LOCUS       AY497057                5889 bp    mRNA    linear   HUM 18-FEB-2005
DEFINITION  Homo sapiens bromodomain and WD repeat domain containing 3 variant
            BRWD3-M (BRWD3) mRNA, complete cds, alternatively spliced.
ACCESSION   AY497057
VERSION     AY497057.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5889)
  AUTHORS   Kalla,C., Nentwich,H., Schlotter,M., Mertens,D., Wildenberger,K.,
            Dohner,H., Stilgenbauer,S. and Lichter,P.
  TITLE     Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic
            leukemia disrupts two novel genes
  JOURNAL   Genes Chromosomes Cancer 42 (2), 128-143 (2005)
   PUBMED   15543602
REFERENCE   2  (bases 1 to 5889)
  AUTHORS   Schaffner,C. and Schlotter,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-DEC-2003) Div. Molecular Genetics (B060), Deutsches
            Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg
            D-69120, Germany
FEATURES             Location/Qualifiers
     source          1..5889
                     /db_xref="H-InvDB:HIT000254963"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13"
     gene            1..5889
                     /gene="BRWD3"
     CDS             1280..5476
                     /gene="BRWD3"
                     /note="transcription factor; alternatively spliced;
                     contains exons 4b and 12a, but lacks exons 5 and 9"
                     /codon_start=1
                     /product="bromodomain and WD repeat domain containing 3
                     variant BRWD3-M"
                     /protein_id="AAS45482.1"
                     /translation="MATKMTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLK
                     VWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFN
                     MIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFGCSKYYEKIPDQMFFHTDYRPL
                     IRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVPGRENCKDEQLIPQLGY
                     VANGDGEVVEQVIGQQTNDQDESILDGIIRELQREQDLRLINEGDVPHLPVNRAYSVN
                     GALRSPNMDISSSPNIRLRRHSSQIEGVRQMHNNAPRSQMATERDLMAWSRRVVVNEL
                     NNGVSRVQEECRTAKGDIEISLYTVEKKKKPSYTTQRNDYEPSCGRSLRRTQRKRQHT
                     YQTRSNIEHNSQASCQNSGVQEDSDSSSEEDETVGTSDASVEDPVVEWQSESSSSDSS
                     SEYSDWTADAGINLQPPKRQTRQTTRKICSSSDEENLKSLEERQKKPKQTRKKKGGLV
                     SIAGEPNEEWFAPQWILDTIPRRSPFVPQMGDELIYFRQGHEAYVRAVRKSKIYSVNL
                     QKQPWNKMDLREQEFVKIVGIKYEVGPPTLCCLKLAFLDPISGKMTGESFSIKYHDMP
                     DVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQQPFQPEYPDSSFQCYS
                     VHWDNNEREKMSPWDMEPIPEGTAFPDEVGAGVPVSQEELTALLYKPQEGEWGAHSRD
                     EECERVIQGINHLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRR
                     ISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGDQSCTDILDTYNKIKAE
