LOCUS       AY352048                7743 bp    mRNA    linear   HUM 15-JUN-2004
DEFINITION  Homo sapiens putative protein kinase WNK3 (PRKWNK3) mRNA, complete
            cds.
ACCESSION   AY352048
VERSION     AY352048.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7743)
  AUTHORS   Holden,S., Cox,J. and Raymond,F.L.
  TITLE     Cloning, genomic organization, alternative splicing and expression
            analysis of the human gene WNK3 (PRKWNK3)
  JOURNAL   Gene 335, 109-119 (2004)
   PUBMED   15194194
REFERENCE   2  (bases 1 to 7743)
  AUTHORS   Holden,S.T. and Raymond,F.L.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-JUL-2003) Department of Medical Genetics, Cambridge
            Institute for Medical Research, Addenbrook'e Hospital Site,
            Cambridge CB2 2XY, UK
FEATURES             Location/Qualifiers
     source          1..7743
                     /db_xref="H-InvDB:HIT000252083"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.2"
                     /tissue_type="brain"
                     /dev_stage="fetal"
     gene            1..7743
                     /gene="PRKWNK3"
     5'UTR           1..439
                     /gene="PRKWNK3"
     CDS             440..5842
                     /gene="PRKWNK3"
                     /codon_start=1
                     /product="putative protein kinase WNK3"
                     /protein_id="AAR89465.1"
                     /translation="MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNS
                     TFSASGETVERKRFFRKSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQ
                     EVKYEQCSKSTSEISKDCFKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKT
                     VYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILK
                     GKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDL
                     KCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAF
                     GMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSE
                     RLSIRDLLNHAFFAEDTGLRVELAEEDDCSNSSLALRLWVEDPKKLKGKHKDNEAIEF
                     SFNLETDTPEEVAYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTREKKPAGCLEERRD
                     SQCKSMGNVFPQPQNTTLPLAPAQQTGAECEETEVDQHVRQQLLQRKPQQHCSSVTGD
                     NLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMVSNIPQAEVNVPGQIYSSQQLVGHY
                     QQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPTVVSQPQVSPLTVQKVPQIKPVS
                     QPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPSGNGKQDRIKQRRASCPRPEK
                     GTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLES
                     EKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSSQTGSSEQVQINSTSTQ
                     TSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGRHPLPSPKNTSNKEI
                     SRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAILYQVEDNRQIMAP
                     VTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSHPGESTQTSGN
                     SLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTPGLEPTTLQ
                     PTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQSIDSPFS
                     SSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVFKRDL
                     NVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGGGYFGLSFTCPSLKN
                     PISKKSWTRKLKSWAYRLRQSTSFFKRSKVRQVETEEMRSAIAPDPIPLTRESTADTR
                     ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKS
                     QLVEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPE
                     KEFEETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESN
                     QCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQ
                     TQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGI
                     VATGKSCLINELENPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIK
                     PSLNQLKQSQHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPS
                     FPGPLSSYGMPHVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAF
                     PTSSVQNPATIPPGPK"
     3'UTR           5843..7743
                     /gene="PRKWNK3"
BASE COUNT         2333 a         1645 c         1679 g         2086 t
ORIGIN      
        1 ctcagctccg ggccgagcgc gagcttgggc tcgtaccccg ctcccctctc tccgcccgct
       61 ctttacctac cggccgtagc tggcccggtg ggctcgcggg gagacgctcg cgcgcgcaag
      121 cgcacacgac gcggagcgga gctcgagaca tcgaggagag gagtaagaag catcggagga
      181 ggcgatcgag gaggaggcgg tgtgtgtgta tgtgtctatt ctacggtgtg gctcgtcgtg
      241 gggcgagagg aggctcgaga gagggcgagg gagaagcgaa aagagtaaga gagtcttcct
      301 ttgcgagagc ctctaatctg gttgctatgg aaatacatga ccacgcaaaa ggaagtccat
      361 tctgataatt ctgatacctg agatgtaact ggactgaaga gtagaaacag gaaaaatttt
      421 agtgccaact ttaattacaa tggccactga ttcaggggat ccagccagca cagaagattc
      481 tgagaaacct gatggaattt catttgaaaa cagagttccc caggtcgctg caactttgac
      541 agtagaagct agactaaagg agaaaaacag taccttctct gcttctgggg aaactgtaga
      601 aaggaagaga tttttccgaa agagtgttga aatgacggaa gatgacaaag ttgccgaatc
      661 atcccccaaa gatgagagaa ttaaggctgc aatgaatatt ccaagagtag ataagcttcc
      721 ttcaaatgtg ttgagaggtg gacaagaagt taaatatgaa cagtgttcaa agtcaacctc
      781 agaaatctca aaagattgtt tcaaggagaa aaatgaaaag gaaatggaag aagaagcaga
      841 aatgaaggct gtagctactt ctcctagtgg cagattcctg aaatttgaca tagaactagg
      901 aagaggagca tttaaaacag tatataaagg actggacact gaaacatggg ttgaggttgc
      961 ttggtgtgag ctgcaggacc gaaagttaac caaagctgag cagcaaagat tcaaggaaga
     1021 agcagagatg ttgaagggtc tccagcaccc caatatagtt cgattttatg attcctggga
     1081 atctatatta aaaggaaaga aatgtattgt attagtgact gaactaatga catctgggac
     1141 cttaaagacg tacttaaaac gatttaaagt catgaaacca aaggtcttaa ggagctggtg
     1201 caggcaaatt ttaaaggggt tgcagttctt gcacactagg actcctccta ttattcaccg
     1261 ggatctgaag tgtgacaata ttttcatcac gggacccact ggatctgtga agattggtga
     1321 tctaggatta gccaccttaa tgcgtacctc atttgctaag agtgtcattg gaactcctga
     1381 gtttatggct ccagagatgt atgaagaaca ctatgatgaa tccgtagatg tttatgcttt
     1441 tggaatgtgt atgctggaaa tggccacatc ggagtatcct tattctgagt gtcagaatgc
     1501 agctcaaata taccggaaag taactagtgg cataaaacca gccagcttca ataaagtcac
     1561 tgatcctgaa gtcaaagaaa tcattgaagg atgtattcgt caaaacaaat ctgaaaggtt
     1621 gtctatcagg gacctattaa accatgcatt ttttgctgag gatacaggac tgagggtgga
     1681 gttagcagaa gaagatgatt gctcaaattc atcccttgct ttaagactct gggttgaaga
     1741 ccctaaaaaa ttgaaaggca aacacaaaga caatgaagct attgaattta gtttcaactt
     1801 agaaacagat acacctgagg aagtagcata tgaaatggtc aagtctgggt tcttccatga
     1861 aagtgattcc aaagctgttg ctaaatccat tagagaccgg gtgacgccaa taaagaagac
     1921 aagagagaag aagcctgctg gctgtttgga agaacgcagg gattctcagt gcaagtctat
     1981 ggggaatgta ttccctcagc cccagaatac aactttaccc cttgctcccg ctcagcaaac
     2041 tggggctgaa tgtgaagaaa ctgaagttga tcaacatgtt agacaacagc ttctacaaag
     2101 aaaaccacag cagcactgct cctctgttac aggtgacaat ttgtctgagg caggagctgc
