LOCUS AY327900 5574 bp mRNA linear HUM 06-JUL-2005
DEFINITION Homo sapiens mixed-lineage protein kinase 1 (MAP3K9) mRNA, complete
cds.
ACCESSION AY327900
VERSION AY327900.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5574)
AUTHORS Durkin,J.T., Holskin,B.P., Kopec,K.K., Reed,M.S., Spais,C.M.,
Steffy,B., Gessner,G., Angeles,T.S., Pohl,J., Ator,M.A. and
Meyer,S.L.
TITLE Phosphoregulation of mixed-lineage kinase 1 activity by multiple
phosphorylation in the activation loop
JOURNAL Biochemistry 43 (51), 16348-16355 (2004)
PUBMED 15610029
REFERENCE 2 (bases 1 to 5574)
AUTHORS Durkin,J.T., Holskin,B.P., Spais,C.M., Lang,D.M. and Meyer,S.L.
TITLE Direct Submission
JOURNAL Submitted (24-JUN-2003) Biochemistry, Cephalon, Inc., 145
Brandywine Parkway, West Chester, PA 19380, USA
FEATURES Location/Qualifiers
source 1..5574
/db_xref="H-InvDB:HIT000251818"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="14"
/map="14q24.3"
gene 1..>5574
/gene="MAP3K9"
CDS 1..3315
/gene="MAP3K9"
/note="MLK1"
/codon_start=1
/product="mixed-lineage protein kinase 1"
/protein_id="AAQ23054.1"
/translation="MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVG
PGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQR
VGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYR
AFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCL
VMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILI
LQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWS
YGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHS
RPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQETFDQLRAKEKELRTWEEE
LTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKS
RLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTP
GESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKAN
GLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEG
PGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLK
RGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLF
QRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDE
IVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRR
TPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTP
RRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPS
NLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAEL
NTHRPAPYEIQQEFWS"
misc_feature 175..333
/gene="MAP3K9"
/note="Region: SH3 domain"
misc_feature 430..1209
/gene="MAP3K9"
/note="Region: kinase domain"
misc_feature 880..957
/gene="MAP3K9"
/note="Region: activation loop"
misc_feature 1279..1467
/gene="MAP3K9"
/note="Region: two tandem leucine zippers"
misc_feature 1483..1539
/gene="MAP3K9"
/note="Region: basic domain; predicted pI=12.6"
misc_feature 1552..1593
/gene="MAP3K9"
/note="Region: Cdc42/Rac interactive binding motif; CRIB
domain"
misc_feature 1594..3312
/gene="MAP3K9"
/note="Region: Pro and Ser-rich COOH-terminal domain"
variation 1298
/gene="MAP3K9"
/note="compared to AC004816; point mutation; generates
threonine to methionine amino acid change"
/replace="c"
3'UTR 3316..>5574
/gene="MAP3K9"
variation 5400..5405
/gene="MAP3K9"
BASE COUNT 1248 a 1550 c 1575 g 1201 t
ORIGIN
1 atggagccct ccagagcgct tctcggctgc ctagcgagcg ccgccgctgc cgccccgccg
61 ggggaggatg gagcaggggc cggggccgag gaggaggagg aggaggagga ggaggcggcg
