LOCUS AY392882 170 bp mRNA linear HUM 04-JUN-2004 DEFINITION Homo sapiens clone RA702-A1-9.fa nonfunctional immunoglobulin heavy chain mRNA, partial sequence. ACCESSION AY392882 VERSION AY392882.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 170) AUTHORS Miura,Y., Chu,C.C., Dines,D.M., Asnis,S.E., Furie,R.A. and Chiorazzi,N. TITLE Diversification of the Ig variable region gene repertoire of synovial B lymphocytes by nucleotide insertion and deletion JOURNAL Mol. Med. 9 (5-8), 166-174 (2003) PUBMED 14571324 REFERENCE 2 (bases 1 to 170) AUTHORS Miura,Y., Chu,C.C., Dines,D.M., Krauss,E.S., Asnis,S.E., Furie,R.A. and Chiorazzi,N. TITLE Direct Submission JOURNAL Submitted (17-SEP-2003) Center for Immunology and Inflammation, North Shore - LIJ Research Institute, 350 Community Drive, Manhasset, NY 11030, USA FEATURES Location/Qualifiers source 1..170 /db_xref="H-InvDB:HIT000253523_04" /organism="Homo sapiens" /mol_type="mRNA" /isolate="RA702" /db_xref="taxon:9606" /clone="RA702-A1-9.fa" /cell_type="B lymphocyte" /tissue_type="rheumatoid arthritis synovial tissue" misc_feature <1..>170 /inference="non-experimental evidence, no additional details recorded" /note="IgA; nonfunctional immunoglobin heavy chain due to rearrangement of VH CDR1 region and D-J junction resulting in large deletion, frameshift and premature stop codon" BASE COUNT 33 a 57 c 49 g 31 t ORIGIN 1 gtgcagtctg gggctgaggt gaagaggcct ggggcctcag tgagggtccc ctgcaaggct 61 tctggataca ccttcaccaa ctacactaca tggacgtctg gggcaaaggg accacggtca 121 ccgtctcctc agcatccccg accagcccca aggtcttccc gctgagcctc //