LOCUS AY457063 6522 bp mRNA linear HUM 20-APR-2006
DEFINITION Homo sapiens FYVE domain-containing phosphoinositide kinase mRNA,
complete cds.
ACCESSION AY457063
VERSION AY457063.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6522)
AUTHORS Cabezas,A., Pattni,K. and Stenmark,H.
TITLE Cloning and subcellular localization of a human
phosphatidylinositol 3-phosphate 5-kinase, PIKfyve/Fab1
JOURNAL Gene 371 (1), 34-41 (2006)
PUBMED 16448788
REFERENCE 2 (bases 1 to 6522)
AUTHORS Cabezas,A., Pattni,K. and Stenmark,H.
TITLE Direct Submission
JOURNAL Submitted (04-NOV-2003) Dept. of Biochemistry, The Norwegian Radium
Hospital, Montebello, Oslo N-0310, Norway
FEATURES Location/Qualifiers
source 1..6522
/db_xref="H-InvDB:HIT000254792"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/tissue_type="brain"
/clone_lib="Marathon-Ready human brain cDNA library
(Clontech)"
CDS 163..6459
/note="PIKfyve; phosphatidylinositol 3-phosphate 5-kinase"
/codon_start=1
/product="FYVE domain-containing phosphoinositide kinase"
/protein_id="AAR19397.1"
/translation="MATDDKTSPTLDSANDLPRSPTSPSHLTHFKPLTPDQDEPPFKS
AYSSFVNLFRFNKERAEGGQGEQQPLSGSWTSPQLPSRTQSVRSPTPYKKQLNEELQR
RSSALDTRRKAEPTFGGHDPRTAVQLRSLSTVLKRLKEIMEGKSQDSDLKQYWMPDSQ
CKECYDCSEKFTTFRRRHHCRLCGQIFCSRCCNQEIPGKFMGYTGDLRACTYCRKIAL
SYAHSTDSNSIGEDLNALSDSACSVSVLDPSEPRTPVGSRKASRNIFLEDDLAWQSLI
HPDSSNTPLSTRLVSVQEDAGKSPARNRSASITNLSLDRSGSPMVPSYETSVSPQANR
TYVRTETTEDERKILLDSVQLKDLWKKICHHSSGMEFQDHRYWLRTHPNCIVGKELVN
WLIRNGHIATRAQAIAIGQAMVDGRWLDCVSHHDQLFRDEYALYRPLQSTEFSETPSP
DSDSVNSVEGHSEPSWFKDIKFDDSDTEQIAEEGDDNLANSASPSKRTSVSSFQSTVD
SDSAASISLNVELDNVNFHIKKPSKYPHVPPHPADQKEYLISDTGGQQLSISDAFIKE
SLFNRRVEEKSKELPFTPLGWHHNNLELLREENGEKQAMERLLSANHNHMMALLQQLL
HSDSLSSSWRDIIVSLVCQVVQTVRPDVKNQDDDMDIRQFVHIKKIPGGKKFDSVVVN
GFVCTKNIAHKKMNSCIKNPKILLLKCSIEYLYREETKFTCIDPIVLQEREFLKNYVQ
RIVDVRPTLVLVEKTVSRIAQDMLLEHGITLVINVKSQVLERISRMTQGDLVMSMDQL
LTKPHLGTCHKFYMQIFQLPNEQTKTLMFFEGCPQHLGCTIKLRGGSDYELARVKEIL
IFMICVAYHSQLEISFLMDEFAMPPTLMQNPSFHSLIEGRGHEGAVQEQYGGGSIPWD
PDIPPESLPCDDSSLLESRIVFEKGEQENKNLPQAVASVKHQEHSTTACPAGLPCAFF
APVPESLLPLPVDDQQDALGSELPESLQQTVVLQDPKSQIRAFRDPLQDDTGLYVTEE
VTSSEDKRKTYSLAFKQELKDVILCISPVITFREPFLLTEKGMRCSTRDYFAEQVYWS
PLLNKEFKEMENRRKKQLLRDLSGLQGMNGSIQAKSIQVLPSHELVSTRIAEHLGDSQ
SLGRMLADYRARGGRIQPKNSDPFAHSKDASSTSSGKSGSKNEGDEERGLILSDAVWS
TKVDCLNPINHQRLCVLFSSSSAQSSNAPSACVSPWIVTMEFYGKNDLTLGIFLERYC
FRPSYQCPSMFCDTPMVHHIRRFVHGQGCVQIILKELDSPVPGYQHTILTYSWCRICK
QVTPVVALSNESWSMSFAKYLELRFYGHQYTRRANAEPCGHSIHHDYHQYFSYNQMVA
SFSYSPIRLLEVCVPLPKIFIKRQAPLKVSLLQDLKDFFQKVSQVYVAIDERLASLKT
DTFSKTREEKMEDIFAQKEMEEGEFKNWIEKMQARLMSSSVDTPQQLQSVFESLIAKK
QSLCEVLQAWNNRLQDLFQQEKGRKRPSVPPSPGRLRQGEESKISAMDASPRNISPGL
QNGEKEDRFLTTLSSQSSTSSTHLQLPTPPEVMSEQSVGGPPELDTASSSEDVFDGHL
LGSTDSQVKEKSTMKAIFANLLPGNSYNPIPFPFDPDKHYLMYEHERVPIAVCEKEPS
