LOCUS AY497047 6017 bp mRNA linear HUM 18-FEB-2005
DEFINITION Homo sapiens bromodomain and WD repeat domain containing 3 variant
BRWD3-B (BRWD3) mRNA, complete cds, alternatively spliced.
ACCESSION AY497047
VERSION AY497047.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6017)
AUTHORS Kalla,C., Nentwich,H., Schlotter,M., Mertens,D., Wildenberger,K.,
Dohner,H., Stilgenbauer,S. and Lichter,P.
TITLE Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic
leukemia disrupts two novel genes
JOURNAL Genes Chromosomes Cancer 42 (2), 128-143 (2005)
PUBMED 15543602
REFERENCE 2 (bases 1 to 6017)
AUTHORS Schaffner,C. and Schlotter,M.
TITLE Direct Submission
JOURNAL Submitted (08-DEC-2003) Div. Molecular Genetics (B060), Deutsches
Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg
D-69120, Germany
FEATURES Location/Qualifiers
source 1..6017
/db_xref="H-InvDB:HIT000254953"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xq13"
gene 1..6017
/gene="BRWD3"
CDS 709..5604
/gene="BRWD3"
/note="transcription factor; alternatively spliced;
contains first exon 4b"
/codon_start=1
/product="bromodomain and WD repeat domain containing 3
variant BRWD3-B"
/protein_id="AAS45472.1"
/translation="MHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLL
ATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFC
PSTKGTNRYLTSTGADGTICFWQWHVKTMKFRDRPVKFTERSRPGVQISCSSFSSGGM
FITTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTAR
IWQYQQQEWKSIVLDMATKMTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLL
KVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYF
NMIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFGCSKYYEKIPDQMFFHTDYRP
LIRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVPGRENCKDEQLIPQLG
YVANGDGEVVEQVIGQQTNDQDESILDGIIRELQREQDLRLINEGDVPHLPVNRAYSV
NGALRSPNMDISSSPNIRLRRHSSQIEGVRQMHNNAPRSQMATERDLMAWSRRVVVNE
LNNGVSRVQEECRTAKGDIEISLYTVEKKKKPSYTTQRNDYEPSCGRSLRRTQRKRQH
TYQTRSNIEHNSQASCQNSGVQEDSDSSSEEDETVGTSDASVEDPVVEWQSESSSSDS
SSEYSDWTADAGINLQPPKRQTRQTTRKICSSSDEENLKSLEERQKKPKQTRKKKGGL
VSIAGEPNEEWFAPQWILDTIPRRSPFVPQMGDELIYFRQGHEAYVRAVRKSKIYSVN
LQKQPWNKMDLREQEFVKIVGIKYEVGPPTLCCLKLAFLDPISGKMTGESFSIKYHDM
PDVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQQPFQPEYPDSSFQCY
SVHWDNNEREKMSPWDMEPIPEGTAFPDEVGAGVPVSQEELTALLYKPQEGEWGAHSR
DEECERVIQGINHLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYR
RISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGDQSCTDILDTYNKIKA
EERNSTDAEEDTEIVDLDSDGPGTSSGRRVKCRGRRQSLKCNPDAWKKQCKELLSLIY
EREDSEPFRQPADLLSYPGHQEQEGESSESVVPERQQDSSLSEDYQDVIDTPVDFSTV
KETLEAGNYGSPLEFYKDVRQIFNNSKAYTSNKKSRIYSMMLRLSALFESHIKNIISE
