LOCUS AY497052 6244 bp mRNA linear HUM 18-FEB-2005
DEFINITION Homo sapiens bromodomain and WD repeat domain containing 3 variant
BRWD3-G (BRWD3) mRNA, complete cds, alternatively spliced.
ACCESSION AY497052
VERSION AY497052.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6244)
AUTHORS Kalla,C., Nentwich,H., Schlotter,M., Mertens,D., Wildenberger,K.,
Dohner,H., Stilgenbauer,S. and Lichter,P.
TITLE Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic
leukemia disrupts two novel genes
JOURNAL Genes Chromosomes Cancer 42 (2), 128-143 (2005)
PUBMED 15543602
REFERENCE 2 (bases 1 to 6244)
AUTHORS Schaffner,C. and Schlotter,M.
TITLE Direct Submission
JOURNAL Submitted (08-DEC-2003) Div. Molecular Genetics (B060), Deutsches
Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg
D-69120, Germany
FEATURES Location/Qualifiers
source 1..6244
/db_xref="H-InvDB:HIT000254958"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xq13"
gene 1..6244
/gene="BRWD3"
CDS 1635..5831
/gene="BRWD3"
/note="transcription factor; alternatively spliced;
contains exons 1, 2, 3, 4a, 6b, and 12a"
/codon_start=1
/product="bromodomain and WD repeat domain containing 3
variant BRWD3-G"
/protein_id="AAS45477.1"
/translation="MATKMTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLK
VWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFN
MIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFGCSKYYEKIPDQMFFHTDYRPL
IRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVPGRENCKDEQLIPQLGY
VANGDGEVVEQVIGQQTNDQDESILDGIIRELQREQDLRLINEGDVPHLPVNRAYSVN
GALRSPNMDISSSPNIRLRRHSSQIEGVRQMHNNAPRSQMATERDLMAWSRRVVVNEL
NNGVSRVQEECRTAKGDIEISLYTVEKKKKPSYTTQRNDYEPSCGRSLRRTQRKRQHT
YQTRSNIEHNSQASCQNSGVQEDSDSSSEEDETVGTSDASVEDPVVEWQSESSSSDSS
SEYSDWTADAGINLQPPKRQTRQTTRKICSSSDEENLKSLEERQKKPKQTRKKKGGLV
SIAGEPNEEWFAPQWILDTIPRRSPFVPQMGDELIYFRQGHEAYVRAVRKSKIYSVNL
QKQPWNKMDLREQEFVKIVGIKYEVGPPTLCCLKLAFLDPISGKMTGESFSIKYHDMP
DVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQQPFQPEYPDSSFQCYS
VHWDNNEREKMSPWDMEPIPEGTAFPDEVGAGVPVSQEELTALLYKPQEGEWGAHSRD
EECERVIQGINHLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRR
ISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGDQSCTDILDTYNKIKAE
ERNSTDAEEDTEIVDLDSDGPGTSSGRRVKCRGRRQSLKCNPDAWKKQCKELLSLIYE
REDSEPFRQPADLLSYPGHQEQEGESSESVVPERQQDSSLSEDYQDVIDTPVDFSTVK
ETLEAGNYGSPLEFYKDVRQIFNNSKAYTSNKKSRIYSMMLRLSALFESHIKNIISEY
KSAIQSQKRRRPRYRKRLRSSSSSLSSSGAPSPKGKQKQMKLQPKNDQNTSVSHARTS
SPFSSPVSDAAEGLSLYLLDDEPDGPFSSSSFGGYSRSGNSHDPGKAKSFRNRVLPVK
QDHSLDGPLTNGDGREPRTGIKRKLLSASEEDENMGGEDKEKKETKEKSHLSTSESGE
LGSSLSSESTCGSDSDSESTSRTDQDYVDGDHDYSKFIQTRPKRKLRKQHGNGKRNWK