121 gcggcggtgg gccccgggga gctgggctgc gacgcgccgc tgccctactg gacggccgtg
181 ttcgagtacg aggcggcggg cgaggacgag ctgaccctgc ggctgggcga cgtggtggag
241 gtgctgtcca aggactcgca ggtgtccggc gacgagggct ggtggaccgg gcagctgaac
301 cagcgggtgg gcatcttccc cagcaactac gtgaccccgc gcagcgcctt ctccagccgc
361 tgccagcccg gcggcgagga ccccagttgc tacccgccca ttcagttgtt agaaattgat
421 tttgcggagc tcaccttgga agagattatt ggcatcgggg gctttgggaa ggtctatcgt
481 gctttctgga taggggatga ggttgctgtg aaagcagctc gccacgaccc tgatgaggac
541 atcagccaga ccatagagaa tgttcgccaa gaggccaagc tcttcgccat gctgaagcac
601 cccaacatca ttgccctaag aggggtatgt ctgaaggagc ccaacctctg cttggtcatg
661 gagtttgctc gtggaggacc tttgaataga gtgttatctg ggaaaaggat tcccccagac
721 atcctggtga attgggctgt gcagattgcc agagggatga actacttaca tgatgaggca
781 attgttccca tcatccaccg cgaccttaag tccagcaaca tattgatcct ccagaaggtg
841 gagaatggag acctgagcaa caagattctg aagatcactg attttggcct ggctcgggaa
901 tggcaccgaa ccaccaagat gagtgcggca gggacgtatg cttggatggc acccgaagtc
961 atccgggcct ccatgttttc caaaggcagt gatgtgtgga gctatggggt gctactttgg
1021 gagttgctga ctggtgaggt gccctttcga ggcattgatg gcttagcagt cgcttatgga
1081 gtggccatga acaaactcgc ccttcctatt ccttctacgt gcccagaacc ttttgccaaa
1141 ctcatggaag actgctggaa tcctgatccc cactcacgac catctttcac gaatatcctg
1201 gaccagctaa ccaccataga ggagtctggt ttctttgaaa tgcccaagga ctccttccac
1261 tgcctgcagg acaactggaa acacgagatt caggagacgt ttgaccaact cagggccaaa
1321 gaaaaggaac ttcgcacctg ggaggaggag ctgacgcggg ctgcactgca gcagaagaac
1381 caggaggaac tgctgcggcg tcgggagcag gagctggccg agcgggagat tgacatcctg
1441 gaacgggagc tcaacatcat catccaccag ctgtgccagg agaagccccg ggtgaagaaa
1501 cgcaagggca agttcaggaa gagccggctg aagctcaagg atggcaaccg catcagcctc
1561 ccttctgatt tccagcacaa gttcacggtg caggcctccc ctaccatgga taaaaggaag
1621 agtcttatca acagccgctc cagtcctcct gcaagcccca ccatcattcc tcgccttcga
1681 gccatccagt tgacaccagg tgaaagcagc aaaacctggg gcaggagctc agtcgtccca
1741 aaggaggaag gggaggagga ggagaagagg gccccaaaga agaagggacg gacgtggggg
1801 ccagggacgc ttggtcagaa ggagcttgcc tcgggagatg aaggatcccc tcagagacgt
1861 gagaaagcta atggtttaag taccccatca gaatctccac atttccactt gggcctcaag
1921 tccctggtag atggatataa gcagtggtcg tccagtgccc ccaacctggt gaagggccca
1981 aggagtagcc cggccctgcc agggttcacc agccttatgg agatggagga tgaggacagt
2041 gaaggcccag ggagtggaga gagtcgccta cagcattcac ccagccagtc ctacctctgt
2101 atcccattcc ctcgtggaga ggatggcgat ggcccctcca gtgatggaat ccatgaggag
2161 cccaccccag tcaactcggc cacgagtacc cctcagctga cgccaaccaa cagcctcaag
2221 cggggcggtg cccaccaccg ccgctgcgag gtggctctgc tcggctgtgg ggctgttctg
2281 gcagccacag gcctagggtt tgacttgctg gaagctggca agtgccagct gcttcccctg
2341 gaggagcctg agccaccagc ccgggaggag aagaaaagac gggagggtct ttttcagagg
2401 tccagccgtc ctcgtcggag caccagcccc ccatcccgaa agcttttcaa gaaggaggag
2461 cccatgctgt tgctaggaga cccctctgcc tccctgacgc tgctctccct ctcctccatc
2521 tccgagtgca actccacacg ctccctgctg cgctccgaca gcgatgaaat tgtcgtgtat
2581 gagatgccag tcagcccagt cgaggcccct cccctgagtc catgtaccca caaccccctg
2641 gtcaatgtcc gagtagagcg cttcaaacga gatcctaacc aatctctgac tcccacccat
2701 gtcaccctca ccaccccctc gcagcccagc agtcaccggc ggactccttc tgatggggcc
2761 cttaagccag agactctcct agccagcagg agcccctcca gcaatgggtt gagccccagt
2821 cctggagcag gaatgttgaa aacccccagt cccagccgag acccaggtga attcccccgt
