LOCUS       AY497046                6085 bp    mRNA    linear   HUM 18-FEB-2005
DEFINITION  Homo sapiens bromodomain and WD repeat domain containing 3 variant
            BRWD3-A (BRWD3) mRNA, complete cds, alternatively spliced.
ACCESSION   AY497046
VERSION     AY497046.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6085)
  AUTHORS   Kalla,C., Nentwich,H., Schlotter,M., Mertens,D., Wildenberger,K.,
            Dohner,H., Stilgenbauer,S. and Lichter,P.
  TITLE     Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic
            leukemia disrupts two novel genes
  JOURNAL   Genes Chromosomes Cancer 42 (2), 128-143 (2005)
   PUBMED   15543602
REFERENCE   2  (bases 1 to 6085)
  AUTHORS   Schaffner,C. and Schlotter,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-DEC-2003) Div. Molecular Genetics (B060), Deutsches
            Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg
            D-69120, Germany
FEATURES             Location/Qualifiers
     source          1..6085
                     /db_xref="H-InvDB:HIT000254952"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13"
     gene            1..6085
                     /gene="BRWD3"
     CDS             264..5672
                     /gene="BRWD3"
                     /note="transcription factor; alternatively spliced;
                     contains first exons 1, 2, 3, and 4a"
                     /codon_start=1
                     /product="bromodomain and WD repeat domain containing 3
                     variant BRWD3-A"
                     /protein_id="AAS45471.1"
                     /translation="MAAAPTQIEAELYYLIARFLQSGPCNKSAQVLVQELEEHQLIPR
                     RLDWEGKEHRRSFEDLVAANAHIPPDYLLKICERIGPLLDKEIPQSVPGVQTLLGVGR
                     QSLLRDAKDCKSTLWNGSAFAALHRGRPPELPVNYVKPPNVVNITSARQLTGCSRFGH
                     IFPSSAYQHIKMHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATL
                     RGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPST
                     KGTNRYLTSTGADGTICFWQWHVKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFIT
                     TGSTDHVIRIYYLGSEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQ
                     YQQQEWKSIVLDMATKMTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVW
                     NSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMI
                     EGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFGCSKYYEKIPDQMFFHTDYRPLIR
                     DANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVPGRENCKDEQLIPQLGYVA
                     NGDGEVVEQVIGQQTNDQDESILDGIIRELQREQDLRLINEGDVPHLPVNRAYSVNGA
                     LRSPNMDISSSPNIRLRRHSSQIEGVRQMHNNAPRSQMATERDLMAWSRRVVVNELNN
                     GVSRVQEECRTAKGDIEISLYTVEKKKKPSYTTQRNDYEPSCGRSLRRTQRKRQHTYQ
                     TRSNIEHNSQASCQNSGVQEDSDSSSEEDETVGTSDASVEDPVVEWQSESSSSDSSSE
                     YSDWTADAGINLQPPKRQTRQTTRKICSSSDEENLKSLEERQKKPKQTRKKKGGLVSI
                     AGEPNEEWFAPQWILDTIPRRSPFVPQMGDELIYFRQGHEAYVRAVRKSKIYSVNLQK
                     QPWNKMDLREQEFVKIVGIKYEVGPPTLCCLKLAFLDPISGKMTGESFSIKYHDMPDV
