LOCUS AY497053 5833 bp mRNA linear HUM 18-FEB-2005
DEFINITION Homo sapiens bromodomain and WD repeat domain containing 3 variant
BRWD3-H (BRWD3) mRNA, complete cds, alternatively spliced.
ACCESSION AY497053
VERSION AY497053.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5833)
AUTHORS Kalla,C., Nentwich,H., Schlotter,M., Mertens,D., Wildenberger,K.,
Dohner,H., Stilgenbauer,S. and Lichter,P.
TITLE Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic
leukemia disrupts two novel genes
JOURNAL Genes Chromosomes Cancer 42 (2), 128-143 (2005)
PUBMED 15543602
REFERENCE 2 (bases 1 to 5833)
AUTHORS Schaffner,C. and Schlotter,M.
TITLE Direct Submission
JOURNAL Submitted (08-DEC-2003) Div. Molecular Genetics (B060), Deutsches
Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg
D-69120, Germany
FEATURES Location/Qualifiers
source 1..5833
/db_xref="H-InvDB:HIT000254959"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xq13"
gene 1..5833
/gene="BRWD3"
CDS 1002..5420
/gene="BRWD3"
/note="transcription factor; alternatively spliced;
contains first exons 1, 2, 3, and 4a, but lacks exons 5
and 9"
/codon_start=1
/product="bromodomain and WD repeat domain containing 3
variant BRWD3-H"
/protein_id="AAS45478.1"
/translation="MFITTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVAVQFCNNG
DSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKITKLKVTMVAWD
RYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNI
FIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFGCSKYY
EKIPDQMFFHTDYRPLIRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVP
GRENCKDEQLIPQLGYVANGDGEVVEQVIGQQTNDQDESILDGIIRELQREQDLRLIN
EGDVPHLPVNRAYSVNGALRSPNMDISSSPNIRLRRHSSQIEGVRQMHNNAPRSQMAT
ERDLMAWSRRVVVNELNNGVSRVQEECRTAKGDIEISLYTVEKKKKPSYTTQRNDYEP
SCGRSLRRTQRKRQHTYQTRSNIEHNSQASCQNSGVQEDSDSSSEEDETVGTSDASVE
DPVVEWQSESSSSDSSSEYSDWTADAGINLQPPKRQTRQTTRKICSSSDEENLKSLEE
RQKKPKQTRKKKGGLVSIAGEPNEEWFAPQWILDTIPRRSPFVPQMGDELIYFRQGHE
AYVRAVRKSKIYSVNLQKQPWNKMDLREQEFVKIVGIKYEVGPPTLCCLKLAFLDPIS
GKMTGESFSIKYHDMPDVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQ
QPFQPEYPDSSFQCYSVHWDNNEREKMSPWDMEPIPEGTAFPDEVGAGVPVSQEELTA
LLYKPQEGEWGAHSRDEECERVIQGINHLLSLDFASPFAVPVDLSAYPLYCTVVAYPT
DLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGD
QSCTDILDTYNKIKAEERNSTDAEEDTEIVDLDSDGPGTSSGRRVKCRGRRQSLKCNP
DAWKKQCKELLSLIYEREDSEPFRQPADLLSYPGHQEQEGESSESVVPERQQDSSLSE
DYQDVIDTPVDFSTVKETLEAGNYGSPLEFYKDVRQIFNNSKAYTSNKKSRIYSMMLR
LSALFESHIKNIISEYKSAIQSQKRRRPRYRKRLRSSSSSLSSSGAPSPKGKQKQMKL
QPKNDQNTSVSHARTSSPFSSPVSDAAEGLSLYLLDDEPDGPFSSSSFGGYSRSGNSH
DPGKAKSFRNRVLPVKQDHSLDGPLTNGDGREPRTGIKRKLLSASEEDENMGGEDKEK
KETKEKSHLSTSESGELGSSLSSESTCGSDSDSESTSRTDQDYVDGDHDYSKFIQTRP
KRKLRKQHGNGKRNWKTRGTGGRGRWGRWGRWSRGGRGRGGRGRGSRGRGGGGTRGRG
RGRGGRGASRGATRAKRARIADDEFDTMFSGRFSRLPRIKTRNQGRRTVLYNDDSDND
NFVSTEDPLNLGTSRSGRVRKMTEKARVSHLMGWNY"
misc_feature 1059..1634
/gene="BRWD3"
/note="Region: contains four WD40 repeats"
misc_feature 3429..3749
/gene="BRWD3"
/note="Region: bromo domain"
misc_feature 3915..4304
/gene="BRWD3"
/note="Region: bromo domain"
BASE COUNT 1808 a 1174 c 1365 g 1486 t
ORIGIN
1 tctctctctc tctcactcac tcactctctc tctccctctc cctctcctct ccttcctcct
61 ccgcctcctc agctcttggg ctagaatatc tatgggtcga aacgtgatgc gatgaattcg
121 agagagagcg aaactaggac gaggagtgcg gcggaagcgg cgggactccc gggcatgggg
181 gcttcaccac aatagaggca gcgcccccac ccgcccccgc cagcccctcc ggagcgaagc
