LOCUS AY331591 3798 bp mRNA linear HUM 17-FEB-2004
DEFINITION Homo sapiens NFkB activating protein 1 isoform A (TAB3) mRNA,
complete cds, alternatively spliced.
ACCESSION AY331591
VERSION AY331591.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3798)
AUTHORS Jin,G., Klika,A., Callahan,M., Faga,B., Danzig,J., Jiang,Z., Li,X.,
Stark,G.R., Harrington,J. and Sherf,B.
TITLE Identification of a human NF-kappaB-activating protein, TAB3
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 101 (7), 2028-2033 (2004)
PUBMED 14766965
REFERENCE 2 (bases 1 to 3798)
AUTHORS Jin,G., Klika,A., Callahan,M., Faga,B., Danzig,J., Sherf,B. and
Harrington,J.
TITLE Direct Submission
JOURNAL Submitted (27-JUN-2003) Molecular Biology, Athersys Inc., 3201
Carnegie Ave., Cleveland, OH 44115, USA
COMMENT Name: NAP1a; NFkB activating protein, isoform A.
FEATURES Location/Qualifiers
source 1..3798
/db_xref="H-InvDB:HIT000251872"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..3798
/gene="TAB3"
5'UTR 1..547
/gene="TAB3"
/note="exons 1 and 2 are alternatively expressed in
various tissues, including kidney, PBL cells, brain, lung,
prostate, and U937 cells; 5'UTR missing an additional
upstream exon because of cloning method"
variation 59
/gene="TAB3"
/experiment="experimental evidence, no additional details
recorded"
/replace="c"
CDS 548..2686
/gene="TAB3"
/note="TAB3a; ortholog of Xenopus laevis TAB3;
alternatively spliced"
/codon_start=1
/product="NFkB activating protein 1 isoform A"
/protein_id="AAQ92938.1"
/translation="MAQSSPQLDIQVLHDLRQRFPEIPEGVVSQCMLQNNNNLEACCR
ALSQESSKYLYMEYHSPDDNRMNRNRLLHINLGIHSPSSYHPGDGAQLNGGRTLVHSS
SDGHIDPQHAAGKQLICLVQEPHSAPAVVAATPNYNPFFMNEQNRSAATPPSQPPQQP
SSMQTGMNPSAMQGPSPPPPPPSYMHIPRYSTNPITVTVSQNLPSGQTVPRALQILPQ
IPSNLYGSPGSIYIRQTSQSSSGRQTPQSTPWQSSPQGPVPHYSQRPLPVYPHQQNYQ
PSQYSPKQQQIPQSAYHSPPPSQCPSPFSSPQHQVQPSQLGHIFMPPSPSTTPPHPYQ
QGPPSYQKQGSHSVAYLPYTASSLSKGSMKKIEITVEPSQRPGTAINRSPSPISNQPS
PRNQHSLYTATTPPSSSPSRGISSQPKPPFSVNPVYITYTQPTGPSCTPSPSPRVIPN
PTTVFKITVGRATTENLLNLVDQEERSAAPEPIQPISVIPGSGGEKGSHKYQRSSSSG
SDDYAYTQALLLHQRARMERLAKQLKLEKEELERLKSEVNGMEHDLMQRRLRRVSCTT
AIPTPEEMTRLRSMNRQLQINVDCTLKEVDLLQSRGNFDPKAMNNFYDNIEPGPVVPP
KPSKKDSSDPCTIERKARRISVTSKVQADIHDTQAAAADEHRTGSTQSPRTQPRDEDY
EGAPWNCDSCTFLNHPALNRCEQCEMPRYT"
misc_feature 569..697
/gene="TAB3"
/inference="non-experimental evidence, no additional
details recorded"
/note="Region: CUE Domain"
misc_feature 2096..2227
/gene="TAB3"
/inference="non-experimental evidence, no additional
details recorded"
/note="Region: coiled coil"
misc_feature 2600..2674
/gene="TAB3"
