LOCUS       AY497048                6108 bp    mRNA    linear   HUM 18-FEB-2005
DEFINITION  Homo sapiens bromodomain and WD repeat domain containing 3 variant
            BRWD3-C (BRWD3) mRNA, complete cds, alternatively spliced.
ACCESSION   AY497048
VERSION     AY497048.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6108)
  AUTHORS   Kalla,C., Nentwich,H., Schlotter,M., Mertens,D., Wildenberger,K.,
            Dohner,H., Stilgenbauer,S. and Lichter,P.
  TITLE     Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic
            leukemia disrupts two novel genes
  JOURNAL   Genes Chromosomes Cancer 42 (2), 128-143 (2005)
   PUBMED   15543602
REFERENCE   2  (bases 1 to 6108)
  AUTHORS   Schaffner,C. and Schlotter,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-DEC-2003) Div. Molecular Genetics (B060), Deutsches
            Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg
            D-69120, Germany
FEATURES             Location/Qualifiers
     source          1..6108
                     /db_xref="H-InvDB:HIT000254954"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13"
     gene            1..6108
                     /gene="BRWD3"
     CDS             1499..5695
                     /gene="BRWD3"
                     /note="transcription factor; alternatively spliced;
                     contains exons 1, 2, 3, 4a, and 12a, but lacks exon 9"
                     /codon_start=1
                     /product="bromodomain and WD repeat domain containing 3
                     variant BRWD3-C"
                     /protein_id="AAS45473.1"
                     /translation="MATKMTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLK
                     VWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFN
                     MIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFGCSKYYEKIPDQMFFHTDYRPL
                     IRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVPGRENCKDEQLIPQLGY
                     VANGDGEVVEQVIGQQTNDQDESILDGIIRELQREQDLRLINEGDVPHLPVNRAYSVN
                     GALRSPNMDISSSPNIRLRRHSSQIEGVRQMHNNAPRSQMATERDLMAWSRRVVVNEL
                     NNGVSRVQEECRTAKGDIEISLYTVEKKKKPSYTTQRNDYEPSCGRSLRRTQRKRQHT
                     YQTRSNIEHNSQASCQNSGVQEDSDSSSEEDETVGTSDASVEDPVVEWQSESSSSDSS
                     SEYSDWTADAGINLQPPKRQTRQTTRKICSSSDEENLKSLEERQKKPKQTRKKKGGLV
                     SIAGEPNEEWFAPQWILDTIPRRSPFVPQMGDELIYFRQGHEAYVRAVRKSKIYSVNL
                     QKQPWNKMDLREQEFVKIVGIKYEVGPPTLCCLKLAFLDPISGKMTGESFSIKYHDMP
                     DVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQQPFQPEYPDSSFQCYS
                     VHWDNNEREKMSPWDMEPIPEGTAFPDEVGAGVPVSQEELTALLYKPQEGEWGAHSRD
                     EECERVIQGINHLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRR
                     ISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGDQSCTDILDTYNKIKAE
                     ERNSTDAEEDTEIVDLDSDGPGTSSGRRVKCRGRRQSLKCNPDAWKKQCKELLSLIYE
