LOCUS AY497055 6019 bp mRNA linear HUM 18-FEB-2005
DEFINITION Homo sapiens bromodomain and WD repeat domain containing 3 variant
BRWD3-K (BRWD3) mRNA, complete cds, alternatively spliced.
ACCESSION AY497055
VERSION AY497055.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6019)
AUTHORS Kalla,C., Nentwich,H., Schlotter,M., Mertens,D., Wildenberger,K.,
Dohner,H., Stilgenbauer,S. and Lichter,P.
TITLE Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic
leukemia disrupts two novel genes
JOURNAL Genes Chromosomes Cancer 42 (2), 128-143 (2005)
PUBMED 15543602
REFERENCE 2 (bases 1 to 6019)
AUTHORS Schaffner,C. and Schlotter,M.
TITLE Direct Submission
JOURNAL Submitted (08-DEC-2003) Div. Molecular Genetics (B060), Deutsches
Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg
D-69120, Germany
FEATURES Location/Qualifiers
source 1..6019
/db_xref="H-InvDB:HIT000254961"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xq13"
gene 1..6019
/gene="BRWD3"
CDS 1188..5606
/gene="BRWD3"
/note="transcription factor; alternatively spliced;
contains exons 1, 2, 3, 4a, and 6b, but lacks exon 9"
/codon_start=1
/product="bromodomain and WD repeat domain containing 3
variant BRWD3-K"
/protein_id="AAS45480.1"
/translation="MFITTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVAVQFCNNG
DSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKITKLKVTMVAWD
RYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNI
FIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFGCSKYY
EKIPDQMFFHTDYRPLIRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVP
GRENCKDEQLIPQLGYVANGDGEVVEQVIGQQTNDQDESILDGIIRELQREQDLRLIN
EGDVPHLPVNRAYSVNGALRSPNMDISSSPNIRLRRHSSQIEGVRQMHNNAPRSQMAT
ERDLMAWSRRVVVNELNNGVSRVQEECRTAKGDIEISLYTVEKKKKPSYTTQRNDYEP
SCGRSLRRTQRKRQHTYQTRSNIEHNSQASCQNSGVQEDSDSSSEEDETVGTSDASVE
DPVVEWQSESSSSDSSSEYSDWTADAGINLQPPKRQTRQTTRKICSSSDEENLKSLEE
RQKKPKQTRKKKGGLVSIAGEPNEEWFAPQWILDTIPRRSPFVPQMGDELIYFRQGHE
AYVRAVRKSKIYSVNLQKQPWNKMDLREQEFVKIVGIKYEVGPPTLCCLKLAFLDPIS
GKMTGESFSIKYHDMPDVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQ
QPFQPEYPDSSFQCYSVHWDNNEREKMSPWDMEPIPEGTAFPDEVGAGVPVSQEELTA
LLYKPQEGEWGAHSRDEECERVIQGINHLLSLDFASPFAVPVDLSAYPLYCTVVAYPT
DLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGD
QSCTDILDTYNKIKAEERNSTDAEEDTEIVDLDSDGPGTSSGRRVKCRGRRQSLKCNP
DAWKKQCKELLSLIYEREDSEPFRQPADLLSYPGHQEQEGESSESVVPERQQDSSLSE
DYQDVIDTPVDFSTVKETLEAGNYGSPLEFYKDVRQIFNNSKAYTSNKKSRIYSMMLR
LSALFESHIKNIISEYKSAIQSQKRRRPRYRKRLRSSSSSLSSSGAPSPKGKQKQMKL
QPKNDQNTSVSHARTSSPFSSPVSDAAEGLSLYLLDDEPDGPFSSSSFGGYSRSGNSH
