LOCUS AY339601 5745 bp mRNA linear HUM 19-APR-2004
DEFINITION Homo sapiens long myosin light chain kinase mRNA, complete cds.
ACCESSION AY339601
VERSION AY339601.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5745)
AUTHORS Dulyaninova,N.G., Patskovsky,Y.V. and Bresnick,A.R.
TITLE The N-terminus of the long MLCK induces a disruption in normal
spindle morphology and metaphase arrest
JOURNAL J. Cell. Sci. 117 (PT 8), 1481-1493 (2004)
PUBMED 15020676
REFERENCE 2 (bases 1 to 5745)
AUTHORS Dulyaninova,N.G., Patskovsky,Y.V. and Bresnick,A.R.
TITLE Direct Submission
JOURNAL Submitted (10-JUL-2003) Biochemistry, Albert Einstein College of
Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
FEATURES Location/Qualifiers
source 1..5745
/db_xref="H-InvDB:HIT000251951"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="HeLa"
CDS 1..5745
/function="phosphorylates myosin-II"
/note="MLCK"
/codon_start=1
/product="long myosin light chain kinase"
/protein_id="AAQ02673.1"
/translation="MGDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCI
KEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRG
KYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSASAVETRPSIWGECP
PKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVL
EIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQGLDSANRSFVRETKATNSDVRKEVT
NVISKESKLDSLEAAAKSKNCSSPQRGGSPPWAANSQPQPPRESKLESCKDSPRTAPQ
TPVLQKTSSSITLQAARVQPEPRAPGLGVLSPSGEERKRPAPPRPATFPTRQPGLGSQ
DVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLE
GTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQVSCSWTLQVERLA
VMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVA
ELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPI
FLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCI
QEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLI
SCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKN
RVGECSCQVSLMLQNSSARALPRGREPASCEDLCGGGVGADGGGSDRYGSLRPGWPAR
GQGWLEEEDGEDVRGVLKRRVETRQHTEEAIRQQEVEQLDFRDLLGKKVSTKTLSEDD
LKEIPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVP
PPKPATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAK
PAETLKPMGNAKPAETLKPMGNAKPDENLKSASKEELKKDVKNDVNCKRGHAGTTDNE
KRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIIL
SQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSR
RPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGKVT
GTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQ
AQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTW
KELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPKDEVE
VSDDDEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKF
FKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIID
EDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLAR
RLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNE
TLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWLMKDTKNM
EAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAE
KLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVW
FKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVE
TMEEGEGEGEEEEE"
BASE COUNT 1486 a 1529 c 1674 g 1056 t
ORIGIN
1 atgggggatg tgaagctggt tgcctcgtca cacatttcca aaacctccct cagtgtggat
61 ccctcaagag ttgactccat gcccctgaca gaggcccctg ctttcatttt gccccctcgg
121 aacctctgca tcaaagaagg agccaccgcc aagttcgaag ggcgggtccg gggttaccca