/inference="non-experimental evidence, no additional
details recorded"
/note="Region: Zn-finger in Ran-binding protein domain"
variation 905
/gene="TAB3"
/experiment="experimental evidence, no additional details
recorded"
/replace="c"
variation 1612
/gene="TAB3"
/experiment="experimental evidence, no additional details
recorded"
/replace="g"
variation 1651
/gene="TAB3"
/experiment="experimental evidence, no additional details
recorded"
/replace="c"
regulatory 3756..3761
/regulatory_class="polyA_signal_sequence"
/gene="TAB3"
/inference="non-experimental evidence, no additional
details recorded"
BASE COUNT 1157 a 900 c 747 g 994 t
ORIGIN
1 cacatgacca ttggctggag cccagttgac caagaaggaa gccagagaaa gccacacatt
61 cgggcgagca aggatcacaa ggagacacat ctgagcctga tatagaggat tgcacatcag
121 cacatcattc agagatcctg gactttgaga tgtatgtagt aacaggacac tgtcttcagc
181 cttttcttca agtttttgac cgtggattgt gttgtgtcaa actggacgaa ttatcttagt
241 tgaattttca ccagttgaaa aattggagat ttctagacta ctgaaaagaa gttgctttca
301 gagctggaga tgtgaataaa atttctgtgc cagggttgat aaaccatctt gaggattcca
361 tccaggaaac cccatcacag ttggttgtta tgtctcctta gactcctctt ggctgtgaca
421 gtttctcaga cttttgttct tgaggagtac tgatcagaaa atgactgtgg tgctagaaga
481 tcattacttt tggaaagccg gttaacatcc atttcctaag agaaacttgg ccaccatttg
541 ctctggcatg gcgcaaagca gcccacagct tgatattcag gttctccatg atcttcgaca
601 acgtttccct gaaattccag agggcgtggt gtctcagtgc atgttacaga ataacaacaa
661 tcttgaagcc tgttgccgag ccctttccca ggagagtagc aaatacttat atatggaata
721 ccatagtcca gatgacaata ggatgaatag aaatcgcctt ttacatatta acctgggtat
781 ccattctcct agtagctatc acccaggaga tggagcccaa cttaatggtg gtcgaacact
841 ggtacatagc tcaagtgatg gacatattga tcctcagcat gcagcaggta aacagctgat
901 atgtttagtt caagaaccac actcagctcc agctgttgtt gctgctactc ccaactacaa
961 tccatttttt atgaacgaac agaacagaag tgcagctact cctccttcac aaccacctca
1021 acagccatct tccatgcaaa caggaatgaa tccgtctgct atgcaagggc cttcaccacc
1081 accgccacct ccttcataca tgcacatacc tcggtatagt acaaatccaa ttactgttac
1141 agtatcccag aacctccctt ctggacagac tgtaccaaga gctttacaaa ttcttccaca
1201 aattccaagc aatctctatg ggtctcctgg ttctatttat attagacaga catctcagag
1261 ttcatcagga agacaaactc ctcagagtac gccgtggcag tcctcaccac agggcccagt
1321 gcctcactat agccagcgtc ctttacctgt ttatccacac caacagaact atcagccttc
1381 tcagtattct cccaaacagc agcagatccc tcagtctgct taccattcac cacctccttc
1441 tcaatgtcct tcacccttca gctctccaca gcatcaagtg caaccttccc agttgggcca
1501 catctttatg ccacctagtc cttcaactac tccaccccat ccatatcaac aaggacctcc
1561 tagctatcag aaacagggaa gccattcagt agcctatctt ccatacacag catctagttt
