LOCUS AY481573 18883 bp mRNA linear HUM 30-MAR-2004
DEFINITION Homo sapiens Usher syndrome 2A isoform B (USH2A) mRNA, complete
cds.
ACCESSION AY481573
VERSION AY481573.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 18883)
AUTHORS van Wijk,E., Pennings,R.J., te Brinke,H., Claassen,A., Yntema,H.G.,
Hoefsloot,L.H., Cremers,F.P., Cremers,C.W. and Kremer,H.
TITLE Identification of 51 novel exons of the Usher syndrome type 2A
(USH2A) gene that encode multiple conserved functional domains and
that are mutated in patients with Usher syndrome type II
JOURNAL Am. J. Hum. Genet. 74 (4), 738-744 (2004)
PUBMED 15015129
REFERENCE 2 (bases 1 to 18883)
AUTHORS van Wijk,E., te Brinke,H. and Kremer,H.
TITLE Direct Submission
JOURNAL Submitted (19-NOV-2003) Otorhinolaryngology, UMC Nijmegen, Geert
Grooteplein 10, Nijmegen 6525 GA, Netherlands
FEATURES Location/Qualifiers
source 1..18883
/db_xref="H-InvDB:HIT000254882"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q41"
gene 1..18883
/gene="USH2A"
5'UTR 1..387
/gene="USH2A"
CDS 388..15996
/gene="USH2A"
/note="usherin"
/codon_start=1
/product="Usher syndrome 2A isoform B"
/protein_id="AAS47698.1"
/translation="MNCPVLSLGSGFLFQVIEMLIFAYFASISLTESRGLFPRLENVG
AFKKVSIVPTQAVCGLPDRSTFCHSSAAAESIQFCTQRFCIQDCPYRSSHPTYTALFS
AGLSSCITPDKNDLHPNAHSNSASFIFGNHKSCFSSPPSPKLMASFTLAVWLKPEQQG
VMCVIEKTVDGQIVFKLTISEKETMFYYRTVNGLQPPIKVMTLGRILVKKWIHLSVQV
HQTKISFFINGVEKDHTPFNARTLSGSITDFASGTVQIGQSLNGLEQFVGRMQDFRLY
QVALTNREILEVFSGDLLRLHAQSHCRCPGSHPRVHPLAQRYCIPNDAGDTADNRVSR
LNPEAHPLSFVNDNDVGTSWVSNVFTNITQLNQGVTISVDLENGQYQVFYIIIQFFSP
QPTEIRIQRKKENSLDWEDWQYFARNCGAFGMKNNGDLEKPDSVNCLQLSNFTPYSRG
NVTFSILTPGPNYRPGYNNFYNTPSLQEFVKATQIRFHFHGQYYTTETAVNLRHRYYA
VDEITISGRCQCHGHADNCDTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQ
VYAFNCKPCQCNSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYF
FRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQCQNGFYN
LQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSFN
DVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCD
TAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTIN
GSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTLPGTICD
PISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHTTGAVNHICNSLTGQCVC
QDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLVTGQCFCKQFVTGS
KCDACVPSASHLDVNNLLGCSKTPFQQPPPRGQVQSSSAINLSWSPPDSPNAHWLTYS
LLRDGFEIYTTEDQYPYSIQYFLDTDLLPYTKYSYYIETTNVHGSTRSVAVTYKTKPG
VPEGNLTLSYIIPIGSDSVTLTWTTLSNQSGPIEKYILSCAPLAGGQPCVSYEGHETS
ATIWNLVPFAKYDFSVQACTSGGCLHSLPITVTTAQAPPQRLSPPKMQKISSTELHVE
WSPPAELNGIIIRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPP
QTMTTITGLEPYTKYEFRVLAVNMAGSVSSAWVSERTGESAPVFMIPPSVFPLSSYSL
NISWEKPADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKP
YRIYEFTITLCNSVGCVTSASGAGQTLAAAPAQLRPPLVKGINSTTIHLRWFPPEELN
GPSPIYQLERRESSLPALMTTMMKGIRFIGNGYCKFPSSTHPVNTDFTGIKASFRTKV
PEGLIVFAASPGNQEEYFALQLKKGRLYFLFDPQGSPVEVTTTNDHGKQYSDGKWHEI
IAIRHQAFGQITLDGIYTGSSAILNGSTVIGDNTGVFLGGLPRSYTILRKDPEIIQKG
FVGCLKDVHFMKNYNPSAIWEPLDWQSSEEQINVYNSWEGCPASLNEGAQFLGAGFLE
LHPYMFHGGMNFEISFKFRTDQLNGLLLFVYNKDGPDFLAMELKSGILTFRLNTSLAF
TQVDLLLGLSYCNGKWNKVIIKKEGSFISASVNGLMKHASESGDQPLVVNSPVYVGGI
PQELLNSYQHLCLEQGFGGCMKDVKFTRGAVVNLASVSSGAVRVNLDGCLSTDSAVNC
RGNDSILVYQGKEQSVYEGGLQPFTEYLYRVIASHEGGSVYSDWSRGRTTGAAPQSVP
TPSRVRSLNGYSIEVTWDEPVVRGVIEKYILKAYSEDSTRPPRMPSASAEFVNTSNLT
GILTGLLPFKNYAVTLTACTLAGCTESSHALNISTPQEAPQEVQPPVAKSLPSSLLLS
WNPPKKANGIITQYCLYMDGRLIYSGSEENYIVTDLAVFTPHQFLLSACTHVGCTNSS
WVLLYTAQLPPEHVDSPVLTVLDSRTIHIQWKQPRKISGILERYVLYMSNHTHDFTIW
SVIYNSTELFQDHMLQYVLPGNKYLIKLGACTGGGCTVSEASEALTDEDIPEGVPAPK
AHSYSPDSFNVSWTEPEYPNGVITSYGLYLDGILIHNSSELSYRAYGFAPWSLHSFRV
QACTAKGCALGPLVENRTLEAPPEGTVNVFVKTQGSRKAHVRWEAPFRPNGLLTHSVL
FTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVLIDGLVPFTNYTVQVNISNSQGSLI
TDPITIAMPPGAPDGVLPPRLSSATPTSLQVVWSTPARNNAPGSPRYQLQMRSGDSTH
GFLELFSNPSASLSYEVSDLQPYTEYMFRLVASNGFGSAHSSWIPFMTAEDKPGPVVP
PILLDVKSRMMLVTWQHPRKSNGVITHYNIYLHGRLYLRTPGNVTNCTVMHLHPYTAY
KFQVEACTSKGCSLSPESQTVWTLPGAPEGIPSPELFSDTPTSVIISWQPPTHPNGLV
ENFTIERRVKGKEEVTTLVTLPRSHSMRFIDKTSALSPWTKYEYRVLMSTLHGGTNSS
AWVEVTTRPSRPAGVQPPVVTVLEPDAVQVTWKPPLIQNGDILSYEIHMPDPHITLTN
VTSAVLSQKVTHLIPFTNYSVTIVACSGGNGYLGGCTESLPTYVTTHPTVPQNVGPLS
VIPLSESYVVISWQPPSKPNGPNLRYELLRRKIQQPLASNPPEDLNRWHNIYSGTQWL
YEDKGLSRFTTYEYMLFVHNSVGFTPSREVTVTTLAGLPERGANLTASVLNHTAIDVR
WAKPTVQDLQGEVEYYTLFWSSATSNDSLKILPDVNSHVIGHLKPNTEYWIFISVFNG
VHSINSAGLHATTCDGEPQGMLPPEVVIINSTAVRVIWTSPSNPNGVVTEYSIYVNNK
LYKTGMNVPGSFILRDLSPFTIYDIQVEVCTIYACVKSNGTQITTVEDTPSDIPTPTI
RGITSRSLQIDWVSPRKPNGIILGYDLLWKTWYPCAKTQKLVQDQSDELCKAVRCQKP
ESICGHICYSSEAKVCCNGVLYNPKPGHRCCEEKYIPFVLNSTGVCCGGRIQEAQPNH
QCCSGYYARILPGEVCCPDEQHNRVSVGIGDSCCGRMPYSTSGNQICCAGRLHDGHGQ
KCCGRQIVSNDLECCGGEEGVVYNRLPGMFCCGQDYVNMSDTICCSASSGESKAHIKK
NDPVPVKCCETELIPKSQKCCNGVGYNPLKYVCSDKISTGMMMKETKECRILCPASME
ATEHCGRCDFNFTSHICTVIRGSHNSTGKASIEEMCSSAEETIHTGSVNTYSYTDVNL
KPYMTYEYRISAWNSYGRGLSKAVRARTKEDVPQGVSPPTWTKIDNLEDTIVLNWRKP
IQSNGPIIYYILLRNGIERFRGTSLSFSDKEGIQPFQEYSYQLKACTVAGCATSSKVV
AATTQGVPESILPPSITALSAVALHLSWSVPEKSNGVIKEYQIRQVGKGLIHTDTTDR
RQHTVTGLQPYTNYSFTLTACTSAGCTSSEPFLGQTLQAAPEGVWVTPRHIIINSTTV
ELYWSLPEKPNGLVSQYQLSRNGNLLFLGGSEEQNFTDKNLEPNSRYTYKLEVKTGGG
SSASDDYIVQTPMSTPEEIYPPYNITVIGPYSIFVAWIPPGILIPEIPVEYNVLLNDG
SVTPLAFSVGHHQSTLLENLTPFTQYEIRIQACQNGSCGVSSRMFVKTPEAAPMDLNS
PVLKALGSACIEIKWMPPEKPNGIIINYFIYRRPAGIEEESVLFVWSEGALEFMDEGD
TLRPFTLYEYRVRACNSKGSVESLWSLTQTLEAPPQDFPAPWAQATSAHSVLLNWTKP
ESPNGIISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAA
NHAGEILSPWTLIQTLESSPSGLRNFIVEQKENGRALLLQWSEPMRTNGVIKTYNIFS
DGFLEYSGLNRQFLFRRLDPFTLYTLTLEACTRAGCAHSAPQPLWTDEAPPDSQLAPT
VHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNTER
NTFMYNDTGLQPWTQCEYKIYTWNSAGHTCSSWNVVRTLQAPPEGLSPPVISYVSMNP
QKLLISWIPPEQSNGIIQSYRLQRNEMLYPFSFDPVTFNYTDEELLPFSTYSYALQAC
TSGGCSTSKPTSITTLEAAPSEVSPPDLWAVSATQMNVCWSPPTVQNGKITKYLVRYD
NKESLAGQGLCLLVSHLQPYSQYNFSLVACTNGGCTASVSKSAWTMEALPENMDSPTL
QVTGSESIEITWKPPRNPNGQIRSYELRRDGTIVYTGLETRYRDFTLTPGVEYSYTVT
ASNSQGGILSPLVKDRTSPSAPSGMEPPKLQARGPQEILVNWDPPVRTNGDIINYTLF
IRELFERETKIIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLGCASSDWTFIQ
TPEIAPLMQPPPHLEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQPRKS
NPVLIYNGSSTSFIDSELLPFTEYEYQVWAVNSAGKAPSSWTWCRTGPAPPEGLRAPT
FHVISSTQAVVNISAPGKPNGIVSLYRLFSSSAHGAETVLSEGMATQQTLHGLQAFTN
YSIGVEACTCFNCCSKGPTAELRTHPAPPSGLSSPQIGTLASRTASFRWSPPMFPNGV
IHSYELQFHVACPPDSALPCTPSQIETKYTGLGQKASLGGLQPYTTYKLRVVAHNEVG
STASEWISFTTQKELPQYRAPFSVDSNLSVVCVNWSDTFLLNGQLKEYVLTDGGRRVY
SGLDTTLYIPRTADKTFFFQVICTTDEGSVKTPLIQYDTSTGLGLVLTTPGKKKGSRS
KSTEFYSELWFIVLMAMLGLILLAIFLSLILQRKIHKEPYIRERPPLVPLQKRMSPLN
VYPPGENHMGLADTKIPRSGTPVSIRSNRSACVLRIPSQNQTSLTYSQGSLHRSVSQL
MDIQDKKVLMDNSLWEAIMGHNSGLYVDEEDLMNAIKDFSSVTKERTTFTDTHL"
3'UTR 15997..18883
/gene="USH2A"
BASE COUNT 5410 a 4292 c 4051 g 5130 t
ORIGIN
1 tgtttgctct gcagaatact ttacctgggc acccaagtct tccttccagc attcctgctg
61 ctacagccta tttgctgagt aaccaggggt tacagcagcg ttgccaggca acgagggaca
121 gcggtcctgt tgaagagcca tttgtcacac tgaggggact ggttgaaatg caataaagaa
181 atgataccag cagctactca tgtcttcgcc attgctaaga acgtcgttgg tattacctta
241 ctctgagaac gtgtctgcag tttccagaaa atggagtatc gcaacatcac ttaaagtacc
301 ctgcttcaaa gtattgctgg caagtggcgt gggcctgatt atttatttag aaatgcttta
361 tcaggaggag aatgcttttt tgtaaacatg aattgcccag ttctttcatt gggctctggc
421 ttcttgtttc aggtcattga aatgttgatc tttgcctatt ttgcttcaat atccttgact
481 gagtcacgag gtcttttccc aaggctggag aacgtgggag ctttcaagaa agtttccatc
