LOCUS AY352048 7743 bp mRNA linear HUM 15-JUN-2004 DEFINITION Homo sapiens putative protein kinase WNK3 (PRKWNK3) mRNA, complete cds. ACCESSION AY352048 VERSION AY352048.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 7743) AUTHORS Holden,S., Cox,J. and Raymond,F.L. TITLE Cloning, genomic organization, alternative splicing and expression analysis of the human gene WNK3 (PRKWNK3) JOURNAL Gene 335, 109-119 (2004) PUBMED 15194194 REFERENCE 2 (bases 1 to 7743) AUTHORS Holden,S.T. and Raymond,F.L. TITLE Direct Submission JOURNAL Submitted (26-JUL-2003) Department of Medical Genetics, Cambridge Institute for Medical Research, Addenbrook'e Hospital Site, Cambridge CB2 2XY, UK FEATURES Location/Qualifiers source 1..7743 /db_xref="H-InvDB:HIT000252083" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="X" /map="Xp11.2" /tissue_type="brain" /dev_stage="fetal" gene 1..7743 /gene="PRKWNK3" 5'UTR 1..439 /gene="PRKWNK3" CDS 440..5842 /gene="PRKWNK3" /codon_start=1 /product="putative protein kinase WNK3" /protein_id="AAR89465.1" /translation="MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNS TFSASGETVERKRFFRKSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQ EVKYEQCSKSTSEISKDCFKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKT VYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILK GKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDL KCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAF GMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSE RLSIRDLLNHAFFAEDTGLRVELAEEDDCSNSSLALRLWVEDPKKLKGKHKDNEAIEF SFNLETDTPEEVAYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTREKKPAGCLEERRD SQCKSMGNVFPQPQNTTLPLAPAQQTGAECEETEVDQHVRQQLLQRKPQQHCSSVTGD NLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMVSNIPQAEVNVPGQIYSSQQLVGHY QQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPTVVSQPQVSPLTVQKVPQIKPVS QPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPSGNGKQDRIKQRRASCPRPEK GTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLES EKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSSQTGSSEQVQINSTSTQ TSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGRHPLPSPKNTSNKEI SRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAILYQVEDNRQIMAP VTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSHPGESTQTSGN SLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTPGLEPTTLQ PTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQSIDSPFS SSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVFKRDL NVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGGGYFGLSFTCPSLKN PISKKSWTRKLKSWAYRLRQSTSFFKRSKVRQVETEEMRSAIAPDPIPLTRESTADTR ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKS QLVEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPE KEFEETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESN QCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQ TQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGI VATGKSCLINELENPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIK PSLNQLKQSQHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPS FPGPLSSYGMPHVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAF PTSSVQNPATIPPGPK" 3'UTR 5843..7743 /gene="PRKWNK3" BASE COUNT 2333 a 1645 c 1679 g 2086 t ORIGIN 1 ctcagctccg ggccgagcgc gagcttgggc tcgtaccccg ctcccctctc tccgcccgct 61 ctttacctac cggccgtagc tggcccggtg ggctcgcggg gagacgctcg cgcgcgcaag 121 cgcacacgac gcggagcgga gctcgagaca tcgaggagag gagtaagaag catcggagga 181 ggcgatcgag gaggaggcgg tgtgtgtgta tgtgtctatt ctacggtgtg gctcgtcgtg 241 gggcgagagg aggctcgaga gagggcgagg gagaagcgaa aagagtaaga gagtcttcct 301 ttgcgagagc ctctaatctg gttgctatgg aaatacatga ccacgcaaaa ggaagtccat 361 tctgataatt ctgatacctg agatgtaact ggactgaaga gtagaaacag gaaaaatttt 421 agtgccaact ttaattacaa tggccactga ttcaggggat ccagccagca cagaagattc 481 tgagaaacct gatggaattt catttgaaaa cagagttccc caggtcgctg caactttgac 541 agtagaagct agactaaagg agaaaaacag taccttctct gcttctgggg aaactgtaga 601 aaggaagaga tttttccgaa agagtgttga aatgacggaa gatgacaaag ttgccgaatc 661 atcccccaaa gatgagagaa ttaaggctgc aatgaatatt ccaagagtag ataagcttcc 721 ttcaaatgtg ttgagaggtg gacaagaagt taaatatgaa cagtgttcaa agtcaacctc 781 agaaatctca aaagattgtt tcaaggagaa aaatgaaaag gaaatggaag aagaagcaga 841 aatgaaggct gtagctactt ctcctagtgg cagattcctg aaatttgaca tagaactagg 901 aagaggagca tttaaaacag tatataaagg actggacact gaaacatggg ttgaggttgc 961 ttggtgtgag ctgcaggacc gaaagttaac caaagctgag cagcaaagat tcaaggaaga 1021 agcagagatg ttgaagggtc tccagcaccc caatatagtt cgattttatg attcctggga 1081 atctatatta aaaggaaaga aatgtattgt attagtgact gaactaatga catctgggac 1141 cttaaagacg tacttaaaac gatttaaagt catgaaacca aaggtcttaa ggagctggtg 1201 caggcaaatt ttaaaggggt tgcagttctt gcacactagg actcctccta ttattcaccg 1261 ggatctgaag tgtgacaata ttttcatcac gggacccact ggatctgtga agattggtga 1321 tctaggatta gccaccttaa tgcgtacctc atttgctaag agtgtcattg gaactcctga 1381 gtttatggct ccagagatgt atgaagaaca ctatgatgaa tccgtagatg tttatgcttt 1441 tggaatgtgt atgctggaaa tggccacatc ggagtatcct tattctgagt gtcagaatgc 1501 agctcaaata taccggaaag taactagtgg cataaaacca gccagcttca ataaagtcac 1561 tgatcctgaa gtcaaagaaa tcattgaagg atgtattcgt caaaacaaat ctgaaaggtt 1621 gtctatcagg gacctattaa accatgcatt ttttgctgag gatacaggac tgagggtgga 1681 gttagcagaa gaagatgatt gctcaaattc atcccttgct ttaagactct gggttgaaga 1741 ccctaaaaaa ttgaaaggca aacacaaaga caatgaagct attgaattta gtttcaactt 1801 agaaacagat acacctgagg aagtagcata tgaaatggtc aagtctgggt tcttccatga 1861 aagtgattcc aaagctgttg ctaaatccat tagagaccgg gtgacgccaa taaagaagac 1921 aagagagaag aagcctgctg gctgtttgga agaacgcagg gattctcagt gcaagtctat 1981 ggggaatgta ttccctcagc cccagaatac aactttaccc cttgctcccg ctcagcaaac 2041 tggggctgaa tgtgaagaaa ctgaagttga tcaacatgtt agacaacagc ttctacaaag 2101 aaaaccacag cagcactgct cctctgttac aggtgacaat ttgtctgagg caggagctgc 2161 atcagttata cattcagata cttcaagtca gcccagtgta gcctattcct caaatcaaac 2221 gatgggctct caaatggttt ctaatatccc gcaggctgaa gtaaatgttc cagggcaaat 2281 ttattcatct cagcaactag taggacatta ccagcaagtt tcagggttac agaagcattc 2341 aaagctgact cagccgcaga ttttgccttt ggttcaaggt cagtccactg ttttacctgt 2401 acatgtcctt ggaccgacag ttgtttcaca accccaggtt tccccattaa ctgttcagaa 2461 ggtcccacag ataaagcctg tatcccaacc agttggagct gaacaacaag cagctcttct 2521 aaaaccagat