1621 atccaaaggt tccatgaaga agatagaaat tacagttgaa ccttctcaaa gacctgggac
1681 agcaattaat aggagtcctt cacccatcag taatcaacca tctccacgga atcaacactc
1741 actgtacaca gccaccacgc caccttcaag ttctccttca agagggatat ctagtcaacc
1801 aaaacctcca tttagtgtta atcctgtgta tattacatat acacagccaa ctggaccttc
1861 ttgtactcca tcaccatctc ctcgagtgat accaaaccca actacagttt ttaaaattac
1921 cgtaggccga gcaacgactg aaaatctttt aaatttagtg gaccaagaag agcgctctgc
1981 agcaccagaa cctattcagc ccatttcagt gataccaggc tctgggggag aaaagggaag
2041 ccataaatat cagagaagtt ctagttctgg atcagatgac tatgcctaca cacaagcctt
2101 gctgttacat caacgagcaa ggatggagag gttagcaaag caactgaaac ttgagaaaga
2161 ggagctagag cggttgaagt ctgaagttaa tggtatggag catgacctga tgcagagacg
2221 gctcagaaga gtcagctgca ccactgcgat ccctacgcct gaggaaatga caagattgag
2281 aagcatgaac agacaactcc agataaatgt tgactgtaca ctgaaagaag ttgacctcct
2341 tcaatctaga ggaaactttg atccaaaagc catgaataat ttttatgaca acatagaacc
2401 tggcccagtt gtaccaccca agccatctaa aaaagactcc tcagacccct gcacaattga
2461 gagaaaagcc cgaagaatta gcgtgacctc caaagtacag gcagacatcc atgacaccca
2521 ggcagcagct gcagatgagc atcgaactgg ctccacacaa agtcctcgga cacaacctcg
2581 agatgaagac tacgaagggg ctccatggaa ttgtgatagc tgcacctttc ttaaccaccc
2641 agcactaaat cgctgtgagc agtgcgagat gccacggtac acctgaattc agaaaagtct
2701 gcgccaggtt gaaagtgaaa ctttgagcac taccagaaga aaaggaaacc tcgggactct
2761 attcatccac ccagcctttt cattttcgat tgcacagcgg ggaggaggaa tggctttgtg
2821 gtcgtcgttg tgctcacgaa aggaaaaatg gggaggtctt ttttttctcc tttcttaact
2881 cactacagag tgagagatag aaagggatac ttgaaactgg gaaaggattc actctgtgaa
2941 agaatgtaca cacagaagtc aagagctctt ctgtggtgga atcccaattg ttaaagttac
3001 tgctgagtgg cccttatttt ttaaagtagt actttgaatc atagtatgaa atgttacagt
3061 ttatgcaaac tgtgaattcc cagagcagac ttacctggtc accgctctct ggaaaaccaa
3121 ggctccccgt gcttcttccc attgcttcct actaaagagg acaacaggaa aaagcaccta
3181 gaatatttgg gggggggggg gggcaaatta attaagggta tttgtaattg ctgctttttt
3241 caggggtaat ttccaacaca catacatgca cacaaacaaa atgttttaaa atgtgatttg
3301 tagcagtcag gaactaggca tatcatgcct ttgtttaaaa gtacaatcag aggtggtaag
3361 atgcctttgg cttgtacagt gtgattcatc gagctctatc aacactggta actaagacct
3421 acttatgcca cataagagat gcattttttt aagttactgc atgtttttat taaggccatt
3481 ggttttcaaa ataacaagtc cttacaaagt atgattttat aaatgatatt ctcgtaaaac
3541 tgcgctttgc cagtagcaca gtgaatgtat gccaaatgca agtccattcc aaaatccatt
3601 tggaaatctt gagctcagct gtggttctta aacttttgca gtccataggg cctttttttt
3661 ttccttccaa ttttgtgata aattcatgat gtttacagca cagataaaac tttgtgccat
3721 aatcctaatt tagctgaaat caatattaac tgttcaataa aaacttactt gcatatgtta
3781 acaaaaaaaa aaaaaaaa
//