DPGKAKSFRNRVLPVKQDHSLDGPLTNGDGREPRTGIKRKLLSASEEDENMGGEDKEK
KETKEKSHLSTSESGELGSSLSSESTCGSDSDSESTSRTDQDYVDGDHDYSKFIQTRP
KRKLRKQHGNGKRNWKTRGTGGRGRWGRWGRWSRGGRGRGGRGRGSRGRGGGGTRGRG
RGRGGRGASRGATRAKRARIADDEFDTMFSGRFSRLPRIKTRNQGRRTVLYNDDSDND
NFVSTEDPLNLGTSRSGRVRKMTEKARVSHLMGWNY"
misc_feature 1245..1820
/gene="BRWD3"
/note="Region: contains four WD40 repeats"
misc_feature 3615..3935
/gene="BRWD3"
/note="Region: bromo domain"
misc_feature 4101..4490
/gene="BRWD3"
/note="Region: bromo domain"
BASE COUNT 1857 a 1210 c 1417 g 1535 t
ORIGIN
1 tctctctctc tctcactcac tcactctctc tctccctctc cctctcctct ccttcctcct
61 ccgcctcctc agctcttggg ctagaatatc tatgggtcga aacgtgatgc gatgaattcg
121 agagagagcg aaactaggac gaggagtgcg gcggaagcgg cgggactccc gggcatgggg
181 gcttcaccac aatagaggca gcgcccccac ccgcccccgc cagcccctcc ggagcgaagc
241 ccccaaaccc cctcgggaaa aggatggcgg cagcacctac ccagatcgaa gccgagctgt
301 attacctgat cgctaggttc ttgcagtctg gaccctgcaa caaatccgct caggtgctag
361 tgcaggagct cgaggagcat cagctgattc cgcgccgctt agattgggag gggaaagagc
421 accgaagaag cttcgaggat ctggtggcag caaatgcaca cattcctcca gactacctcc
481 ttaaaatttg tgagagaatt ggtcctttac tagataaaga gatccctcag agtgttcctg
541 gggtacagac attattaggt gttggtcggc agtctctgct acgggatgcc aaagactgta
601 agagtacact atggaatggg tctgcttttg cggctctgca tagaggcaga cctccagaac
661 tacctgtaaa ttatgtgaaa cctccaaatg tgggggcagt catacatatg gtggataggt
721 gtgaggagtg aatatcacct ctgccaggca attaaccggc tgtagtcgct ttggtcatat
781 tttcccttca tctgcttacc agcacattaa gatgcataag agaattctgg ggcacttgtc
841 atctgtctac tgtgtagcat ttgaccgaag cgggagaaga atttttacag gttccgatga
901 ctgtttagta aaaatttggg ctacagatga tggacgcctt cttgctacac ttcgtggaca
961 ctctgctgaa atttctgaca tggctgttaa ctatgaaaac actcttattg ctgcaggcag
1021 ctgtgataag gtagtaagag tatggtgtct tcgaacttgt gcacccgttg cagtccttca
1081 gggccattca gcttctatta cttccataca gagatcgccc ggtgaaattt actgagagat
1141 ccagacctgg agtccagata tcttgttcat ctttcagttc tggtggtatg ttcattacaa
1201 ctggtagtac tgaccatgtg attagaatat attatttggg ttctgaggtt cctgagaaaa
1261 ttgctgaatt agagtcacat acggataaag ttgttgctgt tcagttctgt aacaatggag
1321 acagtttaag atttgttagt ggaagtcgag atggaacggc aagaatttgg cagtatcagc
1381 aacaagaatg gaagagtata gtgctagaca tggctactaa aatgactggc aataatttgc
1441 catctggaga agacaagatc actaaactta aggtgactat ggtggcctgg gatcgctatg
1501 ataccacagt tattactgca gtgaacaatt ttcttttgaa agtgtggaat tctatcacag
1561 gacagcttct tcatacatta tctggacatg atgatgaagt attcgttcta gaagcccatc
1621 catttgatca aaggatcata ctttcagcag gtcatgatgg gaacattttt atttgggacc
1681 ttgaccgggg gaccaaaatt cggaattact ttaacatgat tgaaggccaa ggccatggtg
