LOCUS AY497049 6078 bp mRNA linear HUM 18-FEB-2005
DEFINITION Homo sapiens bromodomain and WD repeat domain containing 3 variant
BRWD3-D (BRWD3) mRNA, complete cds, alternatively spliced.
ACCESSION AY497049
VERSION AY497049.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6078)
AUTHORS Kalla,C., Nentwich,H., Schlotter,M., Mertens,D., Wildenberger,K.,
Dohner,H., Stilgenbauer,S. and Lichter,P.
TITLE Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic
leukemia disrupts two novel genes
JOURNAL Genes Chromosomes Cancer 42 (2), 128-143 (2005)
PUBMED 15543602
REFERENCE 2 (bases 1 to 6078)
AUTHORS Schaffner,C. and Schlotter,M.
TITLE Direct Submission
JOURNAL Submitted (08-DEC-2003) Div. Molecular Genetics (B060), Deutsches
Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg
D-69120, Germany
FEATURES Location/Qualifiers
source 1..6078
/db_xref="H-InvDB:HIT000254955"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xq13"
gene 1..6078
/gene="BRWD3"
CDS 1469..5665
/gene="BRWD3"
/note="transcription factor; alternatively spliced;
contains exons 1, 2, 3, 4a, and 12a, but lacks exons 3 and
9"
/codon_start=1
/product="bromodomain and WD repeat domain containing 3
variant BRWD3-D"
/protein_id="AAS45474.1"
/translation="MATKMTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLK
VWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFN
MIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFGCSKYYEKIPDQMFFHTDYRPL
IRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVPGRENCKDEQLIPQLGY
VANGDGEVVEQVIGQQTNDQDESILDGIIRELQREQDLRLINEGDVPHLPVNRAYSVN
GALRSPNMDISSSPNIRLRRHSSQIEGVRQMHNNAPRSQMATERDLMAWSRRVVVNEL
NNGVSRVQEECRTAKGDIEISLYTVEKKKKPSYTTQRNDYEPSCGRSLRRTQRKRQHT
YQTRSNIEHNSQASCQNSGVQEDSDSSSEEDETVGTSDASVEDPVVEWQSESSSSDSS
SEYSDWTADAGINLQPPKRQTRQTTRKICSSSDEENLKSLEERQKKPKQTRKKKGGLV
SIAGEPNEEWFAPQWILDTIPRRSPFVPQMGDELIYFRQGHEAYVRAVRKSKIYSVNL
QKQPWNKMDLREQEFVKIVGIKYEVGPPTLCCLKLAFLDPISGKMTGESFSIKYHDMP
DVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQQPFQPEYPDSSFQCYS
VHWDNNEREKMSPWDMEPIPEGTAFPDEVGAGVPVSQEELTALLYKPQEGEWGAHSRD
EECERVIQGINHLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRR
ISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGDQSCTDILDTYNKIKAE
ERNSTDAEEDTEIVDLDSDGPGTSSGRRVKCRGRRQSLKCNPDAWKKQCKELLSLIYE
REDSEPFRQPADLLSYPGHQEQEGESSESVVPERQQDSSLSEDYQDVIDTPVDFSTVK
ETLEAGNYGSPLEFYKDVRQIFNNSKAYTSNKKSRIYSMMLRLSALFESHIKNIISEY
KSAIQSQKRRRPRYRKRLRSSSSSLSSSGAPSPKGKQKQMKLQPKNDQNTSVSHARTS
SPFSSPVSDAAEGLSLYLLDDEPDGPFSSSSFGGYSRSGNSHDPGKAKSFRNRVLPVK
QDHSLDGPLTNGDGREPRTGIKRKLLSASEEDENMGGEDKEKKETKEKSHLSTSESGE