                     REDSEPFRQPADLLSYPGHQEQEGESSESVVPERQQDSSLSEDYQDVIDTPVDFSTVK
                     ETLEAGNYGSPLEFYKDVRQIFNNSKAYTSNKKSRIYSMMLRLSALFESHIKNIISEY
                     KSAIQSQKRRRPRYRKRLRSSSSSLSSSGAPSPKGKQKQMKLQPKNDQNTSVSHARTS
                     SPFSSPVSDAAEGLSLYLLDDEPDGPFSSSSFGGYSRSGNSHDPGKAKSFRNRVLPVK
                     QDHSLDGPLTNGDGREPRTGIKRKLLSASEEDENMGGEDKEKKETKEKSHLSTSESGE
                     LGSSLSSESTCGSDSDSESTSRTDQDYVDGDHDYSKFIQTRPKRKLRKQHGNGKRNWK
                     TRGTGGRGRWGRWGRWSRGGRGRGGRGRGSRGRGGGGTRGRGRGRGGRGASRGATRAK
                     RARIADDEFDTMFSGRFSRLPRIKTRNQGRRTVLYNDDSDNDNFVSTEDPLNLGTSRS
                     GRVRKMTEKARVSHLMGWNY"
     misc_feature    1517..1909
                     /gene="BRWD3"
                     /note="Region: contains three WD40 repeats"
     misc_feature    3704..4024
                     /gene="BRWD3"
                     /note="Region: bromo domain"
     misc_feature    4190..4579
                     /gene="BRWD3"
                     /note="Region: bromo domain"
BASE COUNT         1899 a         1223 c         1425 g         1561 t
ORIGIN      
        1 tctctctctc tctcactcac tcactctctc tctccctctc cctctcctct ccttcctcct
       61 ccgcctcctc agctcttggg ctagaatatc tatgggtcga aacgtgatgc gatgaattcg
      121 agagagagcg aaactaggac gaggagtgcg gcggaagcgg cgggactccc gggcatgggg
      181 gcttcaccac aatagaggca gcgcccccac ccgcccccgc cagcccctcc ggagcgaagc
      241 ccccaaaccc cctcgggaaa aggatggcgg cagcacctac ccagatcgaa gccgagctgt
      301 attacctgat cgctaggttc ttgcagtctg gaccctgcaa caaatccgct caggtgctag
      361 tgcaggagct cgaggagcat cagctgattc cgcgccgctt agattgggag gggaaagagc
      421 accgaagaag cttcgaggat ctggtggcag caaatgcaca cattcctcca gactacctcc
      481 ttaaaatttg tgagagaatt ggtcctttac tagataaaga gatccctcag agtgttcctg
      541 gggtacagac attattaggt gttggtcggc agtctctgct acgggatgcc aaagactgta
      601 agagtacact atggaatggg tctgcttttg cggctctgca tagaggcaga cctccagaac
      661 tacctgtaaa ttatgtgaaa cctccaaatg tggtgaatat cacctctgcc aggcaattaa
      721 ccggctgtag tcgctttggt catattttcc cttcatctgc ttaccagcac attaagatgc
      781 ataagagaat tctggggcac ttgtcatctg tctactgtgt agcatttgac cgaagcggga
      841 gaagaatttt tacaggttcc gatgactgtt tagtaaaaat ttgggctaca gatgatggac
      901 gccttcttgc tacacttcgt ggacactctg ctgaaatttc tgacatggct gttaactatg
      961 aaaacactct tattgctgca ggcagctgtg ataaggtagt aagagtatgg tgtcttcgaa
     1021 cttgtgcacc cgttgcagtc cttcagggcc attcagcttc tattacttcc atacagagat
     1081 cgcccggtga aatttactga gagatccaga cctggagtcc agatatcttg ttcatctttc
     1141 agttctggtg gtatgttcat tacaactggt agtactgacc atgtgattag aatatattat
     1201 ttgggttctg aggttcctga gaaaattgct gaattagagt cacatacgga taaagttgtt
     1261 gctgttcagt tctgtaacaa tggagacaga atgacaagat aatgaaaaat gataatccca
     1321 atattgccaa gggttttggg aaaatggaca cttctacaac tcgtgatgag attataaatt
     1381 attaaaaaaa cttttcgggg aaacaatttg gcatttaaga tttgttagtg gaagtcgaga