YKSAIQSQKRRRPRYRKRLRSSSSSLSSSGAPSPKGKQKQMKLQPKNDQNTSVSHART
SSPFSSPVSDAAEGLSLYLLDDEPDGPFSSSSFGGYSRSGNSHDPGKAKSFRNRVLPV
KQDHSLDGPLTNGDGREPRTGIKRKLLSASEEDENMGGEDKEKKETKEKSHLSTSESG
ELGSSLSSESTCGSDSDSESTSRTDQDYVDGDHDYSKFIQTRPKRKLRKQHGNGKRNW
KTRGTGGRGRWGRWGRWSRGGRGRGGRGRGSRGRGGGGTRGRGRGRGGRGASRGATRA
KRARIADDEFDTMFSGRFSRLPRIKTRNQGRRTVLYNDDSDNDNFVSTEDPLNLGTSR
SGRVRKMTEKARVSHLMGWNY"
misc_feature 709..1818
/gene="BRWD3"
/note="Region: contains eight WD40 repeats"
misc_feature 3613..3933
/gene="BRWD3"
/note="Region: bromo domain"
misc_feature 4099..4488
/gene="BRWD3"
/note="Region: bromo domain"
BASE COUNT 1859 a 1185 c 1404 g 1569 t
ORIGIN
1 gatctgggta cccgtagctg ttgtcaccgg ggtgaattgg cttcttccct caaaaggggc
61 agacaacgct ggggtcttaa ctcgtccccg ctttatgctt gtgggaggca gtttttcagg
121 atttccttct cgacccccct tccccccccc cccatatact tgtctagctc tgagccaata
181 gctatcaggc cgagagaaat aaagacggta aagtgttgag gactgggaca caggttgggt
241 ccagttgatg gggagcggag gcttttcctt catcatttgc ctccgcttcc ccctttcttt
301 tcgtccggcc cccagctgat tccgcgccgc ttagattggg aggggaaaga gcaccgaaga
361 agcttcgagg atctggtggc agcaaatgca cacattcctc cagactacct ccttaaaatt
421 tgtgagagaa ttggtccttt actagataaa gagatccctc agagtgttcc tggggtacag
481 acattattag gtgttggtcg gcagtctctg ctacgggatg ccaaagactg taagagtaca
541 ctatggaatg ggtctgcttt tgcggctctg catagaggca gacctccaga actacctgta
601 aattatgtga aacctccaaa tgtggtgaat atcacctctg ccaggcaatt aaccggctgt
661 agtcgctttg gtcatatttt cccttcatct gcttaccagc acattaagat gcataagaga
721 attctggggc acttgtcatc tgtctactgt gtagcatttg accgaagcgg gagaagaatt
781 tttacaggtt ccgatgactg tttagtaaaa atttgggcta cagatgatgg acgccttctt
841 gctacacttc gtggacactc tgctgaaatt tctgacatgg ctgttaacta tgaaaacact
901 cttattgctg caggcagctg tgataaggta gtaagagtat ggtgtcttcg aacttgtgca
961 cccgttgcag tccttcaggg ccattcagct tctattactt ccatacagtt ttgtccatca
1021 actaaaggca caaacagata cctcacttct actggtgctg atggaacaat ctgtttctgg
1081 caatggcatg taaaaacaat gaagtttaga gatcgcccgg tgaaatttac tgagagatcc
1141 agacctggag tccagatatc ttgttcatct ttcagttctg gtggtatgtt cattacaact
1201 ggtagtactg accatgtgat tagaatatat tatttgggtt ctgaggttcc tgagaaaatt
1261 gctgaattag agtcacatac ggataaagtt gttgctgttc agttctgtaa caatggagac
1321 agtttaagat ttgttagtgg aagtcgagat ggaacggcaa gaatttggca gtatcagcaa
1381 caagaatgga agagtatagt gctagacatg gctactaaaa tgactggcaa taatttgcca
1441 tctggagaag acaagatcac taaacttaag gtgactatgg tggcctggga tcgctatgat
1501 accacagtta ttactgcagt gaacaatttt cttttgaaag tgtggaattc tatcacagga
1561 cagcttcttc atacattatc tggacatgat gatgaagtat tcgttctaga agcccatcca
1621 tttgatcaaa ggatcatact ttcagcaggt catgatggga acatttttat ttgggacctt