541 gtgccaaccc aagcagtatg tggactccca gaccgaagca ctttttgtca cagctctgct
601 gctgctgaaa gtattcagtt ctgtacccag cggttttgta ttcaggattg cccatacaga
661 tcttcacacc ctacctacac tgcccttttc tcagcaggcc tcagtagctg catcacacca
721 gacaagaatg atctgcatcc taacgcccat agcaattctg caagttttat ttttggaaat
781 cacaagagct gcttttcttc tcctccttct ccaaagctga tggcatcatt taccttagct
841 gtatggctga aacctgagca acaaggtgta atgtgtgtta tagaaaagac agtagatggg
901 cagattgtgt tcaaacttac aatatctgag aaagagacca tgttttatta tcgcacagta
961 aatggtttgc aacctccaat aaaagtaatg acactgggga gaattcttgt gaagaaatgg
1021 attcatctta gtgtgcaggt gcatcagaca aaaatcagct tctttatcaa tggcgtggag
1081 aaggatcata cacctttcaa tgcaagaact ctaagtggtt caattacaga ttttgcatct
1141 ggtactgtgc aaataggaca gagtttaaat ggtttagagc agtttgtcgg aagaatgcaa
1201 gattttcgat tataccaagt ggcacttaca aacagagaga ttctggaagt cttctctgga
1261 gatcttctca gattgcatgc ccaatcacat tgccgttgcc ctggcagcca cccgcgggtc
1321 caccctttgg cacagcggta ctgcattcct aatgatgcag gagacacagc tgataataga
1381 gtgtcacggt tgaatcctga agcccatcct ctctcttttg tcaatgataa tgatgttggt
1441 acttcatggg tttcaaatgt gtttacaaac attacacagc ttaatcaagg agtgactatt
1501 tcagttgatt tggaaaatgg acagtatcag gtgttttata ttatcattca gttctttagt
1561 ccacaaccaa cggaaataag gattcaaagg aagaaggaaa atagtttaga ttgggaggac
1621 tggcaatatt ttgccaggaa ttgtggtgct tttggaatga aaaacaatgg agatttggaa
1681 aaacctgatt ctgtcaactg tcttcagctt tccaatttta ctccatattc ccgtggcaat
1741 gtcacattta gcatcctgac acctggacca aattatcgtc ctggatacaa taacttctat
1801 aataccccat ctcttcaaga gttcgtaaaa gccacgcaaa taaggtttca ttttcatggg
1861 cagtactata caactgagac tgctgttaac ctcagacaca gatattatgc agtggacgaa
1921 atcaccatta gtgggagatg tcagtgccat ggtcatgccg ataactgcga cacaacaagc
1981 cagccatata gatgcctctg ctcccaggag agcttcactg aaggacttca ttgtgatcgc
2041 tgcttgcctc tttataatga caagcctttc cgccaaggtg atcaagttta cgctttcaat
2101 tgtaaacctt gtcaatgcaa cagccattcc aaaagctgcc attacaacat ctctgtagac
2161 ccatttcctt ttgagcactt cagaggggga ggaggagttt gtgatgattg tgagcataac
2221 actacaggaa ggaactgtga gctgtgcaag gattactttt tccgacaagt tggtgcagat
2281 ccttcggcca tagatgtttg caaaccctgt gactgtgata cagttggcac tagaaatggt
2341 agcattcttt gtgatcagat tggaggacag tgtaattgta agagacacgt gtctggcagg
2401 cagtgcaatc agtgccagaa tggattctac aatctacaag agttggatcc tgatggctgc
2461 agtccctgta actgcaatac ctctgggaca gtggatggag atattacctg tcaccaaaat
2521 tcaggccagt gcaagtgcaa agcaaacgtt attgggctta ggtgtgatca ttgcaatttt
2581 ggatttaaat ttctccgaag ctttaatgat gttggatgtg agccctgcca gtgtaacctc
2641 catggctcag tgaacaaatt ctgcaatcct cactctgggc agtgtgagtg caaaaaagaa
2701 gccaaaggac ttcagtgtga cacctgcaga gaaaactttt atgggttaga tgtcaccaat
2761 tgtaaggcct gtgactgtga cacagctgga tccctccctg ggactgtctg taatgctaag
2821 acagggcagt gcatctgcaa gcccaatgtt gaagggagac agtgcaataa atgtttggag
2881 ggaaacttct acctacggca aaataattct ttcctctgtc tgccttgcaa ctgtgataag
2941 actgggacaa taaatggctc tctgctgtgt aacaaatcaa caggacaatg tccttgcaaa
3001 ttaggggtaa caggtcttcg ctgtaatcag tgtgagcctc acaggtacaa tttgaccatt
3061 gacaattttc aacactgcca gatgtgtgag tgtgattcct tggggacatt acctgggacc
3121 atttgtgacc caatcagtgg ccagtgcctg tgtgtgccta atcgtcaagg aagaaggtgt
3181 aatcagtgtc aaccaggttt ttatatttct ccaggcaatg ccactggctg cctgccatgc
3241 tcatgccata caactggtgc agttaatcac atctgtaata gcctgactgg tcagtgtgtt
3301 tgccaagatg cttccattgc tgggcaacgt tgtgaccaat gcaaagacca ttactttgga
3361 tttgatcctc agactggaag atgtcagcct tgtaattgtc atctctcagg agccttgaat
3421 gaaacctgtc acttggtcac aggccagtgt ttctgtaaac aatttgtcac tggctcaaag
3481 tgtgatgctt gtgttcccag tgcaagccac ttggatgtca acaatctatt gggttgcagc
3541 aaaactccat tccagcaacc tccgcccaga ggacaagttc aaagttcttc tgctatcaat
