LOCUS AY572488 6769 bp mRNA linear HUM 30-JUN-2006
DEFINITION Homo sapiens 200 kDa U5 snRNP-specific spliceosomal protein (BRR2)
mRNA, complete cds.
ACCESSION AY572488
VERSION AY572488.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6769)
AUTHORS Liu,S., Rauhut,R., Vornlocher,H.P. and Luhrmann,R.
TITLE The network of protein-protein interactions within the human
U4/U6.U5 tri-snRNP
JOURNAL RNA 12 (7), 1418-1430 (2006)
PUBMED 16723661
REFERENCE 2 (bases 1 to 6769)
AUTHORS Liu,S.
TITLE Direct Submission
JOURNAL Submitted (12-MAR-2004) Dep. of Cellular Biochemistry, Max Planck
Institute for Biophysical Chemistry, Am Fassberg 11, Goettingen
37077, Germany
FEATURES Location/Qualifiers
source 1..6769
/db_xref="H-InvDB:HIT000255549"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..6769
/gene="BRR2"
CDS 79..6489
/gene="BRR2"
/note="contains two DEXH helicase domains; hBRR2/200K
protein; U5-200K; similar to the Saccharomyces cerevisiae
BRR2 gene; involved in the unwinding of the U4/U6 snRNA
duplex"
/codon_start=1
/product="200 kDa U5 snRNP-specific spliceosomal protein"
/protein_id="AAS78571.1"
/translation="MADVTARSLQYEYKANSNLVLQADRSLIDRTRRDEPTGEVLSLV
GKLEGTRMGDKAQRTKPQMQEERRAKRRKRDEDRHDINKMKGYTLLSEGIDEMVGIIY
KPKTKETRETYEVLLSFIQAALGDQPRDILCGAADEVLAVLKNEKLRDKERRKEIDLL
LGQTDDTRYHVLVNLGKKITDYGGDKEIQNMDDNIDETYGVNVQFESDEEEGDEDVYG
EVREEASDDDMEGDEAVVRCTLSANLVASGELMSSKKKDLHPRDIDAFWLQRQLSRFY
DDAIVSQKKADEVLEILKTASDDRECENQLVLLLGFNTFDFIKVLRQHRMMILYCTLL
ASAQSEAEKERIMGKMEADPELSKFLYQLHETEKEDLIREERSRRERVRQSRMDTDLE
TMDLDQGGEALAPRQVLDLEDLVFTQGSHFMANKRCQLPDGSFRRQRKGYEEVHVPAL
KPKPFGSEEQLLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETDENLLLCAPTGAG
KTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFGKRLATYGITV
AELTGDHQLCKEEISATQIIVCTPEKWDIITRKGGERTYTQLVRLIILDEIHLLHDDR
GPVLEALVARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLRVDPAKGLFYFDNSFRP
VPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHAGKNQVLVFVHSRKETGKTARAIRD
MCLEKDTLGLFLREGSASTEVLRTEAEQCKNLELKDLLPYGFAIHHAGMTRVDRTLVE
DLFADKHIQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRA
GRPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLPDMLNAEIVLGNVQNAK
DAVNWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTAALMLDKNNLVKY
DKKTGNFQVTELGRIASHYYITNDTVQTYNQLLKPTLSEIELFRVFSLSSEFKNITVR
EEEKLELQKLLERVPIPVKESIEEPSAKINVLLQAFISQLKLEGFALMADMVYVTQLA
GRLMRAIFEIVLNRGWAQLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVVKKIEKK
NFPFERLYDLNHNEIGELIRMPKMGKTIHKYVHLFPKLELSVHLQPITRSTLKVELTI
TPDFQWDEKVHGSSEAFWILVEDVDSEVILHHEYFLLKAKYAQDEHLITFFVPVFEPL
PPQYFIRVVSDRWLSCETQLPVSFRHLILPEKYPPPTELLDLQPLPVSALRNSAFESL
YQDKFPFFNPIQTQVFNTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQSSEGRCVY
ITPMEALAEQVYMDWYEKFQDRLNKKVVLLTGETSTDLKLLGKGNIIISTPEKWDILS
RRWKQRKNVQNINLFVVDEVHLIGGENGPVLEVICSRMRYISSQIERPIRIVALSSSL
SNAKDVAHWLGCSATSTFNFHPNVRPVPLELHIQGFNISHTQTRLLSMAKPVYHAITK
