LOCUS AY497058 5728 bp mRNA linear HUM 18-FEB-2005
DEFINITION Homo sapiens bromodomain and WD repeat domain containing 3 variant
BRWD3-N (BRWD3) mRNA, complete cds, alternatively spliced.
ACCESSION AY497058
VERSION AY497058.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5728)
AUTHORS Kalla,C., Nentwich,H., Schlotter,M., Mertens,D., Wildenberger,K.,
Dohner,H., Stilgenbauer,S. and Lichter,P.
TITLE Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic
leukemia disrupts two novel genes
JOURNAL Genes Chromosomes Cancer 42 (2), 128-143 (2005)
PUBMED 15543602
REFERENCE 2 (bases 1 to 5728)
AUTHORS Schaffner,C. and Schlotter,M.
TITLE Direct Submission
JOURNAL Submitted (09-DEC-2003) Div. Molecular Genetics (B060), Deutsches
Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg
D-69120, Germany
FEATURES Location/Qualifiers
source 1..5728
/db_xref="H-InvDB:HIT000254964"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xq13"
gene 1..5728
/gene="BRWD3"
CDS 1119..5315
/gene="BRWD3"
/note="transcription factor; alternatively spliced;
contains exons 4b and 12a, but lacks exons 5, 7, and 9"
/codon_start=1
/product="bromodomain and WD repeat domain containing 3
variant BRWD3-N"
/protein_id="AAS45483.1"
/translation="MATKMTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLK
VWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFN
MIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFGCSKYYEKIPDQMFFHTDYRPL
IRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVPGRENCKDEQLIPQLGY
VANGDGEVVEQVIGQQTNDQDESILDGIIRELQREQDLRLINEGDVPHLPVNRAYSVN
GALRSPNMDISSSPNIRLRRHSSQIEGVRQMHNNAPRSQMATERDLMAWSRRVVVNEL
NNGVSRVQEECRTAKGDIEISLYTVEKKKKPSYTTQRNDYEPSCGRSLRRTQRKRQHT
YQTRSNIEHNSQASCQNSGVQEDSDSSSEEDETVGTSDASVEDPVVEWQSESSSSDSS
SEYSDWTADAGINLQPPKRQTRQTTRKICSSSDEENLKSLEERQKKPKQTRKKKGGLV
SIAGEPNEEWFAPQWILDTIPRRSPFVPQMGDELIYFRQGHEAYVRAVRKSKIYSVNL
QKQPWNKMDLREQEFVKIVGIKYEVGPPTLCCLKLAFLDPISGKMTGESFSIKYHDMP
DVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQQPFQPEYPDSSFQCYS
VHWDNNEREKMSPWDMEPIPEGTAFPDEVGAGVPVSQEELTALLYKPQEGEWGAHSRD
EECERVIQGINHLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRR
ISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGDQSCTDILDTYNKIKAE
ERNSTDAEEDTEIVDLDSDGPGTSSGRRVKCRGRRQSLKCNPDAWKKQCKELLSLIYE
REDSEPFRQPADLLSYPGHQEQEGESSESVVPERQQDSSLSEDYQDVIDTPVDFSTVK
ETLEAGNYGSPLEFYKDVRQIFNNSKAYTSNKKSRIYSMMLRLSALFESHIKNIISEY
KSAIQSQKRRRPRYRKRLRSSSSSLSSSGAPSPKGKQKQMKLQPKNDQNTSVSHARTS
SPFSSPVSDAAEGLSLYLLDDEPDGPFSSSSFGGYSRSGNSHDPGKAKSFRNRVLPVK
QDHSLDGPLTNGDGREPRTGIKRKLLSASEEDENMGGEDKEKKETKEKSHLSTSESGE
LGSSLSSESTCGSDSDSESTSRTDQDYVDGDHDYSKFIQTRPKRKLRKQHGNGKRNWK
TRGTGGRGRWGRWGRWSRGGRGRGGRGRGSRGRGGGGTRGRGRGRGGRGASRGATRAK
RARIADDEFDTMFSGRFSRLPRIKTRNQGRRTVLYNDDSDNDNFVSTEDPLNLGTSRS
GRVRKMTEKARVSHLMGWNY"
misc_feature 1137..1529
/gene="BRWD3"
/note="Region: contains three WD40 repeats"
misc_feature 3324..3644
/gene="BRWD3"
/note="Region: bromo domain"
misc_feature 3810..4199
/gene="BRWD3"
/note="Region: bromo domain"
BASE COUNT 1796 a 1112 c 1337 g 1483 t
ORIGIN
1 gatctgggta cccgtagctg ttgtcaccgg ggtgaattgg cttcttccct caaaaggggc
61 agacaacgct ggggtcttaa ctcgtccccg ctttatgctt gtgggaggca gtttttcagg
121 atttccttct cgacccccct tccccccccc cccatatact tgtctagctc tgagccaata
181 gctatcaggc cgagagaaat aaagacggta aagtgttgag gactgggaca caggttgggt