3601 ctctcctgga gtccacctga ttctccaaat gcccactggc ttacttacag tttactcagg
3661 gatggttttg aaatctacac aacagaggat caatacccat acagtattca atacttctta
3721 gacacagacc tgttaccata taccaaatat tcctattaca ttgagaccac caatgtgcat
3781 ggttcaacaa ggagtgtagc tgtcacttac aagacaaaac caggggtccc agagggaaac
3841 ttgactttaa gttatatcat tcctattggc tcagactctg tgacacttac ctggacaaca
3901 ctctcaaatc aatctggtcc catagagaaa tatattttgt cctgtgcccc tttggctggt
3961 ggtcagccat gtgtttccta cgaaggtcat gaaacctcag ctaccatctg gaatctggtt
4021 ccatttgcca agtacgattt ttctgtacag gcgtgtacta gcgggggctg tttacacagc
4081 ttgcccatta cagtgaccac agcccaggcc cctccccaaa gactaagtcc acctaagatg
4141 cagaaaatca gttctacaga acttcatgta gaatggtctc caccagcgga actaaatgga
4201 ataattataa gatatgaact atacatgaga agactgagat ctactaaaga aaccacatct
4261 gaggaaagtc gagtttttca gagcagtggt tggctcagtc ctcattcatt tgtagaatcg
4321 gccaatgaaa atgcattaaa acctcctcaa acaatgacaa ccatcactgg cttggagcca
4381 tacaccaagt atgagttcag agtcttagct gtgaatatgg ctggaagtgt gtcttctgcc
4441 tgggtctcag aaagaacggg agaatcagca cctgtattca tgatccctcc ttcagtcttt
4501 cccctctctt cgtactctct caatatctcc tgggagaagc cagcagataa tgttacaaga
4561 ggaaaagttg tggggtatga catcaatatg ctttctgaac aatcacctca acagtctatt
4621 cccatggcgt tttcacagct gttgcacact gctaaatccc aagaactatc ttacactgta
4681 gaaggactga aaccttatag gatatatgag tttactatta ctctctgcaa ttcagttggt
4741 tgtgtgacca gtgcttcggg agcaggacaa actttagcag cagcaccagc acaactgagg
4801 ccacctctgg ttaaaggaat caacagcaca acaatccatc ttaggtggtt tccacctgaa
4861 gaactgaatg gaccctctcc tatatatcag ctggaaagga gagagtcatc tctaccagct
4921 ctgatgacca cgatgatgaa aggaatccgt ttcataggaa atgggtattg taaatttccc
4981 agctccactc acccagtcaa tacagacttc actggcatta aggccagctt tcgaacaaaa
5041 gtgcctgaag gtttgattgt ctttgcagca tcacctggca atcaggaaga gtattttgca
5101 cttcagttga agaagggacg tctttatttt ctttttgatc ctcaggggtc accagtggaa
5161 gtaactacaa ctaatgatca tggcaaacaa tatagtgatg gaaaatggca tgaaataatt
5221 gctattaggc atcaggcttt tggccaaatc actctggatg ggatatatac aggttcctct
5281 gccatcctga atggtagtac tgttattgga gataacacag gagtctttct gggagggctc
5341 ccgcgaagtt ataccatcct caggaaggat cctgagataa tccaaaaagg ttttgtgggc
5401 tgtctcaagg atgtacattt tatgaagaat tacaatccgt cagctatttg ggaacctctg
5461 gattggcaga gttctgaaga acaaatcaac gtgtataaca gctgggaggg atgtcccgct
5521 tcattaaatg agggagctca gttcctagga gcagggttcc tggaacttca tccatatatg
5581 tttcatggtg gaatgaactt tgagatttcc tttaagttca gaactgacca attaaatgga
5641 ttgcttcttt tcgtttataa caaagatgga cctgattttc ttgctatgga gctgaaaagt
5701 ggaatattga ccttccggtt aaataccagt cttgccttta cacaagtgga tctattgctg
5761 gggctatcct attgtaatgg aaagtggaat aaagtcatta ttaaaaagga aggctctttc
5821 atatcagcaa gtgtgaatgg actgatgaag catgcatcgg agtccggaga ccagccactg
5881 gtggtgaatt caccagttta tgtgggagga atcccacagg aactgctgaa ctcttatcaa
5941 catttgtgtt tggaacaagg tttcggtggt tgcatgaagg atgttaaatt tacacggggt
6001 gctgtcgtta acttggcatc tgtgtccagc ggtgctgtca gagtcaatct ggatggatgc
6061 ctatcaactg acagtgctgt taactgcagg ggaaatgact ccatcctggt ttaccaggga
6121 aaagagcaga gtgtttacga gggtggtctc cagcctttta cagaatacct gtatcgagtg
6181 atagcctcgc atgaaggagg ttcagtatat agtgattgga gtcgaggacg tacaacagga
6241 gcagctccac aaagtgtgcc aactccctca agagtccgca gcttaaatgg atacagcatt
6301 gaggtgacct gggatgaacc tgttgtcaga ggtgtaattg agaagtacat tctgaaagcc
6361 tatagtgagg acagcacccg tccaccccgc atgccctctg ccagtgctga atttgtcaat
6421 acaagcaacc tcacaggcat attgacaggc ttgctaccct tcaaaaacta tgcagtaacc
6481 ctaactgctt gcactttggc tggctgtact gagagctcac atgcattgaa catctctact
6541 ccacaagaag ccccacaaga ggttcagcca ccagtagcca aatcccttcc cagttctttg
6601 ctgctctcct ggaacccacc caaaaaggca aatggtatta taactcagta ctgtttatac