                     IDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQQPFQPEYPDSSFQCYSVH
                     WDNNEREKMSPWDMEPIPEGTAFPDEVGAGVPVSQEELTALLYKPQEGEWGAHSRDEE
                     CERVIQGINHLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRRIS
                     ALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGDQSCTDILDTYNKIKAEER
                     NSTDAEEDTEIVDLDSDGPGTSSGRRVKCRGRRQSLKCNPDAWKKQCKELLSLIYERE
                     DSEPFRQPADLLSYPGHQEQEGESSESVVPERQQDSSLSEDYQDVIDTPVDFSTVKET
                     LEAGNYGSPLEFYKDVRQIFNNSKAYTSNKKSRIYSMMLRLSALFESHIKNIISEYKS
                     AIQSQKRRRPRYRKRLRSSSSSLSSSGAPSPKGKQKQMKLQPKNDQNTSVSHARTSSP
                     FSSPVSDAAEGLSLYLLDDEPDGPFSSSSFGGYSRSGNSHDPGKAKSFRNRVLPVKQD
                     HSLDGPLTNGDGREPRTGIKRKLLSASEEDENMGGEDKEKKETKEKSHLSTSESGELG
                     SSLSSESTCGSDSDSESTSRTDQDYVDGDHDYSKFIQTRPKRKLRKQHGNGKRNWKTR
                     GTGGRGRWGRWGRWSRGGRGRGGRGRGSRGRGGGGTRGRGRGRGGRGASRGATRAKRA
                     RIADDEFDTMFSGRFSRLPRIKTRNQGRRTVLYNDDSDNDNFVSTEDPLNLGTSRSGR
                     VRKMTEKARVSHLMGWNY"
     misc_feature    768..1886
                     /gene="BRWD3"
                     /note="Region: contains eight WD40 repeats"
     misc_feature    3681..4001
                     /gene="BRWD3"
                     /note="Region: bromo domain"
     misc_feature    4167..4556
                     /gene="BRWD3"
                     /note="Region: bromo domain"
BASE COUNT         1881 a         1227 c         1421 g         1556 t
ORIGIN      
        1 tctctctctc tctcactcac tcactctctc tctccctctc cctctcctct ccttcctcct
       61 ccgcctcctc agctcttggg ctagaatatc tatgggtcga aacgtgatgc gatgaattcg
      121 agagagagcg aaactaggac gaggagtgcg gcggaagcgg cgggactccc gggcatgggg
      181 gcttcaccac aatagaggca gcgcccccac ccgcccccgc cagcccctcc ggagcgaagc
      241 ccccaaaccc cctcgggaaa aggatggcgg cagcacctac ccagatcgaa gccgagctgt
      301 attacctgat cgctaggttc ttgcagtctg gaccctgcaa caaatccgct caggtgctag
      361 tgcaggagct cgaggagcat cagctgattc cgcgccgctt agattgggag gggaaagagc
      421 accgaagaag cttcgaggat ctggtggcag caaatgcaca cattcctcca gactacctcc
      481 ttaaaatttg tgagagaatt ggtcctttac tagataaaga gatccctcag agtgttcctg
      541 gggtacagac attattaggt gttggtcggc agtctctgct acgggatgcc aaagactgta
      601 agagtacact atggaatggg tctgcttttg cggctctgca tagaggcaga cctccagaac
      661 tacctgtaaa ttatgtgaaa cctccaaatg tggtgaatat cacctctgcc aggcaattaa
      721 ccggctgtag tcgctttggt catattttcc cttcatctgc ttaccagcac attaagatgc
      781 ataagagaat tctggggcac ttgtcatctg tctactgtgt agcatttgac cgaagcggga
      841 gaagaatttt tacaggttcc gatgactgtt tagtaaaaat ttgggctaca gatgatggac
      901 gccttcttgc tacacttcgt ggacactctg ctgaaatttc tgacatggct gttaactatg
      961 aaaacactct tattgctgca ggcagctgtg ataaggtagt aagagtatgg tgtcttcgaa
     1021 cttgtgcacc cgttgcagtc cttcagggcc attcagcttc tattacttcc atacagtttt
     1081 gtccatcaac taaaggcaca aacagatacc tcacttctac tggtgctgat ggaacaatct
     1141 gtttctggca atggcatgta aaaacaatga agtttagaga tcgcccggtg aaatttactg
