LOCUS AY497059 6099 bp mRNA linear HUM 18-FEB-2005
DEFINITION Homo sapiens bromodomain and WD repeat domain containing 3 variant
BRWD3-O (BRWD3) mRNA, complete cds, alternatively spliced.
ACCESSION AY497059
VERSION AY497059.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6099)
AUTHORS Kalla,C., Nentwich,H., Schlotter,M., Mertens,D., Wildenberger,K.,
Dohner,H., Stilgenbauer,S. and Lichter,P.
TITLE Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic
leukemia disrupts two novel genes
JOURNAL Genes Chromosomes Cancer 42 (2), 128-143 (2005)
PUBMED 15543602
REFERENCE 2 (bases 1 to 6099)
AUTHORS Schaffner,C. and Schlotter,M.
TITLE Direct Submission
JOURNAL Submitted (09-DEC-2003) Div. Molecular Genetics (B060), Deutsches
Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg
D-69120, Germany
FEATURES Location/Qualifiers
source 1..6099
/db_xref="H-InvDB:HIT000254965"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xq13"
gene 1..6099
/gene="BRWD3"
CDS 1490..5686
/gene="BRWD3"
/note="transcription factor; alternatively spliced;
contains exons 4b, 6a, and 12a, but lacks exon 9"
/codon_start=1
/product="bromodomain and WD repeat domain containing 3
variant BRWD3-O"
/protein_id="AAS45484.1"
/translation="MATKMTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLK
VWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFN
MIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFGCSKYYEKIPDQMFFHTDYRPL
IRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVPGRENCKDEQLIPQLGY
VANGDGEVVEQVIGQQTNDQDESILDGIIRELQREQDLRLINEGDVPHLPVNRAYSVN
GALRSPNMDISSSPNIRLRRHSSQIEGVRQMHNNAPRSQMATERDLMAWSRRVVVNEL
NNGVSRVQEECRTAKGDIEISLYTVEKKKKPSYTTQRNDYEPSCGRSLRRTQRKRQHT
YQTRSNIEHNSQASCQNSGVQEDSDSSSEEDETVGTSDASVEDPVVEWQSESSSSDSS
SEYSDWTADAGINLQPPKRQTRQTTRKICSSSDEENLKSLEERQKKPKQTRKKKGGLV
SIAGEPNEEWFAPQWILDTIPRRSPFVPQMGDELIYFRQGHEAYVRAVRKSKIYSVNL
QKQPWNKMDLREQEFVKIVGIKYEVGPPTLCCLKLAFLDPISGKMTGESFSIKYHDMP
DVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQQPFQPEYPDSSFQCYS
VHWDNNEREKMSPWDMEPIPEGTAFPDEVGAGVPVSQEELTALLYKPQEGEWGAHSRD
EECERVIQGINHLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRR
ISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGDQSCTDILDTYNKIKAE
ERNSTDAEEDTEIVDLDSDGPGTSSGRRVKCRGRRQSLKCNPDAWKKQCKELLSLIYE
REDSEPFRQPADLLSYPGHQEQEGESSESVVPERQQDSSLSEDYQDVIDTPVDFSTVK
ETLEAGNYGSPLEFYKDVRQIFNNSKAYTSNKKSRIYSMMLRLSALFESHIKNIISEY
KSAIQSQKRRRPRYRKRLRSSSSSLSSSGAPSPKGKQKQMKLQPKNDQNTSVSHARTS
SPFSSPVSDAAEGLSLYLLDDEPDGPFSSSSFGGYSRSGNSHDPGKAKSFRNRVLPVK
QDHSLDGPLTNGDGREPRTGIKRKLLSASEEDENMGGEDKEKKETKEKSHLSTSESGE