HSPKKPVIVFVPSRKQTRLTAIDILTTCAADIQRQRFLHCTEKDLIPYLEKLSDSTLK
ETLLNGVGYLHEGLSPMERRLVEQLFSSGAIQVVVASRSLCWGMNVAAHLVIIMDTQY
YNGKIHAYVDYPIYDVLQMVGHANRPLQDDEGRCVIMCQGSKKDFFKKFLYEPLPVES
HLDHCMHDHFNAEIVTKTIENKQDAVDYLTWTFLYRRMTQNPNYYNLQGISHRHLSDH
LSELVEQTLSDLEQSKCISIEDEMDVAPLNLGMIAAYYYINYTTIELFSMSLNAKTKV
RGLIEIISNAAEYENIPIRHHEDNLLRQLAQKVPHKLNNPKFNDPHVKTNLLLQAHLS
RMQLSAELQSDTEEILSKAIRLIQACVDVLSSNGWLSPALAAMELAQMVTQAMWSKDS
YLKQLPHFTSEHIKRCTDKGVESVFDIMEMEDEERNALLQLTDSQIADVARFCNRYPN
IELSYEVVDKDSIRSGGPVVVLVQLEREEEVTGPVIAPLFPQKREEGWWVVIGDAKSN
SLISIKRLTLQQKAKVKLDFVAPATGAHNYTLYFMSDAYMGCDQEYKFSVDVKEAETD
SDSD"
BASE COUNT 1703 a 1716 c 1834 g 1516 t
ORIGIN
1 cgggagcaga gatctgcggc cgtttgcagc ttgcggtagg gaggcgtggt ggtctgaagc
61 ctccgagcag ccgcggccat ggcggatgta accgcccgta gtctgcaata cgagtacaag
121 gcgaactcga atcttgtgct ccaagctgac cgttctctca ttgaccggac ccgccgggat
181 gaacccacag gagaggtgct gtcccttgtt gggaagctgg agggcacccg tatgggagac
241 aaggctcaac ggaccaaacc gcagatgcag gaggaaagaa gagccaagcg aagaaagcgt
301 gatgaggacc ggcatgacat caacaagatg aagggttata ctctgctgtc ggagggcatt
361 gatgagatgg tgggcatcat ctacaagccc aaaactaaag agactcggga gacctatgag
421 gtgctactca gcttcatcca ggctgctctt ggggaccagc cacgtgatat cctttgtggg
481 gcagctgatg aagttctagc tgttctaaag aatgaaaagc tgcgggacaa ggaaaggcga
541 aaggagattg acctgctgct gggtcaaaca gatgatacca gataccatgt gctagtgaac
601 ctgggcaaaa agatcacaga ctatggtgga gataaggaaa tccaaaatat ggatgacaac
661 attgatgaga catacggtgt gaatgtgcag tttgagtctg atgaggagga aggtgatgaa
721 gacgtatacg gggaggttcg agaagaggca tctgatgatg acatggaagg ggacgaggct
781 gtcgtgcgct gcaccctctc ggctaatctc gtagcctcag gtgaactgat gagttccaag
841 aagaaggatt tgcaccctcg ggatattgat gcattttggc tgcagcggca gctcagtcgt
901 ttctatgatg atgccatcgt gtcgcagaag aaggcagatg aagtattgga gattttgaag
961 acggccagtg atgatcggga atgtgaaaat cagctggttc tgctgcttgg tttcaacacc
1021 tttgatttca ttaaagtgtt gcggcagcac aggatgatga ttttatactg taccttgctg
1081 gccagtgcac aaagtgaagc tgaaaaggaa aggattatgg gaaagatgga agctgaccca
1141 gagctatcca agttcctcta ccagcttcat gaaaccgaga aggaggatct gatccgagag
1201 gaaaggtccc ggagagagcg agtgcgtcag tctcgaatgg acacagatct ggaaaccatg
1261 gatctcgacc agggtggaga ggcactggct ccacggcagg ttctggactt ggaggacctg
1321 gtttttaccc aagggagcca ctttatggcc aataaacgct gtcagcttcc tgatggatcc
1381 ttccgtcgcc agcgtaaggg ctatgaagag gtgcatgtgc ctgctctgaa gcccaagccc
1441 tttggctcag aagaacaact gcttccagtg gaaaagctgc caaagtatgc ccaggctggg
1501 tttgagggct tcaaaacact gaatcggatc cagagtaagc tctaccgtgc tgcccttgag
1561 acggatgaga atctgctgct gtgtgctcct actggtgctg ggaagaccaa cgtggccctg
1621 atgtgcatgc tccgagagat tgggaaacac ataaacatgg acggcaccat caatgtggat
1681 gacttcaaga ttatctacat tgcccccatg cgctccttgg tgcaggagat ggtgggcagc
1741 tttggaaagc gcctggccac ttatggcatc actgttgctg aactgactgg ggaccaccag
1801 ctgtgcaaag aagagatcag tgccactcag atcatcgtct gcacccccga gaagtgggac
1861 atcatcaccc gcaagggtgg tgagcgcacc tacacccagc tggtgcggct catcattctg