SIIAFALSCKEYRNALEELSKATQWNSAEEGLPTNSTSDSRPKSSSPIRLPEMSGGQT
NRTTETEPQPTKKASGMLSFFRGTAGKSPDLSSQKRETLRGADSAYYQVGQTGKEGTE
NQGVEPQDEVDGGDTQKKQLINPHVELQFSDANAKFYCRLYYAGEFHKMREVILDSSE
EDFIRSLSHSSPWQARGGKSGAAFYATEDDRFILKQMPRLEVQSFLDFAPHYFNYITN
AVQQKRPTALAKILGVYRIGYKNSQNNTEKKLDLLVMENLFYGRKMAQVFDLKGSLRN
RNVKTDTGKESCDVVLLDENLLKMVRDNPLYIRSHSKAVLRTSIHSDSHFLSSHLIID
YSLLVGRDDTSNELVVGIIDYIRTFTWDKKLEMVVKSTGILGGQGKMPTVVSPELYRT
RFCEAMDKYFLMVPDHWTGLGLNC"
BASE COUNT 1893 a 1428 c 1522 g 1679 t
ORIGIN
1 gtcgcaacca tgtaagcagc ttcgcttcct gccgcaaccg tccgcggcct gaggagccca
61 ccgccgctct cgggggccga cttccggggg ctgagccgtt gaagcggagg ctggggcggg
121 gggcagccgg cgcggccggg gcaggaggcg cagactcatg aaatggccac agatgataag
181 acgtccccaa cactggactc tgctaatgat ttgcctcgat ctcctactag tccttctcat
241 ctcacacact ttaaaccttt gactcctgat caagatgagc ccccttttaa atcagcttat
301 agttcttttg taaatctctt tcgttttaac aaagagagag cagaaggagg ccagggagaa
361 cagcagcctt tgagtggaag ttggaccagc cctcagctcc cttcgaggac acagtctgtt
421 aggtcaccca caccttataa aaagcagctt aatgaggaac tccagcggcg ctcttcagca
481 ttagacacaa gaaggaaagc agaacctacc tttggaggtc atgaccctcg tacagctgtt
541 cagcttcgaa gcctcagcac agtattaaaa cgcctcaagg aaatcatgga ggggaaaagc
601 caggatagtg acctgaaaca atactggatg ccagatagcc aatgtaaaga gtgctatgac
661 tgtagtgaga aatttacaac ctttaggcgc agacaccatt gccgactatg tgggcagatt
721 ttctgcagtc gttgctgtaa tcaagaaatc cctggaaaat ttatgggcta tacaggagac
781 ctccgagctt gcacatattg tagaaaaata gccttaagtt atgctcattc cacagacagt
841 aattctattg gggaagactt gaatgctctt tcagattctg cttgctctgt gtctgtgctt
901 gatccaagtg aaccccgaac acctgttggg agtaggaaag ccagccgtaa catattttta
961 gaggatgatt tggcctggca aagtttgatt catccagatt cctcaaatac tcctctttca
1021 acaagacttg tatctgtgca agaggatgct gggaaatctc ctgctcgaaa tagatcagcc
1081 agcattacta acctgtcact ggatagatct ggttctccta tggtaccttc atatgagaca
1141 tctgtcagtc cccaggctaa ccgaacatat gttaggacag agaccactga ggatgaacgc
1201 aaaattcttc tggacagtgt gcagttaaaa gacctgtgga aaaaaatctg ccatcacagc
1261 agtggaatgg agtttcagga tcaccgctac tggttgagaa cgcatcccaa ctgcattgta
1321 ggaaaggaat tagtcaactg gctaatccga aatgggcata ttgccacaag ggcacaagct
1381 atagcaattg gacaagcaat ggttgatgga cgttggctgg attgtgttag tcatcacgac
1441 cagcttttca gagatgagta tgcgctgtat agaccactgc agagtacaga attttctgag
1501 acgccttctc ccgacagtga ctcagtgaac tccgtggaag gacactctga gccatcctgg
1561 tttaaagaca taaagtttga tgacagtgac acagaacaga tagctgaaga aggtgacgat
1621 aatttggcta attctgccag tcctagcaag cgcacatcag tcagcagttt ccagtccaca
1681 gtggacagtg actcagccgc ttctatcagc ctgaacgtgg agctggacaa cgtgaacttc
1741 catatcaaga agccctccaa gtacccacat gtgccccctc accctgctga ccaaaaagag
1801 tatttgattt ctgacactgg aggacaacag ctctcaataa gtgacgcttt catcaaagaa
1861 tccttattta atcgccgagt agaggaaaaa tccaaagagc tgcctttcac acctttgggc