241 ccccaaaccc cctcgggaaa aggatggcgg cagcacctac ccagatcgaa gccgagctgt
301 attacctgat cgctaggttc ttgcagtctg gaccctgcaa caaatccgct caggtgctag
361 tgcaggagct cgaggagcat cagctgattc cgcgccgctt agattgggag gggaaagagc
421 accgaagaag cttcgaggat ctgactgtaa gagtacacta tggaatgggt ctgcttttgc
481 ggctctgcat agaggcagac ctccagaact acctgtaaat tatgtgaaac ctccaaatgt
541 ggtgaatatc acctctgcca ggcaattaac cggctgtagt cgctttggtc atattttccc
601 ttcatctgct taccagcaca ttaagatgca taagagaatt ctggggcact tgtcatctgt
661 ctactgtgta gcatttgacc gaagcgggag aagaattttt acaggttccg atgactgttt
721 agtaaaaatt tgggctacag atgatggacg ccttcttgct acacttcgtg gacactctgc
781 tgaaatttct gacatggctg ttaactatga aaacactctt attgctgcag gcagctgtga
841 taaggtagta agagtatggt gtcttcgaac ttgtgcaccc gttgcagtcc ttcagggcca
901 ttcagcttct attacttcca tacagagatc gcccggtgaa atttactgag agatccagac
961 ctggagtcca gatatcttgt tcatctttca gttctggtgg tatgttcatt acaactggta
1021 gtactgacca tgtgattaga atatattatt tgggttctga ggttcctgag aaaattgctg
1081 aattagagtc acatacggat aaagttgttg ctgttcagtt ctgtaacaat ggagacagtt
1141 taagatttgt tagtggaagt cgagatggaa cggcaagaat ttggcagtat cagcaacaag
1201 aatggaagag tatagtgcta gacatggcta ctaaaatgac tggcaataat ttgccatctg
1261 gagaagacaa gatcactaaa cttaaggtga ctatggtggc ctgggatcgc tatgatacca
1321 cagttattac tgcagtgaac aattttcttt tgaaagtgtg gaattctatc acaggacagc
1381 ttcttcatac attatctgga catgatgatg aagtattcgt tctagaagcc catccatttg
1441 atcaaaggat catactttca gcaggtcatg atgggaacat ttttatttgg gaccttgacc
1501 gggggaccaa aattcggaat tactttaaca tgattgaagg ccaaggccat ggtgcggtgt
1561 ttgattgtaa attttcacca gatggaaacc attttgcctg cacagattct catggacatt
1621 tgctgctttt tggttttgga tgcagtaaat actacgaaaa gattccagat cagatgttct
1681 tccacacgga ttatcgtcct cttattcgtg atgccaataa ctatgtattg gatgaacaaa
1741 cccaacaagc tcctcacctc atgcctcctc catttttggt ggatgttgat ggaaatcctc
1801 atcccacaaa attccaacgg ttggtaccag gacgggaaaa ttgtaaagat gaacagctta
1861 taccacagct gggatatgtg gctaatggtg atggtgaggt agtagaacag gtaattgggc
1921 agcaaaccaa tgaccaagat gagagcattc ttgatggaat aatcagggag ctgcagagag
1981 aacaagacct gagactaatt aatgaaggag atgttccaca tttaccagtt aatagagcat
2041 actctgttaa tggtgctctg agaagtccaa acatggacat atcttcttcc ccaaacatca
2101 ggcttcgaag acatagtagt caaattgaag gtgttagaca aatgcataac aatgctcctc
2161 ggagccagat ggccactgaa agagatctca tggcgtggag cagaagagtg gtggtcaatg
2221 aactaaataa tggggttagt agggtacagg aagaatgtcg aactgcaaaa ggtgacatag
2281 aaatcagtct ttatacagtt gaaaagaaga aaaagccatc ttacactact caaaggaatg
2341 attatgagcc tagctgtggg cgttctttac gcaggacaca gcgcaaacgt cagcatactt
2401 accaaacacg gtccaacata gagcataatt cacaggcatc atgtcaaaat tcaggtgtac
2461 aggaagactc agacagttct tcagaggaag atgaaactgt tggcacaagt gacgcttcgg
2521 tagaggatcc tgttgttgaa tggcaaagtg aaagttcttc cagtgactca tcaagtgaat
2581 attctgattg gacagcagat gctggaataa atttacaacc cccaaaaaga caaaccagac
2641 agacaacacg taaaatatgc agcagctctg atgaggaaaa tttgaagtcc ctagaagaaa
2701 ggcagaagaa acctaagcag actagaaaga agaaaggagg actggtttct atagcaggtg
2761 agcctaatga agaatggttt gcccctcagt ggatcttgga tactataccc cgacgttccc
2821 catttgtccc acaaatggga gatgagctta tctattttag gcaaggacat gaagcttatg
2881 ttcgggctgt aaggaaatcg aaaatataca gtgttaattt acaaaaacag ccatggaaca
2941 aaatggatct cagggagcaa gagtttgtta agattgtagg aatcaaatat gaggttggcc
3001 cacccacact gtgctgcttg aagcttgcat ttctggaccc aatttcaggc aaaatgactg