TRGTGGRGRWGRWGRWSRGGRGRGGRGRGSRGRGGGGTRGRGRGRGGRGASRGATRAK
RARIADDEFDTMFSGRFSRLPRIKTRNQGRRTVLYNDDSDNDNFVSTEDPLNLGTSRS
GRVRKMTEKARVSHLMGWNY"
misc_feature 1653..2045
/gene="BRWD3"
/note="Region: contains three WD40 repeats"
misc_feature 3840..4160
/gene="BRWD3"
/note="Region: bromo domain"
misc_feature 4326..4715
/gene="BRWD3"
/note="Region: bromo domain"
BASE COUNT 1941 a 1246 c 1459 g 1598 t
ORIGIN
1 tctctctctc tctcactcac tcactctctc tctccctctc cctctcctct ccttcctcct
61 ccgcctcctc agctcttggg ctagaatatc tatgggtcga aacgtgatgc gatgaattcg
121 agagagagcg aaactaggac gaggagtgcg gcggaagcgg cgggactccc gggcatgggg
181 gcttcaccac aatagaggca gcgcccccac ccgcccccgc cagcccctcc ggagcgaagc
241 ccccaaaccc cctcgggaaa aggatggcgg cagcacctac ccagatcgaa gccgagctgt
301 attacctgat cgctaggttc ttgcagtctg gaccctgcaa caaatccgct caggtgctag
361 tgcaggagct cgaggagcat cagctgattc cgcgccgctt agattgggag gggaaagagc
421 accgaagaag cttcgaggat ctggtggcag caaatgcaca cattcctcca gactacctcc
481 ttaaaatttg tgagagaatt ggtcctttac tagataaaga gatccctcag agtgttcctg
541 gggtacagac attattaggt gttggtcggc agtctctgct acgggatgcc aaagactgta
601 agagtacact atggaatggg tctgcttttg cggctctgca tagaggcaga cctccagaac
661 tacctgtaaa ttatgtgaaa cctccaaatg tgggggcagt catacatatg gtggataggt
721 gtgaggagtg aatatcacct ctgccaggca attaaccggc tgtagtcgct ttggtcatat
781 tttcccttca tctgcttacc agcacattaa gatgcataag agaattctgg ggcacttgtc
841 atctgtctac tgtgtagcat ttgaccgaag cgggagaaga atttttacag gttccgatga
901 ctgtttagta aaaatttggg ctacagatga tggacgcctt cttgctacac ttcgtggaca
961 ctctgctgaa atttctgaca tggctgttaa ctatgaaaac actcttattg ctgcaggcag
1021 ctgtgataag gtagtaagag tatggtgtct tcgaacttgt gcacccgttg cagtccttca
1081 gggccattca gcttctatta cttccataca gttttgtcca tcaactaaag gcacaaacag
1141 atacctcact tctactggtg ctgatggaac aatctgtttc tggcaatggc atgtaaaaac
1201 aatgaagttt agagatcgcc cggtgaaatt tactgagaga tccagacctg gagtccagat
1261 atcttgttca tctttcagtt ctggtggtat gttcattaca actggtagta ctgaccatgt
1321 gattagaata tattatttgg gttctgaggt tcctgagaaa attgctgaat tagagtcaca
1381 tacggataaa gttgttgctg ttcagttctg taacaatgga gacagaatga caagataatg
1441 aaaaatgata atcccaatat tgccaagggt tttgggaaaa tggacacttc tacaactcgt
1501 gatgagatta taaattatta aaaaaacttt tcggggaaac aatttggcat ttaagatttg
1561 ttagtggaag tcgagatgga acggcaagaa tttggcagta tcagcaacaa gaatggaaga
1621 gtatagtgct agacatggct actaaaatga ctggcaataa tttgccatct ggagaagaca
1681 agatcactaa acttaaggtg actatggtgg cctgggatcg ctatgatacc acagttatta
1741 ctgcagtgaa caattttctt ttgaaagtgt ggaattctat cacaggacag cttcttcata
1801 cattatctgg acatgatgat gaagtattcg ttctagaagc ccatccattt gatcaaagga