1921 tggcatcata acaacctgga gctcctgagg gaggagaatg gggagaaaca agccatggag
1981 aggttgcttt cagctaatca taaccacatg atggcactac tccagcagtt gctccatagt
2041 gactcactgt catcatcttg gagggacatc atcgtgtcat tggtctgcca ggttgttcag
2101 acagtccgac ctgatgtcaa gaaccaggat gatgacatgg atatccgtca gtttgtccac
2161 atcaaaaaaa tcccaggtgg aaagaagttt gattctgtgg ttgtcaatgg ctttgtttgt
2221 accaagaaca ttgcacataa aaagatgaat tcttgtatta aaaaccctaa aattcttctg
2281 ttgaagtgtt ccattgagta tctctacaga gaagaaacta agtttacttg cattgatcct
2341 attgtgcttc aggaaaggga attcttgaag aattatgtcc agcgaatagt tgatgttcga
2401 cccaccttgg ttcttgttga gaaaacagtg tctcggattg cccaggacat gttattggaa
2461 catggcatta ctttggtcat taatgtaaag tcacaagttt tggaacgaat cagtcgaatg
2521 acccaaggtg atttagtgat gtcaatggac cagctgctta cgaaaccaca cctgggcact
2581 tgtcacaaat tttatatgca gatatttcag ttgcctaatg aacaaaccaa gacactgatg
2641 ttttttgaag gttgtccaca gcacctaggc tgtacaatca agctaagagg aggctctgat
2701 tatgagctgg ctcgagttaa ggagatccta atatttatga tctgtgttgc ttatcattct
2761 caactagaaa tatcctttct catggatgaa tttgctatgc ctcccacatt aatgcaaaac
2821 ccttcattcc attccctgat tgagggacga gggcatgagg gggctgtcca agagcagtac
2881 ggtggaggtt ccatcccctg ggatcctgac atccctcctg agtctctgcc ctgtgatgat
2941 agcagtttgc tggaatcgag gattgtgttt gagaagggtg agcaggaaaa taaaaatctt
3001 ccgcaggctg ttgcctctgt gaagcatcaa gaacatagca caacagcttg cccggcgggt
3061 ctcccttgtg ctttctttgc acctgtaccg gaatcattgt tgccactccc tgtggatgac
3121 caacaagatg ctttaggcag cgagctgcca gagagtttgc agcaaacagt tgtgctgcag
3181 gatcccaaaa gccagataag agcctttaga gaccctctac aggatgacac tggattatat
3241 gttactgagg aagtcacctc ctctgaagat aaacgaaaga cttattcttt ggcctttaag
3301 caggaattaa aagatgtgat cctctgtatc tccccagtaa tcacattccg agaacccttt
3361 cttttaactg aaaaggggat gagatgctct acccgagatt attttgcaga gcaggtttac
3421 tggtctcctc tcctcaataa agaattcaaa gaaatggaga acaggaggaa gaaacagctg
3481 ctcagggatc tctctggact tcagggcatg aatggaagta ttcaggccaa gtctattcaa
3541 gtcttaccct cacatgagct agtgagcact agaattgctg agcatctggg cgatagccag
3601 agcttgggta gaatgctggc cgattatcga gccagaggag gaagaattca gcccaaaaat
3661 tcagaccctt ttgctcattc aaaggatgca tcaagtactt caagtggcaa atcaggaagc
3721 aaaaatgagg gtgatgaaga gagagggctt attctgagtg atgctgtgtg gtcaacaaag
3781 gtggactgtc tgaatcccat taatcaccag agactttgtg tgctcttcag cagctcttct
3841 gcccagtcca gcaatgctcc tagtgcctgt gtcagtcctt ggattgtaac aatggaattt
3901 tatggaaaga atgatcttac attaggaata tttttagaga gatactgttt caggccttct
3961 tatcagtgtc caagcatgtt ctgtgatacc cccatggtac atcatattcg gcgctttgtt
4021 catggccaag gctgtgtgca gataatcctg aaggagttgg attctccagt acctggatat
4081 cagcatacaa ttcttacata ttcctggtgt agaatctgca aacaggtaac accagttgtt
4141 gctctttcca atgagtcctg gtctatgtca tttgcaaaat accttgaact taggttttat