ttagttcgaa gcttgaatca agatgtggca actacgaagg aaaacgtcag 2581 tagccctgat aacccaagtg gaaatggcaa acaggatcgg atcaaacaga gaagagcttc 2641 ctgtccccga ccagagaagg ggactaaatt tcagcttacc gtccttcagg tatcaacctc 2701 tggagataac atggtagagt gtcagctgga gacacacaac aacaagatgg tcaccttcaa 2761 gtttgatgtt gatggtgatg cgccagagga tattgcagac tatatggttg aagataactt 2821 tgtgctggaa agtgagaaag aaaaatttgt agaagaattg agagctattg taggtcaagc 2881 ccaggagatc cttcatgtcc actttgccac agaaagagcc actggagttg attctattac 2941 tgtggactcc aacagtagcc agacagggtc atctgaacaa gtacagataa attctacatc 3001 tactcaaacc agcaatgaat ctgctcctca gtcatcccca gttggtcggt ggcgattctg 3061 tatcaatcag acgataagaa accgtgagac tcagtctcct ccttctcttc agcattccat 3121 gtctgcggtt cctggccgac atccacttcc tagtccaaaa aacacaagta ataaggaaat 3181 atcacgggac acattgctca ctatagaaaa taatccatgc caccgtgcac ttttcacctc 3241 caaatcagaa cacaaggatg tggttgatgg taagatttct gaatgtgcta gtgtagaaac 3301 caagcagcca gctatacttt atcaagtgga agataacagg cagataatgg caccagttac 3361 taatagttcc agttactcta ctacttcagt tcgtgcagtt ccagctgaat gtgagggact 3421 caccaaacaa gcaagcatat tcatacctgt gtatccatgt caccaaactg ccagtcaggc 3481 tgatgcactt atgtcccatc ctggcgaatc aactcagact tctggtaact ctcttacaac 3541 tctggcattt gatcaaaagc ctcaaacctt atcagtacag cagccagcta tggatgcaga 3601 gtttatttct caagaaggag aaactacagt gaacactgaa gcaagttctc ctaagacagt 3661 cattcccact cagacccctg gccttgaacc aactaccctt caacccacta ctgtcctgga 3721 atcagatgga gaaagacctc caaaactgga gtttgcagac aaccgaatta aaactctgga 3781 tgaaaaatta agaaacttgc tctatcagga gcacagcatc tctagcatct atcccgagag 3841 tcagaaggat acccaaagca tagactctcc attttcttcc tctgctgaag ataccctctc 3901 ctgtccagtg acagaagtca tagccatcag tcactgtgga attaaagata gccctgtaca 3961 atcccctaat ttccaacaga caggctctaa gcttctgtcc aatgtggctg caagtcagcc 4021 tgctaatata tcagtgttca aaagggacct gaatgtgata acttctgtac ccagcgaatt 4081 gtgtttacat gagatgtcct cagatgcttc acttccaggg gatccagagg cctatcctgc 4141 tgctgtgtca agcggtggag ccattcatct gcagacagga ggtggatatt ttggcctaag 4201 ctttacttgt cctagtctca aaaatcctat tagcaagaaa tcctggactc gcaaattaaa 4261 aagctgggca tacaggctac ggcagtcaac cagctttttc aagagatcaa aagtccgtca 4321 agtggaaaca gaagagatga gatcagcaat tgctcctgat cccattcctc tgacacggga 4381 gtccacagct gatactaggg ctttgaatag atgtaaagcg atgagtggat catttcagcg 4441 gggtcggttc caggtgatta caattcctca gcagcagtca gcaaaaatga catcttttgg 4501 aatagaacac atatcagtgt tcagtgagac aaaccattct agtgaagaag cctttattaa 4561 aacagcaaag tctcagttgg tagaaataga acctgccaca caaaatccaa aaacttcgtt 4621 ttcttatgag aagttacaag ctcttcagga aacctgtaaa gaaaataaag gagttcccaa 4681 acaaggtgac aacttcttat ctttcagcgc agcttgtgag actgatgtat cttcagtgac 4741 cccagaaaag gaatttgaag aaacttcagc cacaggaagt agcatgcagt ctggatctga 4801 actgttgctt aaagagagag agatattgac tgctgggaaa cagcctagct ctgatagtga 4861 attttcagcc agtcttgctg gcagtggaaa gtcagtggca aagactggtc cagagagtaa 4921 tcagtgctta ccacaccacg aagaacaagc ttatgctcaa acacagagtt cactcttcta 4981 ttcgccatct tccccaatga gcagtgatga tgaatcagaa atagaggatg aggacttgaa 5041 ggtggagctt caaagattac gagaaaaaca cattcaggag gtggtaaatc ttcaaaccca 5101 gcagaataag gagctgcagg agctctatga acgccttcgg