LOCUS AY497060 5666 bp mRNA linear HUM 18-FEB-2005
DEFINITION Homo sapiens bromodomain and WD repeat domain containing 3 variant
BRWD3-P (BRWD3) mRNA, complete cds, alternatively spliced.
ACCESSION AY497060
VERSION AY497060.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5666)
AUTHORS Kalla,C., Nentwich,H., Schlotter,M., Mertens,D., Wildenberger,K.,
Dohner,H., Stilgenbauer,S. and Lichter,P.
TITLE Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic
leukemia disrupts two novel genes
JOURNAL Genes Chromosomes Cancer 42 (2), 128-143 (2005)
PUBMED 15543602
REFERENCE 2 (bases 1 to 5666)
AUTHORS Schaffner,C. and Schlotter,M.
TITLE Direct Submission
JOURNAL Submitted (09-DEC-2003) Div. Molecular Genetics (B060), Deutsches
Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg
D-69120, Germany
FEATURES Location/Qualifiers
source 1..5666
/db_xref="H-InvDB:HIT000254966"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xq13"
gene 1..5666
/gene="BRWD3"
CDS 835..5253
/gene="BRWD3"
/note="transcription factor; alternatively spliced;
contains first exon 4b, but lacks exons 5, 6, and 9"
/codon_start=1
/product="bromodomain and WD repeat domain containing 3
variant BRWD3-P"
/protein_id="AAS45485.1"
/translation="MFITTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVAVQFCNNG
DSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKITKLKVTMVAWD
RYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNI
FIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFGCSKYY
EKIPDQMFFHTDYRPLIRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVP
GRENCKDEQLIPQLGYVANGDGEVVEQVIGQQTNDQDESILDGIIRELQREQDLRLIN
EGDVPHLPVNRAYSVNGALRSPNMDISSSPNIRLRRHSSQIEGVRQMHNNAPRSQMAT
ERDLMAWSRRVVVNELNNGVSRVQEECRTAKGDIEISLYTVEKKKKPSYTTQRNDYEP
SCGRSLRRTQRKRQHTYQTRSNIEHNSQASCQNSGVQEDSDSSSEEDETVGTSDASVE
DPVVEWQSESSSSDSSSEYSDWTADAGINLQPPKRQTRQTTRKICSSSDEENLKSLEE
RQKKPKQTRKKKGGLVSIAGEPNEEWFAPQWILDTIPRRSPFVPQMGDELIYFRQGHE
AYVRAVRKSKIYSVNLQKQPWNKMDLREQEFVKIVGIKYEVGPPTLCCLKLAFLDPIS
GKMTGESFSIKYHDMPDVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQ
QPFQPEYPDSSFQCYSVHWDNNEREKMSPWDMEPIPEGTAFPDEVGAGVPVSQEELTA
LLYKPQEGEWGAHSRDEECERVIQGINHLLSLDFASPFAVPVDLSAYPLYCTVVAYPT
DLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGD
QSCTDILDTYNKIKAEERNSTDAEEDTEIVDLDSDGPGTSSGRRVKCRGRRQSLKCNP
DAWKKQCKELLSLIYEREDSEPFRQPADLLSYPGHQEQEGESSESVVPERQQDSSLSE
DYQDVIDTPVDFSTVKETLEAGNYGSPLEFYKDVRQIFNNSKAYTSNKKSRIYSMMLR
LSALFESHIKNIISEYKSAIQSQKRRRPRYRKRLRSSSSSLSSSGAPSPKGKQKQMKL
QPKNDQNTSVSHARTSSPFSSPVSDAAEGLSLYLLDDEPDGPFSSSSFGGYSRSGNSH
DPGKAKSFRNRVLPVKQDHSLDGPLTNGDGREPRTGIKRKLLSASEEDENMGGEDKEK
KETKEKSHLSTSESGELGSSLSSESTCGSDSDSESTSRTDQDYVDGDHDYSKFIQTRP
KRKLRKQHGNGKRNWKTRGTGGRGRWGRWGRWSRGGRGRGGRGRGSRGRGGGGTRGRG
RGRGGRGASRGATRAKRARIADDEFDTMFSGRFSRLPRIKTRNQGRRTVLYNDDSDND
NFVSTEDPLNLGTSRSGRVRKMTEKARVSHLMGWNY"
misc_feature 892..1467
/gene="BRWD3"
/note="Region: contains four WD40 repeats"
misc_feature 3262..3582
/gene="BRWD3"
/note="Region: bromo domain"
misc_feature 3748..4137
/gene="BRWD3"
/note="Region: bromo domain"
BASE COUNT 1758 a 1111 c 1324 g 1473 t
ORIGIN
1 gatctgggta cccgtagctg ttgtcaccgg ggtgaattgg cttcttccct caaaaggggc
61 agacaacgct ggggtcttaa ctcgtccccg ctttatgctt gtgggaggca gtttttcagg
121 atttccttct cgacccccct tccccccccc cccatatact tgtctagctc tgagccaata
