LOCUS       AY392882                 170 bp    mRNA    linear   HUM 04-JUN-2004
DEFINITION  Homo sapiens clone RA702-A1-9.fa nonfunctional immunoglobulin heavy
            chain mRNA, partial sequence.
ACCESSION   AY392882
VERSION     AY392882.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 170)
  AUTHORS   Miura,Y., Chu,C.C., Dines,D.M., Asnis,S.E., Furie,R.A. and
            Chiorazzi,N.
  TITLE     Diversification of the Ig variable region gene repertoire of
            synovial B lymphocytes by nucleotide insertion and deletion
  JOURNAL   Mol. Med. 9 (5-8), 166-174 (2003)
   PUBMED   14571324
REFERENCE   2  (bases 1 to 170)
  AUTHORS   Miura,Y., Chu,C.C., Dines,D.M., Krauss,E.S., Asnis,S.E., Furie,R.A.
            and Chiorazzi,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-SEP-2003) Center for Immunology and Inflammation,
            North Shore - LIJ Research Institute, 350 Community Drive,
            Manhasset, NY 11030, USA
FEATURES             Location/Qualifiers
     source          1..170
                     /db_xref="H-InvDB:HIT000253523_04"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /isolate="RA702"
                     /db_xref="taxon:9606"
                     /clone="RA702-A1-9.fa"
                     /cell_type="B lymphocyte"
                     /tissue_type="rheumatoid arthritis synovial tissue"
     misc_feature    <1..>170
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="IgA; nonfunctional immunoglobin heavy chain due to
                     rearrangement of VH CDR1 region and D-J junction resulting
                     in large deletion, frameshift and premature stop codon"
BASE COUNT           33 a           57 c           49 g           31 t
ORIGIN      
        1 gtgcagtctg gggctgaggt gaagaggcct ggggcctcag tgagggtccc ctgcaaggct
       61 tctggataca ccttcaccaa ctacactaca tggacgtctg gggcaaaggg accacggtca
      121 ccgtctcctc agcatccccg accagcccca aggtcttccc gctgagcctc
//