241 ccagttgatg gggagcggag gcttttcctt catcatttgc ctccgcttcc ccctttcttt
301 tcgtccggcc cccagctgat tccgcgccgc ttagattggg aggggaaaga gcaccgaaga
361 agcttcgagg atctgactgt aagagtacac tatggaatgg gtctgctttt gcggctctgc
421 atagaggcag acctccagaa ctacctgtaa attatgtgaa acctccaaat gtggggttcc
481 gatgactgtt tagtaaaaat ttgggctaca gatgatggac gccttcttgc tacacttcgt
541 ggacactctg ctgaaatttc tgacatggct gttaactatg aaaacactct tattgctgca
601 ggcagctgtg ataaggtagt aagagtatgg tgtcttcgaa cttgtgcacc cgttgcagtc
661 cttcagggcc attcagcttc tattacttcc atacagagat cgcccggtga aatttactga
721 gagatccaga cctggagtcc agatatcttg ttcatctttc agttctggtg gtatgttcat
781 tacaactggt agtactgacc atgtgattag aatatattat ttgggttctg aggttcctga
841 gaaaattgct gaattagagt cacatacgga taaagttgtt gctgttcagt tctgtaacaa
901 tggagacaga atgacaagat aatgaaaaat gataatccca atattgccaa gggttttggg
961 aaaatggaca cttctacaac tcgtgatgag attataaatt attaaaaaaa cttttcgggg
1021 aaacaatttg gcatttaaga tttgttagtg gaagtcgaga tggaacggca agaatttggc
1081 agtatcagca acaagaatgg aagagtatag tgctagacat ggctactaaa atgactggca
1141 ataatttgcc atctggagaa gacaagatca ctaaacttaa ggtgactatg gtggcctggg
1201 atcgctatga taccacagtt attactgcag tgaacaattt tcttttgaaa gtgtggaatt
1261 ctatcacagg acagcttctt catacattat ctggacatga tgatgaagta ttcgttctag
1321 aagcccatcc atttgatcaa aggatcatac tttcagcagg tcatgatggg aacattttta
1381 tttgggacct tgaccggggg accaaaattc ggaattactt taacatgatt gaaggccaag
1441 gccatggtgc ggtgtttgat tgtaaatttt caccagatgg aaaccatttt gcctgcacag
1501 attctcatgg acatttgctg ctttttggtt ttggatgcag taaatactac gaaaagattc
1561 cagatcagat gttcttccac acggattatc gtcctcttat tcgtgatgcc aataactatg
1621 tattggatga acaaacccaa caagctcctc acctcatgcc tcctccattt ttggtggatg
1681 ttgatggaaa tcctcatccc acaaaattcc aacggttggt accaggacgg gaaaattgta
1741 aagatgaaca gcttatacca cagctgggat atgtggctaa tggtgatggt gaggtagtag
1801 aacaggtaat tgggcagcaa accaatgacc aagatgagag cattcttgat ggaataatca
1861 gggagctgca gagagaacaa gacctgagac taattaatga aggagatgtt ccacatttac
1921 cagttaatag agcatactct gttaatggtg ctctgagaag tccaaacatg gacatatctt
1981 cttccccaaa catcaggctt cgaagacata gtagtcaaat tgaaggtgtt agacaaatgc
2041 ataacaatgc tcctcggagc cagatggcca ctgaaagaga tctcatggcg tggagcagaa
2101 gagtggtggt caatgaacta aataatgggg ttagtagggt acaggaagaa tgtcgaactg
2161 caaaaggtga catagaaatc agtctttata cagttgaaaa gaagaaaaag ccatcttaca
2221 ctactcaaag gaatgattat gagcctagct gtgggcgttc tttacgcagg acacagcgca
2281 aacgtcagca tacttaccaa acacggtcca acatagagca taattcacag gcatcatgtc
2341 aaaattcagg tgtacaggaa gactcagaca gttcttcaga ggaagatgaa actgttggca
2401 caagtgacgc ttcggtagag gatcctgttg ttgaatggca aagtgaaagt tcttccagtg
2461 actcatcaag tgaatattct gattggacag cagatgctgg aataaattta caacccccaa
2521 aaagacaaac cagacagaca acacgtaaaa tatgcagcag ctctgatgag gaaaatttga
2581 agtccctaga agaaaggcag aagaaaccta agcagactag aaagaagaaa ggaggactgg
2641 tttctatagc aggtgagcct aatgaagaat ggtttgcccc tcagtggatc ttggatacta
2701 taccccgacg ttccccattt gtcccacaaa tgggagatga gcttatctat tttaggcaag
2761 gacatgaagc ttatgttcgg gctgtaagga aatcgaaaat atacagtgtt aatttacaaa
2821 aacagccatg gaacaaaatg gatctcaggg agcaagagtt tgttaagatt gtaggaatca
2881 aatatgaggt tggcccaccc acactgtgct gcttgaagct tgcatttctg gacccaattt
2941 caggcaaaat gactggagaa tctttttcca ttaagtatca tgacatgccg gatgtcattg