181 gctatcaggc cgagagaaat aaagacggta aagtgttgag gactgggaca caggttgggt
241 ccagttgatg gggagcggag gcttttcctt catcatttgc ctccgcttcc ccctttcttt
301 tcgtccggcc cccagctgat tccgcgccgc ttagattggg aggggaaaga gcaccgaaga
361 agcttcgagg atctgtgaat atcacctctg ccaggcaatt aaccggctgt agtcgctttg
421 gtcatatttt cccttcatct gcttaccagc acattaagat gcataagaga attctggggc
481 acttgtcatc tgtctactgt gtagcatttg accgaagcgg gagaagaatt tttacaggtt
541 ccgatgactg tttagtaaaa atttgggcta cagatgatgg acgccttctt gctacacttc
601 gtggacactc tgctgaaatt tctgacatgg ctgttaacta tgaaaacact cttattgctg
661 caggcagctg tgataaggta gtaagagtat ggtgtcttcg aacttgtgca cccgttgcag
721 tccttcaggg ccattcagct tctattactt ccatacagag atcgcccggt gaaatttact
781 gagagatcca gacctggagt ccagatatct tgttcatctt tcagttctgg tggtatgttc
841 attacaactg gtagtactga ccatgtgatt agaatatatt atttgggttc tgaggttcct
901 gagaaaattg ctgaattaga gtcacatacg gataaagttg ttgctgttca gttctgtaac
961 aatggagaca gtttaagatt tgttagtgga agtcgagatg gaacggcaag aatttggcag
1021 tatcagcaac aagaatggaa gagtatagtg ctagacatgg ctactaaaat gactggcaat
1081 aatttgccat ctggagaaga caagatcact aaacttaagg tgactatggt ggcctgggat
1141 cgctatgata ccacagttat tactgcagtg aacaattttc ttttgaaagt gtggaattct
1201 atcacaggac agcttcttca tacattatct ggacatgatg atgaagtatt cgttctagaa
1261 gcccatccat ttgatcaaag gatcatactt tcagcaggtc atgatgggaa catttttatt
1321 tgggaccttg accgggggac caaaattcgg aattacttta acatgattga aggccaaggc
1381 catggtgcgg tgtttgattg taaattttca ccagatggaa accattttgc ctgcacagat
1441 tctcatggac atttgctgct ttttggtttt ggatgcagta aatactacga aaagattcca
1501 gatcagatgt tcttccacac ggattatcgt cctcttattc gtgatgccaa taactatgta
1561 ttggatgaac aaacccaaca agctcctcac ctcatgcctc ctccattttt ggtggatgtt
1621 gatggaaatc ctcatcccac aaaattccaa cggttggtac caggacggga aaattgtaaa
1681 gatgaacagc ttataccaca gctgggatat gtggctaatg gtgatggtga ggtagtagaa
1741 caggtaattg ggcagcaaac caatgaccaa gatgagagca ttcttgatgg aataatcagg
1801 gagctgcaga gagaacaaga cctgagacta attaatgaag gagatgttcc acatttacca
1861 gttaatagag catactctgt taatggtgct ctgagaagtc caaacatgga catatcttct
1921 tccccaaaca tcaggcttcg aagacatagt agtcaaattg aaggtgttag acaaatgcat
1981 aacaatgctc ctcggagcca gatggccact gaaagagatc tcatggcgtg gagcagaaga
2041 gtggtggtca atgaactaaa taatggggtt agtagggtac aggaagaatg tcgaactgca
2101 aaaggtgaca tagaaatcag tctttataca gttgaaaaga agaaaaagcc atcttacact
2161 actcaaagga atgattatga gcctagctgt gggcgttctt tacgcaggac acagcgcaaa
2221 cgtcagcata cttaccaaac acggtccaac atagagcata attcacaggc atcatgtcaa
2281 aattcaggtg tacaggaaga ctcagacagt tcttcagagg aagatgaaac tgttggcaca
2341 agtgacgctt cggtagagga tcctgttgtt gaatggcaaa gtgaaagttc ttccagtgac
2401 tcatcaagtg aatattctga ttggacagca gatgctggaa taaatttaca acccccaaaa
2461 agacaaacca gacagacaac acgtaaaata tgcagcagct ctgatgagga aaatttgaag
2521 tccctagaag aaaggcagaa gaaacctaag cagactagaa agaagaaagg aggactggtt
2581 tctatagcag gtgagcctaa tgaagaatgg tttgcccctc agtggatctt ggatactata
2641 ccccgacgtt ccccatttgt cccacaaatg ggagatgagc ttatctattt taggcaagga
2701 catgaagctt atgttcgggc tgtaaggaaa tcgaaaatat acagtgttaa tttacaaaaa
2761 cagccatgga acaaaatgga tctcagggag caagagtttg ttaagattgt aggaatcaaa
2821 tatgaggttg gcccacccac actgtgctgc ttgaagcttg catttctgga cccaatttca
2881 ggcaaaatga ctggagaatc tttttccatt aagtatcatg acatgccgga tgtcattgac