1861 tcatactttc agcaggtcat gatgggaaca tttttatttg ggaccttgac cgggggacca
1921 aaattcggaa ttactttaac atgattgaag gccaaggcca tggtgcggtg tttgattgta
1981 aattttcacc agatggaaac cattttgcct gcacagattc tcatggacat ttgctgcttt
2041 ttggttttgg atgcagtaaa tactacgaaa agattccaga tcagatgttc ttccacacgg
2101 attatcgtcc tcttattcgt gatgccaata actatgtatt ggatgaacaa acccaacaag
2161 ctcctcacct catgcctcct ccatttttgg tggatgttga tggaaatcct catcccacaa
2221 aattccaacg gttggtacca ggacgggaaa attgtaaaga tgaacagctt ataccacagc
2281 tgggatatgt ggctaatggt gatggtgagg tagtagaaca ggtaattggg cagcaaacca
2341 atgaccaaga tgagagcatt cttgatggaa taatcaggga gctgcagaga gaacaagacc
2401 tgagactaat taatgaagga gatgttccac atttaccagt taatagagca tactctgtta
2461 atggtgctct gagaagtcca aacatggaca tatcttcttc cccaaacatc aggcttcgaa
2521 gacatagtag tcaaattgaa ggtgttagac aaatgcataa caatgctcct cggagccaga
2581 tggccactga aagagatctc atggcgtgga gcagaagagt ggtggtcaat gaactaaata
2641 atggggttag tagggtacag gaagaatgtc gaactgcaaa aggtgacata gaaatcagtc
2701 tttatacagt tgaaaagaag aaaaagccat cttacactac tcaaaggaat gattatgagc
2761 ctagctgtgg gcgttcttta cgcaggacac agcgcaaacg tcagcatact taccaaacac
2821 ggtccaacat agagcataat tcacaggcat catgtcaaaa ttcaggtgta caggaagact
2881 cagacagttc ttcagaggaa gatgaaactg ttggcacaag tgacgcttcg gtagaggatc
2941 ctgttgttga atggcaaagt gaaagttctt ccagtgactc atcaagtgaa tattctgatt
3001 ggacagcaga tgctggaata aatttacaac ccccaaaaag acaaaccaga cagacaacac
3061 gtaaaatatg cagcagctct gatgaggaaa atttgaagtc cctagaagaa aggcagaaga
3121 aacctaagca gactagaaag aagaaaggag gactggtttc tatagcaggt gagcctaatg
3181 aagaatggtt tgcccctcag tggatcttgg atactatacc ccgacgttcc ccatttgtcc
3241 cacaaatggg agatgagctt atctatttta ggcaaggaca tgaagcttat gttcgggctg
3301 taaggaaatc gaaaatatac agtgttaatt tacaaaaaca gccatggaac aaaatggatc
3361 tcagggagca agagtttgtt aagattgtag gaatcaaata tgaggttggc ccacccacac
3421 tgtgctgctt gaagcttgca tttctggacc caatttcagg caaaatgact ggagaatctt
3481 tttccattaa gtatcatgac atgccggatg tcattgactt ccttgtgcta catcagtttt
3541 ataatgaagc caaagaaagg aactggcaga ttggtgatag attccgcagt ataatagatg
3601 acgcctggtg gtttgggact gtggagagtc agcagccttt tcaaccagag tatcctgata
3661 gttctttcca gtgttacagt gttcactggg acaataatga gagagaaaag atgagcccat
3721 gggatatgga gccaattcca gaaggaactg cctttccaga tgaagttggt gctggtgttc
3781 ctgtctccca ggaagaattg actgctttgc tatacaaacc ccaggaagga gagtgggggg
3841 ctcattccag agacgaagaa tgtgaacggg ttattcaggg catcaaccac cttctttccc
3901 tggattttgc cagccctttt gctgttccag tggatctcag tgcctacccc ttgtattgta
3961 ctgtagttgc ttatccaact gacctcaata ccatcaggcg gagacttgaa aatcgctttt
4021 acaggagaat atcagcatta atgtgggagg tacgctatat tgaacataat gccaggactt
