LOCUS AY459346 4784 bp mRNA linear HUM 25-JUL-2006
DEFINITION Homo sapiens cGMP-inhibited cAMP phophodiesterase (PDE3B) mRNA,
complete cds.
ACCESSION AY459346
VERSION AY459346.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4784)
AUTHORS Liu,H., Tang,J.R., Choi,Y.H., Napolitano,M., Hockman,S., Taira,M.,
Degerman,E. and Manganiello,V.C.
TITLE Importance of cAMP-response element-binding protein in regulation
of expression of the murine cyclic nucleotide phosphodiesterase 3B
(Pde3b) gene in differentiating 3T3-L1 preadipocytes
JOURNAL J. Biol. Chem. 281 (30), 21096-21113 (2006)
PUBMED 16702214
REFERENCE 2 (bases 1 to 4784)
AUTHORS Gao,G. and Manganiello,V.C.
TITLE Molecular Cloning and Expression of Human Jurkat T-lymphocyte
Phosphodiesterase 3B
JOURNAL Unpublished
REFERENCE 3 (bases 1 to 4784)
AUTHORS Gao,G. and Manganiello,V.C.
TITLE Direct Submission
JOURNAL Submitted (05-NOV-2003) PCCMB/NHLBI, NIH, 10 Center Drive, 5N323,
Bethesda, MD 20892, USA
FEATURES Location/Qualifiers
source 1..4784
/db_xref="H-InvDB:HIT000254801"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11p15.1-p15.2"
/cell_line="Jurkat"
/cell_type="T-lymphocyte"
gene 1..4784
/gene="PDE3B"
5'UTR 1..291
/gene="PDE3B"
CDS 292..3630
/gene="PDE3B"
/note="cyclic nucleotide phosphodiesterase"
/codon_start=1
/product="cGMP-inhibited cAMP phophodiesterase"
/protein_id="AAR24292.1"
/translation="MRRDERDAKAMRSLQPPDGAGSPPESLRNGYVKSCVSPLRQDPP
RGFFFHLCRFCNVELRPPPASPQQPRRCSPFCRARLSLGALAAFVLALLLGAEPESWA
AGAAWLRTLLSVCSHSLSPLFSIACAFFFLTCFLTRTKRGPGPGRSCGSWWLLALPAC
CYLGDFLVWQWWSWPWGDGDAGSAAPHTPPEAAAGRLLLVLSCVGLLLTLAHPLRLRH
CVLVLLLASFVWWVSFTSLGSLPSALRPLLSGLVGGAGCLLALGLDHFFQIREAPLHP
RLSSAAEEKVPVIRPRRRSSCVSLGETAASYYGSCKIFRRPSLPCISREQMILWDWDL
KQWYKPHYQNSGGGNGVDLSVLNEARNMVSDLLTDPSLPPQVISSLRSISSLMGAFSG
SCRPKINPLTPFPGFYPCSEIEDPAEKGDRKLNKGLNRNSLPTPQLRRSSGTSGLLPV
EQSSRWDRNNGKRPHQEFGISSQGCYLNGPFNSNLLTIPKQRSSSVSLTHHVGLRRAG
VLSSLSPVNSSNHGPVSTGSLTNRSPIEFPDTADFLNKPSVILQRSLGNAPNTPDFYQ
QLRNSDSNLCNSCGHQMLKYVSTSESDGTDCCSGKSGEEENIFSKESFKLMETQQEEE
TEKKDSRKLFQEGDKWLTEEAQSEQQTNIEQEVSLDLILVEEYDSLIEKMSNWNFPIF
ELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENGYRDIPYHNRI
HATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYISSKSCSNPDES
YGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAA
SAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNS
NGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGLP
ISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWLEAEEDNDTESGDDEDG
EELDTEDEEMENNLNPKPPRRKSRRRIFCQLMHHLTENHKIWKEIVEEEEKCKADGNK
LQVENSSLPQADEIQVIEEADEEE"
3'UTR 3631..4784
/gene="PDE3B"
BASE COUNT 1261 a 1101 c 1162 g 1260 t
ORIGIN
1 gaggcgacac tgagtctcca agtccggaga ggtgcccgag ggaaaagagg cggcagctaa
61 actggtcctg gagagaagcc ccttccgccc ctctcctcag ccagcatgtc ccggactccg