2941 ttccttgtgc tacatcagtt ttataatgaa gccaaagaaa ggaactggca gattggtgat
3001 agattccgca gtataataga tgacgcctgg tggtttggga ctgtggagag tcagcagcct
3061 tttcaaccag agtatcctga tagttctttc cagtgttaca gtgttcactg ggacaataat
3121 gagagagaaa agatgagccc atgggatatg gagccaattc cagaaggaac tgcctttcca
3181 gatgaagttg gtgctggtgt tcctgtctcc caggaagaat tgactgcttt gctatacaaa
3241 ccccaggaag gagagtgggg ggctcattcc agagacgaag aatgtgaacg ggttattcag
3301 ggcatcaacc accttctttc cctggatttt gccagccctt ttgctgttcc agtggatctc
3361 agtgcctacc ccttgtattg tactgtagtt gcttatccaa ctgacctcaa taccatcagg
3421 cggagacttg aaaatcgctt ttacaggaga atatcagcat taatgtggga ggtacgctat
3481 attgaacata atgccaggac tttcaatgag ccagacagtc ctatagttaa agcagctaaa
3541 attgtaactg atgtcttact tcgatttatt ggggatcaga gctgtactga tatactggat
3601 acttataata aaattaaagc agaagaacga aacagtactg atgcagagga ggatacagaa
3661 attgttgatt tagattcaga cggtcctggt acttcatctg gaagaagggt caaatgccga
3721 ggcagaagac agtctttaaa gtgtaatcct gatgcttgga aaaaacaatg caaggaacta
3781 ttgagcctca tttatgaacg tgaagactcg gagccatttc gacagccagc tgatcttctt
3841 tcttacccag gtcatcagga gcaagaggga gaatcctcag agtctgttgt tccagaaaga
3901 caacaagatt catctctttc tgaggattat caagatgtta tagatactcc tgtggacttc
3961 agcactgtga aagaaacttt ggaagcagga aactatggta gtcctctgga attttataag
4021 gatgttcgcc aaatattcaa caactccaaa gcttatacct ctaataaaaa gtcaaggatc
4081 tatagcatga tgctgcgatt atctgcctta tttgaaagtc atatcaaaaa tatcatctct
4141 gaatataagt cagcaatcca gagtcagaag aggagaaggc cacggtacag aaaacgtcta
4201 agaagcagca gcagttcatt atctagtagt ggagcaccta gtccaaaagg gaagcagaaa
4261 caaatgaagt tgcagcctaa aaatgaccag aatacctcag tatctcatgc caggactagc
4321 tctcctttct catctcctgt ttcagatgct gctgaagggc tttcactata tctacttgat
4381 gatgagccag atgggccatt ttcttcatcg agcttcggtg gatatagccg aagtggaaat
4441 agccatgacc cagggaaagc caaatcattt cggaatagag ttttgccagt taaacaagat
4501 cactcccttg atggacccct tacaaatggt gatggcagag agccccggac aggaatcaag
4561 agaaaactac ttagtgcatc agaagaagat gaaaacatgg gaggagaaga taaagagaaa
4621 aaagaaacaa aagagaaatc tcatttatcc acctcagaga gtggagagtt aggatccagt
4681 ttaagttctg aaagtacctg tggttctgac tctgactctg aatcaacttc cagaacagat
4741 caagattacg tagatggaga ccatgattat agcaaattca tacaaaccag acctaaaaga
4801 aaactcagaa agcaacatgg caatggaaaa agaaattgga agaccagagg cacaggagga
4861 agaggcagat ggggaagatg gggtagatgg agtagaggag gcagaggaag aggaggcagg
4921 ggacgaggga gtcgaggaag aggtggaggt ggcactaggg ggaggggaag agggagagga
4981 ggaagaggtg cttctagagg agctaccaga gccaaacgag cacgtattgc agatgatgaa
5041 tttgatacca tgttttcagg acgtttcagt agactgcctc gaattaaaac aagaaaccaa
5101 ggcaggagga ctgttttata taatgatgat tctgataatg acaattttgt gtccactgag
5161 gatcctctga atcttggtac atccagatca ggcagagtgc gtaaaatgac agaaaaagcc
5221 agggttagcc atctcatggg atggaattat taacagttaa taaatttaga ataacttaaa
5281 aaattcaatg gccttctact gcagggaatt taccaggaaa tctacaaagc aagttgtgtg
5341 gggacttctg cttcctttca cattggtgct tttccattta tgccagtata catttgtttc
5401 aagacttttg atctccacac ttcatttgtt caaataagcc ttactcatta ggccttaaat
5461 taaaagaaat tctgcccaca cacacacaaa cacatacaca cacatacaca cacacagaca
5521 cacacacacg aaacacaaca cagacactac agatttacta cattaaagga gcattcagct
5581 tcttaagagt agcatgacat ttttatctca atagaatagc cctcttttgc ttttgtatca
5641 cagaagtata gcaccttctt acagag
//