LOCUS AY515704 1758 bp mRNA linear HUM 28-JAN-2004
DEFINITION Homo sapiens bestrophin 1 mRNA, complete cds.
ACCESSION AY515704
VERSION AY515704.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1758)
AUTHORS Sun,H., Tsunenari,T., Yau,K.W. and Nathans,J.
TITLE The vitelliform macular dystrophy protein defines a new family of
chloride channels
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (6), 4008-4013 (2002)
PUBMED 11904445
REFERENCE 2 (bases 1 to 1758)
AUTHORS Tsunenari,T., Sun,H., Williams,J., Cahill,H., Smallwood,P.,
Yau,K.W. and Nathans,J.
TITLE Structure-function analysis of the bestrophin family of anion
channels
JOURNAL J. Biol. Chem. 278 (42), 41114-41125 (2003)
PUBMED 12907679
REFERENCE 3 (bases 1 to 1758)
AUTHORS Sun,H., Tsunenari,T., Yau,K.-W. and Nathans,J.
TITLE Direct Submission
JOURNAL Submitted (02-JAN-2004) Molecular Biology, Neuroscience, Johns
Hopkins University, 725 N. Wolfe Street, Baltimore, MD 21205, USA
FEATURES Location/Qualifiers
source 1..1758
/db_xref="H-InvDB:HIT000255104"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 1..1758
/note="chloride channel"
/codon_start=1
/product="bestrophin 1"
/protein_id="AAR99654.1"
/translation="MTITYTSQVANARLGSFSRLLLCWRGSIYKLLYGEFLIFLLCYY
IIRFIYRLALTEEQQLMFEKLTLYCDSYIQLIPISFVLGFYVTLVVTRWWNQYENLPW
PDRLMSLVSGFVEGKDEQGRLLRRTLIRYANLGNVLILRSVSTAVYKRFPSAQHLVQA
GFMTPAEHKQLEKLSLPHNMFWVPWVWFANLSMKAWLGGRIRDPILLQSLLNEMNTLR
TQCGHLYAYDWISIPLVYTQVVTVAVYSFFLTCLVGRQFLNPAKAYPGHELDLVVPVF
TFLQFFFYVGWLKVAEQLINPFGEDDDDFETNWIVDRNLQVSLLAVDEMHQDLPRMEP
DMYWNKPEPQPPYTAASAQFRRASFMGSTFNISLNKEEMEFQPNQEDEEDAHAGIIGR
FLGLQSHDHHPPRANSRTKLLWPKRESLLHEGLPKNHKAAKQNVRGQEDNKAWKLKAV
DAFKSAPLYQRPGYYSAPQTPLSPTPMFFPLEPSAPSKLHSVTGIDTKDKSLKTVSSG
AKKSFELLSESDGALMEHPEVSQVRRKTVEFNLTDMPEIPENHLKEPLEQSPTNIHTT
LKDHMDPYWALENRDEAHS"
BASE COUNT 420 a 515 c 449 g 374 t
ORIGIN
1 atgaccatca cttacacaag ccaagtggct aatgcccgct taggctcctt ctcccgcctg
61 ctgctgtgct ggcggggcag catctacaag ctgctatatg gcgagttctt aatcttcctg
121 ctctgctact acatcatccg ctttatttat aggctggccc tcacggaaga acaacagctg
181 atgtttgaga aactgactct gtattgcgac agctacatcc agctcatccc catttccttc
241 gtgctgggct tctacgtgac gctggtcgtg acccgctggt ggaaccagta cgagaacctg
301 ccgtggcccg accgcctcat gagcctggtg tcgggcttcg tcgaaggcaa ggacgagcaa
361 ggccggctgc tgcggcgcac gctcatccgc tacgccaacc tgggcaacgt gctcatcctg
421 cgcagcgtca gcaccgcagt ctacaagcgc ttccccagcg cccagcacct ggtgcaagca
481 ggctttatga ctccggcaga acacaagcag ttggagaaac tgagcctacc acacaacatg
541 ttctgggtgc cctgggtgtg gtttgccaac ctgtcaatga aggcgtggct tggaggtcga
601 atccgggacc ctatcctgct ccagagcctg ctgaacgaga tgaacacctt gcgtactcag
661 tgtggacacc tgtatgccta cgactggatt agtatcccac tggtgtatac acaggtggtg
721 actgtggcgg tgtacagctt cttcctgact tgtctagttg ggcggcagtt tctgaaccca
781 gccaaggcct accctggcca tgagctggac ctcgttgtgc ccgtcttcac gttcctgcag
841 ttcttcttct atgttggctg gctgaaggtg gcagagcagc tcatcaaccc ctttggagag
901 gatgatgatg attttgagac caactggatt gtcgacagga atttgcaggt gtccctgttg
961 gctgtggatg agatgcacca ggacctgcct cggatggagc cggacatgta ctggaataag
1021 cccgagccac agccccccta cacagctgct tccgcccagt tccgtcgagc ctcctttatg
1081 ggctccacct tcaacatcag cctgaacaaa gaggagatgg agttccagcc caatcaggag
1141 gacgaggagg atgctcacgc tggcatcatt ggccgcttcc taggcctgca gtcccatgat
1201 caccatcctc ccagggcaaa ctcaaggacc aaactactgt ggcccaagag ggaatccctt
1261 ctccacgagg gcctgcccaa aaaccacaag gcagccaaac agaacgttag gggccaggaa
1321 gacaacaagg cctggaagct taaggctgtg gacgccttca agtctgcccc actgtatcag
1381 aggccaggct actacagtgc cccacagacg cccctcagcc ccactcccat gttcttcccc
1441 ctagaaccat cagcgccgtc aaagcttcac agtgtcacag gcatagacac caaagacaaa
1501 agcttaaaga ctgtgagttc tggggccaag aaaagttttg aattgctctc agagagcgat
1561 ggggccttga tggagcaccc agaagtatct caagtgagga ggaaaactgt ggagtttaac
1621 ctgacggata tgccagagat ccccgaaaat cacctcaaag aacctttgga acaatcacca
1681 accaacatac acactacact caaagatcac atggatcctt attgggcctt ggaaaacagg
1741 gatgaagcac attcctaa
//