2881 ctccctgacc ccaatgtggt cttcccccca accccaaggc gctggaacac tcagcaggac
2941 tctaccttgg agagacccaa gactctggag tttctgcctc ggccgcgtcc ttctgccaac
3001 cggcaacggc tggacccttg gtggtttgtg tcccccagcc atgcccgcag cacctcccca
3061 gccaacagct ccagcacaga gacgcccagc aacctggact cctgctttgc tagcagtagc
3121 agcactgtag aggagcggcc tggacttcca gccctgctcc cgttccaggc agggccgctg
3181 cccccgactg agcggacgct cctggacctg gatgcagagg ggcagagtca ggacagcacc
3241 gtgccgctgt gcagagcgga actgaacaca cacaggcctg ccccttatga gatccagcag
3301 gagttctggt cttagcacga aaaggattgg ggcgggcaag ggggacagcc agcggagatg
3361 aggggagctg gcgggcacag ccctttctca gggttggacc ccctgagatc cagccctact
3421 tcttgcactg ataatgcact ttgaagatgg aagggatgga aacagggcca cttcagaggg
3481 tctcctgccc tgcagggcct ttctacccgt gtccactgga ggggctgtgg ccatcagctc
3541 tggctgtgta ggggaggaag gggtgcatgc atgtccccca ccctccacag tcttccttgc
3601 ctttagagtg accctgcaga gtcactcagc caaatctgtc tgctgctccc tctcctcagc
3661 cagttgggtg tgcgcagagc tgtcataggg tccctttgtc agccccgagt tcagcttccc
3721 aaacaccagt gttggatatt ctgtgattga ttttggtcct cctccgctgt cccccaacac
3781 ccaggaatgg gaatctggct tggttcgaga taggagcttt tctgtgtcct aagccctttc
3841 atgctagcag gaagactgaa agcaaggtgg cccagtgtgg ggtcataggg cttgatagac
3901 ctggcactgc ctatctgcac ttccaggtgc cccacctatt tatctgagcc cacaggtgga
3961 aaggggaact gcctcagtga gaacgggggg acggggatgt taggaaaaat acagtaaagt
4021 tgcaatgaag aggttcatga agtatgtcct tgttcttttt ggaaactctc ggcaaagggc
4081 aaaccagcaa gtattgaggg tacccatcta gctacttggg gtcaggacct cgtcagacca
4141 ggttcggata caatcatctg ctcatcccag gaatagtttc ttgggggact cactcactgg
4201 tgccagttct aagtcagaga caaaattcca ctgtctgttc cttttgctgt ctgaacttta
4261 tgtgttactc ccttcctttg gtcttcactc taatccctgg agtttgtggg cttttggtta
4321 tgtttggtta gtagatatca ccgcaatgcc ctagaacagc tatgaagcag aataccatat
4381 ggccacctgg acattgggac ttgggaattc actctcaact gggccatcca tgttgtgatg
4441 cccttgaagt aaaatggagc cagcaggagt accttctgta aatgcatgtg gcaaagtgct
4501 atttataggg tgcccaggga gccgctgatg tacaataacc ttgaggtccc ccatactgaa
4561 aactgaccaa ggcctgtgca caggtagccc ctcatgctgg gctctggacc atgagctgag
4621 taggaaggat agcagaggcc aaccctgacc ttcctggaag ttgtttcctt aacttgaatg
4681 ttgagcttcc tctaaagctt tctcgtgtat gtcttctcca tgccactact ctgaggcctc
4741 ctgtgttatg tgtgaacagt tgtctttatg tgggaatgac gacttgattg ggagtagagt
4801 ctcaaggtca ttcccctctt ccctcaagac tctctgaatg ctgctccact gtcttttgtc
4861 ttggaggtca ctcagcaggt tccttgcatt tgctgcctgg atgtgcagct ggcaacagtg
4921 atgaattggt cactgctctt tctctataac tgggatagat gtcctgcctt ggggtcacta
4981 aaggggtgac cttgttcctt gctttatgag cccattagca ctttggttca aggggcccac
5041 caagtcttgg acgggaaggc gctactggtt ttattgccca aggttttgtt attgcttctc
5101 ttctgtgtcc ttctctttgt tcagtgaagc caatatgtaa gatactgttt ttgtccccat
5161 tcccctactc ctgagctagg aggaaaaaat gtgaatctta ccagcagttc cagccaacca
5221 agtgattctt cttcattctt gatggggaga agtacataca aagtttgttc tgacagggcg
5281 cggtggctca cgcctgtaat cccagcgctt tgggaggcag aggcaggtgg atcacctgag
5341 gtcgggagtt cgagaccagc ctgaccaaca tggagatatc ctgtctctac taaaaataca
5401 aaaaattagc caggcatggt ggcacgtgcc tgtaatccca gctactcgca aggctgaggc
5461 aggagaatcg cttgaacctg ggaggcggag gttgcagtga gccaagattg cgccattgca
5521 ctccagcctg ggcaacaaga gagaaactct gtctcaaaaa aaaaaaaaaa aaaa
//