LOCUS AY497054 5734 bp mRNA linear HUM 18-FEB-2005
DEFINITION Homo sapiens bromodomain and WD repeat domain containing 3 variant
BRWD3-I (BRWD3) mRNA, complete cds, alternatively spliced.
ACCESSION AY497054
VERSION AY497054.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5734)
AUTHORS Kalla,C., Nentwich,H., Schlotter,M., Mertens,D., Wildenberger,K.,
Dohner,H., Stilgenbauer,S. and Lichter,P.
TITLE Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic
leukemia disrupts two novel genes
JOURNAL Genes Chromosomes Cancer 42 (2), 128-143 (2005)
PUBMED 15543602
REFERENCE 2 (bases 1 to 5734)
AUTHORS Schaffner,C. and Schlotter,M.
TITLE Direct Submission
JOURNAL Submitted (08-DEC-2003) Div. Molecular Genetics (B060), Deutsches
Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg
D-69120, Germany
FEATURES Location/Qualifiers
source 1..5734
/db_xref="H-InvDB:HIT000254960"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xq13"
gene 1..5734
/gene="BRWD3"
CDS 903..5321
/gene="BRWD3"
/note="transcription factor; alternatively spliced;
contains first exons 1, 2, 3, and 4a, but lacks exons 5,
6, and 9"
/codon_start=1
/product="bromodomain and WD repeat domain containing 3
variant BRWD3-I"
/protein_id="AAS45479.1"
/translation="MFITTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVAVQFCNNG
DSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKITKLKVTMVAWD
RYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNI
FIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFGCSKYY
EKIPDQMFFHTDYRPLIRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVP
GRENCKDEQLIPQLGYVANGDGEVVEQVIGQQTNDQDESILDGIIRELQREQDLRLIN
EGDVPHLPVNRAYSVNGALRSPNMDISSSPNIRLRRHSSQIEGVRQMHNNAPRSQMAT
ERDLMAWSRRVVVNELNNGVSRVQEECRTAKGDIEISLYTVEKKKKPSYTTQRNDYEP
SCGRSLRRTQRKRQHTYQTRSNIEHNSQASCQNSGVQEDSDSSSEEDETVGTSDASVE
DPVVEWQSESSSSDSSSEYSDWTADAGINLQPPKRQTRQTTRKICSSSDEENLKSLEE
RQKKPKQTRKKKGGLVSIAGEPNEEWFAPQWILDTIPRRSPFVPQMGDELIYFRQGHE
AYVRAVRKSKIYSVNLQKQPWNKMDLREQEFVKIVGIKYEVGPPTLCCLKLAFLDPIS
GKMTGESFSIKYHDMPDVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQ
QPFQPEYPDSSFQCYSVHWDNNEREKMSPWDMEPIPEGTAFPDEVGAGVPVSQEELTA
LLYKPQEGEWGAHSRDEECERVIQGINHLLSLDFASPFAVPVDLSAYPLYCTVVAYPT
DLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGD
QSCTDILDTYNKIKAEERNSTDAEEDTEIVDLDSDGPGTSSGRRVKCRGRRQSLKCNP
DAWKKQCKELLSLIYEREDSEPFRQPADLLSYPGHQEQEGESSESVVPERQQDSSLSE
DYQDVIDTPVDFSTVKETLEAGNYGSPLEFYKDVRQIFNNSKAYTSNKKSRIYSMMLR
LSALFESHIKNIISEYKSAIQSQKRRRPRYRKRLRSSSSSLSSSGAPSPKGKQKQMKL
QPKNDQNTSVSHARTSSPFSSPVSDAAEGLSLYLLDDEPDGPFSSSSFGGYSRSGNSH
DPGKAKSFRNRVLPVKQDHSLDGPLTNGDGREPRTGIKRKLLSASEEDENMGGEDKEK
KETKEKSHLSTSESGELGSSLSSESTCGSDSDSESTSRTDQDYVDGDHDYSKFIQTRP
KRKLRKQHGNGKRNWKTRGTGGRGRWGRWGRWSRGGRGRGGRGRGSRGRGGGGTRGRG
RGRGGRGASRGATRAKRARIADDEFDTMFSGRFSRLPRIKTRNQGRRTVLYNDDSDND
NFVSTEDPLNLGTSRSGRVRKMTEKARVSHLMGWNY"
misc_feature 960..1535
/gene="BRWD3"
/note="Region: contains four WD40 repeats"
misc_feature 3330..3650
/gene="BRWD3"
/note="Region: bromo domain"
misc_feature 3816..4205
/gene="BRWD3"
/note="Region: bromo domain"
BASE COUNT 1780 a 1153 c 1341 g 1460 t
ORIGIN
1 tctctctctc tctcactcac tcactctctc tctccctctc cctctcctct ccttcctcct
61 ccgcctcctc agctcttggg ctagaatatc tatgggtcga aacgtgatgc gatgaattcg
121 agagagagcg aaactaggac gaggagtgcg gcggaagcgg cgggactccc gggcatgggg