     2161 atcagttata cattcagata cttcaagtca gcccagtgta gcctattcct caaatcaaac
     2221 gatgggctct caaatggttt ctaatatccc gcaggctgaa gtaaatgttc cagggcaaat
     2281 ttattcatct cagcaactag taggacatta ccagcaagtt tcagggttac agaagcattc
     2341 aaagctgact cagccgcaga ttttgccttt ggttcaaggt cagtccactg ttttacctgt
     2401 acatgtcctt ggaccgacag ttgtttcaca accccaggtt tccccattaa ctgttcagaa
     2461 ggtcccacag ataaagcctg tatcccaacc agttggagct gaacaacaag cagctcttct
     2521 aaaaccagat ttagttcgaa gcttgaatca agatgtggca actacgaagg aaaacgtcag
     2581 tagccctgat aacccaagtg gaaatggcaa acaggatcgg atcaaacaga gaagagcttc
     2641 ctgtccccga ccagagaagg ggactaaatt tcagcttacc gtccttcagg tatcaacctc
     2701 tggagataac atggtagagt gtcagctgga gacacacaac aacaagatgg tcaccttcaa
     2761 gtttgatgtt gatggtgatg cgccagagga tattgcagac tatatggttg aagataactt
     2821 tgtgctggaa agtgagaaag aaaaatttgt agaagaattg agagctattg taggtcaagc
     2881 ccaggagatc cttcatgtcc actttgccac agaaagagcc actggagttg attctattac
     2941 tgtggactcc aacagtagcc agacagggtc atctgaacaa gtacagataa attctacatc
     3001 tactcaaacc agcaatgaat ctgctcctca gtcatcccca gttggtcggt ggcgattctg
     3061 tatcaatcag acgataagaa accgtgagac tcagtctcct ccttctcttc agcattccat
     3121 gtctgcggtt cctggccgac atccacttcc tagtccaaaa aacacaagta ataaggaaat
     3181 atcacgggac acattgctca ctatagaaaa taatccatgc caccgtgcac ttttcacctc
     3241 caaatcagaa cacaaggatg tggttgatgg taagatttct gaatgtgcta gtgtagaaac
     3301 caagcagcca gctatacttt atcaagtgga agataacagg cagataatgg caccagttac
     3361 taatagttcc agttactcta ctacttcagt tcgtgcagtt ccagctgaat gtgagggact
     3421 caccaaacaa gcaagcatat tcatacctgt gtatccatgt caccaaactg ccagtcaggc
     3481 tgatgcactt atgtcccatc ctggcgaatc aactcagact tctggtaact ctcttacaac
     3541 tctggcattt gatcaaaagc ctcaaacctt atcagtacag cagccagcta tggatgcaga
     3601 gtttatttct caagaaggag aaactacagt gaacactgaa gcaagttctc ctaagacagt
     3661 cattcccact cagacccctg gccttgaacc aactaccctt caacccacta ctgtcctgga
     3721 atcagatgga gaaagacctc caaaactgga gtttgcagac aaccgaatta aaactctgga
     3781 tgaaaaatta agaaacttgc tctatcagga gcacagcatc tctagcatct atcccgagag
     3841 tcagaaggat acccaaagca tagactctcc attttcttcc tctgctgaag ataccctctc
     3901 ctgtccagtg acagaagtca tagccatcag tcactgtgga attaaagata gccctgtaca
     3961 atcccctaat ttccaacaga caggctctaa gcttctgtcc aatgtggctg caagtcagcc
     4021 tgctaatata tcagtgttca aaagggacct gaatgtgata acttctgtac ccagcgaatt
     4081 gtgtttacat gagatgtcct cagatgcttc acttccaggg gatccagagg cctatcctgc
     4141 tgctgtgtca agcggtggag ccattcatct gcagacagga ggtggatatt ttggcctaag
     4201 ctttacttgt cctagtctca aaaatcctat tagcaagaaa tcctggactc gcaaattaaa
     4261 aagctgggca tacaggctac ggcagtcaac cagctttttc aagagatcaa aagtccgtca
     4321 agtggaaaca gaagagatga gatcagcaat tgctcctgat cccattcctc tgacacggga
     4381 gtccacagct gatactaggg ctttgaatag atgtaaagcg atgagtggat catttcagcg
     4441 gggtcggttc caggtgatta caattcctca gcagcagtca gcaaaaatga catcttttgg
     4501 aatagaacac atatcagtgt tcagtgagac aaaccattct agtgaagaag cctttattaa
     4561 aacagcaaag tctcagttgg tagaaataga acctgccaca caaaatccaa aaacttcgtt
     4621 ttcttatgag aagttacaag ctcttcagga aacctgtaaa gaaaataaag gagttcccaa
     4681 acaaggtgac aacttcttat ctttcagcgc agcttgtgag actgatgtat cttcagtgac
     4741 cccagaaaag gaatttgaag aaacttcagc cacaggaagt agcatgcagt ctggatctga
     4801 actgttgctt aaagagagag agatattgac tgctgggaaa cagcctagct ctgatagtga
     4861 attttcagcc agtcttgctg gcagtggaaa gtcagtggca aagactggtc cagagagtaa
     4921 tcagtgctta ccacaccacg aagaacaagc ttatgctcaa acacagagtt cactcttcta