1921 gatgagattc atcttctcca cgatgacaga ggtcctgtct tagaagcttt agtggccagg
1981 gccatccgaa acattgagat gacccaagag gatgtccgac tcattggtct cagtgccacc
2041 ctacccaact atgaagatgt agccaccttt ctacgtgttg accctgccaa gggtctcttt
2101 tactttgaca acagcttccg tccagtgcct ctggaacaga catatgtggg tatcacagag
2161 aaaaaagcta tcaagcgttt ccagatcatg aatgaaatcg tctatgaaaa aatcatggaa
2221 catgctggaa aaaatcaggt gctggtgttt gtccactccc ggaaggagac tggaaagaca
2281 gccagggcca tccgggacat gtgcctagaa aaggacactc tgggtctgtt tctgagggag
2341 ggctcagcct ccacagaagt cctgcgaaca gaagctgagc agtgcaagaa cctagagctg
2401 aaggatcttc tgccttatgg ctttgctatt catcacgcag gcatgaccag ggttgaccga
2461 acactcgtgg aggatctttt tgctgataaa catattcagg ttttagtttc cacagcaact
2521 ctagcttggg gtgtgaatct ccctgcacat acagtcatca tcaaaggcac ccaggtgtac
2581 agtccagaga aggggcgttg gacagaactg ggagcactgg acattctgca gatgctggga
2641 cgtgccggaa gaccccagta tgacaccaag ggtgaaggca tactcatcac atctcatggg
2701 gagctacagt actacctgtc cctcctcaat caacaacttc ctattgaaag ccagatggtt
2761 tcaaagcttc ctgacatgct caatgcagaa atcgtgctag gaaatgtcca gaatgccaag
2821 gatgcggtga actggctggg ctatgcctac ctctatatcc gaatgctgcg atccccaacc
2881 ctctatggca tctctcatga tgacctcaag ggagatcccc tgctggacca gcgccgacta
2941 gatctggttc atacagctgc cctgatgctg gacaagaaca atctggtcaa gtacgacaag
3001 aagacgggca acttccaggt gacagaactg ggccgtatag ccagccacta ctacatcacc
3061 aatgatacag tgcagactta caaccagctg ctgaagccca ccctgagtga gattgagctt
3121 ttcagggtct tctcattgtc ctctgagttc aagaacatca cagtgagaga ggaggagaag
3181 ctggagctgc agaagttgct ggagagggtg cctatccctg taaaggagag cattgaggaa
3241 cccagtgcta agatcaacgt tcttctgcaa gccttcatct cacagctgaa attggagggc
3301 tttgcactga tggctgacat ggtgtatgtc acacagttgg ctggccggtt gatgcgagcg
3361 atatttgaaa ttgtcctgaa ccgaggttgg gcacagctta cagacaagac cctgaacctc
3421 tgcaagatga tcgacaaacg catgtggcag tccatgtgtc ctctgcgcca gttccggaaa
3481 ctccctgagg aagtagtgaa gaagattgag aagaagaatt tcccctttga gcgtctgtac
3541 gacctgaatc ataatgagat tggggagctt atccgcatgc caaagatggg gaagaccatc
3601 cacaaatatg tccatctgtt tcccaagttg gagttgtcag tgcacctgca gcctatcaca
3661 cgctccaccc tgaaggtgga gctgaccatc acgccagact tccagtggga tgaaaaggtg
3721 catggttcat ccgaggcttt ttggattctg gtggaggatg tggacagcga ggtgattctg
3781 caccatgagt attttctcct caaggccaag tacgcccagg acgagcacct cattacattc
3841 ttcgtgcctg tctttgaacc gctgccccct cagtacttca tccgagtggt gtctgaccgc
3901 tggctctctt gtgagaccca gctgcctgtc tccttccggc acctgatctt gccagagaag
3961 tacccccctc caaccgaact tttggacctg cagcccttgc ccgtgtctgc tctgagaaac
4021 agtgcctttg agagtcttta ccaagataaa tttcctttct tcaatcccat ccagacccag
4081 gtgtttaaca ctgtatacaa cagtgacgac aacgtgtttg tgggggcccc cacgggcagc
4141 gggaagacta tttgtgcaga gtttgccatc ctgcgaatgc tgctgcagag ctcggagggg
4201 cgctgtgtgt acatcacccc catggaggcc ctggcagagc aggtatacat ggactggtac
4261 gagaagttcc aggacaggct caacaagaag gtggtactcc tgacaggcga gaccagcaca