                     ERNSTDAEEDTEIVDLDSDGPGTSSGRRVKCRGRRQSLKCNPDAWKKQCKELLSLIYE
                     REDSEPFRQPADLLSYPGHQEQEGESSESVVPERQQDSSLSEDYQDVIDTPVDFSTVK
                     ETLEAGNYGSPLEFYKDVRQIFNNSKAYTSNKKSRIYSMMLRLSALFESHIKNIISEY
                     KSAIQSQKRRRPRYRKRLRSSSSSLSSSGAPSPKGKQKQMKLQPKNDQNTSVSHARTS
                     SPFSSPVSDAAEGLSLYLLDDEPDGPFSSSSFGGYSRSGNSHDPGKAKSFRNRVLPVK
                     QDHSLDGPLTNGDGREPRTGIKRKLLSASEEDENMGGEDKEKKETKEKSHLSTSESGE
                     LGSSLSSESTCGSDSDSESTSRTDQDYVDGDHDYSKFIQTRPKRKLRKQHGNGKRNWK
                     TRGTGGRGRWGRWGRWSRGGRGRGGRGRGSRGRGGGGTRGRGRGRGGRGASRGATRAK
                     RARIADDEFDTMFSGRFSRLPRIKTRNQGRRTVLYNDDSDNDNFVSTEDPLNLGTSRS
                     GRVRKMTEKARVSHLMGWNY"
     misc_feature    1298..1690
                     /gene="BRWD3"
                     /note="Region: contains three WD40 repeats"
     misc_feature    3485..3805
                     /gene="BRWD3"
                     /note="Region: bromo domain"
     misc_feature    3971..4360
                     /gene="BRWD3"
                     /note="Region: bromo domain"
BASE COUNT         1837 a         1148 c         1371 g         1533 t
ORIGIN      
        1 gatctgggta cccgtagctg ttgtcaccgg ggtgaattgg cttcttccct caaaaggggc
       61 agacaacgct ggggtcttaa ctcgtccccg ctttatgctt gtgggaggca gtttttcagg
      121 atttccttct cgacccccct tccccccccc cccatatact tgtctagctc tgagccaata
      181 gctatcaggc cgagagaaat aaagacggta aagtgttgag gactgggaca caggttgggt
      241 ccagttgatg gggagcggag gcttttcctt catcatttgc ctccgcttcc ccctttcttt
      301 tcgtccggcc cccagctgat tccgcgccgc ttagattggg aggggaaaga gcaccgaaga
      361 agcttcgagg atctgactgt aagagtacac tatggaatgg gtctgctttt gcggctctgc
      421 atagaggcag acctccagaa ctacctgtaa attatgtgaa acctccaaat gtggtgaata
      481 tcacctctgc caggcaatta accggctgta gtcgctttgg tcatattttc ccttcatctg
      541 cttaccagca cattaagatg cataagagaa ttctggggca cttgtcatct gtctactgtg
      601 tagcatttga ccgaagcggg agaagaattt ttacaggttc cgatgactgt ttagtaaaaa
      661 tttgggctac agatgatgga cgccttcttg ctacacttcg tggacactct gctgaaattt
      721 ctgacatggc tgttaactat gaaaacactc ttattgctgc aggcagctgt gataaggtag
      781 taagagtatg gtgtcttcga acttgtgcac ccgttgcagt ccttcagggc cattcagctt
      841 ctattacttc catacagaga tcgcccggtg aaatttactg agagatccag acctggagtc
      901 cagatatctt gttcatcttt cagttctggt ggtatgttca ttacaactgg tagtactgac
      961 catgtgatta gaatatatta tttgggttct gaggttcctg agaaaattgc tgaattagag
     1021 tcacatacgg ataaagttgt tgctgttcag ttctgtaaca atggagacag aatgacaaga
     1081 taatgaaaaa tgataatccc aatattgcca agggttttgg gaaaatggac acttctacaa
     1141 ctcgtgatga gattataaat tattaaaaaa acttttcggg gaaacaattt ggcatttaag
     1201 atttgttagt ggaagtcgag atggaacggc aagaatttgg cagtatcagc aacaagaatg
     1261 gaagagtata gtgctagaca tggctactaa aatgactggc aataatttgc catctggaga