4201 gggcaccagt atactcgcag agccaacgct gagccctgtg gtcactccat ccatcatgat
4261 tatcaccagt atttctccta taaccagatg gtggcgtctt tcagttattc tcccattcgg
4321 cttcttgaag tatgtgttcc actccccaaa atattcatta agcgtcaggc cccattaaaa
4381 gtgtcccttc ttcaggatct gaaggacttc tttcaaaaag tttcacaggt atatgttgcc
4441 attgatgaaa gacttgcatc tttgaaaact gatacattta gtaaaacaag agaggaaaaa
4501 atggaagata tttttgcaca gaaagagatg gaagaaggtg agttcaagaa ctggattgag
4561 aagatgcaag caaggctcat gtcttcctct gtagataccc ctcagcaact gcagtcggtc
4621 tttgagtcac tcattgccaa gaaacaaagt ctctgtgaag tgctgcaagc ttggaataac
4681 aggttgcagg accttttcca acaggaaaag ggtagaaaga gaccttcagt tcctccaagt
4741 cctggaagac tgagacaagg ggaagaaagc aagataagtg cgatggatgc atctccacgg
4801 aatatttctc caggacttca gaatggagaa aaagaggatc gcttcttaac aactttgtcc
4861 agccagagct ccaccagttc tactcatctc caattgccta cgccacctga agtcatgtct
4921 gaacagtcag tgggagggcc ccctgagcta gatacagcca gcagttccga agatgtgttt
4981 gatgggcatt tgctgggatc cacagacagc caagtgaagg aaaagtcaac catgaaagcc
5041 atctttgcaa atttgcttcc aggaaatagc tataatccta ttccatttcc ttttgatcca
5101 gataaacact acttaatgta tgaacatgaa cgagtgccca ttgcagtctg cgagaaggaa
5161 cccagctcca tcattgcttt tgctctcagt tgtaaagaat accgaaatgc cttagaggaa
5221 ttgtctaaag cgactcagtg gaacagtgcc gaagaagggc ttccaacaaa tagtacttca
5281 gatagcagac caaagagtag cagccctatc agattacctg aaatgagtgg aggacagaca
5341 aatcgtacaa cagaaacaga accacaacca accaaaaagg cttctggaat gttgtccttc
5401 ttcagaggga cagcagggaa aagccccgat ctctcttccc agaagagaga gaccttacgt
5461 ggagcagata gtgcttacta ccaggttggg cagacgggca aggaggggac cgagaatcaa
5521 ggcgttgagc ctcaagatga agtagatgga ggagatacac aaaagaagca actcataaat
5581 cctcatgtgg aacttcaatt ttcagatgct aatgccaagt tttactgtcg gctctactat
5641 gcgggagagt ttcataagat gcgtgaagtg attctggaca gcagtgaaga agatttcatt
5701 cgttccctct cccactcatc accctggcag gcccggggag gcaaatcagg agctgccttc
5761 tatgcaactg aggatgatag atttattttg aagcaaatgc ctcgtctgga agtccagtcc
5821 ttcctcgact ttgcaccaca ttacttcaat tatattacaa atgctgttca acaaaagagg
5881 cccacggcgt tggccaaaat tcttggagtt tacagaattg gttataagaa ctctcagaac
5941 aacactgaga agaagttaga tctccttgtc atggaaaatc ttttctacgg gagaaagatg
6001 gcacaggttt ttgatttgaa gggctctctt aggaatcgga atgtaaaaac tgacactgga
6061 aaagagagtt gtgatgtggt cctgctagat gaaaatctcc taaagatggt tcgagacaac
6121 cctctatata ttcgttctca ttccaaagct gtgctgagaa cctcgatcca tagtgactcc
6181 catttccttt ctagccacct cattatagat tattctttgc tggttgggcg agatgatact
6241 agcaatgagc tagtagttgg aattatagat tatattcgaa catttacatg ggacaaaaag
6301 cttgagatgg ttgtgaaatc aacaggaatt ttaggtggac aaggtaaaat gccaacagtg
6361 gtgtctccgg agttgtacag gactaggttt tgtgaggcaa tggacaagta tttcctaatg
6421 gtaccagacc actggacagg cttgggtctg aattgctgaa atcaagcaca tattttgaaa
6481 tggactgtga aggaaaaggg gacaggaaca aaggaccaaa aa
//