6661 atggatggga ggctgatcta ttcaggcagt gaggagaact acatagtcac agatttagca
6721 gtatttacac cccaccagtt tctactaagt gcatgcacac atgtgggctg tacaaacagt
6781 tcctgggtcc tactgtacac agcacagctg ccaccagaac acgtggattc cccagttctg
6841 actgtcctgg attctagaac tatacacata cagtggaaac aaccaagaaa aataagtggg
6901 attctggaac gctatgtatt atatatgtca aaccatacac atgattttac aatttggagt
6961 gtcatctata acagtacaga acttttccag gatcatatgc tacaatacgt tttacctggt
7021 aataaatatc tcatcaagct gggagcttgc acaggtggtg ggtgcacagt gagtgaggcc
7081 agtgaggccc taactgacga ggacataccc gaaggcgtgc cagcccccaa agcccactca
7141 tattcacctg actcctttaa tgtctcctgg actgagcctg aatatccgaa tggtgttatc
7201 acgagttatg gattatatct agatggtata ttaatccaca attcctcaga actcagctat
7261 cgtgcttacg gatttgctcc ttggagttta cattccttca gagtccaagc atgcacggcc
7321 aaaggttgtg ctctgggccc actggtggaa aatcgaactc tagaagctcc tcctgaagga
7381 acagtaaatg tgtttgtcaa aacacaggga tcccggaaag cccacgtgag gtgggaagca
7441 ccttttcgcc ctaatggact cttaacacac tcagtccttt tcactgggat attctatgta
7501 gacccagtag gtaataacta cacccttctg aatgtcacaa aagtcatgta cagcggagaa
7561 gagacaaacc tttgggtgct catcgatggg ctggttcctt ttaccaacta tactgtacaa
7621 gtgaatattt caaatagcca aggcagcttg ataactgatc ctataacaat tgcaatgcct
7681 ccaggagctc cagatggcgt gctgcctccc aggctttcat ctgccactcc aaccagtctt
7741 caggttgtct ggtctacacc agctcgtaat aacgctcctg gctctcccag ataccaactc
7801 cagatgaggt ctggcgactc cacccatgga tttctagagt tattttccaa tccttctgca
7861 tcgttaagct atgaagtgag tgatctccaa ccgtacacag agtatatgtt tcggttggtt
7921 gcctccaatg gatttggcag tgcacatagt tcttggattc cattcatgac cgcagaggac
7981 aaacctggac ctgtagttcc tccgattctt ctggatgtga agtcaagaat gatgttggtc
8041 acctggcagc atcctagaaa atccaatggg gttattaccc attataacat ttatctacat
8101 ggccgtctat acttgagaac tcctggaaat gtcactaatt gcacagtgat gcatttacac
8161 ccatacactg cctataagtt tcaggtagaa gcctgcactt caaaaggatg ttccctttca
8221 ccagagtccc agactgtatg gacactccca ggggcaccgg aagggatccc aagtccagag
8281 ctgttctctg atactccaac atctgtgatt atatcttggc aaccccctac ccaccccaat
8341 ggcttggtgg agaatttcac aattgagaga agagtcaaag gaaaggaaga agttactacc
8401 ctggtgactc tcccgaggag tcattccatg aggtttattg acaagacttc tgctcttagc
8461 ccatggacaa aatatgaata tcgggtactg atgagcactc ttcatggagg cacaaacagc
8521 agtgcttggg tagaagttac cacaagaccc tcacgacctg ctggggtgca gccacctgtg
8581 gtgacagtgc tggaacccga tgcagtccag gtcacttgga aacccccact catccagaac
8641 ggagacatac ttagctatga gattcacatg cctgaccctc acatcacttt aaccaatgtg
8701 acttccgcag tgttaagtca aaaagttact catctgattc ctttcactaa ttattctgtc
8761 accattgttg cttgctcagg gggtaatggg taccttggag ggtgcacaga gagtttacct
8821 acctatgtta ccactcaccc caccgtacct cagaatgttg gcccattgtc tgtgattcca
8881 ctaagtgaat catatgttgt gatttcttgg caaccaccat ccaagccaaa tggacctaat
8941 ttgagatatg agcttctgag acgtaaaatc cagcagccac ttgcatcaaa tcccccagaa
9001 gatttaaatc ggtggcacaa tatttattca ggaactcagt ggctttatga agataagggt
9061 cttagcaggt ttacaaccta tgaatatatg ctcttcgtac acaacagtgt gggttttaca
9121 ccgagccgag aagtgactgt gacaacgtta gctggtcttc cagagagagg agccaatctc
9181 actgcgagtg tccttaacca cacagccatc gacgtgaggt gggctaaacc aactgttcaa
9241 gacctacaag gtgaagttga atattacaca cttttttgga gttctgctac ctcaaacgac
9301 tctctaaaaa tcttgccaga tgtaaactct catgtcattg gccacctaaa gccaaacaca
9361 gagtattgga tctttatctc tgtcttcaat ggagtccaca gcatcaacag tgcaggactt
9421 catgcaacca cttgcgatgg ggagcctcag ggcatgcttc ctccagaggt tgtcatcatc
9481 aacagtacag ctgtacgtgt catctggaca tctccttcaa acccaaatgg tgttgtcact
9541 gagtattcta tctatgtaaa taataagctc tacaagactg gaatgaatgt gcctgggtcg
9601 tttattctga gagacctgtc tcccttcact atctatgaca ttcaggttga agtctgcaca
9661 atatatgcct gcgtgaaaag caatggaacc caaattacca ctgtggaaga cactccaagt
9721 gatataccaa cacccacaat tcgtggcatc acttcaagat ctcttcaaat tgattgggtg