1741 cggtgtttga ttgtaaattt tcaccagatg gaaaccattt tgcctgcaca gattctcatg
1801 gacatttgct gctttttggt tttggatgca gtaaatacta cgaaaagatt ccagatcaga
1861 tgttcttcca cacggattat cgtcctctta ttcgtgatgc caataactat gtattggatg
1921 aacaaaccca acaagctcct cacctcatgc ctcctccatt tttggtggat gttgatggaa
1981 atcctcatcc cacaaaattc caacggttgg taccaggacg ggaaaattgt aaagatgaac
2041 agcttatacc acagctggga tatgtggcta atggtgatgg tgaggtagta gaacaggtaa
2101 ttgggcagca aaccaatgac caagatgaga gcattcttga tggaataatc agggagctgc
2161 agagagaaca agacctgaga ctaattaatg aaggagatgt tccacattta ccagttaata
2221 gagcatactc tgttaatggt gctctgagaa gtccaaacat ggacatatct tcttccccaa
2281 acatcaggct tcgaagacat agtagtcaaa ttgaaggtgt tagacaaatg cataacaatg
2341 ctcctcggag ccagatggcc actgaaagag atctcatggc gtggagcaga agagtggtgg
2401 tcaatgaact aaataatggg gttagtaggg tacaggaaga atgtcgaact gcaaaaggtg
2461 acatagaaat cagtctttat acagttgaaa agaagaaaaa gccatcttac actactcaaa
2521 ggaatgatta tgagcctagc tgtgggcgtt ctttacgcag gacacagcgc aaacgtcagc
2581 atacttacca aacacggtcc aacatagagc ataattcaca ggcatcatgt caaaattcag
2641 gtgtacagga agactcagac agttcttcag aggaagatga aactgttggc acaagtgacg
2701 cttcggtaga ggatcctgtt gttgaatggc aaagtgaaag ttcttccagt gactcatcaa
2761 gtgaatattc tgattggaca gcagatgctg gaataaattt acaaccccca aaaagacaaa
2821 ccagacagac aacacgtaaa atatgcagca gctctgatga ggaaaatttg aagtccctag
2881 aagaaaggca gaagaaacct aagcagacta gaaagaagaa aggaggactg gtttctatag
2941 caggtgagcc taatgaagaa tggtttgccc ctcagtggat cttggatact ataccccgac
3001 gttccccatt tgtcccacaa atgggagatg agcttatcta ttttaggcaa ggacatgaag
3061 cttatgttcg ggctgtaagg aaatcgaaaa tatacagtgt taatttacaa aaacagccat
3121 ggaacaaaat ggatctcagg gagcaagagt ttgttaagat tgtaggaatc aaatatgagg
3181 ttggcccacc cacactgtgc tgcttgaagc ttgcatttct ggacccaatt tcaggcaaaa
3241 tgactggaga atctttttcc attaagtatc atgacatgcc ggatgtcatt gacttccttg
3301 tgctacatca gttttataat gaagccaaag aaaggaactg gcagattggt gatagattcc
3361 gcagtataat agatgacgcc tggtggtttg ggactgtgga gagtcagcag ccttttcaac
3421 cagagtatcc tgatagttct ttccagtgtt acagtgttca ctgggacaat aatgagagag
3481 aaaagatgag cccatgggat atggagccaa ttccagaagg aactgccttt ccagatgaag
3541 ttggtgctgg tgttcctgtc tcccaggaag aattgactgc tttgctatac aaaccccagg
3601 aaggagagtg gggggctcat tccagagacg aagaatgtga acgggttatt cagggcatca
3661 accaccttct ttccctggat tttgccagcc cttttgctgt tccagtggat ctcagtgcct
3721 accccttgta ttgtactgta gttgcttatc caactgacct caataccatc aggcggagac
3781 ttgaaaatcg cttttacagg agaatatcag cattaatgtg ggaggtacgc tatattgaac
3841 ataatgccag gactttcaat gagccagaca gtcctatagt taaagcagct aaaattgtaa