     1441 tggaacggca agaatttggc agtatcagca acaagaatgg aagagtatag tgctagacat
     1501 ggctactaaa atgactggca ataatttgcc atctggagaa gacaagatca ctaaacttaa
     1561 ggtgactatg gtggcctggg atcgctatga taccacagtt attactgcag tgaacaattt
     1621 tcttttgaaa gtgtggaatt ctatcacagg acagcttctt catacattat ctggacatga
     1681 tgatgaagta ttcgttctag aagcccatcc atttgatcaa aggatcatac tttcagcagg
     1741 tcatgatggg aacattttta tttgggacct tgaccggggg accaaaattc ggaattactt
     1801 taacatgatt gaaggccaag gccatggtgc ggtgtttgat tgtaaatttt caccagatgg
     1861 aaaccatttt gcctgcacag attctcatgg acatttgctg ctttttggtt ttggatgcag
     1921 taaatactac gaaaagattc cagatcagat gttcttccac acggattatc gtcctcttat
     1981 tcgtgatgcc aataactatg tattggatga acaaacccaa caagctcctc acctcatgcc
     2041 tcctccattt ttggtggatg ttgatggaaa tcctcatccc acaaaattcc aacggttggt
     2101 accaggacgg gaaaattgta aagatgaaca gcttatacca cagctgggat atgtggctaa
     2161 tggtgatggt gaggtagtag aacaggtaat tgggcagcaa accaatgacc aagatgagag
     2221 cattcttgat ggaataatca gggagctgca gagagaacaa gacctgagac taattaatga
     2281 aggagatgtt ccacatttac cagttaatag agcatactct gttaatggtg ctctgagaag
     2341 tccaaacatg gacatatctt cttccccaaa catcaggctt cgaagacata gtagtcaaat
     2401 tgaaggtgtt agacaaatgc ataacaatgc tcctcggagc cagatggcca ctgaaagaga
     2461 tctcatggcg tggagcagaa gagtggtggt caatgaacta aataatgggg ttagtagggt
     2521 acaggaagaa tgtcgaactg caaaaggtga catagaaatc agtctttata cagttgaaaa
     2581 gaagaaaaag ccatcttaca ctactcaaag gaatgattat gagcctagct gtgggcgttc
     2641 tttacgcagg acacagcgca aacgtcagca tacttaccaa acacggtcca acatagagca
     2701 taattcacag gcatcatgtc aaaattcagg tgtacaggaa gactcagaca gttcttcaga
     2761 ggaagatgaa actgttggca caagtgacgc ttcggtagag gatcctgttg ttgaatggca
     2821 aagtgaaagt tcttccagtg actcatcaag tgaatattct gattggacag cagatgctgg
     2881 aataaattta caacccccaa aaagacaaac cagacagaca acacgtaaaa tatgcagcag
     2941 ctctgatgag gaaaatttga agtccctaga agaaaggcag aagaaaccta agcagactag
     3001 aaagaagaaa ggaggactgg tttctatagc aggtgagcct aatgaagaat ggtttgcccc
     3061 tcagtggatc ttggatacta taccccgacg ttccccattt gtcccacaaa tgggagatga
     3121 gcttatctat tttaggcaag gacatgaagc ttatgttcgg gctgtaagga aatcgaaaat
     3181 atacagtgtt aatttacaaa aacagccatg gaacaaaatg gatctcaggg agcaagagtt
     3241 tgttaagatt gtaggaatca aatatgaggt tggcccaccc acactgtgct gcttgaagct
     3301 tgcatttctg gacccaattt caggcaaaat gactggagaa tctttttcca ttaagtatca
     3361 tgacatgccg gatgtcattg acttccttgt gctacatcag ttttataatg aagccaaaga
     3421 aaggaactgg cagattggtg atagattccg cagtataata gatgacgcct ggtggtttgg
     3481 gactgtggag agtcagcagc cttttcaacc agagtatcct gatagttctt tccagtgtta
     3541 cagtgttcac tgggacaata atgagagaga aaagatgagc ccatgggata tggagccaat
     3601 tccagaagga actgcctttc cagatgaagt tggtgctggt gttcctgtct cccaggaaga
     3661 attgactgct ttgctataca aaccccagga aggagagtgg ggggctcatt ccagagacga
     3721 agaatgtgaa cgggttattc agggcatcaa ccaccttctt tccctggatt ttgccagccc