LGSSLSSESTCGSDSDSESTSRTDQDYVDGDHDYSKFIQTRPKRKLRKQHGNGKRNWK
TRGTGGRGRWGRWGRWSRGGRGRGGRGRGSRGRGGGGTRGRGRGRGGRGASRGATRAK
RARIADDEFDTMFSGRFSRLPRIKTRNQGRRTVLYNDDSDNDNFVSTEDPLNLGTSRS
GRVRKMTEKARVSHLMGWNY"
misc_feature 1487..1879
/gene="BRWD3"
/note="Region: contains three WD40 repeats"
misc_feature 3674..3994
/gene="BRWD3"
/note="Region: bromo domain"
misc_feature 4160..4549
/gene="BRWD3"
/note="Region: bromo domain"
BASE COUNT 1892 a 1217 c 1413 g 1556 t
ORIGIN
1 tctctctctc tctcactcac tcactctctc tctccctctc cctctcctct ccttcctcct
61 ccgcctcctc agctcttggg ctagaatatc tatgggtcga aacgtgatgc gatgaattcg
121 agagagagcg aaactaggac gaggagtgcg gcggaagcgg cgggactccc gggcatgggg
181 gcttcaccac aatagaggca gcgcccccac ccgcccccgc cagcccctcc ggagcgaagc
241 ccccaaaccc cctcgggaaa aggatggcgg cagcacctac ccagatcgaa gccgagctgt
301 attacctgat cgctaggttc ttgcagtctg gaccctgcaa caaatccgct cagctgattc
361 cgcgccgctt agattgggag gggaaagagc accgaagaag cttcgaggat ctggtggcag
421 caaatgcaca cattcctcca gactacctcc ttaaaatttg tgagagaatt ggtcctttac
481 tagataaaga gatccctcag agtgttcctg gggtacagac attattaggt gttggtcggc
541 agtctctgct acgggatgcc aaagactgta agagtacact atggaatggg tctgcttttg
601 cggctctgca tagaggcaga cctccagaac tacctgtaaa ttatgtgaaa cctccaaatg
661 tggtgaatat cacctctgcc aggcaattaa ccggctgtag tcgctttggt catattttcc
721 cttcatctgc ttaccagcac attaagatgc ataagagaat tctggggcac ttgtcatctg
781 tctactgtgt agcatttgac cgaagcggga gaagaatttt tacaggttcc gatgactgtt
841 tagtaaaaat ttgggctaca gatgatggac gccttcttgc tacacttcgt ggacactctg
901 ctgaaatttc tgacatggct gttaactatg aaaacactct tattgctgca ggcagctgtg
961 ataaggtagt aagagtatgg tgtcttcgaa cttgtgcacc cgttgcagtc cttcagggcc
1021 attcagcttc tattacttcc atacagagat cgcccggtga aatttactga gagatccaga
1081 cctggagtcc agatatcttg ttcatctttc agttctggtg gtatgttcat tacaactggt
1141 agtactgacc atgtgattag aatatattat ttgggttctg aggttcctga gaaaattgct
1201 gaattagagt cacatacgga taaagttgtt gctgttcagt tctgtaacaa tggagacaga
1261 atgacaagat aatgaaaaat gataatccca atattgccaa gggttttggg aaaatggaca
1321 cttctacaac tcgtgatgag attataaatt attaaaaaaa cttttcgggg aaacaatttg
1381 gcatttaaga tttgttagtg gaagtcgaga tggaacggca agaatttggc agtatcagca
1441 acaagaatgg aagagtatag tgctagacat ggctactaaa atgactggca ataatttgcc
1501 atctggagaa gacaagatca ctaaacttaa ggtgactatg gtggcctggg atcgctatga
1561 taccacagtt attactgcag tgaacaattt tcttttgaaa gtgtggaatt ctatcacagg
1621 acagcttctt catacattat ctggacatga tgatgaagta ttcgttctag aagcccatcc
1681 atttgatcaa aggatcatac tttcagcagg tcatgatggg aacattttta tttgggacct
1741 tgaccggggg accaaaattc ggaattactt taacatgatt gaaggccaag gccatggtgc