     1321 agacaagatc actaaactta aggtgactat ggtggcctgg gatcgctatg ataccacagt
     1381 tattactgca gtgaacaatt ttcttttgaa agtgtggaat tctatcacag gacagcttct
     1441 tcatacatta tctggacatg atgatgaagt attcgttcta gaagcccatc catttgatca
     1501 aaggatcata ctttcagcag gtcatgatgg gaacattttt atttgggacc ttgaccgggg
     1561 gaccaaaatt cggaattact ttaacatgat tgaaggccaa ggccatggtg cggtgtttga
     1621 ttgtaaattt tcaccagatg gaaaccattt tgcctgcaca gattctcatg gacatttgct
     1681 gctttttggt tttggatgca gtaaatacta cgaaaagatt ccagatcaga tgttcttcca
     1741 cacggattat cgtcctctta ttcgtgatgc caataactat gtattggatg aacaaaccca
     1801 acaagctcct cacctcatgc ctcctccatt tttggtggat gttgatggaa atcctcatcc
     1861 cacaaaattc caacggttgg taccaggacg ggaaaattgt aaagatgaac agcttatacc
     1921 acagctggga tatgtggcta atggtgatgg tgaggtagta gaacaggtaa ttgggcagca
     1981 aaccaatgac caagatgaga gcattcttga tggaataatc agggagctgc agagagaaca
     2041 agacctgaga ctaattaatg aaggagatgt tccacattta ccagttaata gagcatactc
     2101 tgttaatggt gctctgagaa gtccaaacat ggacatatct tcttccccaa acatcaggct
     2161 tcgaagacat agtagtcaaa ttgaaggtgt tagacaaatg cataacaatg ctcctcggag
     2221 ccagatggcc actgaaagag atctcatggc gtggagcaga agagtggtgg tcaatgaact
     2281 aaataatggg gttagtaggg tacaggaaga atgtcgaact gcaaaaggtg acatagaaat
     2341 cagtctttat acagttgaaa agaagaaaaa gccatcttac actactcaaa ggaatgatta
     2401 tgagcctagc tgtgggcgtt ctttacgcag gacacagcgc aaacgtcagc atacttacca
     2461 aacacggtcc aacatagagc ataattcaca ggcatcatgt caaaattcag gtgtacagga
     2521 agactcagac agttcttcag aggaagatga aactgttggc acaagtgacg cttcggtaga
     2581 ggatcctgtt gttgaatggc aaagtgaaag ttcttccagt gactcatcaa gtgaatattc
     2641 tgattggaca gcagatgctg gaataaattt acaaccccca aaaagacaaa ccagacagac
     2701 aacacgtaaa atatgcagca gctctgatga ggaaaatttg aagtccctag aagaaaggca
     2761 gaagaaacct aagcagacta gaaagaagaa aggaggactg gtttctatag caggtgagcc
     2821 taatgaagaa tggtttgccc ctcagtggat cttggatact ataccccgac gttccccatt
     2881 tgtcccacaa atgggagatg agcttatcta ttttaggcaa ggacatgaag cttatgttcg
     2941 ggctgtaagg aaatcgaaaa tatacagtgt taatttacaa aaacagccat ggaacaaaat
     3001 ggatctcagg gagcaagagt ttgttaagat tgtaggaatc aaatatgagg ttggcccacc
     3061 cacactgtgc tgcttgaagc ttgcatttct ggacccaatt tcaggcaaaa tgactggaga
     3121 atctttttcc attaagtatc atgacatgcc ggatgtcatt gacttccttg tgctacatca
     3181 gttttataat gaagccaaag aaaggaactg gcagattggt gatagattcc gcagtataat
     3241 agatgacgcc tggtggtttg ggactgtgga gagtcagcag ccttttcaac cagagtatcc
     3301 tgatagttct ttccagtgtt acagtgttca ctgggacaat aatgagagag aaaagatgag
     3361 cccatgggat atggagccaa ttccagaagg aactgccttt ccagatgaag ttggtgctgg
     3421 tgttcctgtc tcccaggaag aattgactgc tttgctatac aaaccccagg aaggagagtg
     3481 gggggctcat tccagagacg aagaatgtga acgggttatt cagggcatca accaccttct
     3541 ttccctggat tttgccagcc cttttgctgt tccagtggat ctcagtgcct accccttgta