9781 tctccacgga agccaaatgg catcattctt ggatatgatc tcctatggaa aacatggtat
9841 ccatgcgcta aaactcaaaa gttagtgcag gatcagagtg atgagctctg caaggcagtg
9901 aggtgtcaaa aacctgaatc tatctgtgga cacatttgct attcttctga agctaaggtt
9961 tgttgtaacg gagtgctcta taaccccaag cctggacatc gctgttgtga agaaaagtat
10021 atcccgtttg ttctgaattc tactggagtt tgttgtggtg gccgaataca ggaggcacaa
10081 ccaaatcatc agtgctgctc tgggtattac gctagaattc taccaggtga agtatgctgt
10141 ccagatgaac agcacaatcg ggtttctgtt ggcattggtg attcctgctg tggcagaatg
10201 ccgtactcca cctcaggaaa ccagatttgc tgtgctggga ggcttcatga tggccatggc
10261 cagaagtgct gtggcagaca gattgtgagc aacgatttag agtgttgtgg tggagaagaa
10321 ggagtggtgt acaatcgcct tccaggtatg ttctgttgtg ggcaggatta tgtgaatatg
10381 tcagatacca tatgctgctc agcttccagt ggagagtcta aagcacatat taaaaagaat
10441 gacccggtgc cagtaaaatg ctgtgagact gaacttattc caaagagcca gaaatgctgt
10501 aatggagttg gatataatcc tttgaaatat gtttgctctg acaagatttc aactggaatg
10561 atgatgaagg aaaccaaaga gtgcaggatc ctctgcccag catctatgga agccacagaa
10621 cattgtggca ggtgtgactt caactttacc agccacattt gcactgtgat aagagggtct
10681 cacaattcca cagggaaggc atcaattgaa gaaatgtgtt catctgccga agaaaccatt
10741 catacaggga gtgtaaacac gtactcttac acagatgtga acctcaagcc ctacatgaca
10801 tatgagtaca ggatttctgc ctggaacagc tatgggcgag gactcagcaa agctgtgaga
10861 gccagaacaa aagaagatgt gcctcaagga gtgagtcccc ctacgtggac caaaatagac
10921 aatcttgaag atacaattgt cttaaactgg agaaaaccta tacaatcaaa tggtcctatt
10981 atttactaca tccttcttcg aaatggaatt gaacgttttc ggggaacatc actgagcttc
11041 tctgataaag agggaattca accatttcag gaatattcat atcagctgaa agcttgcacg
11101 gttgctggct gtgccaccag tagcaaggta gttgcagcta ctacccaagg agttccggag
11161 agcatcctgc caccaagcat cacagcccta agtgcagtgg ctctgcatct gagctggagt
11221 gtccctgaga aatcaaacgg cgtcattaaa gagtaccaga tcaggcaggt tgggaaaggt
11281 ctcatccaca ctgacaccac tgacaggaga cagcatacgg tcacaggtct ccagccatac
11341 accaactaca gcttcactct tacagcttgt acatctgctg ggtgcacttc aagcgagcct
11401 tttctaggtc agacactgca ggcagctcct gaaggagttt gggtgacacc tcgacacatt
11461 atcatcaatt ctacaacagt ggaattatat tggagtctgc cagaaaagcc caatggcctc
11521 gtttctcaat atcaattgag tcgtaatgga aacttgcttt tcctgggtgg cagtgaggag
11581 cagaatttca ctgataaaaa cctggagccc aatagcagat acacttacaa gttagaagtc
11641 aaaactggag gtggcagcag tgctagtgat gattacattg ttcaaacacc tatgtcaaca
11701 ccagaagaaa tctatcctcc atataatatc acagtaattg ggccttattc tatatttgta
11761 gcttggatac caccagggat cctcatcccc gaaattcctg tggagtacaa tgtcttactc
11821 aatgatggaa gtgtaacacc tctggccttc tccgttggtc atcatcaatc cacccttctg
11881 gaaaatttga ctccattcac acagtatgag ataaggatac aagcatgtca aaatggaagt
11941 tgtggagtta gcagtaggat gtttgtcaaa acacctgaag cagccccaat ggatcttaat
12001 tctcctgttc ttaaggcact ggggtcagct tgcatagaga ttaagtggat gccacctgaa
12061 aaaccaaatg gaatcatcat caactacttt atttacagac gccctgctgg cattgaagag
12121 gagtctgttt tatttgtctg gtcagaagga gcccttgaat ttatggatga aggagacacc
12181 ctgaggcctt tcacactcta cgaatatcgg gtcagagcct gtaactccaa gggttcagtg
12241 gagagtctgt ggtcattaac acaaactctg gaagctccac ctcaagattt tccagctcct
12301 tgggctcaag ccacgagtgc tcattcagtt ctgttgaatt ggacaaagcc agaatctccc
12361 aatggcatta tctcccatta ccgtgtggtc taccaggaga gacccgacga tcctacattt
12421 aacagcccta ccgtgcatgc tttcacagtg aagggaacaa gccatcaagc ccacctgtac
12481 gggttagaac cattcacaac atatcgcatt ggtgttgtgg ctgcaaacca tgcaggagaa
12541 attttaagcc cttggactct gattcaaacc ttagaatctt ccccaagtgg actgagaaac
12601 tttatagtag aacagaaaga gaatggccgg gcattgctac tacagtggtc agaacctatg
12661 agaaccaatg gtgtgattaa gacatacaac atcttcagtg acgggttcct ggagtactct
12721 ggtttgaatc gtcagtttct cttccgccgc ctggatcctt tcactctcta cacactgacc
12781 ctggaggcct gcaccagagc aggttgtgca cactcggcgc ctcagcctct gtggacagat