181 gagccccagg tgacatggca cagaaacggg caacccatca ccagcggggg ccgcttcctg
241 ctggattgcg gcatccgggg gactttcagc cttgtgattc atgctgtcca tgaggaggac
301 aggggaaagt atacctgtga agccaccaat ggcagtggtg ctcgccaggt gacagtggag
361 ttgacagtag aaggaagttt tgcgaagcag cttggtcagc ctgttgtttc caaaacctta
421 ggggatagat tttcagcttc agcagtggag acccgtccta gcatctgggg ggagtgccca
481 ccaaagtttg ctaccaagct gggccgagtt gtggtcaaag aaggacagat gggacgattc
541 tcctgcaaga tcactggccg gccccaaccg caggtcacct ggctcaaggg aaatgttcca
601 ctgcagccga gtgcccgtgt gtctgtgtct gagaagaacg gcatgcaggt tctggaaatc
661 catggagtca accaagatga cgtgggagtg tacacgtgcc tggtggtgaa cgggtcgggg
721 aaggcctcga tgtcagctga actttccatc caaggtttgg acagtgccaa taggtcattt
781 gtgagagaaa caaaagccac caattcagat gtcaggaaag aggtgaccaa tgtaatctca
841 aaggagtcga agctggacag tctggaggct gcagccaaaa gcaagaactg ctccagcccc
901 cagagaggtg gctccccacc ctgggctgca aacagccagc ctcagccccc aagggagtcc
961 aagctggagt catgcaagga ctcgcccaga acggccccgc agactccggt ccttcagaag
1021 acttccagct ccatcaccct gcaggccgca agagttcagc cggaaccaag agcaccaggc
1081 ctgggggtcc tatcaccttc tggagaagag aggaagaggc cagctcctcc ccgtccagcc
1141 accttcccca ccaggcagcc tggcctgggg agccaagatg ttgtgagcaa ggctgctaac
1201 aggagaatcc ccatggaggg ccagagggat tcagcattcc ccaaatttga gagcaagccc
1261 caaagccagg aggtcaagga aaatcaaact gtcaagttca gatgtgaagt ttccgggatt
1321 ccaaagcctg aagtggcctg gttcctggaa ggcacccccg tgaggagaca ggaaggcagc
1381 attgaggttt atgaagatgc tggctcccat tacctctgcc tgctgaaagc ccggaccagg
1441 gacagtggga catacagctg cactgcttcc aacgcccaag gccaggtgtc ctgtagctgg
1501 accctccaag tggaaaggct tgccgtgatg gaggtggccc cctccttctc cagtgtcctg
1561 aaggactgcg ctgttattga gggccaggat tttgtgctgc agtgctccgt acgggggacc
1621 ccagtgcccc ggatcacttg gctgctgaat gggcagccca tccagtacgc tcgctccacc
1681 tgcgaggccg gcgtggctga gctccacatc caggatgccc tgccggagga ccatggcacc
1741 tacacctgcc tagctgagaa tgccttgggg caggtgtcct gcagcgcctg ggtcaccgtc
1801 catgaaaaga agagtagcag gaagagtgag taccttctgc ctgtggctcc cagcaagccc
1861 actgcaccca tcttcctgca gggcctctct gatctcaaag tcatggatgg aagccaggtc
1921 actatgactg tccaagtgtc agggaatcca ccccctgaag tcatctggct gcacaatggg
1981 aatgagatcc aagagtcaga ggacttccac tttgaacaga gaggaactca gcacagcctt
2041 tgtatccagg aagtgttccc ggaggacacg ggcacgtaca cctgcgaggc ctggaacagc
2101 gctggagagg tccgcaccca ggccgtgctc acggtacaag agcctcacga tggcacccag
2161 ccctggttca tcagtaagcc tcgctcagtg acagcctccc tgggccagag tgtcctcatc
2221 tcctgcgcca tagctggtga cccctttcct accgtgcact ggctcagaga tggcaaagcc
2281 ctctgcaaag acactggcca cttcgaggtg cttcagaatg aggacgtgtt caccctggtt
2341 ctaaagaagg tgcagccctg gcatgccggc cagtatgaga tcctgctcaa gaaccgggtt
2401 ggcgaatgca gttgccaggt gtcactgatg ctacagaaca gctctgccag agcccttcca
2461 cgggggaggg agcctgccag ctgcgaggac ctctgtggtg gaggagttgg tgctgatggt
2521 ggtggtagtg accgctatgg gtccctgagg cctggctggc cagcaagagg gcagggttgg
2581 ctagaggagg aagacggcga ggacgtgcga ggggtgctga agaggcgcgt ggagacgagg
2641 cagcacactg aggaggcgat ccgccagcag gaggtggagc agctggactt ccgagacctc
2701 ctggggaaga aggtgagtac aaagacccta tcggaagacg acctgaagga gatcccagcc
2761 gagcagatgg atttccgtgc caacctgcag cggcaagtga agccaaagac tgtgtctgag
2821 gaagagagga aggtgcacag cccccagcag gtcgattttc gctctgtcct ggccaagaag
2881 gggacttcca agacccccgt gcctgagaag gtgccaccgc caaaacctgc caccccggat
2941 tttcgctcag tgctgggtgg caagaagaaa ttaccagcag agaatggcag cagcagtgcc
