LOCUS AY593872 2707 bp mRNA linear HUM 16-APR-2009
DEFINITION Homo sapiens cAMP-specific phosphodiesterase (PDE4A) mRNA, complete
cds.
ACCESSION AY593872
VERSION AY593872.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2707)
AUTHORS Mackenzie,K.F., Topping,E.C., Bugaj-Gaweda,B., Deng,C.,
Cheung,Y.F., Olsen,A.E., Stockard,C.R., High Mitchell,L.,
Baillie,G.S., Grizzle,W.E., De Vivo,M., Houslay,M.D., Wang,D. and
Bolger,G.B.
TITLE Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific
phosphodiesterase that has undergone rapid evolutionary change
JOURNAL Biochem. J. 411 (2), 361-369 (2008)
PUBMED 18095939
REFERENCE 2 (bases 1 to 2707)
AUTHORS Bolger,G.B. and Wang,D.
TITLE Direct Submission
JOURNAL Submitted (07-APR-2004) Cancer Center, University of Alabama at
Birmingham, 1530 3rd Ave. S., Birmingham, AL 35294-3300, USA
FEATURES Location/Qualifiers
source 1..2707
/db_xref="H-InvDB:HIT000255659"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19p13.2"
gene 1..2707
/gene="PDE4A"
CDS 85..2679
/gene="PDE4A"
/note="PDE4A8 isoform"
/codon_start=1
/product="cAMP-specific phosphodiesterase"
/protein_id="AAT00628.1"
/translation="MKRSRSALSVAGTGDERSRETPESDRANMLGADLRRPRRRLSSG
PGLGWAQPEPSDPGVPLPPRPTTLPLLIPPRISITRAENDSFEAENGPTPSPGRSPLD
SQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFA
QVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDW
CLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEV
EIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFG
VKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDT
MVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAI
HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQR
QSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVH
CADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFI
DYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLP
DKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLE
VMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPL
LPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGG
GGSGGDPT"
BASE COUNT 595 a 873 c 776 g 463 t
ORIGIN
1 cgtcacgccc caggagaggc aataggaggc cctggccctg ccgacatggc caccgcagtc
61 ccaacggcgc gctaggttgg cgagatgaag aggagtcgca gtgccctgtc ggtggcaggg
121 accggggacg agaggtcgag ggagaccccc gaatccgacc gtgccaacat gctgggggcc
181 gacctgcgtc gccctcgccg ccgcctctcg tccggtcctg gcctaggctg ggcccagcct
241 gagccctcgg accctggggt ccctctgccg ccacggccca ccaccctgcc gctgctgatc
301 ccaccgcgga tttccatcac cagggccgag aacgacagct tcgaggcaga gaatgggccg
361 acaccatctc ctggccgcag ccccctggac tcgcaggcga gcccaggact cgtgctgcac
421 gccggggcgg ccaccagcca gcgccgggag tccttcctgt accgctcaga cagcgactat
481 gacatgtcac ccaagaccat gtcccggaac tcatcggtca ccagcgaggc gcacgctgaa
541 gacctcatcg taacaccatt tgctcaggtg ctggccagcc tccggagcgt ccgtagcaac
601 ttctcactcc tgaccaatgt gcccgttccc agtaacaagc ggtccccgct gggcggcccc
661 acccctgtct gcaaggccac gctgtcagaa gaaacgtgtc agcagttggc ccgggagact
721 ctggaggagc tggactggtg tctggagcag ctggagacca tgcagaccta tcgctctgtc
781 agcgagatgg cctcgcacaa gttcaaaagg atgttgaacc gtgagctcac acacctgtca
841 gaaatgagca ggtccggaaa ccaggtctca gagtacattt ccacaacatt cctggacaaa
901 cagaatgaag tggagatccc atcacccacg atgaaggaac gagaaaaaca gcaagcgccg
961 cgaccaagac cctcccagcc gcccccgccc cctgtaccac acttacagcc catgtcccaa
1021 atcacagggt tgaaaaagtt gatgcatagt aacagcctga acaactctaa cattccccga
1081 tttggggtga agaccgatca agaagagctc ctggcccaag aactggagaa cctgaacaag
1141 tggggcctga acatcttttg cgtgtcggat tacgctggag gccgctcact cacctgcatc
1201 atgtacatga tattccagga gcgggacctg ctgaagaaat tccgcatccc tgtggacacg
1261 atggtgacat acatgctgac gctggaggat cactaccacg ctgacgtggc ctaccataac
1321 agcctgcacg cagctgacgt gctgcagtcc acccacgtac tgctggccac gcctgcacta
1381 gatgcagtgt tcacggacct ggagattctc gccgccctct tcgcggctgc catccacgat
1441 gtggatcacc ctggggtctc caaccagttc ctcatcaaca ccaattcgga gctggcgctc
1501 atgtacaacg atgagtcggt gctcgagaat caccacctgg ccgtgggctt caagctgctg
1561 caggaggaca actgcgacat cttccagaac ctcagcaagc gccagcggca gagcctacgc
1621 aagatggtca tcgacatggt gctggccacg gacatgtcca agcacatgac cctcctggct
1681 gacctgaaga ccatggtgga gaccaagaaa gtgaccagct caggggtcct cctgctagat
1741 aactactccg accgcatcca ggtcctccgg aacatggtgc actgtgccga cctcagcaac
1801 cccaccaagc cgctggagct gtaccgccag tggacagacc gcatcatggc cgagttcttc
1861 cagcagggtg accgagagcg cgagcgtggc atggaaatca gccccatgtg tgacaagcac
1921 actgcctccg tggagaagtc tcaggtgggt tttattgact acattgtgca cccattgtgg
1981 gagacctggg cggaccttgt ccacccagat gcccaggaga tcttggacac tttggaggac
2041 aaccgggact ggtactacag cgccatccgg cagagcccat ctccgccacc cgaggaggag
2101 tcaagggggc caggccaccc acccctgcct gacaagttcc agtttgagct gacgctggag
2161 gaggaagagg aggaagaaat atcaatggcc cagataccgt gcacagccca agaggcattg
2221 actgcgcagg gattgtcagg agtcgaggaa gctctggatg caaccatagc ctgggaggca
2281 tccccggccc aggagtcgtt ggaagttatg gcacaggaag catccctgga ggccgagctg
2341 gaggcagtgt atttgacaca gcaggcacag tccacaggca gtgcacctgt ggctccggat
2401 gagttctcgt cccgggagga attcgtggtt gctgtaagcc acagcagccc ctctgccctg
2461 gctcttcaaa gcccccttct ccctgcttgg aggaccctgt ctgtttcaga gcatgccccg
2521 ggcctcccgg gcctcccctc cacggcggcc gaggtggagg cccaacgaga gcaccaggct
2581 gccaagaggg cttgcagtgc ctgcgcaggg acatttgggg aggacacatc cgcactccca
2641 gctcctggtg gcggggggtc aggtggagac cctacctgat ccccagacct ctgtccctgt
2701 tcccctc
//