3061 gagaatcttt ttccattaag tatcatgaca tgccggatgt cattgacttc cttgtgctac
3121 atcagtttta taatgaagcc aaagaaagga actggcagat tggtgataga ttccgcagta
3181 taatagatga cgcctggtgg tttgggactg tggagagtca gcagcctttt caaccagagt
3241 atcctgatag ttctttccag tgttacagtg ttcactggga caataatgag agagaaaaga
3301 tgagcccatg ggatatggag ccaattccag aaggaactgc ctttccagat gaagttggtg
3361 ctggtgttcc tgtctcccag gaagaattga ctgctttgct atacaaaccc caggaaggag
3421 agtggggggc tcattccaga gacgaagaat gtgaacgggt tattcagggc atcaaccacc
3481 ttctttccct ggattttgcc agcccttttg ctgttccagt ggatctcagt gcctacccct
3541 tgtattgtac tgtagttgct tatccaactg acctcaatac catcaggcgg agacttgaaa
3601 atcgctttta caggagaata tcagcattaa tgtgggaggt acgctatatt gaacataatg
3661 ccaggacttt caatgagcca gacagtccta tagttaaagc agctaaaatt gtaactgatg
3721 tcttacttcg atttattggg gatcagagct gtactgatat actggatact tataataaaa
3781 ttaaagcaga agaacgaaac agtactgatg cagaggagga tacagaaatt gttgatttag
3841 attcagacgg tcctggtact tcatctggaa gaagggtcaa atgccgaggc agaagacagt
3901 ctttaaagtg taatcctgat gcttggaaaa aacaatgcaa ggaactattg agcctcattt
3961 atgaacgtga agactcggag ccatttcgac agccagctga tcttctttct tacccaggtc
4021 atcaggagca agagggagaa tcctcagagt ctgttgttcc agaaagacaa caagattcat
4081 ctctttctga ggattatcaa gatgttatag atactcctgt ggacttcagc actgtgaaag
4141 aaactttgga agcaggaaac tatggtagtc ctctggaatt ttataaggat gttcgccaaa
4201 tattcaacaa ctccaaagct tatacctcta ataaaaagtc aaggatctat agcatgatgc
4261 tgcgattatc tgccttattt gaaagtcata tcaaaaatat catctctgaa tataagtcag
4321 caatccagag tcagaagagg agaaggccac ggtacagaaa acgtctaaga agcagcagca
4381 gttcattatc tagtagtgga gcacctagtc caaaagggaa gcagaaacaa atgaagttgc
4441 agcctaaaaa tgaccagaat acctcagtat ctcatgccag gactagctct cctttctcat
4501 ctcctgtttc agatgctgct gaagggcttt cactatatct acttgatgat gagccagatg
4561 ggccattttc ttcatcgagc ttcggtggat atagccgaag tggaaatagc catgacccag
4621 ggaaagccaa atcatttcgg aatagagttt tgccagttaa acaagatcac tcccttgatg
4681 gaccccttac aaatggtgat ggcagagagc cccggacagg aatcaagaga aaactactta
4741 gtgcatcaga agaagatgaa aacatgggag gagaagataa agagaaaaaa gaaacaaaag
4801 agaaatctca tttatccacc tcagagagtg gagagttagg atccagttta agttctgaaa
4861 gtacctgtgg ttctgactct gactctgaat caacttccag aacagatcaa gattacgtag
4921 atggagacca tgattatagc aaattcatac aaaccagacc taaaagaaaa ctcagaaagc
4981 aacatggcaa tggaaaaaga aattggaaga ccagaggcac aggaggaaga ggcagatggg
5041 gaagatgggg tagatggagt agaggaggca gaggaagagg aggcagggga cgagggagtc
5101 gaggaagagg tggaggtggc actaggggga ggggaagagg gagaggagga agaggtgctt
5161 ctagaggagc taccagagcc aaacgagcac gtattgcaga tgatgaattt gataccatgt
5221 tttcaggacg tttcagtaga ctgcctcgaa ttaaaacaag aaaccaaggc aggaggactg
5281 ttttatataa tgatgattct gataatgaca attttgtgtc cactgaggat cctctgaatc
5341 ttggtacatc cagatcaggc agagtgcgta aaatgacaga aaaagccagg gttagccatc
5401 tcatgggatg gaattattaa cagttaataa atttagaata acttaaaaaa ttcaatggcc
5461 ttctactgca gggaatttac caggaaatct acaaagcaag ttgtgtgggg acttctgctt
5521 cctttcacat tggtgctttt ccatttatgc cagtatacat ttgtttcaag acttttgatc
5581 tccacacttc atttgttcaa ataagcctta ctcattaggc cttaaattaa aagaaattct
5641 gcccacacac acacaaacac atacacacac atacacacac acagacacac acacacgaaa
5701 cacaacacag acactacaga tttactacat taaaggagca ttcagcttct taagagtagc
5761 atgacatttt tatctcaata gaatagccct cttttgcttt tgtatcacag aagtatagca
5821 ccttcttaca gag
//