LOCUS       AY422721                 509 bp    mRNA    linear   HUM 22-OCT-2003
DEFINITION  Homo sapiens N-TACE (ADAM17) mRNA, complete sequence, alternatively
            spliced.
ACCESSION   AY422721
VERSION     AY422721.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Buckley,C., Rouhani,F.N., Kaler,M., Hawari,F.I. and Levine,S.J.
  TITLE     N-TACE Inhibits TACE-Mediated TNFR2 Ectodomain Cleavage by a
            Cysteine Switch-Independent Mechanism
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Buckley,C., Rouhani,F.N., Kaler,M., Hawari,F.I. and Levine,S.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-SEP-2003) Pulmonary - Critical Care Medicine Branch,
            National Heart, Lung, and Blood Institute, NIH, Building 10, Room
            6D03, MSC 1590, Bethesda, MD 20892-1590, USA
FEATURES             Location/Qualifiers
     source          1..509
                     /db_xref="H-InvDB:HIT000254395"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /cell_line="NCI-H292"
                     /cell_type="pulmonary mucoepidermoid carcinoma"
     gene            1..509
                     /gene="ADAM17"
                     /gene_synonym="TACE"
                     /note="N-TACE; alternatively spliced TNF-alpha converting
                     enzyme; contains exon 1, truncated exon 2 and partial exon
                     19; contains internal stop codon"
BASE COUNT          125 a          158 c          119 g          107 t
ORIGIN      
        1 cgggaacatg aggcagtctc tcctattcct gaccagcgtg gttcctttcg tgctggcgcc
       61 gcgacctccg gatgacccgg gcttcggccc ccaccagaga ctcgagaagc ttgattcttt
      121 gctctcagac tacgatattc tctctttatc taatatccag cagcattcgt aacgtcgaaa
      181 tgctgagcag catggattct gcatcggttc gcattatcaa accctttcct gcgccccaga
      241 ctccaggccg cctgcagcct gcccctgtga tcccttcggc gccagcagct ccaaaactgg
      301 accaccagag aatggacacc atccaggaag accccagcac agactcacat atggacgagg
      361 atgggtttga gaaggacccc ttcccaaata gcagcacagc tgccaagtca tttgaggatc
      421 tcacggacca tccggtcacc agaagtgaaa aggctgcctc ctttaaactg cagcgtcaga
      481 atcgtgttaa cagcaaagaa acagagtgc
//