     4981 ttcgccatct tccccaatga gcagtgatga tgaatcagaa atagaggatg aggacttgaa
     5041 ggtggagctt caaagattac gagaaaaaca cattcaggag gtggtaaatc ttcaaaccca
     5101 gcagaataag gagctgcagg agctctatga acgccttcgg tcaattaaag atagcaaaac
     5161 ccaatctact gagattcctt tgccacctgc atcaccacgt cgaccaagat ctttcaaaag
     5221 caaacttcga agccgccccc agtccttgac acatgtggac aatggcatag ttgctacagg
     5281 gaaaagctgc cttataaatg agttggaaaa tccactgtgt gtggagagta atgcagcatc
     5341 atgccaacag tctccagcca gtaaaaaagg gatgttcaca gatgacttac acaagctggt
     5401 ggatgactgg acaaaggaag cagtaggaaa ttctcttatt aagccaagtt taaaccaact
     5461 taaacaaagt caacacaaac tagagacaga aaactggaat aaagtatctg aaaatactcc
     5521 gtctactatg ggctacacat caacatggat ttcttctctg tcccaaatcc gtggagctgt
     5581 cccaacttcc ttgccacaag gactctcact cccttcattt cctgggccat tatcatcata
     5641 tggaatgcct cacgtttgtc agtataatgc tgtggcgggg gcggggtatc cagtacagtg
     5701 ggtaggaatt tcaggaacaa cacaacaatc tgtagtaatt cccgcccaat ctgggggacc
     5761 attccagcca gggatgaata tgcaggcatt tccaacttca tcagtgcaga atcctgccac
     5821 aatccctcct ggtcctaaat gaatcagagt agatggtgat aaaaagggag gttttttcag
     5881 aattattttc aggacaccca agatattaaa gtttcttcct cttgggttct gtcatatttt
     5941 ccctcatttg agtttacttt agactatata ttttttgttc cagtgtggta tttgatacag
     6001 ctcatcattc tgtagaaatg tgcagtttgc agatagaaca ctgcacacag aaatgttttt
     6061 tcacttcaaa ttctatcctc tttgatactt gattttttaa aaatactgtt cagaatgctt
     6121 taataagctc agcttgagca ttaccatttc caggacactt tccatgaatt gttgagaagc
     6181 tccccatccc ccgccttttt tttttttttt ttaactgctg ctatctgcag ctggatactc
     6241 ttctttaaaa atgtttaaaa attatttaga ttgattctcc ccaaatgtgg atgaactgag
     6301 accctccatc agccagagtc ttatgggatc ttcacttcac atgtttgtct taggtttacc
     6361 tttcacagaa ggcagggtaa cttgctgcag gaaacgtttt ggtgtataaa attagaatca
     6421 cttttttttt tttttttgag atggagtctc tctctgtcac ccaggttgga gtgcagtggt
     6481 gtgatcttgg ctcactgctg caacctcccc ctcctgggtt caagcgattc tcctgcctca
     6541 gcctcctgag tagctgggac tacaggcgcc agccaccatg cctggctaat ttttgtattt
     6601 ttagtagagg atggggtttc actatgttgg ccagactggt ctcaaactcc taaccttgtg
     6661 atccgccctc cttagccccc ccaaaaaatt acaataattt tgtcaaccaa tacagaacat
     6721 gagccctttt taaatgtgat ttcccgtcat cacagcagta ggatgaagcc ttgttttggg
     6781 tgagacagag ggaaagggaa aaaacagaat tgtaacagtt ccttgattct gcagatactg
     6841 ctgctgtttt acgatttcag taataattca aagcagctgt ctccttgttt ctcacatgca
     6901 tactacattg gttttgagca tctgagaggc attggtttgt cttgcattct tttgcaaggc
     6961 atatattgca gctgatatga atctcgtttg gggggaatcc ttgtattcct aacaaggggg
     7021 attaaagcta cacctcaatc cattcttctg aagtgaaatt tacttgacac agtaggtttc
     7081 gagacttaca tatgaaacac tggctttaca gggttctcag agatgtgggg tatacactgt
     7141 cctgcagtga gatagtagac cctagaagga tactatttaa gttgtcctta gctcttttta
     7201 attacaattt ttagttgtta gaatttcttt ttagtatcta tagtatctta gatgatttta
     7261 gatcttaaat gagtttggca gcctctttag aatctgagag agatcactgt caagttgcac
     7321 tttactgggt tttatccagt tttaggagga ggggaggcaa tgtcaaaatg tacacctttg
     7381 gtttttaaga aggttaacta taataatgtt aaaggctagt cacagggtta cctaatgctc
     7441 agtctgtgaa acctaaatag aattcttaaa atgttattta ccaactaagt attcatgttc
     7501 aaattactta ccttccactc tgaagacttt aaggtcattt ctaatacaca tttacctaat
     7561 taggagttct gtctactagt aaacattcca aattgctacc caacattact gttaacagat
     7621 tttcctccgt attcttctaa aaattatacc ccatgggctt gccaggtaat gacgaaaact
     7681 taatgggtgt actttttttt ttttttgcac agtctacttt gtgacattaa gtacctcttt
     7741 tcc
//