LOCUS AY497056 5990 bp mRNA linear HUM 18-FEB-2005
DEFINITION Homo sapiens bromodomain and WD repeat domain containing 3 variant
BRWD3-L (BRWD3) mRNA, complete cds, alternatively spliced.
ACCESSION AY497056
VERSION AY497056.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5990)
AUTHORS Kalla,C., Nentwich,H., Schlotter,M., Mertens,D., Wildenberger,K.,
Dohner,H., Stilgenbauer,S. and Lichter,P.
TITLE Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic
leukemia disrupts two novel genes
JOURNAL Genes Chromosomes Cancer 42 (2), 128-143 (2005)
PUBMED 15543602
REFERENCE 2 (bases 1 to 5990)
AUTHORS Schaffner,C. and Schlotter,M.
TITLE Direct Submission
JOURNAL Submitted (09-DEC-2003) Div. Molecular Genetics (B060), Deutsches
Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg
D-69120, Germany
FEATURES Location/Qualifiers
source 1..5990
/db_xref="H-InvDB:HIT000254962"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xq13"
gene 1..5990
/gene="BRWD3"
CDS 1381..5577
/gene="BRWD3"
/note="transcription factor; alternatively spliced;
contains exons 4b and 12a, but lacks exon 5"
/codon_start=1
/product="bromodomain and WD repeat domain containing 3
variant BRWD3-L"
/protein_id="AAS45481.1"
/translation="MATKMTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLK
VWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFN
MIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFGCSKYYEKIPDQMFFHTDYRPL
IRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVPGRENCKDEQLIPQLGY
VANGDGEVVEQVIGQQTNDQDESILDGIIRELQREQDLRLINEGDVPHLPVNRAYSVN
GALRSPNMDISSSPNIRLRRHSSQIEGVRQMHNNAPRSQMATERDLMAWSRRVVVNEL
NNGVSRVQEECRTAKGDIEISLYTVEKKKKPSYTTQRNDYEPSCGRSLRRTQRKRQHT
YQTRSNIEHNSQASCQNSGVQEDSDSSSEEDETVGTSDASVEDPVVEWQSESSSSDSS
SEYSDWTADAGINLQPPKRQTRQTTRKICSSSDEENLKSLEERQKKPKQTRKKKGGLV
SIAGEPNEEWFAPQWILDTIPRRSPFVPQMGDELIYFRQGHEAYVRAVRKSKIYSVNL
QKQPWNKMDLREQEFVKIVGIKYEVGPPTLCCLKLAFLDPISGKMTGESFSIKYHDMP
DVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQQPFQPEYPDSSFQCYS
VHWDNNEREKMSPWDMEPIPEGTAFPDEVGAGVPVSQEELTALLYKPQEGEWGAHSRD
EECERVIQGINHLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRR
ISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGDQSCTDILDTYNKIKAE
ERNSTDAEEDTEIVDLDSDGPGTSSGRRVKCRGRRQSLKCNPDAWKKQCKELLSLIYE
REDSEPFRQPADLLSYPGHQEQEGESSESVVPERQQDSSLSEDYQDVIDTPVDFSTVK
ETLEAGNYGSPLEFYKDVRQIFNNSKAYTSNKKSRIYSMMLRLSALFESHIKNIISEY
KSAIQSQKRRRPRYRKRLRSSSSSLSSSGAPSPKGKQKQMKLQPKNDQNTSVSHARTS
SPFSSPVSDAAEGLSLYLLDDEPDGPFSSSSFGGYSRSGNSHDPGKAKSFRNRVLPVK
QDHSLDGPLTNGDGREPRTGIKRKLLSASEEDENMGGEDKEKKETKEKSHLSTSESGE