1801 ggtgtttgat tgtaaatttt caccagatgg aaaccatttt gcctgcacag attctcatgg
1861 acatttgctg ctttttggtt ttggatgcag taaatactac gaaaagattc cagatcagat
1921 gttcttccac acggattatc gtcctcttat tcgtgatgcc aataactatg tattggatga
1981 acaaacccaa caagctcctc acctcatgcc tcctccattt ttggtggatg ttgatggaaa
2041 tcctcatccc acaaaattcc aacggttggt accaggacgg gaaaattgta aagatgaaca
2101 gcttatacca cagctgggat atgtggctaa tggtgatggt gaggtagtag aacaggtaat
2161 tgggcagcaa accaatgacc aagatgagag cattcttgat ggaataatca gggagctgca
2221 gagagaacaa gacctgagac taattaatga aggagatgtt ccacatttac cagttaatag
2281 agcatactct gttaatggtg ctctgagaag tccaaacatg gacatatctt cttccccaaa
2341 catcaggctt cgaagacata gtagtcaaat tgaaggtgtt agacaaatgc ataacaatgc
2401 tcctcggagc cagatggcca ctgaaagaga tctcatggcg tggagcagaa gagtggtggt
2461 caatgaacta aataatgggg ttagtagggt acaggaagaa tgtcgaactg caaaaggtga
2521 catagaaatc agtctttata cagttgaaaa gaagaaaaag ccatcttaca ctactcaaag
2581 gaatgattat gagcctagct gtgggcgttc tttacgcagg acacagcgca aacgtcagca
2641 tacttaccaa acacggtcca acatagagca taattcacag gcatcatgtc aaaattcagg
2701 tgtacaggaa gactcagaca gttcttcaga ggaagatgaa actgttggca caagtgacgc
2761 ttcggtagag gatcctgttg ttgaatggca aagtgaaagt tcttccagtg actcatcaag
2821 tgaatattct gattggacag cagatgctgg aataaattta caacccccaa aaagacaaac
2881 cagacagaca acacgtaaaa tatgcagcag ctctgatgag gaaaatttga agtccctaga
2941 agaaaggcag aagaaaccta agcagactag aaagaagaaa ggaggactgg tttctatagc
3001 aggtgagcct aatgaagaat ggtttgcccc tcagtggatc ttggatacta taccccgacg
3061 ttccccattt gtcccacaaa tgggagatga gcttatctat tttaggcaag gacatgaagc
3121 ttatgttcgg gctgtaagga aatcgaaaat atacagtgtt aatttacaaa aacagccatg
3181 gaacaaaatg gatctcaggg agcaagagtt tgttaagatt gtaggaatca aatatgaggt
3241 tggcccaccc acactgtgct gcttgaagct tgcatttctg gacccaattt caggcaaaat
3301 gactggagaa tctttttcca ttaagtatca tgacatgccg gatgtcattg acttccttgt
3361 gctacatcag ttttataatg aagccaaaga aaggaactgg cagattggtg atagattccg
3421 cagtataata gatgacgcct ggtggtttgg gactgtggag agtcagcagc cttttcaacc
3481 agagtatcct gatagttctt tccagtgtta cagtgttcac tgggacaata atgagagaga
3541 aaagatgagc ccatgggata tggagccaat tccagaagga actgcctttc cagatgaagt
3601 tggtgctggt gttcctgtct cccaggaaga attgactgct ttgctataca aaccccagga
3661 aggagagtgg ggggctcatt ccagagacga agaatgtgaa cgggttattc agggcatcaa
3721 ccaccttctt tccctggatt ttgccagccc ttttgctgtt ccagtggatc tcagtgccta
3781 ccccttgtat tgtactgtag ttgcttatcc aactgacctc aataccatca ggcggagact
3841 tgaaaatcgc ttttacagga gaatatcagc attaatgtgg gaggtacgct atattgaaca
3901 taatgccagg actttcaatg agccagacag tcctatagtt aaagcagcta aaattgtaac
