LOCUS AY639608 2982 bp mRNA linear HUM 04-SEP-2004
DEFINITION Homo sapiens signal peptide, CUB and EGF-like domain containing
protein 3 (SCUBE3) mRNA, complete cds.
ACCESSION AY639608
VERSION AY639608.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2982)
AUTHORS Wu,B.T., Su,Y.H., Tsai,M.T., Wasserman,S.M., Topper,J.N. and
Yang,R.B.
TITLE A novel secreted, cell-surface glycoprotein containing multiple
epidermal growth factor-like repeats and one CUB domain is highly
expressed in primary osteoblasts and bones
JOURNAL J. Biol. Chem. 279 (36), 37485-37490 (2004)
PUBMED 15234972
REFERENCE 2 (bases 1 to 2982)
AUTHORS Wu,B.T., Su,Y.H., Tsai,M.T., Wasserman,S.M., Topper,J.N. and
Yang,R.B.
TITLE Direct Submission
JOURNAL Submitted (27-MAY-2004) Institute of Biomedical Sciences, Academia
Sinica, 128 Academia Road, Sec. 2, Taipei 11529, Taiwan
FEATURES Location/Qualifiers
source 1..2982
/db_xref="H-InvDB:HIT000255803"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="6"
/map="6p21"
/cell_type="primary osteoblasts"
gene 1..2982
/gene="SCUBE3"
CDS 1..2982
/gene="SCUBE3"
/codon_start=1
/product="signal peptide, CUB and EGF-like domain
containing protein 3"
/protein_id="AAU08347.1"
/translation="MGSGRVPGLCLLVLLVHARAAQYSKAAQDVDECVEGTDNCHIDA
ICQNTPRSYKCICKSGYTGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFH
LAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMN
CMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNGGCQHTCDDTEQG
PRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCK
DIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECSFDRTCDHICVN
TPGSFQCLCHRGYLLYGITHCGDVDECSINRGGCRFGCINTPGSYQCTCPAGQGRLHW
NGKDCTEPLKCQGSPGASKAMLSCNRSGKKDTCALTCPSRARFLPESENGFTVSCGTP
SPRAAPARAGHNGNSTNSNHCHEAAVLSIKQRASFKIKDAKCRLHLRNKGKTEEAGRI
TGPGGAPCSECQVTFIHLKCDSSRKGKGRRARTPPGKEVTRLTLELEAEVRAEETTAS
CGLPCLRQRMERRLKGSLKMLRKSINQDRFLLRLAGLDYELAHKPGLVAGERAEPMES
CRPGQHRAGTKCVSCPQGTYYHGQTEQCVPCPAGTFQEREGQLSCDLCPGSDAHGPLG
ATNVTTCAGQCPPGQHSVDGFKPCQPCPRGTYQPEAGRTLCFPCGGGLTTKHEGAISF
QDCDTKVQCSPGHYYNTSIHRCIRCAMGSYQPDFRQNFCSRCPGNTSTDFDGSTSVAQ
CKNRQCGGELGEFTGYIESPNYPGNYPAGVECIWNINPPPKRKILIVVPEIFLPSEDE
CGDVLVMRKNSSPSSITTYETCQTYERPIAFTARSRKLWINFKTSEANSARGFQIPYV
TYDEDYEQLVEDIVRDGRLYASENHQEILKDKKLIKAFFEVLAHPQNYFKYTEKHKEM
LPKSFIKLLRSKVSSFLRPYK"
sig_peptide 1..84
/gene="SCUBE3"
misc_feature 97..204
/gene="SCUBE3"
/note="Region: EGF-like domain 1"
misc_feature 220..330
/gene="SCUBE3"
/note="Region: EGF-like domain 2"
misc_feature 346..453
/gene="SCUBE3"
/note="Region: EGF-like domain 3"
misc_feature 481..591
/gene="SCUBE3"
/note="Region: EGF-like domain 4"
misc_feature 601..708
/gene="SCUBE3"
/note="Region: EGF-like domain 5"
misc_feature 718..825
/gene="SCUBE3"
/note="Region: EGF-like domain 6"
misc_feature 841..948
/gene="SCUBE3"
/note="Region: EGF-like domain 7"
misc_feature 964..1065
/gene="SCUBE3"
/note="Region: EGF-like domain 8"
misc_feature 1081..1191
/gene="SCUBE3"
/note="Region: EGF-like domain 9"
misc_feature 1192..2409
/gene="SCUBE3"
/note="Region: spacer region"
misc_feature 1609..1620
/gene="SCUBE3"
/note="potential furin cleavage site"
misc_feature 2410..2739
/gene="SCUBE3"
/note="Region: CUB domain"
BASE COUNT 713 a 865 c 834 g 570 t
ORIGIN
1 atgggctcgg ggcgcgtacc cgggctctgc ctgcttgtcc tgctggtcca cgcccgcgcc
61 gcccagtaca gcaaagccgc gcaagatgtg gatgagtgtg tggaggggac tgacaactgc
