LOCUS AY365124 2280 bp mRNA linear HUM 10-NOV-2003
DEFINITION Homo sapiens cullin 4A (CUL4A) mRNA, complete cds.
ACCESSION AY365124
VERSION AY365124.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2280)
AUTHORS Higa,L.A., Mihaylov,I.S., Banks,D.P., Zheng,J. and Zhang,H.
TITLE Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN
complexes constitutes a new checkpoint
JOURNAL Nat. Cell Biol. 5 (11), 1008-1015 (2003)
PUBMED 14578910
REMARK Erratum:[Nat Cell Biol. 2003 Dec;5(12):1122]
REFERENCE 2 (bases 1 to 2280)
AUTHORS Higa,L.A., Mihaylov,I.S., Banks,D.P., Zheng,J. and Zhang,H.
TITLE Direct Submission
JOURNAL Submitted (11-AUG-2003) Genetics, Yale University School of
Medicine, 333 Cedar Street, New Haven, CT 06520, USA
FEATURES Location/Qualifiers
source 1..2280
/db_xref="H-InvDB:HIT000253220"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..2280
/gene="CUL4A"
CDS 1..2280
/gene="CUL4A"
/note="ubiquitin E3 ligase"
/codon_start=1
/product="cullin 4A"
/protein_id="AAR13072.1"
/translation="MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLV
IKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPML
YKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTY
VLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLL
GMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVIT
YLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQ
ALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKE
SFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFE
AFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHF
KQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRK
LQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSEL
RRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQV
STTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLI
DRDYMERDKDNPNQYHYVA"
BASE COUNT 685 a 500 c 603 g 492 t
ORIGIN
1 atggcggacg aggccccgcg gaagggcagc ttctcggcgc tcgtgggccg caccaacggc
61 ctcaccaagc ccgcggccct ggccgccgcg cccgccaagc cggggggcgc gggcggctcc
121 aagaagctgg tcatcaagaa cttccgagac agacctcggc tgcccgacaa ctacacgcag
181 gacacgtggc ggaagctgca cgaggcggtg cgggccgtgc agagcagcac ctccatcagg
241 tacaacctcg aggagctcta ccaggctgtg gaaaatctct gttctcacaa agtctcccca
301 atgctctaca agcaactgcg tcaggcctgt gaagaccacg tccaggcaca gatccttccg
361 tttagagaag actcactaga tagtgtttta tttttaaaga agattaacac gtgctggcag
421 gaccactgca gacaaatgat catgatcaga agcatcttcc tgttcttgga ccgcacctat
481 gtgctgcaga actccacgct gccctccatc tgggatatgg gattagaact gtttagaacc
541 catattatta gtgataaaat ggttcagagt aaaaccattg atggaatcct actgctgatc
601 gagcgcgaga ggagcggcga ggccgtggac cggagcctgt tgcggagcct cctgggcatg
661 ctgtctgacc tgcaggtgta taaagattca tttgaactga aatttttgga agagactaat
721 tgcttatatg ctgccgaagg ccaaaggtta atgcaggaaa gagaggttcc agaatatctt
781 aaccatgtaa gtaaacgctt agaggaagag ggagacagag taatcactta cttggaccac
841 agcacacaga aaccactgat tgcttgtgtg gagaaacagc tattaggaga acatttaaca
901 gcaattctgc agaaagggct cgaccactta ctggatgaga acagagtgcc ggacctcgca
961 cagatgtacc agctgttcag ccgggtgagg ggcgggcagc aggcgctgct gcagcactgg
1021 agcgagtaca tcaagacttt tggaacagcg atcgtaatca atcctgagaa agacaaagac
1081 atggtccaag acctgttgga cttcaaggac aaggtggacc acgtgatcga ggtctgcttc
1141 cagaagaatg agcggttcgt caacctgatg aaggagtcct ttgagacgtt catcaacaag
1201 agacccaaca agcctgcaga actgatcgca aagcatgtgg attcaaagtt aagagcaggc
1261 aacaaagaag ccacagacga ggagctggag cggacgttgg acaagatcat gatcctgttc
1321 aggtttatcc acggtaaaga tgtctttgaa gcattttata aaaaagattt ggcaaaaaga
1381 ctccttgttg ggaaaagtgc ctcagtcgat gctgaaaagt ctatgttgtc aaagctcaag
1441 catgagtgcg gtgcagcctt caccagcaag ctggaaggca tgttcaagga catggagctt
1501 tcgaaggaca tcatggttca tttcaagcag catatgcaga atcagagtga ctcaggccct
1561 atagacctca cagtgaacat actcacaatg ggctactggc caacatacac gcccatggaa
1621 gtgcacttaa ccccagaaat gattaaactt caggaagtat ttaaggcatt ttatcttgga
1681 aagcacagtg gtcgaaaact tcagtggcaa actactttgg gacatgctgt tttaaaagcg
1741 gagtttaaag aagggaagaa ggaattccag gtgtccctct tccagacact ggtgctcctc
1801 atgttcaacg agggagatgg cttcagcttt gaggagataa aaatggccac ggggatagag
1861 gatagtgaat tgcgcagaac gctgcagtcc ctggcctgtg gcaaagcacg tgtgctgatt
1921 aaaagtccca aaggaaagga agtggaagat ggagacaagt tcatttttaa tggagagttc
1981 aagcacaagt tgtttagaat aaagatcaat caaattcaga tgaaggaaac tgttgaggaa
2041 caggttagca ccactgagag agtgtttcag gatagacaat atcagattga tgctgctatc
2101 gtcagaataa tgaagatgag aaagactctt ggtcataatc ttctagtttc tgaattatat
2161 aatcagctga aatttccagt aaagcctgga gatttgaaaa agagaattga atctctgata
2221 gacagagact atatggagag agacaaagac aatccgaatc agtaccacta cgtggcctga
//