12841 gaagcccctc cagactctca gctggctcct actgtccact ctgtgaagtc caccagtgtt
12901 gagctgagct ggtctgagcc tgttaaccca aatggaaaaa taattcgcta tgaagtgatt
12961 cgcagatgct tcgagggaaa agcttgggga aatcagacaa tccaggccga cgagaaaatt
13021 gttttcacag aatataacac tgaaaggaat acatttatgt ataatgacac aggtttgcaa
13081 ccatggacgc agtgtgaata taaaatctac acttggaatt cagctgggca tacctgtagc
13141 tcttggaatg tggtgaggac attgcaagca cctccagaag gtctctctcc acctgtgata
13201 tcctatgttt ctatgaatcc ccaaaaactg ctgatttcct ggatcccacc agaacagtct
13261 aatggtatta tccagtccta taggcttcaa aggaatgaaa tgctctatcc ttttagcttt
13321 gatcctgtga ctttcaatta cactgatgaa gagcttcttc ctttttccac ctatagctat
13381 gcactccaag cctgcacgag tggaggatgc tccaccagca aacccaccag catcacaact
13441 ctggaggctg ctccatcaga agtcagccct ccagatcttt gggccgtcag tgccactcaa
13501 atgaatgtat gttggtcacc gcccacagtg caaaatggaa agattactaa atatttagtt
13561 agatatgata ataaagagtc ccttgctggc cagggcctgt gcctgctggt ttcccacctg
13621 cagccttact ctcagtataa cttctccctt gtagcctgca cgaatggagg ttgcacagct
13681 agtgtgtcaa aatctgcctg gacaatggag gccctgccag agaacatgga ctctccaaca
13741 ttgcaagtca caggctcaga atcaatagaa atcacctgga aacctccaag aaacccaaat
13801 ggccagatca gaagttatga acttaggagg gatggaacca ttgtatatac aggcttggaa
13861 acacgctatc gtgattttac tctcacccca ggtgtggagt atagctacac agtaactgcc
13921 agcaacagcc aagggggtat tttgagtcct cttgtcaaag atcgaaccag cccctcagca
13981 ccctcaggga tggaacctcc aaaattgcag gccaggggtc ctcaggagat cttagtgaac
14041 tgggaccctc cagtgagaac aaatggtgat atcatcaatt ataccctctt catccgtgaa
14101 ctatttgaaa gagaaactaa aatcatacac ataaacacaa ctcataattc ttttggtatg
14161 cagtcatata tagtaaacca gctgaagcca tttcacaggt atgaaatacg aattcaagcg
14221 tgcaccaccc tgggatgtgc atcaagtgac tggacattca tacagacccc tgagattgca
14281 cctttgatgc aaccccctcc acatctggag gtacaaatgg ctccaggagg attccagcca
14341 actgtttctc ttttgtggac aggaccgctg cagccaaatg gaaaagtttt gtattacgaa
14401 ttatacagaa gacaaatagc aactcagcct agaaaatcca atccagtcct aatctataac
14461 ggaagctcaa catcttttat agattccgaa ctattgcctt tcacagagta tgagtatcag
14521 gtctgggcag tgaattctgc aggaaaagcc cccagtagct ggacatggtg cagaaccggg
14581 ccagccccac cagaaggtct cagagccccc acgttccatg tgatctcttc tacccaagca
14641 gtggtcaaca tcagtgcccc tgggaagccc aacgggatcg tcagtctcta caggctgttc
14701 tccagcagcg cccatggggc tgagacagtg ctatccgaag gcatggccac ccagcagact
14761 ctccatggcc ttcaagcctt cactaactac tctattggag tagaggcctg cacctgcttc
14821 aactgttgca gcaaaggacc gacagctgaa ctgagaaccc atcctgcccc accctcagga
14881 ctgtcctctc cacaaatcgg gacgctggcc tcaaggacgg cctccttccg gtggagtccc
14941 cccatgttcc ccaatggtgt cattcacagc tatgaactcc aattccacgt ggcttgccct
15001 cctgactcag ccctcccctg tactcccagc caaatagaaa caaagtacac ggggctgggg
15061 cagaaagcca gccttggggg tctccagccc tacaccacat acaagctgag agtggtggca
15121 cacaacgagg tgggcagtac ggcttccgag tggatcagtt tcaccaccca aaaagaattg
15181 cctcagtacc gagccccatt ttcggtggac agcaatttgt ctgtggtgtg tgtgaactgg
15241 agtgacacct tcctcctgaa cggccaactg aaggagtacg tgttaaccga cggagggcga
15301 cgcgtgtaca gcggcttgga caccaccctc tacataccga gaacggcgga caaaaccttc
15361 tttttccagg tcatctgcac gactgacgaa ggaagtgtta agacgccgtt gatccaatat
15421 gatacctcta ctggacttgg cttggtccta acaactcctg ggaaaaagaa gggatcgcgg
15481 agcaaaagca cagagttcta cagcgagctg tggttcatag tgttaatggc gatgctgggc
15541 ttgatcttgt tggccatttt tctgtccctg atactacaaa gaaaaatcca caaagagcca
15601 tatatcagag aaagacctcc cttggtacct cttcagaaga ggatgtctcc attgaatgtt
15661 tacccaccgg gggaaaacca tatggggtta gccgatacca aaattccccg gtctgggaca
15721 cctgtgagta tccgcagcaa ccggagtgca tgtgtcctgc gcatcccgag tcaaaaccaa
15781 accagcctaa cctactccca gggttctctt caccgcagcg tcagccagct catggacatt
