LOCUS AY491781 1740 bp mRNA linear HUM 29-DEC-2003
DEFINITION Homo sapiens alpha 1A adrenoceptor isoform 6 (ADRA1A) mRNA,
complete cds, alternatively spliced.
ACCESSION AY491781
VERSION AY491781.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1740)
AUTHORS Coge,F., Guenin,S.P., Renouard-Try,A., Rique,H., Ouvry,C.,
Fabry,N., Beauverger,P., Nicolas,J.P., Galizzi,J.P., Boutin,J.A.
and Canet,E.
TITLE Truncated isoforms inhibit [3H]prazosin binding and cellular
trafficking of native human alpha1A-adrenoceptors
JOURNAL Biochem. J. 343 (PT 1), 231-239 (1999)
PUBMED 10493934
REFERENCE 2 (bases 1 to 1740)
AUTHORS Coge,F., Guenin,S.-P., Rique,H., Galizzi,J.-P., Boutin,J.A. and
Canet,E.
TITLE Direct Submission
JOURNAL Submitted (01-DEC-2003) Pharmacologie Moleculaire Et Cellulaire,
Institut De Recherches Servier, 125, Chemin De Ronde,
Croissy-Sur-Seine, Yvelines 78290, France
FEATURES Location/Qualifiers
source 1..1740
/db_xref="H-InvDB:HIT000254925"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="8"
/map="8p21-p11.2"
/clone="6"
/tissue_type="liver"
gene 1..1740
/gene="ADRA1A"
CDS 437..1465
/gene="ADRA1A"
/note="G protein coupled receptor; alternatively spliced"
/codon_start=1
/product="alpha 1A adrenoceptor isoform 6"
/protein_id="AAR84650.1"
/translation="MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGN
ILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIW
AAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIG
PLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGL
KSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGI
VVGCFVLCWLPFFLVMPIDEETEAQQGKNDSPSFKQPVHHAAVLGLEVMEKENLEGVS
RKDTCGVW"
BASE COUNT 396 a 523 c 463 g 358 t
ORIGIN
1 gaattccgaa tcatgtgcag aatgctgaat cttcccccag ccaggacgaa taagacagcg
61 cggaaaagca gattctcgta attctggaat tgcatgttgc aaggagtctc ctggatcttc
121 gcacccagct tcgggtaggg agggagtccg ggtcccgggc taggccagcc cggcaggtgg
181 agagggtccc cggcagcccc gcgcgcccct ggccatgtct ttaatgccct gccccttcat
241 gtggccttct gagggttccc agggctggcc agggttgttt cccacccgcg cgcgcgctct
301 cacccccagc caaacccacc tggcagggct ccctccagcc gagacctttt gattcccggc
361 tcccgcgctc ccgcctccgc gccagcccgg gaggtggccc tggacagccg gacctcgccc
421 ggccccggct gggaccatgg tgtttctctc gggaaatgct tccgacagct ccaactgcac
481 ccaaccgccg gcaccggtga acatttccaa ggccattctg ctcggggtga tcttgggggg
541 cctcattctt ttcggggtgc tgggtaacat cctagtgatc ctctccgtag cctgtcaccg
601 acacctgcac tcagtcacgc actactacat cgtcaacctg gcggtggccg acctcctgct
661 cacctccacg gtgctgccct tctccgccat cttcgaggtc ctaggctact gggccttcgg
721 cagggtcttc tgcaacatct gggcggcagt ggatgtgctg tgctgcaccg cgtccatcat
781 gggcctctgc atcatctcca tcgaccgcta catcggcgtg agctacccgc tgcgctaccc
841 aaccatcgtc acccagagga ggggtctcat ggctctgctc tgcgtctggg cactctccct
901 ggtcatatcc attggacccc tgttcggctg gaggcagccg gcccccgagg acgagaccat
961 ctgccagatc aacgaggagc cgggctacgt gctcttctca gcgctgggct ccttctacct
1021 gcctctggcc atcatcctgg tcatgtactg ccgcgtctac gtggtggcca agagggagag
1081 ccggggcctc aagtctggcc tcaagaccga caagtcggac tcggagcaag tgacgctccg
1141 catccatcgg aaaaacgccc cggcaggagg cagcgggatg gccagcgcca agaccaagac
1201 gcacttctca gtgaggctcc tcaagttctc ccgggagaag aaagcggcca aaacgctggg
1261 catcgtggtc ggctgcttcg tcctctgctg gctgcctttt ttcttagtca tgcccattga
1321 tgaggaaact gaggcccaac aaggaaaaaa tgactcaccc agctttaaac aaccagttca
1381 ccatgcagca gtgctggggt tggaggtgat ggaaaaggaa aatttggaag gtgtttcaag
1441 gaaagacacc tgtggggttt ggtgaccact tggaatgtaa gaggcaaaaa aaagggagaa
1501 ggaactatat acatattctt ctggcaggaa ctgttaattg ggttcctgct cccatcttgc
1561 actacagtga gagagataac ctggtctcct accattggaa agcatatcat ctgtgctctg
1621 gaagatgaaa caatccagaa aaccagttaa taagaaaact taaaacctgt gatattttcc
1681 cctgaaataa ataatcccaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
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