3001 gagaccctga atgccaaggc agtggagagt tccaagcccc tgagcaatgc acagccttca
3061 gggcccttga aacccgtggg caacgccaag cctgctgaga ccctgaagcc aatgggcaac
3121 gccaagcctg ccgagaccct gaagcccatg ggcaatgcca agcctgatga gaacctgaaa
3181 tccgctagca aagaagaact caagaaagac gttaagaatg atgtgaactg caagagaggc
3241 catgcaggga ccacagataa tgaaaagaga tcagagagcc aggggacagc cccagccttc
3301 aagcagaagc tgcaagatgt tcatgtggca gagggcaaga agctgctgct ccagtgccag
3361 gtgtcttctg accccccagc caccatcatc tggacgctga acggaaagac cctcaagacc
3421 accaagttca tcatcctctc ccaggaaggc tcactctgct ccgtctccat cgagaaggca
3481 ctgcctgagg acagaggctt atacaagtgt gtagccaaga atgacgctgg ccaggcggag
3541 tgctcctgcc aagtcaccgt ggatgatgct ccagccagtg agaacaccaa ggccccagag
3601 atgaaatccc ggaggcccaa gagctctctt cctcccgtgc taggaactga gagtgatgcg
3661 actgtgaaaa agaaacctgc ccccaagaca cctccgaagg cagcaatgcc ccctcagatc
3721 atccagttcc ctgaggacca gaaggtacgc gcaggagagt cagtggagct gtttggcaaa
3781 gtgacaggca ctcagcccat cacctgtacc tggatgaagt tccgaaagca gatccaggaa
3841 agcgagcaca tgaaggtgga gaacagcgag aatggcagca agctcaccat cctggccgcg
3901 cgccaggagc actgcggctg ctacacactg ctggtggaga acaagctggg cagcaggcag
3961 gcccaggtca acctcactgt cgtggataag ccagaccccc cagctggcac accttgtgcc
4021 tctgacattc ggagctcctc actgaccctg tcctggtatg gctcctcata tgatgggggc
4081 agtgctgtac agtcctacag catcgagatc tgggactcag ccaacaagac gtggaaggaa
4141 ctagccacat gccgcagcac ctctttcaac gtccaggacc tgctgcctga ccacgaatat
4201 aagttccgtg tacgtgcaat caacgtgtat ggaaccagtg agccaagcca ggagtctgaa
4261 ctcacaacgg taggagagaa acctgaagag ccgaaggatg aagtggaggt gtcagatgat
4321 gatgagaagg agcccgaggt tgattaccgg acagtgacaa tcaatactga acaaaaagta
4381 tctgacttct acgacattga ggagagatta ggatctggga aatttggaca ggtctttcga
4441 cttgtagaaa agaaaactcg aaaagtctgg gcagggaagt tcttcaaggc atattcagca
4501 aaagagaaag agaatatccg gcaggagatt agcatcatga actgcctcca ccaccctaag
4561 ctggtccagt gtgtggatgc ctttgaagaa aaggccaaca tcgtcatggt cctggagatc
4621 gtgtcaggag gggagctgtt tgagcgcatc attgacgagg actttgagct gacggagcgt
4681 gagtgcatca agtacatgcg gcagatctcg gagggagtgg agtacatcca caagcagggc
4741 atcgtgcacc tggacctcaa gccggagaac atcatgtgtg tcaacaagac gggcaccagg
4801 atcaagctca tcgactttgg tctggccagg aggctggaga atgcggggtc tctgaaggtc
4861 ctctttggca ccccagaatt tgtggctcct gaagtgatca actatgagcc catcggctac
4921 gccacagaca tgtggagcat cggggtcatc tgctacatcc tagtcagtgg cctttccccc
4981 ttcatgggag acaacgataa cgaaaccttg gccaacgtta cctcagccac ctgggacttc
5041 gacgacgagg cattcgatga gatctccgac gatgccaagg atttcatcag caatctgctg
5101 aagaaagata tgaaaaaccg cctggactgc acgcagtgcc ttcagcatcc atggctaatg
5161 aaagatacca agaacatgga ggccaagaaa ctctccaagg accggatgaa gaagtacatg
5221 gcaagaagga aatggcagaa aacgggcaat gctgtgagag ccattggaag actgtcctct
5281 atggcaatga tctcagggct cagtggcagg aaatcctcaa cagggtcacc aaccagcccg
5341 ctcaatgcag aaaaactaga atctgaagaa gatgtgtccc aagctttcct tgaggctgtt
5401 gctgaggaaa agcctcatgt aaaaccctat ttctctaaga ccattcgcga tttagaagtt
5461 gtggagggaa gtgctgctag atttgactgc aagattgaag gatacccaga ccccgaggtt
5521 gtctggttca aagatgacca gtcaatcagg gagtcccgcc acttccagat agactacgat
5581 gaggacggga actgctcttt aattattagt gatgtttgcg gggatgacga tgccaagtac
5641 acctgcaagg ctgtcaacag tcttggagaa gccacctgca cagcagagct cattgtggaa
5701 acgatggagg aaggtgaagg ggaaggggaa gaggaagaag agtga
//