181 gcttcaccac aatagaggca gcgcccccac ccgcccccgc cagcccctcc ggagcgaagc
241 ccccaaaccc cctcgggaaa aggatggcgg cagcacctac ccagatcgaa gccgagctgt
301 attacctgat cgctaggttc ttgcagtctg gaccctgcaa caaatccgct caggtgctag
361 tgcaggagct cgaggagcat cagctgattc cgcgccgctt agattgggag gggaaagagc
421 accgaagaag cttcgaggat ctgtgaatat cacctctgcc aggcaattaa ccggctgtag
481 tcgctttggt catattttcc cttcatctgc ttaccagcac attaagatgc ataagagaat
541 tctggggcac ttgtcatctg tctactgtgt agcatttgac cgaagcggga gaagaatttt
601 tacaggttcc gatgactgtt tagtaaaaat ttgggctaca gatgatggac gccttcttgc
661 tacacttcgt ggacactctg ctgaaatttc tgacatggct gttaactatg aaaacactct
721 tattgctgca ggcagctgtg ataaggtagt aagagtatgg tgtcttcgaa cttgtgcacc
781 cgttgcagtc cttcagggcc attcagcttc tattacttcc atacagagat cgcccggtga
841 aatttactga gagatccaga cctggagtcc agatatcttg ttcatctttc agttctggtg
901 gtatgttcat tacaactggt agtactgacc atgtgattag aatatattat ttgggttctg
961 aggttcctga gaaaattgct gaattagagt cacatacgga taaagttgtt gctgttcagt
1021 tctgtaacaa tggagacagt ttaagatttg ttagtggaag tcgagatgga acggcaagaa
1081 tttggcagta tcagcaacaa gaatggaaga gtatagtgct agacatggct actaaaatga
1141 ctggcaataa tttgccatct ggagaagaca agatcactaa acttaaggtg actatggtgg
1201 cctgggatcg ctatgatacc acagttatta ctgcagtgaa caattttctt ttgaaagtgt
1261 ggaattctat cacaggacag cttcttcata cattatctgg acatgatgat gaagtattcg
1321 ttctagaagc ccatccattt gatcaaagga tcatactttc agcaggtcat gatgggaaca
1381 tttttatttg ggaccttgac cgggggacca aaattcggaa ttactttaac atgattgaag
1441 gccaaggcca tggtgcggtg tttgattgta aattttcacc agatggaaac cattttgcct
1501 gcacagattc tcatggacat ttgctgcttt ttggttttgg atgcagtaaa tactacgaaa
1561 agattccaga tcagatgttc ttccacacgg attatcgtcc tcttattcgt gatgccaata
1621 actatgtatt ggatgaacaa acccaacaag ctcctcacct catgcctcct ccatttttgg
1681 tggatgttga tggaaatcct catcccacaa aattccaacg gttggtacca ggacgggaaa
1741 attgtaaaga tgaacagctt ataccacagc tgggatatgt ggctaatggt gatggtgagg
1801 tagtagaaca ggtaattggg cagcaaacca atgaccaaga tgagagcatt cttgatggaa
1861 taatcaggga gctgcagaga gaacaagacc tgagactaat taatgaagga gatgttccac
1921 atttaccagt taatagagca tactctgtta atggtgctct gagaagtcca aacatggaca
1981 tatcttcttc cccaaacatc aggcttcgaa gacatagtag tcaaattgaa ggtgttagac
2041 aaatgcataa caatgctcct cggagccaga tggccactga aagagatctc atggcgtgga
2101 gcagaagagt ggtggtcaat gaactaaata atggggttag tagggtacag gaagaatgtc
2161 gaactgcaaa aggtgacata gaaatcagtc tttatacagt tgaaaagaag aaaaagccat
2221 cttacactac tcaaaggaat gattatgagc ctagctgtgg gcgttcttta cgcaggacac
2281 agcgcaaacg tcagcatact taccaaacac ggtccaacat agagcataat tcacaggcat
2341 catgtcaaaa ttcaggtgta caggaagact cagacagttc ttcagaggaa gatgaaactg
2401 ttggcacaag tgacgcttcg gtagaggatc ctgttgttga atggcaaagt gaaagttctt
2461 ccagtgactc atcaagtgaa tattctgatt ggacagcaga tgctggaata aatttacaac
2521 ccccaaaaag acaaaccaga cagacaacac gtaaaatatg cagcagctct gatgaggaaa
2581 atttgaagtc cctagaagaa aggcagaaga aacctaagca gactagaaag aagaaaggag
2641 gactggtttc tatagcaggt gagcctaatg aagaatggtt tgcccctcag tggatcttgg
2701 atactatacc ccgacgttcc ccatttgtcc cacaaatggg agatgagctt atctatttta
2761 ggcaaggaca tgaagcttat gttcgggctg taaggaaatc gaaaatatac agtgttaatt
2821 tacaaaaaca gccatggaac aaaatggatc tcagggagca agagtttgtt aagattgtag
2881 gaatcaaata tgaggttggc ccacccacac tgtgctgctt gaagcttgca tttctggacc