3961 tgatgtctta cttcgattta ttggggatca gagctgtact gatatactgg atacttataa
4021 taaaattaaa gcagaagaac gaaacagtac tgatgcagag gaggatacag aaattgttga
4081 tttagattca gacggtcctg gtacttcatc tggaagaagg gtcaaatgcc gaggcagaag
4141 acagtcttta aagtgtaatc ctgatgcttg gaaaaaacaa tgcaaggaac tattgagcct
4201 catttatgaa cgtgaagact cggagccatt tcgacagcca gctgatcttc tttcttaccc
4261 aggtcatcag gagcaagagg gagaatcctc agagtctgtt gttccagaaa gacaacaaga
4321 ttcatctctt tctgaggatt atcaagatgt tatagatact cctgtggact tcagcactgt
4381 gaaagaaact ttggaagcag gaaactatgg tagtcctctg gaattttata aggatgttcg
4441 ccaaatattc aacaactcca aagcttatac ctctaataaa aagtcaagga tctatagcat
4501 gatgctgcga ttatctgcct tatttgaaag tcatatcaaa aatatcatct ctgaatataa
4561 gtcagcaatc cagagtcaga agaggagaag gccacggtac agaaaacgtc taagaagcag
4621 cagcagttca ttatctagta gtggagcacc tagtccaaaa gggaagcaga aacaaatgaa
4681 gttgcagcct aaaaatgacc agaatacctc agtatctcat gccaggacta gctctccttt
4741 ctcatctcct gtttcagatg ctgctgaagg gctttcacta tatctacttg atgatgagcc
4801 agatgggcca ttttcttcat cgagcttcgg tggatatagc cgaagtggaa atagccatga
4861 cccagggaaa gccaaatcat ttcggaatag agttttgcca gttaaacaag atcactccct
4921 tgatggaccc cttacaaatg gtgatggcag agagccccgg acaggaatca agagaaaact
4981 acttagtgca tcagaagaag atgaaaacat gggaggagaa gataaagaga aaaaagaaac
5041 aaaagagaaa tctcatttat ccacctcaga gagtggagag ttaggatcca gtttaagttc
5101 tgaaagtacc tgtggttctg actctgactc tgaatcaact tccagaacag atcaagatta
5161 cgtagatgga gaccatgatt atagcaaatt catacaaacc agacctaaaa gaaaactcag
5221 aaagcaacat ggcaatggaa aaagaaattg gaagaccaga ggcacaggag gaagaggcag
5281 atggggaaga tggggtagat ggagtagagg aggcagagga agaggaggca ggggacgagg
5341 gagtcgagga agaggtggag gtggcactag ggggagggga agagggagag gaggaagagg
5401 tgcttctaga ggagctacca gagccaaacg agcacgtatt gcagatgatg aatttgatac
5461 catgttttca ggacgtttca gtagactgcc tcgaattaaa acaagaaacc aaggcaggag
5521 gactgtttta tataatgatg attctgataa tgacaatttt gtgtccactg aggatcctct
5581 gaatcttggt acatccagat caggcagagt gcgtaaaatg acagaaaaag ccagggttag
5641 ccatctcatg ggatggaatt attaacagtt aataaattta gaataactta aaaaattcaa
5701 tggccttcta ctgcagggaa tttaccagga aatctacaaa gcaagttgtg tggggacttc
5761 tgcttccttt cacattggtg cttttccatt tatgccagta tacatttgtt tcaagacttt
5821 tgatctccac acttcatttg ttcaaataag ccttactcat taggccttaa attaaaagaa
5881 attctgccca cacacacaca aacacataca cacacataca cacacacaga cacacacaca
5941 cgaaacacaa cacagacact acagatttac tacattaaag gagcattcag cttcttaaga
6001 gtagcatgac atttttatct caatagaata gccctctttt gcttttgtat cacagaagta
6061 tagcaccttc ttacagag
//