1681 gaccggggga ccaaaattcg gaattacttt aacatgattg aaggccaagg ccatggtgcg
1741 gtgtttgatt gtaaattttc accagatgga aaccattttg cctgcacaga ttctcatgga
1801 catttgctgc tttttggttt tggatgcagt aaatactacg aaaagattcc agatcagatg
1861 ttcttccaca cggattatcg tcctcttatt cgtgatgcca ataactatgt attggatgaa
1921 caaacccaac aagctcctca cctcatgcct cctccatttt tggtggatgt tgatggaaat
1981 cctcatccca caaaattcca acggttggta ccaggacggg aaaattgtaa agatgaacag
2041 cttataccac agctgggata tgtggctaat ggtgatggtg aggtagtaga acaggtaatt
2101 gggcagcaaa ccaatgacca agatgagagc attcttgatg gaataatcag ggagctgcag
2161 agagaacaag acctgagact aattaatgaa ggagatgttc cacatttacc agttaataga
2221 gcatactctg ttaatggtgc tctgagaagt ccaaacatgg acatatcttc ttccccaaac
2281 atcaggcttc gaagacatag tagtcaaatt gaaggtgtta gacaaatgca taacaatgct
2341 cctcggagcc agatggccac tgaaagagat ctcatggcgt ggagcagaag agtggtggtc
2401 aatgaactaa ataatggggt tagtagggta caggaagaat gtcgaactgc aaaaggtgac
2461 atagaaatca gtctttatac agttgaaaag aagaaaaagc catcttacac tactcaaagg
2521 aatgattatg agcctagctg tgggcgttct ttacgcagga cacagcgcaa acgtcagcat
2581 acttaccaaa cacggtccaa catagagcat aattcacagg catcatgtca aaattcaggt
2641 gtacaggaag actcagacag ttcttcagag gaagatgaaa ctgttggcac aagtgacgct
2701 tcggtagagg atcctgttgt tgaatggcaa agtgaaagtt cttccagtga ctcatcaagt
2761 gaatattctg attggacagc agatgctgga ataaatttac aacccccaaa aagacaaacc
2821 agacagacaa cacgtaaaat atgcagcagc tctgatgagg aaaatttgaa gtccctagaa
2881 gaaaggcaga agaaacctaa gcagactaga aagaagaaag gaggactggt ttctatagca
2941 ggtgagccta atgaagaatg gtttgcccct cagtggatct tggatactat accccgacgt
3001 tccccatttg tcccacaaat gggagatgag cttatctatt ttaggcaagg acatgaagct
3061 tatgttcggg ctgtaaggaa atcgaaaata tacagtgtta atttacaaaa acagccatgg
3121 aacaaaatgg atctcaggga gcaagagttt gttaagattg taggaatcaa atatgaggtt
3181 ggcccaccca cactgtgctg cttgaagctt gcatttctgg acccaatttc aggcaaaatg
3241 actggagaat ctttttccat taagtatcat gacatgccgg atgtcattga cttccttgtg
3301 ctacatcagt tttataatga agccaaagaa aggaactggc agattggtga tagattccgc
3361 agtataatag atgacgcctg gtggtttggg actgtggaga gtcagcagcc ttttcaacca
3421 gagtatcctg atagttcttt ccagtgttac agtgttcact gggacaataa tgagagagaa
3481 aagatgagcc catgggatat ggagccaatt ccagaaggaa ctgcctttcc agatgaagtt
3541 ggtgctggtg ttcctgtctc ccaggaagaa ttgactgctt tgctatacaa accccaggaa
3601 ggagagtggg gggctcattc cagagacgaa gaatgtgaac gggttattca gggcatcaac
3661 caccttcttt ccctggattt tgccagccct tttgctgttc cagtggatct cagtgcctac
3721 cccttgtatt gtactgtagt tgcttatcca actgacctca ataccatcag gcggagactt
3781 gaaaatcgct tttacaggag aatatcagca ttaatgtggg aggtacgcta tattgaacat