     1201 agagatccag acctggagtc cagatatctt gttcatcttt cagttctggt ggtatgttca
     1261 ttacaactgg tagtactgac catgtgatta gaatatatta tttgggttct gaggttcctg
     1321 agaaaattgc tgaattagag tcacatacgg ataaagttgt tgctgttcag ttctgtaaca
     1381 atggagacag tttaagattt gttagtggaa gtcgagatgg aacggcaaga atttggcagt
     1441 atcagcaaca agaatggaag agtatagtgc tagacatggc tactaaaatg actggcaata
     1501 atttgccatc tggagaagac aagatcacta aacttaaggt gactatggtg gcctgggatc
     1561 gctatgatac cacagttatt actgcagtga acaattttct tttgaaagtg tggaattcta
     1621 tcacaggaca gcttcttcat acattatctg gacatgatga tgaagtattc gttctagaag
     1681 cccatccatt tgatcaaagg atcatacttt cagcaggtca tgatgggaac atttttattt
     1741 gggaccttga ccgggggacc aaaattcgga attactttaa catgattgaa ggccaaggcc
     1801 atggtgcggt gtttgattgt aaattttcac cagatggaaa ccattttgcc tgcacagatt
     1861 ctcatggaca tttgctgctt tttggttttg gatgcagtaa atactacgaa aagattccag
     1921 atcagatgtt cttccacacg gattatcgtc ctcttattcg tgatgccaat aactatgtat
     1981 tggatgaaca aacccaacaa gctcctcacc tcatgcctcc tccatttttg gtggatgttg
     2041 atggaaatcc tcatcccaca aaattccaac ggttggtacc aggacgggaa aattgtaaag
     2101 atgaacagct tataccacag ctgggatatg tggctaatgg tgatggtgag gtagtagaac
     2161 aggtaattgg gcagcaaacc aatgaccaag atgagagcat tcttgatgga ataatcaggg
     2221 agctgcagag agaacaagac ctgagactaa ttaatgaagg agatgttcca catttaccag
     2281 ttaatagagc atactctgtt aatggtgctc tgagaagtcc aaacatggac atatcttctt
     2341 ccccaaacat caggcttcga agacatagta gtcaaattga aggtgttaga caaatgcata
     2401 acaatgctcc tcggagccag atggccactg aaagagatct catggcgtgg agcagaagag
     2461 tggtggtcaa tgaactaaat aatggggtta gtagggtaca ggaagaatgt cgaactgcaa
     2521 aaggtgacat agaaatcagt ctttatacag ttgaaaagaa gaaaaagcca tcttacacta
     2581 ctcaaaggaa tgattatgag cctagctgtg ggcgttcttt acgcaggaca cagcgcaaac
     2641 gtcagcatac ttaccaaaca cggtccaaca tagagcataa ttcacaggca tcatgtcaaa
     2701 attcaggtgt acaggaagac tcagacagtt cttcagagga agatgaaact gttggcacaa
     2761 gtgacgcttc ggtagaggat cctgttgttg aatggcaaag tgaaagttct tccagtgact
     2821 catcaagtga atattctgat tggacagcag atgctggaat aaatttacaa cccccaaaaa
     2881 gacaaaccag acagacaaca cgtaaaatat gcagcagctc tgatgaggaa aatttgaagt
     2941 ccctagaaga aaggcagaag aaacctaagc agactagaaa gaagaaagga ggactggttt
     3001 ctatagcagg tgagcctaat gaagaatggt ttgcccctca gtggatcttg gatactatac
     3061 cccgacgttc cccatttgtc ccacaaatgg gagatgagct tatctatttt aggcaaggac
     3121 atgaagctta tgttcgggct gtaaggaaat cgaaaatata cagtgttaat ttacaaaaac
     3181 agccatggaa caaaatggat ctcagggagc aagagtttgt taagattgta ggaatcaaat
     3241 atgaggttgg cccacccaca ctgtgctgct tgaagcttgc atttctggac ccaatttcag
     3301 gcaaaatgac tggagaatct ttttccatta agtatcatga catgccggat gtcattgact
     3361 tccttgtgct acatcagttt tataatgaag ccaaagaaag gaactggcag attggtgata
     3421 gattccgcag tataatagat gacgcctggt ggtttgggac tgtggagagt cagcagcctt
     3481 ttcaaccaga gtatcctgat agttctttcc agtgttacag tgttcactgg gacaataatg
     3541 agagagaaaa gatgagccca tgggatatgg agccaattcc agaaggaact gcctttccag
     3601 atgaagttgg tgctggtgtt cctgtctccc aggaagaatt gactgctttg ctatacaaac