121 ccgctcctca gtccgcgcgg tggggacccc gggccgtggc ggccggcgca gccctgacgg
181 gttgcgaacc agggggcgcc ccgaacgcgg gggttggggt ctgggagcgc gagcggccgc
241 tacggtacga gcggggtgtg ctgagtcccg tggccacccc cggccccagc catgaggagg
301 gacgagcgag acgccaaagc catgcggtcc ctgcagccgc cggatggggc cggctcgccc
361 cccgagagtc tgaggaacgg ctacgtgaag agctgcgtga gccccttgcg gcaggaccct
421 ccgcgcggct tcttcttcca cctctgccgc ttctgcaacg tggagctgcg gccgccgccg
481 gcctctcccc agcagccgcg gcgctgctcc cccttctgcc gggcgcgcct ctcgctgggc
541 gccctggctg cctttgtcct cgccctgctg ctgggcgcgg aacccgagag ctgggctgcc
601 ggggccgcct ggctgcggac gctgctgagc gtgtgttcgc acagcttgag ccccctcttc
661 agcatcgcct gtgccttctt cttcctcacc tgcttcctca cccggaccaa gcggggaccc
721 ggcccgggcc ggagctgcgg ctcctggtgg ctgctggcgc tgcccgcctg ctgttacctg
781 ggggacttct tggtgtggca gtggtggtct tggccttggg gggatggcga cgcagggtcc
841 gcggccccgc acacgccccc ggaggcggca gcgggcaggt tgctgctggt gctgagctgc
901 gtagggctgc tgctgacgct cgcgcacccg ctgcggctcc ggcactgcgt tctggtgctg
961 ctcctggcca gcttcgtctg gtgggtctcc ttcaccagcc tcgggtcgct gccctccgcc
1021 ctcaggccgc tgctctccgg cctggtgggg ggcgctggct gcctgctggc cctggggttg
1081 gatcacttct ttcaaatcag ggaagcgcct cttcatcctc gactgtccag tgccgccgaa
1141 gaaaaagtgc ctgtgatccg accccggagg aggtccagct gcgtgtcgtt aggagaaact
1201 gcagccagtt actatggcag ttgcaaaata ttcaggagac cgtcgttgcc ttgtatttcc
1261 agagaacaga tgattctttg ggattgggac ttaaaacaat ggtataagcc tcattatcaa
1321 aattctggag gtggaaatgg agttgatctt tcagtgctaa atgaggctcg caatatggtg
1381 tcagatcttc tgactgatcc aagccttcca ccacaagtca tttcctctct acggagtatt
1441 agtagcttaa tgggtgcttt ctcaggttcc tgtaggccaa agattaatcc tctcacacca
1501 tttcctggat tttacccctg ttctgaaata gaggacccag ctgagaaagg ggatagaaaa
1561 cttaacaagg gactaaatag gaatagtttg ccaactccac agctgaggag aagctcagga
1621 acttcaggat tgctacctgt tgaacagtct tcaaggtggg atcgtaataa tggcaaaagg
1681 cctcaccaag aatttggcat ttcaagtcaa ggatgctatc taaatgggcc ttttaattca
1741 aatctactga ctatcccgaa gcaaaggtca tcttctgtat cactgactca ccatgtaggt
1801 ctcagaagag ctggtgtttt gtccagtctg agtcctgtga attcttccaa ccatggacca
1861 gtgtctactg gctctctaac taatcgatca cccatagaat ttcctgatac tgctgatttt
1921 cttaataagc caagcgttat cttgcagaga tctctgggca atgcacctaa tactccagat
1981 ttttatcagc aacttagaaa ttctgatagc aatctgtgta acagctgtgg acatcaaatg
2041 ctgaaatatg tttcaacatc tgaatcagat ggtacagatt gctgcagtgg aaaatcaggt
2101 gaagaagaaa acattttctc gaaagaatca ttcaaactta tggaaactca acaagaagag
2161 gaaacagaga agaaagacag cagaaaatta tttcaggaag gtgataagtg gctaacagaa
2221 gaggcacaga gtgaacagca aacaaatatt gaacaggaag tatcactgga cctgatttta
2281 gtagaagagt atgactcatt aatagaaaag atgagcaact ggaattttcc aatttttgaa
2341 cttgtagaaa agatgggaga gaaatcagga aggattctca gtcaggttat gtatacctta
2401 tttcaagaca ctggtttatt ggaaatattt aaaattccca ctcaacaatt tatgaactat