LGSSLSSESTCGSDSDSESTSRTDQDYVDGDHDYSKFIQTRPKRKLRKQHGNGKRNWK
TRGTGGRGRWGRWGRWSRGGRGRGGRGRGSRGRGGGGTRGRGRGRGGRGASRGATRAK
RARIADDEFDTMFSGRFSRLPRIKTRNQGRRTVLYNDDSDNDNFVSTEDPLNLGTSRS
GRVRKMTEKARVSHLMGWNY"
misc_feature 1508..1900
/gene="BRWD3"
/note="Region: contains three WD40 repeats"
misc_feature 3695..4015
/gene="BRWD3"
/note="Region: bromo domain"
misc_feature 4181..4570
/gene="BRWD3"
/note="Region: bromo domain"
BASE COUNT 1895 a 1192 c 1419 g 1593 t
ORIGIN
1 gatctgggta cccgtagctg ttgtcaccgg ggtgaattgg cttcttccct caaaaggggc
61 agacaacgct ggggtcttaa ctcgtccccg ctttatgctt gtgggaggca gtttttcagg
121 atttccttct cgacccccct tccccccccc cccatatact tgtctagctc tgagccaata
181 gctatcaggc cgagagaaat aaagacggta aagtgttgag gactgggaca caggttgggt
241 ccagttgatg gggagcggag gcttttcctt catcatttgc ctccgcttcc ccctttcttt
301 tcgtccggcc cccagctgat tccgcgccgc ttagattggg aggggaaaga gcaccgaaga
361 agcttcgagg atctggtggc agcaaatgca cacattcctc cagactacct ccttaaaatt
421 tgtgagagaa ttggtccttt actagataaa gagatccctc agagtgttcc tggggtacag
481 acattattag gtgttggtcg gcagtctctg ctacgggatg ccaaagactg taagagtaca
541 ctatggaatg ggtctgcttt tgcggctctg catagaggca gacctccaga actacctgta
601 aattatgtga aacctccaaa tgtggttaaa atggccagtg gatctgcctt tgcctgaaag
661 aaagacttca ttgctcttaa aatttgaata tcacctctgc caggcaatta accggctgta
721 gtcgctttgg tcatattttc ccttcatctg cttaccagca cattaagatg cataagagaa
781 ttctggggca cttgtcatct gtctactgtg tagcatttga ccgaagcggg agaagaattt
841 ttacaggttc cgatgactgt ttagtaaaaa tttgggctac agatgatgga cgccttcttg
901 ctacacttcg tggacactct gctgaaattt ctgacatggc tgttaactat gaaaacactc
961 ttattgctgc aggcagctgt gataaggtag taagagtatg gtgtcttcga acttgtgcac
1021 ccgttgcagt ccttcagggc cattcagctt ctattacttc catacagaga tcgcccggtg
1081 aaatttactg agagatccag acctggagtc cagatatctt gttcatcttt cagttctggt
1141 ggtatgttca ttacaactgg tagtactgac catgtgatta gaatatatta tttgggttct
1201 gaggttcctg agaaaattgc tgaattagag tcacatacgg ataaagttgt tgctgttcag
1261 ttctgtaaca atggagacag aatgacaaga taatgaaaaa tgataatccc aatattgcca
1321 agggttttgg gaaaatggac acttctacaa ctcgtgatga gattataaat tattaaaaaa
1381 acttttcggg gaaacaattt ggcatttaag atttgttagt ggaagtcgag atggaacggc
1441 aagaatttgg cagtatcagc aacaagaatg gaagagtata gtgctagaca tggctactaa
1501 aatgactggc aataatttgc catctggaga agacaagatc actaaactta aggtgactat
1561 ggtggcctgg gatcgctatg ataccacagt tattactgca gtgaacaatt ttcttttgaa
1621 agtgtggaat tctatcacag gacagcttct tcatacatta tctggacatg atgatgaagt
1681 attcgttcta gaagcccatc catttgatca aaggatcata ctttcagcag gtcatgatgg
1741 gaacattttt atttgggacc ttgaccgggg gaccaaaatt cggaattact ttaacatgat