3841 aatgccagga ctttcaatga gccagacagt cctatagtta aagcagctaa aattgtaact
3901 gatgtcttac ttcgatttat tggggatcag agctgtactg atatactgga tacttataat
3961 aaaattaaag cagaagaacg aaacagtact gatgcagagg aggatacaga aattgttgat
4021 ttagattcag acggtcctgg tacttcatct ggaagaaggg tcaaatgccg aggcagaaga
4081 cagtctttaa agtgtaatcc tgatgcttgg aaaaaacaat gcaaggaact attgagcctc
4141 atttatgaac gtgaagactc ggagccattt cgacagccag ctgatcttct ttcttaccca
4201 ggtcatcagg agcaagaggg agaatcctca gagtctgttg ttccagaaag acaacaagat
4261 tcatctcttt ctgaggatta tcaagatgtt atagatactc ctgtggactt cagcactgtg
4321 aaagaaactt tggaagcagg aaactatggt agtcctctgg aattttataa ggatgttcgc
4381 caaatattca acaactccaa agcttatacc tctaataaaa agtcaaggat ctatagcatg
4441 atgctgcgat tatctgcctt atttgaaagt catatcaaaa atatcatctc tgaatataag
4501 tcagcaatcc agagtcagaa gaggagaagg ccacggtaca gaaaacgtct aagaagcagc
4561 agcagttcat tatctagtag tggagcacct agtccaaaag ggaagcagaa acaaatgaag
4621 ttgcagccta aaaatgacca gaatacctca gtatctcatg ccaggactag ctctcctttc
4681 tcatctcctg tttcagatgc tgctgaaggg ctttcactat atctacttga tgatgagcca
4741 gatgggccat tttcttcatc gagcttcggt ggatatagcc gaagtggaaa tagccatgac
4801 ccagggaaag ccaaatcatt tcggaataga gttttgccag ttaaacaaga tcactccctt
4861 gatggacccc ttacaaatgg tgatggcaga gagccccgga caggaatcaa gagaaaacta
4921 cttagtgcat cagaagaaga tgaaaacatg ggaggagaag ataaagagaa aaaagaaaca
4981 aaagagaaat ctcatttatc cacctcagag agtggagagt taggatccag tttaagttct
5041 gaaagtacct gtggttctga ctctgactct gaatcaactt ccagaacaga tcaagattac
5101 gtagatggag accatgatta tagcaaattc atacaaacca gacctaaaag aaaactcaga
5161 aagcaacatg gcaatggaaa aagaaattgg aagaccagag gcacaggagg aagaggcaga
5221 tggggaagat ggggtagatg gagtagagga ggcagaggaa gaggaggcag gggacgaggg
5281 agtcgaggaa gaggtggagg tggcactagg gggaggggaa gagggagagg aggaagaggt
5341 gcttctagag gagctaccag agccaaacga gcacgtattg cagatgatga atttgatacc
5401 atgttttcag gacgtttcag tagactgcct cgaattaaaa caagaaacca aggcaggagg
5461 actgttttat ataatgatga ttctgataat gacaattttg tgtccactga ggatcctctg
5521 aatcttggta catccagatc aggcagagtg cgtaaaatga cagaaaaagc cagggttagc
5581 catctcatgg gatggaatta ttaacagtta ataaatttag aataacttaa aaaattcaat
5641 ggccttctac tgcagggaat ttaccaggaa atctacaaag caagttgtgt ggggacttct
5701 gcttcctttc acattggtgc ttttccattt atgccagtat acatttgttt caagactttt
5761 gatctccaca cttcatttgt tcaaataagc cttactcatt aggccttaaa ttaaaagaaa
5821 ttctgcccac acacacacaa acacatacac acacatacac acacacagac acacacacac
5881 gaaacacaac acagacacta cagatttact acattaaagg agcattcagc ttcttaagag
5941 tagcatgaca tttttatctc aatagaatag ccctcttttg cttttgtatc acagaagtat
6001 agcaccttct tacagag
//