     3601 ttgtactgta gttgcttatc caactgacct caataccatc aggcggagac ttgaaaatcg
     3661 cttttacagg agaatatcag cattaatgtg ggaggtacgc tatattgaac ataatgccag
     3721 gactttcaat gagccagaca gtcctatagt taaagcagct aaaattgtaa ctgatgtctt
     3781 acttcgattt attggggatc agagctgtac tgatatactg gatacttata ataaaattaa
     3841 agcagaagaa cgaaacagta ctgatgcaga ggaggataca gaaattgttg atttagattc
     3901 agacggtcct ggtacttcat ctggaagaag ggtcaaatgc cgaggcagaa gacagtcttt
     3961 aaagtgtaat cctgatgctt ggaaaaaaca atgcaaggaa ctattgagcc tcatttatga
     4021 acgtgaagac tcggagccat ttcgacagcc agctgatctt ctttcttacc caggtcatca
     4081 ggagcaagag ggagaatcct cagagtctgt tgttccagaa agacaacaag attcatctct
     4141 ttctgaggat tatcaagatg ttatagatac tcctgtggac ttcagcactg tgaaagaaac
     4201 tttggaagca ggaaactatg gtagtcctct ggaattttat aaggatgttc gccaaatatt
     4261 caacaactcc aaagcttata cctctaataa aaagtcaagg atctatagca tgatgctgcg
     4321 attatctgcc ttatttgaaa gtcatatcaa aaatatcatc tctgaatata agtcagcaat
     4381 ccagagtcag aagaggagaa ggccacggta cagaaaacgt ctaagaagca gcagcagttc
     4441 attatctagt agtggagcac ctagtccaaa agggaagcag aaacaaatga agttgcagcc
     4501 taaaaatgac cagaatacct cagtatctca tgccaggact agctctcctt tctcatctcc
     4561 tgtttcagat gctgctgaag ggctttcact atatctactt gatgatgagc cagatgggcc
     4621 attttcttca tcgagcttcg gtggatatag ccgaagtgga aatagccatg acccagggaa
     4681 agccaaatca tttcggaata gagttttgcc agttaaacaa gatcactccc ttgatggacc
     4741 ccttacaaat ggtgatggca gagagccccg gacaggaatc aagagaaaac tacttagtgc
     4801 atcagaagaa gatgaaaaca tgggaggaga agataaagag aaaaaagaaa caaaagagaa
     4861 atctcattta tccacctcag agagtggaga gttaggatcc agtttaagtt ctgaaagtac
     4921 ctgtggttct gactctgact ctgaatcaac ttccagaaca gatcaagatt acgtagatgg
     4981 agaccatgat tatagcaaat tcatacaaac cagacctaaa agaaaactca gaaagcaaca
     5041 tggcaatgga aaaagaaatt ggaagaccag aggcacagga ggaagaggca gatggggaag
     5101 atggggtaga tggagtagag gaggcagagg aagaggaggc aggggacgag ggagtcgagg
     5161 aagaggtgga ggtggcacta gggggagggg aagagggaga ggaggaagag gtgcttctag
     5221 aggagctacc agagccaaac gagcacgtat tgcagatgat gaatttgata ccatgttttc
     5281 aggacgtttc agtagactgc ctcgaattaa aacaagaaac caaggcagga ggactgtttt
     5341 atataatgat gattctgata atgacaattt tgtgtccact gaggatcctc tgaatcttgg
     5401 tacatccaga tcaggcagag tgcgtaaaat gacagaaaaa gccagggtta gccatctcat
     5461 gggatggaat tattaacagt taataaattt agaataactt aaaaaattca atggccttct
     5521 actgcaggga atttaccagg aaatctacaa agcaagttgt gtggggactt ctgcttcctt
     5581 tcacattggt gcttttccat ttatgccagt atacatttgt ttcaagactt ttgatctcca
     5641 cacttcattt gttcaaataa gccttactca ttaggcctta aattaaaaga aattctgccc
     5701 acacacacac aaacacatac acacacatac acacacacag acacacacac acgaaacaca
     5761 acacagacac tacagattta ctacattaaa ggagcattca gcttcttaag agtagcatga
     5821 catttttatc tcaatagaat agccctcttt tgcttttgta tcacagaagt atagcacctt
     5881 cttacagag
//