     3661 cccaggaagg agagtggggg gctcattcca gagacgaaga atgtgaacgg gttattcagg
     3721 gcatcaacca ccttctttcc ctggattttg ccagcccttt tgctgttcca gtggatctca
     3781 gtgcctaccc cttgtattgt actgtagttg cttatccaac tgacctcaat accatcaggc
     3841 ggagacttga aaatcgcttt tacaggagaa tatcagcatt aatgtgggag gtacgctata
     3901 ttgaacataa tgccaggact ttcaatgagc cagacagtcc tatagttaaa gcagctaaaa
     3961 ttgtaactga tgtcttactt cgatttattg gggatcagag ctgtactgat atactggata
     4021 cttataataa aattaaagca gaagaacgaa acagtactga tgcagaggag gatacagaaa
     4081 ttgttgattt agattcagac ggtcctggta cttcatctgg aagaagggtc aaatgccgag
     4141 gcagaagaca gtctttaaag tgtaatcctg atgcttggaa aaaacaatgc aaggaactat
     4201 tgagcctcat ttatgaacgt gaagactcgg agccatttcg acagccagct gatcttcttt
     4261 cttacccagg tcatcaggag caagagggag aatcctcaga gtctgttgtt ccagaaagac
     4321 aacaagattc atctctttct gaggattatc aagatgttat agatactcct gtggacttca
     4381 gcactgtgaa agaaactttg gaagcaggaa actatggtag tcctctggaa ttttataagg
     4441 atgttcgcca aatattcaac aactccaaag cttatacctc taataaaaag tcaaggatct
     4501 atagcatgat gctgcgatta tctgccttat ttgaaagtca tatcaaaaat atcatctctg
     4561 aatataagtc agcaatccag agtcagaaga ggagaaggcc acggtacaga aaacgtctaa
     4621 gaagcagcag cagttcatta tctagtagtg gagcacctag tccaaaaggg aagcagaaac
     4681 aaatgaagtt gcagcctaaa aatgaccaga atacctcagt atctcatgcc aggactagct
     4741 ctcctttctc atctcctgtt tcagatgctg ctgaagggct ttcactatat ctacttgatg
     4801 atgagccaga tgggccattt tcttcatcga gcttcggtgg atatagccga agtggaaata
     4861 gccatgaccc agggaaagcc aaatcatttc ggaatagagt tttgccagtt aaacaagatc
     4921 actcccttga tggacccctt acaaatggtg atggcagaga gccccggaca ggaatcaaga
     4981 gaaaactact tagtgcatca gaagaagatg aaaacatggg aggagaagat aaagagaaaa
     5041 aagaaacaaa agagaaatct catttatcca cctcagagag tggagagtta ggatccagtt
     5101 taagttctga aagtacctgt ggttctgact ctgactctga atcaacttcc agaacagatc
     5161 aagattacgt agatggagac catgattata gcaaattcat acaaaccaga cctaaaagaa
     5221 aactcagaaa gcaacatggc aatggaaaaa gaaattggaa gaccagaggc acaggaggaa
     5281 gaggcagatg gggaagatgg ggtagatgga gtagaggagg cagaggaaga ggaggcaggg
     5341 gacgagggag tcgaggaaga ggtggaggtg gcactagggg gaggggaaga gggagaggag
     5401 gaagaggtgc ttctagagga gctaccagag ccaaacgagc acgtattgca gatgatgaat
     5461 ttgataccat gttttcagga cgtttcagta gactgcctcg aattaaaaca agaaaccaag
     5521 gcaggaggac tgttttatat aatgatgatt ctgataatga caattttgtg tccactgagg
     5581 atcctctgaa tcttggtaca tccagatcag gcagagtgcg taaaatgaca gaaaaagcca
     5641 gggttagcca tctcatggga tggaattatt aacagttaat aaatttagaa taacttaaaa
     5701 aattcaatgg ccttctactg cagggaattt accaggaaat ctacaaagca agttgtgtgg
     5761 ggacttctgc ttcctttcac attggtgctt ttccatttat gccagtatac atttgtttca
     5821 agacttttga tctccacact tcatttgttc aaataagcct tactcattag gccttaaatt
     5881 aaaagaaatt ctgcccacac acacacaaac acatacacac acatacacac acacagacac
     5941 acacacacga aacacaacac agacactaca gatttactac attaaaggag cattcagctt
     6001 cttaagagta gcatgacatt tttatctcaa tagaatagcc ctcttttgct tttgtatcac
     6061 agaagtatag caccttctta cagag
//