3901 ctgatgtctt acttcgattt attggggatc agagctgtac tgatatactg gatacttata
3961 ataaaattaa agcagaagaa cgaaacagta ctgatgcaga ggaggataca gaaattgttg
4021 atttagattc agacggtcct ggtacttcat ctggaagaag ggtcaaatgc cgaggcagaa
4081 gacagtcttt aaagtgtaat cctgatgctt ggaaaaaaca atgcaaggaa ctattgagcc
4141 tcatttatga acgtgaagac tcggagccat ttcgacagcc agctgatctt ctttcttacc
4201 caggtcatca ggagcaagag ggagaatcct cagagtctgt tgttccagaa agacaacaag
4261 attcatctct ttctgaggat tatcaagatg ttatagatac tcctgtggac ttcagcactg
4321 tgaaagaaac tttggaagca ggaaactatg gtagtcctct ggaattttat aaggatgttc
4381 gccaaatatt caacaactcc aaagcttata cctctaataa aaagtcaagg atctatagca
4441 tgatgctgcg attatctgcc ttatttgaaa gtcatatcaa aaatatcatc tctgaatata
4501 agtcagcaat ccagagtcag aagaggagaa ggccacggta cagaaaacgt ctaagaagca
4561 gcagcagttc attatctagt agtggagcac ctagtccaaa agggaagcag aaacaaatga
4621 agttgcagcc taaaaatgac cagaatacct cagtatctca tgccaggact agctctcctt
4681 tctcatctcc tgtttcagat gctgctgaag ggctttcact atatctactt gatgatgagc
4741 cagatgggcc attttcttca tcgagcttcg gtggatatag ccgaagtgga aatagccatg
4801 acccagggaa agccaaatca tttcggaata gagttttgcc agttaaacaa gatcactccc
4861 ttgatggacc ccttacaaat ggtgatggca gagagccccg gacaggaatc aagagaaaac
4921 tacttagtgc atcagaagaa gatgaaaaca tgggaggaga agataaagag aaaaaagaaa
4981 caaaagagaa atctcattta tccacctcag agagtggaga gttaggatcc agtttaagtt
5041 ctgaaagtac ctgtggttct gactctgact ctgaatcaac ttccagaaca gatcaagatt
5101 acgtagatgg agaccatgat tatagcaaat tcatacaaac cagacctaaa agaaaactca
5161 gaaagcaaca tggcaatgga aaaagaaatt ggaagaccag aggcacagga ggaagaggca
5221 gatggggaag atggggtaga tggagtagag gaggcagagg aagaggaggc aggggacgag
5281 ggagtcgagg aagaggtgga ggtggcacta gggggagggg aagagggaga ggaggaagag
5341 gtgcttctag aggagctacc agagccaaac gagcacgtat tgcagatgat gaatttgata
5401 ccatgttttc aggacgtttc agtagactgc ctcgaattaa aacaagaaac caaggcagga
5461 ggactgtttt atataatgat gattctgata atgacaattt tgtgtccact gaggatcctc
5521 tgaatcttgg tacatccaga tcaggcagag tgcgtaaaat gacagaaaaa gccagggtta
5581 gccatctcat gggatggaat tattaacagt taataaattt agaataactt aaaaaattca
5641 atggccttct actgcaggga atttaccagg aaatctacaa agcaagttgt gtggggactt
5701 ctgcttcctt tcacattggt gcttttccat ttatgccagt atacatttgt ttcaagactt
5761 ttgatctcca cacttcattt gttcaaataa gccttactca ttaggcctta aattaaaaga
5821 aattctgccc acacacacac aaacacatac acacacatac acacacacag acacacacac
5881 acgaaacaca acacagacac tacagattta ctacattaaa ggagcattca gcttcttaag
5941 agtagcatga catttttatc tcaatagaat agccctcttt tgcttttgta tcacagaagt
6001 atagcacctt cttacagag
//