4321 gacctgaagc tgctgggcaa agggaacatt atcatcagca cccctgagaa gtgggacata
4381 ctttcccggc gatggaagca gcgcaagaac gtgcagaaca tcaacctctt cgtggtggat
4441 gaggtccacc ttatcggggg cgagaatggg cctgtcttag aagtgatctg ctcccgaatg
4501 cgctacatct cctcccagat tgagcggccc attcgcattg tggcactcag ctcttcgctc
4561 tccaatgcca aggatgtggc ccactggctg ggctgcagtg ccacctccac cttcaacttc
4621 catcccaatg tgcgtcccgt ccccttggag ctgcacatcc agggcttcaa catcagccat
4681 acacaaaccc gcctgctctc catggccaag cctgtgtacc atgctatcac caagcactcg
4741 cccaagaagc ctgtcattgt ctttgtgccg tctcgcaagc agacccgcct cactgccatt
4801 gacatcctca ccacctgtgc agcagacatc caacggcaga ggttcttgca ctgcaccgag
4861 aaggatctga ttccgtacct ggagaagcta agtgacagca cgctcaagga aacgctgcta
4921 aatggggtgg gctacctgca tgaggggctc agccccatgg agcgacgcct ggtggagcag
4981 ctcttcagct caggggctat ccaggtggtg gtggcttctc ggagtctctg ctggggcatg
5041 aacgtggctg cccacctggt aatcatcatg gatacccagt actacaatgg caagatccac
5101 gcctatgtgg attaccccat ctatgacgtg cttcagatgg tgggccacgc caaccgccct
5161 ttgcaggacg atgaggggcg ctgtgtcatc atgtgtcagg gctccaagaa ggatttcttc
5221 aagaagttct tatatgagcc attgccagta gaatctcacc tggaccactg tatgcatgac
5281 cacttcaatg ctgagatcgt caccaagacc attgagaaca agcaggatgc tgtggactac
5341 ctcacctgga cctttctgta ccgccgcatg acacagaacc ccaattacta caacctgcag
5401 ggcatctccc atcgtcactt gtcggaccac ttgtcagagc tggtggagca gaccctgagt
5461 gacctggagc agtccaagtg catcagcatc gaggacgaga tggacgtggc gcctctgaac
5521 ctaggcatga tcgccgccta ctattacatc aactacacca ccattgagct cttcagcatg
5581 tccctcaatg ccaagaccaa ggtgcgaggg cttatcgaga tcatctccaa tgcagcagag
5641 tatgagaaca ttcccatccg gcaccatgaa gacaatctcc tgaggcagtt ggctcagaag
5701 gtcccccaca agctgaataa ccctaagttc aatgatccgc acgtcaagac caacctgctc
5761 ctgcaggctc acttgtctcg catgcagctg agtgctgagt tgcagtcaga tacggaggaa
5821 atccttagta aggcaatccg gctcatccag gcctgcgtgg atgtcctttc cagcaatggg
5881 tggctcagcc ctgctctggc agctatggaa ctggcccaga tggtcaccca agccatgtgg
5941 tccaaggact catacctgaa gcagctgcca cacttcacct ctgagcatat caaacgttgc
6001 acagacaagg gagtggagag tgttttcgac atcatggaga tggaggatga agaacggaac
6061 gcgttgcttc agctgactga cagccagatt gcagatgtgg ctcgcttttg taaccgctac
6121 cctaatatcg aactatctta tgaggtggta gataaggaca gcatccgcag tggcgggcca
6181 gttgtggtgc tggtgcagct ggagcgagag gaggaagtca caggccctgt cattgcgcct
6241 ctcttcccgc agaaacgtga agagggctgg tgggtggtga ttggagatgc caagtccaat
6301 agcctcatct ccatcaagag gctgaccttg cagcagaagg ccaaggtgaa gttggacttt
6361 gtggccccag ccactggtgc ccacaactac actctgtact tcatgagtga cgcttacatg
6421 ggatgtgacc aggagtacaa attcagcgtg gatgtgaaag aagctgagac agacagtgat
6481 tcagattgag tcctgaggca tttacttttg ggtaaaggag agttgagcct gaattaggaa
6541 tgtgtacatt gtaggaatcc tggttgtggg gaccaggtct gtgggcctca ggtctggcca
6601 gccagggctg gtgctgtccc cgcctacctc cacttccttt cccttgctca ctctggatcc
6661 agtgacagca ggtgtcatgg gtcaagcata aatcatatat agcattttca ggcatgttcc
6721 tggtagttct tttgagtctg acattctaat aaaataattt gtagaaacc
//