1801 tgaaggccaa ggccatggtg cggtgtttga ttgtaaattt tcaccagatg gaaaccattt
1861 tgcctgcaca gattctcatg gacatttgct gctttttggt tttggatgca gtaaatacta
1921 cgaaaagatt ccagatcaga tgttcttcca cacggattat cgtcctctta ttcgtgatgc
1981 caataactat gtattggatg aacaaaccca acaagctcct cacctcatgc ctcctccatt
2041 tttggtggat gttgatggaa atcctcatcc cacaaaattc caacggttgg taccaggacg
2101 ggaaaattgt aaagatgaac agcttatacc acagctggga tatgtggcta atggtgatgg
2161 tgaggtagta gaacaggtaa ttgggcagca aaccaatgac caagatgaga gcattcttga
2221 tggaataatc agggagctgc agagagaaca agacctgaga ctaattaatg aaggagatgt
2281 tccacattta ccagttaata gagcatactc tgttaatggt gctctgagaa gtccaaacat
2341 ggacatatct tcttccccaa acatcaggct tcgaagacat agtagtcaaa ttgaaggtgt
2401 tagacaaatg cataacaatg ctcctcggag ccagatggcc actgaaagag atctcatggc
2461 gtggagcaga agagtggtgg tcaatgaact aaataatggg gttagtaggg tacaggaaga
2521 atgtcgaact gcaaaaggtg acatagaaat cagtctttat acagttgaaa agaagaaaaa
2581 gccatcttac actactcaaa ggaatgatta tgagcctagc tgtgggcgtt ctttacgcag
2641 gacacagcgc aaacgtcagc atacttacca aacacggtcc aacatagagc ataattcaca
2701 ggcatcatgt caaaattcag gtgtacagga agactcagac agttcttcag aggaagatga
2761 aactgttggc acaagtgacg cttcggtaga ggatcctgtt gttgaatggc aaagtgaaag
2821 ttcttccagt gactcatcaa gtgaatattc tgattggaca gcagatgctg gaataaattt
2881 acaaccccca aaaagacaaa ccagacagac aacacgtaaa atatgcagca gctctgatga
2941 ggaaaatttg aagtccctag aagaaaggca gaagaaacct aagcagacta gaaagaagaa
3001 aggaggactg gtttctatag caggtgagcc taatgaagaa tggtttgccc ctcagtggat
3061 cttggatact ataccccgac gttccccatt tgtcccacaa atgggagatg agcttatcta
3121 ttttaggcaa ggacatgaag cttatgttcg ggctgtaagg aaatcgaaaa tatacagtgt
3181 taatttacaa aaacagccat ggaacaaaat ggatctcagg gagcaagagt ttgttaagat
3241 tgtaggaatc aaatatgagg ttggcccacc cacactgtgc tgcttgaagc ttgcatttct
3301 ggacccaatt tcaggcaaaa tgactggaga atctttttcc attaagtatc atgacatgcc
3361 ggatgtcatt gacttccttg tgctacatca gttttataat gaagccaaag aaaggaactg
3421 gcagattggt gatagattcc gcagtataat agatgacgcc tggtggtttg ggactgtgga
3481 gagtcagcag ccttttcaac cagagtatcc tgatagttct ttccagtgtt acagtgttca
3541 ctgggacaat aatgagagag aaaagatgag cccatgggat atggagccaa ttccagaagg
3601 aactgccttt ccagatgaag ttggtgctgg tgttcctgtc tcccaggaag aattgactgc
3661 tttgctatac aaaccccagg aaggagagtg gggggctcat tccagagacg aagaatgtga
3721 acgggttatt cagggcatca accaccttct ttccctggat tttgccagcc cttttgctgt
3781 tccagtggat ctcagtgcct accccttgta ttgtactgta gttgcttatc caactgacct
3841 caataccatc aggcggagac ttgaaaatcg cttttacagg agaatatcag cattaatgtg
3901 ggaggtacgc tatattgaac ataatgccag gactttcaat gagccagaca gtcctatagt
