LOCUS AY425005 345 bp mRNA linear HUM 26-JUL-2016 DEFINITION Homo sapiens P-glycoprotein 1 (ABCB1) mRNA, partial cds, alternatively spliced. ACCESSION AY425005 VERSION AY425005.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 345) AUTHORS Raguz,S., Tamburo De Bella,M., Tripuraneni,G., Slade,M.J., Higgins,C.F., Coombes,R.C. and Yague,E. TITLE Activation of the MDR1 upstream promoter in breast carcinoma as a surrogate for metastatic invasion JOURNAL Clin. Cancer Res. 10 (8), 2776-2783 (2004) PUBMED 15102684 REFERENCE 2 (bases 1 to 345) AUTHORS Yague,E. and Raguz,S. TITLE Direct Submission JOURNAL Submitted (01-OCT-2003) Clinical Sciences Centre, Medical Research Council, DuCane Road, London W12 0NN, United Kingdom FEATURES Location/Qualifiers source 1..345 /db_xref="H-InvDB:HIT000254567" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="7" /map="7q21.1" gene 1..>345 /gene="ABCB1" 5'UTR 1..277 /gene="ABCB1" exon 201..271 /gene="ABCB1" /note="alternatively spliced exon not present in transcript in GenBank Accession Number AY425006" variation 277 /gene="ABCB1" /replace="g" CDS 278..>345 /gene="ABCB1" /note="energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells; derived from upstream promoter; found in drug resistant cell lines, breast carcinoma patients and chronic myelogenous leukemia patients; alternatively spliced" /codon_start=1 /product="P-glycoprotein 1" /protein_id="AAR91621.1" /translation="MDLEGDRNGGAKKKNFFKLNNK" BASE COUNT 103 a 75 c 79 g 88 t ORIGIN 1 ctactttatt cagatattct ccagattcct aaagattaga gatcatttct cattctccta 61 ggagtactca cttcaggaag caaccagata aaagagaggt gcaacggaag ccagaacatt 121 cctcctggaa attcaacctg tttcgcagtt tctcgaggaa tcagcattca gtcaatccgg 181 gccgggagca gtcatctgtg gtctttccac taaagtcgga gtatcttctt ccaaaatttc 241 acgtcttggt ggccgttcca aggagcgcga ggtcggaatg gatcttgaag gggaccgcaa 301 tggaggagca aagaagaaga acttttttaa actgaacaat aaaag //