3001 acttccttgt gctacatcag ttttataatg aagccaaaga aaggaactgg cagattggtg
3061 atagattccg cagtataata gatgacgcct ggtggtttgg gactgtggag agtcagcagc
3121 cttttcaacc agagtatcct gatagttctt tccagtgtta cagtgttcac tgggacaata
3181 atgagagaga aaagatgagc ccatgggata tggagccaat tccagaagga actgcctttc
3241 cagatgaagt tggtgctggt gttcctgtct cccaggaaga attgactgct ttgctataca
3301 aaccccagga aggagagtgg ggggctcatt ccagagacga agaatgtgaa cgggttattc
3361 agggcatcaa ccaccttctt tccctggatt ttgccagccc ttttgctgtt ccagtggatc
3421 tcagtgccta ccccttgtat tgtactgtag ttgcttatcc aactgacctc aataccatca
3481 ggcggagact tgaaaatcgc ttttacagga gaatatcagc attaatgtgg gaggtacgct
3541 atattgaaca taatgccagg actttcaatg agccagacag tcctatagtt aaagcagcta
3601 aaattgtaac tgatgtctta cttcgattta ttggggatca gagctgtact gatatactgg
3661 atacttataa taaaattaaa gcagaagaac gaaacagtac tgatgcagag gaggatacag
3721 aaattgttga tttagattca gacggtcctg gtacttcatc tggaagaagg gtcaaatgcc
3781 gaggcagaag acagtcttta aagtgtaatc ctgatgcttg gaaaaaacaa tgcaaggaac
3841 tattgagcct catttatgaa cgtgaagact cggagccatt tcgacagcca gctgatcttc
3901 tttcttaccc aggtcatcag gagcaagagg gagaatcctc agagtctgtt gttccagaaa
3961 gacaacaaga ttcatctctt tctgaggatt atcaagatgt tatagatact cctgtggact
4021 tcagcactgt gaaagaaact ttggaagcag gaaactatgg tagtcctctg gaattttata
4081 aggatgttcg ccaaatattc aacaactcca aagcttatac ctctaataaa aagtcaagga
4141 tctatagcat gatgctgcga ttatctgcct tatttgaaag tcatatcaaa aatatcatct
4201 ctgaatataa gtcagcaatc cagagtcaga agaggagaag gccacggtac agaaaacgtc
4261 taagaagcag cagcagttca ttatctagta gtggagcacc tagtccaaaa gggaagcaga
4321 aacaaatgaa gttgcagcct aaaaatgacc agaatacctc agtatctcat gccaggacta
4381 gctctccttt ctcatctcct gtttcagatg ctgctgaagg gctttcacta tatctacttg
4441 atgatgagcc agatgggcca ttttcttcat cgagcttcgg tggatatagc cgaagtggaa
4501 atagccatga cccagggaaa gccaaatcat ttcggaatag agttttgcca gttaaacaag
4561 atcactccct tgatggaccc cttacaaatg gtgatggcag agagccccgg acaggaatca
4621 agagaaaact acttagtgca tcagaagaag atgaaaacat gggaggagaa gataaagaga
4681 aaaaagaaac aaaagagaaa tctcatttat ccacctcaga gagtggagag ttaggatcca
4741 gtttaagttc tgaaagtacc tgtggttctg actctgactc tgaatcaact tccagaacag
4801 atcaagatta cgtagatgga gaccatgatt atagcaaatt catacaaacc agacctaaaa
4861 gaaaactcag aaagcaacat ggcaatggaa aaagaaattg gaagaccaga ggcacaggag
4921 gaagaggcag atggggaaga tggggtagat ggagtagagg aggcagagga agaggaggca
4981 ggggacgagg gagtcgagga agaggtggag gtggcactag ggggagggga agagggagag
5041 gaggaagagg tgcttctaga ggagctacca gagccaaacg agcacgtatt gcagatgatg
5101 aatttgatac catgttttca ggacgtttca gtagactgcc tcgaattaaa acaagaaacc
5161 aaggcaggag gactgtttta tataatgatg attctgataa tgacaatttt gtgtccactg
5221 aggatcctct gaatcttggt acatccagat caggcagagt gcgtaaaatg acagaaaaag
5281 ccagggttag ccatctcatg ggatggaatt attaacagtt aataaattta gaataactta
5341 aaaaattcaa tggccttcta ctgcagggaa tttaccagga aatctacaaa gcaagttgtg
5401 tggggacttc tgcttccttt cacattggtg cttttccatt tatgccagta tacatttgtt
5461 tcaagacttt tgatctccac acttcatttg ttcaaataag ccttactcat taggccttaa
5521 attaaaagaa attctgccca cacacacaca aacacataca cacacataca cacacacaga
5581 cacacacaca cgaaacacaa cacagacact acagatttac tacattaaag gagcattcag
5641 cttcttaaga gtagcatgac atttttatct caatagaata gccctctttt gcttttgtat
5701 cacagaagta tagcaccttc ttacagag
//