctg agcgccgtct gcaggaggcc
2341 gagaagcaga gccaggccct gcaacaggag ctcgccatgc tgcgggagga gctgcgggcc
2401 cgagggccag tggacaccaa gccctcaaac tccctgattc ccttcctgtc cttccggagc
2461 tcagagaagg attctgccaa ggaccctggc atctcaggag aggccacaag gcatggagga
2521 gagccagatc tgaggccgga gggccgacgc agcctgcgca tgggggctgt gttccccaga
2581 gcacccactg ccaacacagc ctctacagaa ggtcttcctg ctaagcccgg ctcacacacg
2641 ctgcgccccc ggagcttccc atccccgacc aagtgtctcc gctgcacctc gctgatgctg
2701 ggcctgggcc gccagggcct gggttgtgat gcctgcggct acttttgtca cacaacctgt
2761 gccccacagg ccccaccctg ccccgtgccc cctgacctcc tccgcacagc cctgggagta
2821 caccccgaaa caggcacagg cactgcctat gagggctttc tgtcggtgcc gcggccctca
2881 ggtgtccggc ggggctggca gcgcgtgttt gctgccctga gtgactcacg cctgctgctg
2941 tttgacgccc ctgacctgag gctcagcccg cccagtgggg ccctcctgca ggtcctagat
3001 ctgagggacc cccagttctc ggctacccct gtcctggcct ctgatgttat ccatgcccaa
3061 tccagggacc tgccacgcat ctttagggtg acaacctccc agctggcagt gccgcccacc
3121 acgtgcactg tgctgctgct ggcagagagc gagggggagc gggaacgctg gctgcaggtg
3181 ctgggtgagc tgcagcggct gctgctggac gcgcggccaa gaccccggcc cgtgtacaca
3241 ctcaaggagg cttacgacaa cgggctgccg ctgctgcctc acacgctctg cgctgccatc
3301 ctcgaccagg atcgacttgc gcttggcacc gaggaggggc tctttgtcat ccatctgcgc
3361 agcaacgaca tcttccaggt gggggagtgc cggcgcgtgc agcagctgac cttgagcccc
3421 agtgcaggcc tgctggtcgt gctgtgtggc cgcggcccca gcgtgcgtct ctttgccctg
3481 gcggagctgg agaacataga ggtagcaggt gccaagatcc ccgagtctcg aggctgccag
3541 gtgctggcag ctggaagcat cctgcaggcc cgcaccccgg tgctctgtgt agccgtcaag
3601 cgccaggtgc tctgctacca gctgggcccg ggccctgggc cctggcagcg ccgcatccgt
3661 gagctgcagg cacctgccac tgtgcagagc ctggggctgc tgggcgaccg gctatgtgtg
3721 ggcgccgccg gtggctttgc actctacccg ctgctcaacg aggctgcgcc gttggcgctg
3781 ggggccggtt tggtgcctga ggagctgcca ccatcccgcg ggggcctggg tgaggcactg
3841 ggtgccgtgg agcttagcct cagcgagttc ctgctactct tcaccactgc tggcatctac
3901 gtggatggcg caggccgcaa gtctcgtggc cacgagctgt tgtggccagc agcgcccatg
3961 ggctgggggt atgcggcccc ctacctgaca gtgttcagcg agaactccat cgatgtgttt
4021 gacgtgagga gggcagaatg ggtgcagacc gtgccgctca agaaggtgcg gcccctcaat
4081 ccagagggct ccctgttcct ctacggcacc gagaaggtcc gcctgaccta cctcaggaac
4141 cagctggcag agaaggacga gttcgacatc ccggacctca ccgacaacag ccggcgccag
4201 ctgttccgca ccaagagcaa gcgccgcttc tttttccgcg tgtcggagga gcagcagaag
4261 cagcagcgca gggagatgct gaaggaccct tttgtgcgct ccaagctcat ctcgccgcct
4321 accaacttca accacctagt acacgtgggc cctgccaacg ggcggcccgg cgccagggac
4381 aagtccccgg ctcccgaaga gaagggccga gttgcccgcg gctccggccc acagcggccc
4441 cacagcttct ccgaggcgtt gcggcgccca gcctccatgg gcagcgaagg cctcggtgga
4501 gacgcagacc ccatgaagag gaaaccctgg acatccctgt ccagcgagtc tgtgtcctgc
4561 ccccagggat cgctgagccc tgcaacctcc ctaatgcagg tctcagaacg gccccgaagc
4621 ctccccctat cccctgaatt ggagagctct ccttgatgcc ctctgttagg gcccacccca
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