LGSSLSSESTCGSDSDSESTSRTDQDYVDGDHDYSKFIQTRPKRKLRKQHGNGKRNWK
TRGTGGRGRWGRWGRWSRGGRGRGGRGRGSRGRGGGGTRGRGRGRGGRGASRGATRAK
RARIADDEFDTMFSGRFSRLPRIKTRNQGRRTVLYNDDSDNDNFVSTEDPLNLGTSRS
GRVRKMTEKARVSHLMGWNY"
misc_feature 1399..1791
/gene="BRWD3"
/note="Region: contains three WD40 repeats"
misc_feature 3586..3906
/gene="BRWD3"
/note="Region: bromo domain"
misc_feature 4072..4461
/gene="BRWD3"
/note="Region: bromo domain"
BASE COUNT 1870 a 1168 c 1390 g 1562 t
ORIGIN
1 gatctgggta cccgtagctg ttgtcaccgg ggtgaattgg cttcttccct caaaaggggc
61 agacaacgct ggggtcttaa ctcgtccccg ctttatgctt gtgggaggca gtttttcagg
121 atttccttct cgacccccct tccccccccc cccatatact tgtctagctc tgagccaata
181 gctatcaggc cgagagaaat aaagacggta aagtgttgag gactgggaca caggttgggt
241 ccagttgatg gggagcggag gcttttcctt catcatttgc ctccgcttcc ccctttcttt
301 tcgtccggcc cccagctgat tccgcgccgc ttagattggg aggggaaaga gcaccgaaga
361 agcttcgagg atctgactgt aagagtacac tatggaatgg gtctgctttt gcggctctgc
421 atagaggcag acctccagaa ctacctgtaa attatgtgaa acctccaaat gtggtgaata
481 tcacctctgc caggcaatta accggctgta gtcgctttgg tcatattttc ccttcatctg
541 cttaccagca cattaagatg cataagagaa ttctggggca cttgtcatct gtctactgtg
601 tagcatttga ccgaagcggg agaagaattt ttacaggttc cgatgactgt ttagtaaaaa
661 tttgggctac agatgatgga cgccttcttg ctacacttcg tggacactct gctgaaattt
721 ctgacatggc tgttaactat gaaaacactc ttattgctgc aggcagctgt gataaggtag
781 taagagtatg gtgtcttcga acttgtgcac ccgttgcagt ccttcagggc cattcagctt
841 ctattacttc catacagttt tgtccatcaa ctaaaggcac aaacagatac ctcacttcta
901 ctggtgctga tggaacaatc tgtttctggc aatggcatgt aaaaacaatg aagtttagag
961 atcgcccggt gaaatttact gagagatcca gacctggagt ccagatatct tgttcatctt
1021 tcagttctgg tggtatgttc attacaactg gtagtactga ccatgtgatt agaatatatt
1081 atttgggttc tgaggttcct gagaaaattg ctgaattaga gtcacatacg gataaagttg
1141 ttgctgttca gttctgtaac aatggagaca gaatgacaag ataatgaaaa atgataatcc
1201 caatattgcc aagggttttg ggaaaatgga cacttctaca actcgtgatg agattataaa
1261 ttattaaaaa aacttttcgg ggaaacaatt tggcatttaa gatttgttag tggaagtcga
1321 gatggaacgg caagaatttg gcagtatcag caacaagaat ggaagagtat agtgctagac
1381 atggctacta aaatgactgg caataatttg ccatctggag aagacaagat cactaaactt
1441 aaggtgacta tggtggcctg ggatcgctat gataccacag ttattactgc agtgaacaat
1501 tttcttttga aagtgtggaa ttctatcaca ggacagcttc ttcatacatt atctggacat
1561 gatgatgaag tattcgttct agaagcccat ccatttgatc aaaggatcat actttcagca
1621 ggtcatgatg ggaacatttt tatttgggac cttgaccggg ggaccaaaat tcggaattac
1681 tttaacatga ttgaaggcca aggccatggt gcggtgtttg attgtaaatt ttcaccagat