2461 tttcgtgcat tagaaaatgg ctatcgagac attccttatc acaatcgtat acatgccaca
2521 gatgtgctac atgcagtttg gtatctgaca acacggccag ttcctggctt acagcagatc
2581 cacaatggtt gtggaacagg aaatgaaaca gattctgatg gtagaattaa ccatgggcga
2641 attgcttata tttcttcgaa gagctgctct aatcctgatg agagttatgg ctgcctgtct
2701 tcaaacattc ctgcattaga attgatggct ctatacgtgg cagctgccat gcatgattat
2761 gatcacccag ggaggacaaa tgcatttcta gtggctacaa atgcccctca ggcagtttta
2821 tacaatgaca gatctgttct ggaaaatcat catgctgcgt cagcttggaa tctatatctt
2881 tctcgcccag aatacaactt ccttcttcat cttgatcatg tggaattcaa gcgctttcgt
2941 tttttagtca ttgaagcaat ccttgctacg gatcttaaaa agcattttga ttttctcgca
3001 gaattcaatg ccaaggcaaa tgatgtaaat agtaatggca tagaatggag taatgaaaat
3061 gatcgcctct tggtatgcca ggtgtgcatc aaactggcag atataaatgg cccagcaaaa
3121 gttcgagact tgcatttgaa atggacagaa ggcattgtca atgaatttta tgagcaggga
3181 gatgaagaag caaatcttgg tctgcccatc agtccattca tggatcgttc ttctcctcaa
3241 ctagcaaaac tccaagaatc ttttatcacc cacatagtgg gtcccctgtg taactcctat
3301 gatgctgctg gtttgctacc aggtcagtgg ttagaagcag aagaggataa tgatactgaa
3361 agtggtgatg atgaagacgg tgaagaatta gatacagaag atgaagaaat ggaaaacaat
3421 ctaaatccaa aaccaccaag aaggaaaagc agacggcgaa tattttgtca gctaatgcac
3481 cacctcactg aaaaccacaa gatatggaag gaaatcgtag aggaagaaga aaaatgtaaa
3541 gctgatggga ataaactgca ggtggagaat tcctccttac ctcaagcaga tgagattcag
3601 gtaattgaag aggcagatga agaggaatag cgacagtttg agtaaaagaa aagtcatatt
3661 gaagaagccc agagggttgt gcccaggggc agaaatcatt gcctagtgtt caccggctga
3721 ctctcaactg accattccca tgtggacagg ccttaatact gtgagaggat ccttgctctg
3781 ctggcagttt cccactccta tgcactttca caggaactag aaaactattc ttaaaccaaa
3841 aataccatcc gtgttgaccc atgttgcaga gcccttactt aaatccttca ctggtgtatg
3901 aatactttgt cataatgctg ctttgctggg tagtgagctc ttatttttca ctgggggtca
3961 gctataacta aaaactcaag tgacatattt cagttaccaa agtggccagg aactttttgc
4021 ttttatgaaa atagattcat attgtatttc ccagtgtgtc ttttatgtct ttgaatgttt
4081 tggagaaaag tctatgcctg tctaaaaatg aatccagtgt tgcctttctg agggatttct
4141 gctcaatgca atacactgtt cagtgctatt ctcccagcta ggtttatcca tgaaggactg
4201 agtgaccttt gttgtattta acaaaatcca ggtgcatcaa tttctgatgc tttttactat
4261 tgtgtattat ctactatgtg tgttttattt ctgctgagag tattcaggtt tgccatggac
4321 atcagaagtt tgaattccag tcttatctta tgttccatgg ctgaatttta aagctgttta
4381 ggtttaacaa tgaagggatt tattctttag tcaaaattgt tgtttttact ctagctcagg
4441 attcgtattt ttaaagattt agttaatata aacacagcac agatttgtca gaagaaaaaa
4501 aatttgctgt aataccaaaa ctaacctcat caaagataca gaaaaaaaga aatatagtga
4561 gccctaaagg acacatacat tgaataaata attggaacat gtggttatct ttagatccac
4621 atcttagctg tcatttgttc actctaaaac tgatgttcat ctttctgtta atttccctct
4681 gcctaaagag tacatgacag aaatgaccta tcactactta ttatttctga agcctaactg
4741 caagagtgat ttcttgagaa caagtaaaga actggctcgt gccg
//