2941 caatttcagg caaaatgact ggagaatctt tttccattaa gtatcatgac atgccggatg
3001 tcattgactt ccttgtgcta catcagtttt ataatgaagc caaagaaagg aactggcaga
3061 ttggtgatag attccgcagt ataatagatg acgcctggtg gtttgggact gtggagagtc
3121 agcagccttt tcaaccagag tatcctgata gttctttcca gtgttacagt gttcactggg
3181 acaataatga gagagaaaag atgagcccat gggatatgga gccaattcca gaaggaactg
3241 cctttccaga tgaagttggt gctggtgttc ctgtctccca ggaagaattg actgctttgc
3301 tatacaaacc ccaggaagga gagtgggggg ctcattccag agacgaagaa tgtgaacggg
3361 ttattcaggg catcaaccac cttctttccc tggattttgc cagccctttt gctgttccag
3421 tggatctcag tgcctacccc ttgtattgta ctgtagttgc ttatccaact gacctcaata
3481 ccatcaggcg gagacttgaa aatcgctttt acaggagaat atcagcatta atgtgggagg
3541 tacgctatat tgaacataat gccaggactt tcaatgagcc agacagtcct atagttaaag
3601 cagctaaaat tgtaactgat gtcttacttc gatttattgg ggatcagagc tgtactgata
3661 tactggatac ttataataaa attaaagcag aagaacgaaa cagtactgat gcagaggagg
3721 atacagaaat tgttgattta gattcagacg gtcctggtac ttcatctgga agaagggtca
3781 aatgccgagg cagaagacag tctttaaagt gtaatcctga tgcttggaaa aaacaatgca
3841 aggaactatt gagcctcatt tatgaacgtg aagactcgga gccatttcga cagccagctg
3901 atcttctttc ttacccaggt catcaggagc aagagggaga atcctcagag tctgttgttc
3961 cagaaagaca acaagattca tctctttctg aggattatca agatgttata gatactcctg
4021 tggacttcag cactgtgaaa gaaactttgg aagcaggaaa ctatggtagt cctctggaat
4081 tttataagga tgttcgccaa atattcaaca actccaaagc ttatacctct aataaaaagt
4141 caaggatcta tagcatgatg ctgcgattat ctgccttatt tgaaagtcat atcaaaaata
4201 tcatctctga atataagtca gcaatccaga gtcagaagag gagaaggcca cggtacagaa
4261 aacgtctaag aagcagcagc agttcattat ctagtagtgg agcacctagt ccaaaaggga
4321 agcagaaaca aatgaagttg cagcctaaaa atgaccagaa tacctcagta tctcatgcca
4381 ggactagctc tcctttctca tctcctgttt cagatgctgc tgaagggctt tcactatatc
4441 tacttgatga tgagccagat gggccatttt cttcatcgag cttcggtgga tatagccgaa
4501 gtggaaatag ccatgaccca gggaaagcca aatcatttcg gaatagagtt ttgccagtta
4561 aacaagatca ctcccttgat ggacccctta caaatggtga tggcagagag ccccggacag
4621 gaatcaagag aaaactactt agtgcatcag aagaagatga aaacatggga ggagaagata
4681 aagagaaaaa agaaacaaaa gagaaatctc atttatccac ctcagagagt ggagagttag
4741 gatccagttt aagttctgaa agtacctgtg gttctgactc tgactctgaa tcaacttcca
4801 gaacagatca agattacgta gatggagacc atgattatag caaattcata caaaccagac
4861 ctaaaagaaa actcagaaag caacatggca atggaaaaag aaattggaag accagaggca
4921 caggaggaag aggcagatgg ggaagatggg gtagatggag tagaggaggc agaggaagag
4981 gaggcagggg acgagggagt cgaggaagag gtggaggtgg cactaggggg aggggaagag
5041 ggagaggagg aagaggtgct tctagaggag ctaccagagc caaacgagca cgtattgcag
5101 atgatgaatt tgataccatg ttttcaggac gtttcagtag actgcctcga attaaaacaa
5161 gaaaccaagg caggaggact gttttatata atgatgattc tgataatgac aattttgtgt
5221 ccactgagga tcctctgaat cttggtacat ccagatcagg cagagtgcgt aaaatgacag
5281 aaaaagccag ggttagccat ctcatgggat ggaattatta acagttaata aatttagaat
5341 aacttaaaaa attcaatggc cttctactgc agggaattta ccaggaaatc tacaaagcaa
5401 gttgtgtggg gacttctgct tcctttcaca ttggtgcttt tccatttatg ccagtataca
5461 tttgtttcaa gacttttgat ctccacactt catttgttca aataagcctt actcattagg
5521 ccttaaatta aaagaaattc tgcccacaca cacacaaaca catacacaca catacacaca
5581 cacagacaca cacacacgaa acacaacaca gacactacag atttactaca ttaaaggagc
5641 attcagcttc ttaagagtag catgacattt ttatctcaat agaatagccc tcttttgctt
5701 ttgtatcaca gaagtatagc accttcttac agag
//