1741 ggaaaccatt ttgcctgcac agattctcat ggacatttgc tgctttttgg ttttggatgc
1801 agtaaatact acgaaaagat tccagatcag atgttcttcc acacggatta tcgtcctctt
1861 attcgtgatg ccaataacta tgtattggat gaacaaaccc aacaagctcc tcacctcatg
1921 cctcctccat ttttggtgga tgttgatgga aatcctcatc ccacaaaatt ccaacggttg
1981 gtaccaggac gggaaaattg taaagatgaa cagcttatac cacagctggg atatgtggct
2041 aatggtgatg gtgaggtagt agaacaggta attgggcagc aaaccaatga ccaagatgag
2101 agcattcttg atggaataat cagggagctg cagagagaac aagacctgag actaattaat
2161 gaaggagatg ttccacattt accagttaat agagcatact ctgttaatgg tgctctgaga
2221 agtccaaaca tggacatatc ttcttcccca aacatcaggc ttcgaagaca tagtagtcaa
2281 attgaaggtg ttagacaaat gcataacaat gctcctcgga gccagatggc cactgaaaga
2341 gatctcatgg cgtggagcag aagagtggtg gtcaatgaac taaataatgg ggttagtagg
2401 gtacaggaag aatgtcgaac tgcaaaaggt gacatagaaa tcagtcttta tacagttgaa
2461 aagaagaaaa agccatctta cactactcaa aggaatgatt atgagcctag ctgtgggcgt
2521 tctttacgca ggacacagcg caaacgtcag catacttacc aaacacggtc caacatagag
2581 cataattcac aggcatcatg tcaaaattca ggtgtacagg aagactcaga cagttcttca
2641 gaggaagatg aaactgttgg cacaagtgac gcttcggtag aggatcctgt tgttgaatgg
2701 caaagtgaaa gttcttccag tgactcatca agtgaatatt ctgattggac agcagatgct
2761 ggaataaatt tacaaccccc aaaaagacaa accagacaga caacacgtaa aatatgcagc
2821 agctctgatg aggaaaattt gaagtcccta gaagaaaggc agaagaaacc taagcagact
2881 agaaagaaga aaggaggact ggtttctata gcaggtgagc ctaatgaaga atggtttgcc
2941 cctcagtgga tcttggatac tataccccga cgttccccat ttgtcccaca aatgggagat
3001 gagcttatct attttaggca aggacatgaa gcttatgttc gggctgtaag gaaatcgaaa
3061 atatacagtg ttaatttaca aaaacagcca tggaacaaaa tggatctcag ggagcaagag
3121 tttgttaaga ttgtaggaat caaatatgag gttggcccac ccacactgtg ctgcttgaag
3181 cttgcatttc tggacccaat ttcaggcaaa atgactggag aatctttttc cattaagtat
3241 catgacatgc cggatgtcat tgacttcctt gtgctacatc agttttataa tgaagccaaa
3301 gaaaggaact ggcagattgg tgatagattc cgcagtataa tagatgacgc ctggtggttt
3361 gggactgtgg agagtcagca gccttttcaa ccagagtatc ctgatagttc tttccagtgt
3421 tacagtgttc actgggacaa taatgagaga gaaaagatga gcccatggga tatggagcca
3481 attccagaag gaactgcctt tccagatgaa gttggtgctg gtgttcctgt ctcccaggaa
3541 gaattgactg ctttgctata caaaccccag gaaggagagt ggggggctca ttccagagac
3601 gaagaatgtg aacgggttat tcagggcatc aaccaccttc tttccctgga ttttgccagc
3661 ccttttgctg ttccagtgga tctcagtgcc taccccttgt attgtactgt agttgcttat
3721 ccaactgacc tcaataccat caggcggaga cttgaaaatc gcttttacag gagaatatca
3781 gcattaatgt gggaggtacg ctatattgaa cataatgcca ggactttcaa tgagccagac