     3781 ttttgctgtt ccagtggatc tcagtgccta ccccttgtat tgtactgtag ttgcttatcc
     3841 aactgacctc aataccatca ggcggagact tgaaaatcgc ttttacagga gaatatcagc
     3901 attaatgtgg gaggtacgct atattgaaca taatgccagg actttcaatg agccagacag
     3961 tcctatagtt aaagcagcta aaattgtaac tgatgtctta cttcgattta ttggggatca
     4021 gagctgtact gatatactgg atacttataa taaaattaaa gcagaagaac gaaacagtac
     4081 tgatgcagag gaggatacag aaattgttga tttagattca gacggtcctg gtacttcatc
     4141 tggaagaagg gtcaaatgcc gaggcagaag acagtcttta aagtgtaatc ctgatgcttg
     4201 gaaaaaacaa tgcaaggaac tattgagcct catttatgaa cgtgaagact cggagccatt
     4261 tcgacagcca gctgatcttc tttcttaccc aggtcatcag gagcaagagg gagaatcctc
     4321 agagtctgtt gttccagaaa gacaacaaga ttcatctctt tctgaggatt atcaagatgt
     4381 tatagatact cctgtggact tcagcactgt gaaagaaact ttggaagcag gaaactatgg
     4441 tagtcctctg gaattttata aggatgttcg ccaaatattc aacaactcca aagcttatac
     4501 ctctaataaa aagtcaagga tctatagcat gatgctgcga ttatctgcct tatttgaaag
     4561 tcatatcaaa aatatcatct ctgaatataa gtcagcaatc cagagtcaga agaggagaag
     4621 gccacggtac agaaaacgtc taagaagcag cagcagttca ttatctagta gtggagcacc
     4681 tagtccaaaa gggaagcaga aacaaatgaa gttgcagcct aaaaatgacc agaatacctc
     4741 agtatctcat gccaggacta gctctccttt ctcatctcct gtttcagatg ctgctgaagg
     4801 gctttcacta tatctacttg atgatgagcc agatgggcca ttttcttcat cgagcttcgg
     4861 tggatatagc cgaagtggaa atagccatga cccagggaaa gccaaatcat ttcggaatag
     4921 agttttgcca gttaaacaag atcactccct tgatggaccc cttacaaatg gtgatggcag
     4981 agagccccgg acaggaatca agagaaaact acttagtgca tcagaagaag atgaaaacat
     5041 gggaggagaa gataaagaga aaaaagaaac aaaagagaaa tctcatttat ccacctcaga
     5101 gagtggagag ttaggatcca gtttaagttc tgaaagtacc tgtggttctg actctgactc
     5161 tgaatcaact tccagaacag atcaagatta cgtagatgga gaccatgatt atagcaaatt
     5221 catacaaacc agacctaaaa gaaaactcag aaagcaacat ggcaatggaa aaagaaattg
     5281 gaagaccaga ggcacaggag gaagaggcag atggggaaga tggggtagat ggagtagagg
     5341 aggcagagga agaggaggca ggggacgagg gagtcgagga agaggtggag gtggcactag
     5401 ggggagggga agagggagag gaggaagagg tgcttctaga ggagctacca gagccaaacg
     5461 agcacgtatt gcagatgatg aatttgatac catgttttca ggacgtttca gtagactgcc
     5521 tcgaattaaa acaagaaacc aaggcaggag gactgtttta tataatgatg attctgataa
     5581 tgacaatttt gtgtccactg aggatcctct gaatcttggt acatccagat caggcagagt
     5641 gcgtaaaatg acagaaaaag ccagggttag ccatctcatg ggatggaatt attaacagtt
     5701 aataaattta gaataactta aaaaattcaa tggccttcta ctgcagggaa tttaccagga
     5761 aatctacaaa gcaagttgtg tggggacttc tgcttccttt cacattggtg cttttccatt
     5821 tatgccagta tacatttgtt tcaagacttt tgatctccac acttcatttg ttcaaataag
     5881 ccttactcat taggccttaa attaaaagaa attctgccca cacacacaca aacacataca
     5941 cacacataca cacacacaga cacacacaca cgaaacacaa cacagacact acagatttac
     6001 tacattaaag gagcattcag cttcttaaga gtagcatgac atttttatct caatagaata
     6061 gccctctttt gcttttgtat cacagaagta tagcaccttc ttacagag
//