121 cacatcgatg ctatctgcca gaacaccccg aggtcataca agtgcatctg caagtctggc
181 tacacagggg acggcaaaca ctgcaaagac gtggatgagt gcgagcgaga ggataatgca
241 ggttgtgtgc atgactgtgt caacatccct ggcaattacc ggtgtacctg ctatgatgga
301 ttccacctgg cacatgacgg acacaactgt ctggatgtgg acgagtgtgc cgagggcaac
361 ggcggctgtc agcagagctg tgtcaacatg atgggcagct atgagtgcca ctgccgggaa
421 ggcttcttcc tcagcgacaa ccagcatacc tgtatccagc ggccagaaga aggaatgaat
481 tgcatgaaca agaaccacgg ctgtgcccac atttgccggg agacacccaa ggggggtatt
541 gcctgtgaat gccgtcctgg ctttgagctt accaagaacc aacgggactg taaattgaca
601 tgcaactatg gtaacggcgg ctgccagcac acgtgtgatg acacagagca gggtccccgg
661 tgcggctgcc atatcaagtt tgtgctccat accgacggga agacatgcat cgagacctgt
721 gctgtcaaca acgggggctg tgacagtaag tgccatgatg cagcgactgg tgtccactgc
781 acctgccctg tgggcttcat gctgcagcca gacaggaaga cgtgcaaaga tatagatgag
841 tgccgcttaa acaacggggg ctgtgaccat atttgccgca acacagtggg cagcttcgaa
901 tgcagttgca agaaaggcta taagcttctc atcaatgaga ggaactgcca ggatatagac
961 gagtgttcct ttgatcgaac ctgtgaccac atatgtgtca acacaccagg aagcttccag
1021 tgtctctgcc atcgtggcta cctgttgtat ggtatcaccc actgtgggga tgtggatgaa
1081 tgcagcatca accggggagg ttgccgcttt ggctgcatca acactcctgg cagctaccag
1141 tgtacctgcc cagcaggcca gggtcggctg cactggaatg gcaaagattg cacagagcca
1201 ctgaagtgtc agggcagtcc tggggcctcg aaagccatgc tcagctgcaa ccggtctggc
1261 aagaaggaca cctgtgccct gacctgtccc tccagggccc gatttttgcc agagtctgag
1321 aatggcttca cggtgagctg tgggaccccc agccccaggg ctgctccagc ccgagctggc
1381 cacaatggga acagcaccaa ctccaaccac tgccatgagg ctgcagtgct gtccattaaa
1441 caacgggcct ccttcaagat caaggatgcc aaatgccgtt tgcacctgcg aaacaaaggc
1501 aaaacagagg aggctggcag aatcacaggg ccaggtggtg ccccctgctc tgaatgccag
1561 gtcaccttca tccaccttaa gtgtgactcc tctcggaagg gcaagggccg acgggcccgg
1621 acccctccag gcaaagaggt cacaaggctc accctggaac tggaggcaga ggtcagagcc
1681 gaagaaacca cagccagctg tgggctgccc tgcctccgac agcgaatgga acggcggctg
1741 aaaggatccc tgaagatgct cagaaagtcc atcaaccagg accgcttcct gctgcgcctg
1801 gcaggccttg attatgagct ggcccacaag ccgggcctgg tagccgggga gcgagcagag
1861 ccgatggagt cctgtaggcc cgggcagcac cgtgctggga ccaagtgtgt cagctgcccg
1921 cagggaacgt attaccacgg ccagacggag cagtgtgtgc catgcccagc gggcaccttc
1981 caggagagag aagggcagct ctcctgcgac ctttgccctg ggagtgatgc ccacgggcct
2041 cttggagcca ccaacgtcac cacgtgtgca ggtcagtgcc cacctggcca acactctgta
2101 gatgggttca agccctgtca gccatgccca cgtggcacct accaacctga agcaggacgg
2161 accctatgct tcccttgtgg tgggggcctc accaccaagc atgaaggggc catttccttc
2221 caagactgtg acaccaaagt ccagtgctcc ccagggcact actacaacac cagcatccac
2281 cgctgtattc gctgtgccat gggctcctat cagcccgact tccgtcagaa cttctgcagc
2341 cgctgtccag gaaacacaag cacagacttt gatggctcta ccagtgtggc ccaatgcaag
2401 aatcgtcagt gtggtgggga gctgggtgag ttcactggct atattgagtc ccccaactac
2461 ccgggcaact acccagctgg tgtggagtgc atctggaaca tcaacccccc acccaagcgc
2521 aagatcctta tcgtggtacc agagatcttc ctgccatctg aggatgagtg tggggacgtc
2581 ctcgtcatga gaaagaactc atccccatcc tccattacca cttatgagac ctgccagacc
2641 tacgagcgtc ccattgcctt cactgcccgt tccaggaagc tctggatcaa cttcaagaca
2701 agcgaggcca acagcgcccg tggcttccag attccctatg ttacctatga tgaggactat
2761 gagcagctgg tagaagacat tgtgcgagat ggccggctct atgcctctga aaaccaccag
2821 gagattttaa aggacaagaa gctcatcaag gccttctttg aggtgctagc ccacccccag
2881 aactacttca agtacacaga gaaacacaag gagatgctgc caaaatcctt catcaagctg
2941 ctccgctcca aagtttccag cttcctgagg ccctacaaat ag
//