3841 agtcctatag ttaaagcagc taaaattgta actgatgtct tacttcgatt tattggggat
3901 cagagctgta ctgatatact ggatacttat aataaaatta aagcagaaga acgaaacagt
3961 actgatgcag aggaggatac agaaattgtt gatttagatt cagacggtcc tggtacttca
4021 tctggaagaa gggtcaaatg ccgaggcaga agacagtctt taaagtgtaa tcctgatgct
4081 tggaaaaaac aatgcaagga actattgagc ctcatttatg aacgtgaaga ctcggagcca
4141 tttcgacagc cagctgatct tctttcttac ccaggtcatc aggagcaaga gggagaatcc
4201 tcagagtctg ttgttccaga aagacaacaa gattcatctc tttctgagga ttatcaagat
4261 gttatagata ctcctgtgga cttcagcact gtgaaagaaa ctttggaagc aggaaactat
4321 ggtagtcctc tggaatttta taaggatgtt cgccaaatat tcaacaactc caaagcttat
4381 acctctaata aaaagtcaag gatctatagc atgatgctgc gattatctgc cttatttgaa
4441 agtcatatca aaaatatcat ctctgaatat aagtcagcaa tccagagtca gaagaggaga
4501 aggccacggt acagaaaacg tctaagaagc agcagcagtt cattatctag tagtggagca
4561 cctagtccaa aagggaagca gaaacaaatg aagttgcagc ctaaaaatga ccagaatacc
4621 tcagtatctc atgccaggac tagctctcct ttctcatctc ctgtttcaga tgctgctgaa
4681 gggctttcac tatatctact tgatgatgag ccagatgggc cattttcttc atcgagcttc
4741 ggtggatata gccgaagtgg aaatagccat gacccaggga aagccaaatc atttcggaat
4801 agagttttgc cagttaaaca agatcactcc cttgatggac cccttacaaa tggtgatggc
4861 agagagcccc ggacaggaat caagagaaaa ctacttagtg catcagaaga agatgaaaac
4921 atgggaggag aagataaaga gaaaaaagaa acaaaagaga aatctcattt atccacctca
4981 gagagtggag agttaggatc cagtttaagt tctgaaagta cctgtggttc tgactctgac
5041 tctgaatcaa cttccagaac agatcaagat tacgtagatg gagaccatga ttatagcaaa
5101 ttcatacaaa ccagacctaa aagaaaactc agaaagcaac atggcaatgg aaaaagaaat
5161 tggaagacca gaggcacagg aggaagaggc agatggggaa gatggggtag atggagtaga
5221 ggaggcagag gaagaggagg caggggacga gggagtcgag gaagaggtgg aggtggcact
5281 agggggaggg gaagagggag aggaggaaga ggtgcttcta gaggagctac cagagccaaa
5341 cgagcacgta ttgcagatga tgaatttgat accatgtttt caggacgttt cagtagactg
5401 cctcgaatta aaacaagaaa ccaaggcagg aggactgttt tatataatga tgattctgat
5461 aatgacaatt ttgtgtccac tgaggatcct ctgaatcttg gtacatccag atcaggcaga
5521 gtgcgtaaaa tgacagaaaa agccagggtt agccatctca tgggatggaa ttattaacag
5581 ttaataaatt tagaataact taaaaaattc aatggccttc tactgcaggg aatttaccag
5641 gaaatctaca aagcaagttg tgtggggact tctgcttcct ttcacattgg tgcttttcca
5701 tttatgccag tatacatttg tttcaagact tttgatctcc acacttcatt tgttcaaata
5761 agccttactc attaggcctt aaattaaaag aaattctgcc cacacacaca caaacacata
5821 cacacacata cacacacaca gacacacaca cacgaaacac aacacagaca ctacagattt
5881 actacattaa aggagcattc agcttcttaa gagtagcatg acatttttat ctcaatagaa
5941 tagccctctt ttgcttttgt atcacagaag tatagcacct tcttacagag
//