4081 tcaatgagcc agacagtcct atagttaaag cagctaaaat tgtaactgat gtcttacttc
4141 gatttattgg ggatcagagc tgtactgata tactggatac ttataataaa attaaagcag
4201 aagaacgaaa cagtactgat gcagaggagg atacagaaat tgttgattta gattcagacg
4261 gtcctggtac ttcatctgga agaagggtca aatgccgagg cagaagacag tctttaaagt
4321 gtaatcctga tgcttggaaa aaacaatgca aggaactatt gagcctcatt tatgaacgtg
4381 aagactcgga gccatttcga cagccagctg atcttctttc ttacccaggt catcaggagc
4441 aagagggaga atcctcagag tctgttgttc cagaaagaca acaagattca tctctttctg
4501 aggattatca agatgttata gatactcctg tggacttcag cactgtgaaa gaaactttgg
4561 aagcaggaaa ctatggtagt cctctggaat tttataagga tgttcgccaa atattcaaca
4621 actccaaagc ttatacctct aataaaaagt caaggatcta tagcatgatg ctgcgattat
4681 ctgccttatt tgaaagtcat atcaaaaata tcatctctga atataagtca gcaatccaga
4741 gtcagaagag gagaaggcca cggtacagaa aacgtctaag aagcagcagc agttcattat
4801 ctagtagtgg agcacctagt ccaaaaggga agcagaaaca aatgaagttg cagcctaaaa
4861 atgaccagaa tacctcagta tctcatgcca ggactagctc tcctttctca tctcctgttt
4921 cagatgctgc tgaagggctt tcactatatc tacttgatga tgagccagat gggccatttt
4981 cttcatcgag cttcggtgga tatagccgaa gtggaaatag ccatgaccca gggaaagcca
5041 aatcatttcg gaatagagtt ttgccagtta aacaagatca ctcccttgat ggacccctta
5101 caaatggtga tggcagagag ccccggacag gaatcaagag aaaactactt agtgcatcag
5161 aagaagatga aaacatggga ggagaagata aagagaaaaa agaaacaaaa gagaaatctc
5221 atttatccac ctcagagagt ggagagttag gatccagttt aagttctgaa agtacctgtg
5281 gttctgactc tgactctgaa tcaacttcca gaacagatca agattacgta gatggagacc
5341 atgattatag caaattcata caaaccagac ctaaaagaaa actcagaaag caacatggca
5401 atggaaaaag aaattggaag accagaggca caggaggaag aggcagatgg ggaagatggg
5461 gtagatggag tagaggaggc agaggaagag gaggcagggg acgagggagt cgaggaagag
5521 gtggaggtgg cactaggggg aggggaagag ggagaggagg aagaggtgct tctagaggag
5581 ctaccagagc caaacgagca cgtattgcag atgatgaatt tgataccatg ttttcaggac
5641 gtttcagtag actgcctcga attaaaacaa gaaaccaagg caggaggact gttttatata
5701 atgatgattc tgataatgac aattttgtgt ccactgagga tcctctgaat cttggtacat
5761 ccagatcagg cagagtgcgt aaaatgacag aaaaagccag ggttagccat ctcatgggat
5821 ggaattatta acagttaata aatttagaat aacttaaaaa attcaatggc cttctactgc
5881 agggaattta ccaggaaatc tacaaagcaa gttgtgtggg gacttctgct tcctttcaca
5941 ttggtgcttt tccatttatg ccagtataca tttgtttcaa gacttttgat ctccacactt
6001 catttgttca aataagcctt actcattagg ccttaaatta aaagaaattc tgcccacaca
6061 cacacaaaca catacacaca catacacaca cacagacaca cacacacgaa acacaacaca
6121 gacactacag atttactaca ttaaaggagc attcagcttc ttaagagtag catgacattt
6181 ttatctcaat agaatagccc tcttttgctt ttgtatcaca gaagtatagc accttcttac
6241 agag
//