3961 taaagcagct aaaattgtaa ctgatgtctt acttcgattt attggggatc agagctgtac
4021 tgatatactg gatacttata ataaaattaa agcagaagaa cgaaacagta ctgatgcaga
4081 ggaggataca gaaattgttg atttagattc agacggtcct ggtacttcat ctggaagaag
4141 ggtcaaatgc cgaggcagaa gacagtcttt aaagtgtaat cctgatgctt ggaaaaaaca
4201 atgcaaggaa ctattgagcc tcatttatga acgtgaagac tcggagccat ttcgacagcc
4261 agctgatctt ctttcttacc caggtcatca ggagcaagag ggagaatcct cagagtctgt
4321 tgttccagaa agacaacaag attcatctct ttctgaggat tatcaagatg ttatagatac
4381 tcctgtggac ttcagcactg tgaaagaaac tttggaagca ggaaactatg gtagtcctct
4441 ggaattttat aaggatgttc gccaaatatt caacaactcc aaagcttata cctctaataa
4501 aaagtcaagg atctatagca tgatgctgcg attatctgcc ttatttgaaa gtcatatcaa
4561 aaatatcatc tctgaatata agtcagcaat ccagagtcag aagaggagaa ggccacggta
4621 cagaaaacgt ctaagaagca gcagcagttc attatctagt agtggagcac ctagtccaaa
4681 agggaagcag aaacaaatga agttgcagcc taaaaatgac cagaatacct cagtatctca
4741 tgccaggact agctctcctt tctcatctcc tgtttcagat gctgctgaag ggctttcact
4801 atatctactt gatgatgagc cagatgggcc attttcttca tcgagcttcg gtggatatag
4861 ccgaagtgga aatagccatg acccagggaa agccaaatca tttcggaata gagttttgcc
4921 agttaaacaa gatcactccc ttgatggacc ccttacaaat ggtgatggca gagagccccg
4981 gacaggaatc aagagaaaac tacttagtgc atcagaagaa gatgaaaaca tgggaggaga
5041 agataaagag aaaaaagaaa caaaagagaa atctcattta tccacctcag agagtggaga
5101 gttaggatcc agtttaagtt ctgaaagtac ctgtggttct gactctgact ctgaatcaac
5161 ttccagaaca gatcaagatt acgtagatgg agaccatgat tatagcaaat tcatacaaac
5221 cagacctaaa agaaaactca gaaagcaaca tggcaatgga aaaagaaatt ggaagaccag
5281 aggcacagga ggaagaggca gatggggaag atggggtaga tggagtagag gaggcagagg
5341 aagaggaggc aggggacgag ggagtcgagg aagaggtgga ggtggcacta gggggagggg
5401 aagagggaga ggaggaagag gtgcttctag aggagctacc agagccaaac gagcacgtat
5461 tgcagatgat gaatttgata ccatgttttc aggacgtttc agtagactgc ctcgaattaa
5521 aacaagaaac caaggcagga ggactgtttt atataatgat gattctgata atgacaattt
5581 tgtgtccact gaggatcctc tgaatcttgg tacatccaga tcaggcagag tgcgtaaaat
5641 gacagaaaaa gccagggtta gccatctcat gggatggaat tattaacagt taataaattt
5701 agaataactt aaaaaattca atggccttct actgcaggga atttaccagg aaatctacaa
5761 agcaagttgt gtggggactt ctgcttcctt tcacattggt gcttttccat ttatgccagt
5821 atacatttgt ttcaagactt ttgatctcca cacttcattt gttcaaataa gccttactca
5881 ttaggcctta aattaaaaga aattctgccc acacacacac aaacacatac acacacatac
5941 acacacacag acacacacac acgaaacaca acacagacac tacagattta ctacattaaa
6001 ggagcattca gcttcttaag agtagcatga catttttatc tcaatagaat agccctcttt
6061 tgcttttgta tcacagaagt atagcacctt cttacagag
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