tcaattaaag atagcaaaac 5161 ccaatctact gagattcctt tgccacctgc atcaccacgt cgaccaagat ctttcaaaag 5221 caaacttcga agccgccccc agtccttgac acatgtggac aatggcatag ttgctacagg 5281 gaaaagctgc cttataaatg agttggaaaa tccactgtgt gtggagagta atgcagcatc 5341 atgccaacag tctccagcca gtaaaaaagg gatgttcaca gatgacttac acaagctggt 5401 ggatgactgg acaaaggaag cagtaggaaa ttctcttatt aagccaagtt taaaccaact 5461 taaacaaagt caacacaaac tagagacaga aaactggaat aaagtatctg aaaatactcc 5521 gtctactatg ggctacacat caacatggat ttcttctctg tcccaaatcc gtggagctgt 5581 cccaacttcc ttgccacaag gactctcact cccttcattt cctgggccat tatcatcata 5641 tggaatgcct cacgtttgtc agtataatgc tgtggcgggg gcggggtatc cagtacagtg 5701 ggtaggaatt tcaggaacaa cacaacaatc tgtagtaatt cccgcccaat ctgggggacc 5761 attccagcca gggatgaata tgcaggcatt tccaacttca tcagtgcaga atcctgccac 5821 aatccctcct ggtcctaaat gaatcagagt agatggtgat aaaaagggag gttttttcag 5881 aattattttc aggacaccca agatattaaa gtttcttcct cttgggttct gtcatatttt 5941 ccctcatttg agtttacttt agactatata ttttttgttc cagtgtggta tttgatacag 6001 ctcatcattc tgtagaaatg tgcagtttgc agatagaaca ctgcacacag aaatgttttt 6061 tcacttcaaa ttctatcctc tttgatactt gattttttaa aaatactgtt cagaatgctt 6121 taataagctc agcttgagca ttaccatttc caggacactt tccatgaatt gttgagaagc 6181 tccccatccc ccgccttttt tttttttttt ttaactgctg ctatctgcag ctggatactc 6241 ttctttaaaa atgtttaaaa attatttaga ttgattctcc ccaaatgtgg atgaactgag 6301 accctccatc agccagagtc ttatgggatc ttcacttcac atgtttgtct taggtttacc 6361 tttcacagaa ggcagggtaa cttgctgcag gaaacgtttt ggtgtataaa attagaatca 6421 cttttttttt tttttttgag atggagtctc tctctgtcac ccaggttgga gtgcagtggt 6481 gtgatcttgg ctcactgctg caacctcccc ctcctgggtt caagcgattc tcctgcctca 6541 gcctcctgag tagctgggac tacaggcgcc agccaccatg cctggctaat ttttgtattt 6601 ttagtagagg atggggtttc actatgttgg ccagactggt ctcaaactcc taaccttgtg 6661 atccgccctc cttagccccc ccaaaaaatt acaataattt tgtcaaccaa tacagaacat 6721 gagccctttt taaatgtgat ttcccgtcat cacagcagta ggatgaagcc ttgttttggg 6781 tgagacagag ggaaagggaa aaaacagaat tgtaacagtt ccttgattct gcagatactg 6841 ctgctgtttt acgatttcag taataattca aagcagctgt ctccttgttt ctcacatgca 6901 tactacattg gttttgagca tctgagaggc attggtttgt cttgcattct tttgcaaggc 6961 atatattgca gctgatatga atctcgtttg gggggaatcc ttgtattcct aacaaggggg 7021 attaaagcta cacctcaatc cattcttctg aagtgaaatt tacttgacac agtaggtttc 7081 gagacttaca tatgaaacac tggctttaca gggttctcag agatgtgggg tatacactgt 7141 cctgcagtga gatagtagac cctagaagga tactatttaa gttgtcctta gctcttttta 7201 attacaattt ttagttgtta gaatttcttt ttagtatcta tagtatctta gatgatttta 7261 gatcttaaat gagtttggca gcctctttag aatctgagag agatcactgt caagttgcac 7321 tttactgggt tttatccagt tttaggagga ggggaggcaa tgtcaaaatg tacacctttg 7381 gtttttaaga aggttaacta taataatgtt aaaggctagt cacagggtta cctaatgctc 7441 agtctgtgaa acctaaatag aattcttaaa atgttattta ccaactaagt attcatgttc 7501 aaattactta ccttccactc tgaagacttt aaggtcattt ctaatacaca tttacctaat 7561 taggagttct gtctactagt aaacattcca aattgctacc caacattact gttaacagat 7621 tttcctccgt attcttctaa aaattatacc ccatgggctt gccaggtaat gacgaaaact 7681 taatgggtgt actttttttt ttttttgcac agtctacttt gtgacattaa gtacctcttt 7741 tcc //