15841 caagacaaga aagtcttgat ggacaactca ctgtgggaag ccatcatggg ccacaacagt
15901 ggactgtatg tggatgaaga ggacctgatg aacgccatca aggatttcag ctcagtgact
15961 aaggaacgca ccacattcac agacacccac ctgtaaagga tggaaaccca gaagacgtaa
16021 ccctggaatg caaggtctgc acccatttcc tcctgggtta tcactcacac atcataaatg
16081 ctgaaaagcc attgtttatt atcctataat tctttaaaga aatgatgact gtttttgaaa
16141 gtgttccttc ctaatagagg tctaagaaat gatatttttc tcatcttaaa tgagagagaa
16201 tattcatatg aaaatacttg atttgctctt attttgtaga agacaaagaa gtatgtaatt
16261 gtcacttggt tctgtttggc agtgatgctc ctggttaact gaataatcag tggcaatttc
16321 aagatggctc acagttgtta gaagtagtaa gttagttact ggctcaaaaa tgattctgtt
16381 gaaaggatgt cactgctgtt catttctatc tgccatttct gtcagggttg acacaatcct
16441 gcaagaatag ttattctaat gatcacagct gctaaatgaa tcccaaactt tgcaccaggt
16501 cgacaaactt ttctgaaggt tctatttatt taccatacat agggttactt accaaacttt
16561 ttgacaaggc tgaaggttct atttatttac aatacatagg gttactcacc aaactttttg
16621 acaaggcaac acataactta cacataaatg tctctgttct tgcatttatg aattttccaa
16681 aaatctaagg agtaaacagc ttatttatac attttgagga gaaaacaaag tgtttcacta
16741 ggaacacctc tacttgaacc aatgttttta tttcatatat tttatagttt tgaaactagt
16801 ttctcataaa attctgtcaa ttcactgaat atcagagaat actgacatct tcaacctagc
16861 acatttcaaa tggaaactac tgttctattt gcaatattag gctgcgtgaa attttaaaag
16921 gaaaaatgta tctgttcctt ctagcattaa catatataca tgtagagaca agactatacc
16981 tatgtgtata tatatgtata tcatgtatat attactctgc actatatccc ttctttttgg
17041 agaactagcc attattttag ccacagaatc agtaagaaca gatgatatgc aacagtacca
17101 attacggttc aaaaatgtct gtcacctgct ctagttggat tacaaagtca ttggtgaaag
17161 tcctatggca agaaaaattt tcttgcaaat catccacata aaatcagata tttaaatttg
17221 ttcttcatgg aaaacagagt aagaaaacct cttgtcttcc ttcatcctta aaggtctttg
17281 tgaccccagg aaaatattga ctctgtctaa cacacaatag tcacaatact ttttgtgaat
17341 ctacaaccag agacaggcaa aaacttgtaa agtaagggat agtcttactt attctgcctg
17401 aaaacaatgt attaccccag ggcccaacag taaaagattg tggacttttt gggtattgag
17461 atttcatcta gctctgtgag agagcagctc ctcagactga ccaactccta gacaaagttt
17521 gccaaccata agtgtcaaaa gcacaggcca gtattaagca gaagttctac caccttatta
17581 gaactgctat aaacaaaagc atctgaaata attgtgcaca tctggcagtg actgtagaaa
17641 atacgaaata tatatttctc gccaagtttt tatactttct gaaatgaaaa cataggattg
17701 actagtttac tggtttttat tcccatatgc cgattctggg acaataaagt tgtttaaagc
17761 tggcacaaat aagcattaac caaggctgtg tccaccttct gtgagctact taaggtatat
17821 aggaaaggag tggtcacaaa cttgcatcct aatccttggt ggactcttct aagaatacag
17881 tttgctagtc acaaagaata gtctacaaat atgctttgct aggttcagaa gattgagttt
17941 atcctgattt ttgaaaaatt aaccaggtat ctttatcact gtgtattttt ccaagcacag
18001 tataaaattt taacaacgca caaaaaaata cagaactgca ggggatttta tcttggatca
18061 ttatccattt aatcatctaa ttagacatga actcagttag ctgaatcatt tacattttga
18121 ctccatagct tagggcagac agaagcctgt atggcttctg cccagaactc tgtcccctgc
18181 tacatgtcta agtttacttg tatttatttc agagaagaac tctaagatgt tgctttgcta
18241 ctttaagtgg tattgcgtgc caagcctcta ttatacaaac catgcagact cgcctctaga
18301 gattctgatt cggttgatct ggggtgtgtg gctgaggcat cagtactttt taaagcttcc
18361 aggtgttcta atgttgagac ccactgatgt tccacaatct ggaagaaatc atgtacagga
18421 ataatatgct atgcacaggg actatgctcc ttggctcacc ccttctccct tataaacaat
18481 gagcagttct tgatgaacct ctttaaattt aaatctcctg actcacattt taccaattgt
18541 acatgccaca ttctcagctt acgaactacc atgttttgtt attcttaata tcaactgttt
18601 ggtaagagta cagttgtttt tatacactct aagaaatgtg tttataatct actgtaattt
18661 ccactaaatg gaacccaaat attaatgtta tggtaccata tactgatgta aaaatcatgc
18721 tggcatccat gaacacaccg gtaaataaaa catagtccaa gtggaagaat tcattaataa
18781 ggaactttta attatgtcac aaatgaatag ttggtttcca atgcacaaat atcatgtaaa
18841 ctaatctaaa gatggtttgc ttaataaata tttgaatgtg acc
//