LOCUS AY304583 3453 bp mRNA linear HUM 08-JUL-2009
DEFINITION Homo sapiens TIRAP3a (TIRAP3) mRNA, complete cds.
ACCESSION AY304583
VERSION AY304583.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3453)
AUTHORS Palsson-McDermott,E.M., Doyle,S.L., McGettrick,A.F., Hardy,M.,
Husebye,H., Banahan,K., Gong,M., Golenbock,D., Espevik,T. and
O'Neill,L.A.
TITLE TAG, a splice variant of the adaptor TRAM, negatively regulates the
adaptor MyD88-independent TLR4 pathway
JOURNAL Nat. Immunol. 10 (6), 579-586 (2009)
PUBMED 19412184
REFERENCE 2 (bases 1 to 3453)
AUTHORS Hardy,M.P., McGettrick,A.F., Ejdeback,M. and O'Neill,L.A.J.
TITLE Identification of a novel variant of the Toll-like receptor adaptor
protein TIRAP3
JOURNAL Unpublished
REFERENCE 3 (bases 1 to 3453)
AUTHORS Hardy,M.P., McGettrick,A.F. and O'Neill,L.A.J.
TITLE Direct Submission
JOURNAL Submitted (23-MAY-2003) Biochemistry, Trinity College Dublin,
College Green, Dublin 2, Ireland
FEATURES Location/Qualifiers
source 1..3453
/db_xref="H-InvDB:HIT000251566"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="5"
/map="5q22"
gene 1..3453
/gene="TIRAP3"
CDS 848..1555
/gene="TIRAP3"
/note="adaptor"
/codon_start=1
/product="TIRAP3a"
/protein_id="AAQ97432.1"
/translation="MGIGKSKINSCPLSLSWGKRHSVDTSPGYHESDSKKSEDLSLCN
VAEHSNTTEGPTGKQEGAQSVEEMFEEEAEEEVFLKFVILHAEDDTDEALRVQNLLQD
DFGIKPGIIFAEMPCGRQHLQNLDDAVNGSAWTILLLTENFLRDTWCNFQFYTSLMNS
VNRQHKYNSVIPMRPLNNPLPRERTPFALQTINALEEESRGFPTQVERIFQESVYKTQ
QTIWKETRNMVQRQFIA"
regulatory 1644..1649
/regulatory_class="polyA_signal_sequence"
/gene="TIRAP3"
regulatory 3364..3369
/regulatory_class="polyA_signal_sequence"
/gene="TIRAP3"
BASE COUNT 991 a 710 c 733 g 1019 t
ORIGIN
1 aggccttttc cgcttctctt ttacctcccc aggtccgccc gtctgcgccc ctcacaggaa
61 gccggagggt cgctctgatc ccgaatctcc cacaggcgtg aacctgctct gctgtgtatc
121 tttgcggggt ggcctgcgct gaggcctgcc gcgcgcggtg agtccgcgca gacctgaccc
181 tgcgtctcgc agctcggttg aggccgccgc cgccttctcg ggatgccgcg gccggggtcc
241 gcgcagcgct gggcggccgt cgcgggccgt tgggggtgca ggctgctcgc actgctgcta
301 ctggtgcctg gacccggcgg cgcctctgag atcaccttcg agcttcctga caacgccaag
361 cagtgcttct acgaggacat cgctcagggc accaagtgca ccctggagtt ccaggtgatt
421 actggtggtc actatgatgt agattgtcga ttagaagatc ctgatggtaa agtgttatac
481 aaagagatga agaaacagta tgatagtttt accttcacag cctccaaaaa tgggacatac
541 aaattttgct tcagcaatga attttctact ttcacacata aaactgtata ttttgatttt
601 caagttggag aagacccacc tttgtttcct agtgagaacc gagtcagtgc tcttacccag
661 atggaatctg cctgtgtttc aattcacgaa gctctgaagt ctgtcatcga ttatcagact
721 catttccgtt taagagaagc tcaaggccga agccgagcag aggatctaaa tacaagagtg
781 gcctattgat tgaaaagaaa tgctgagaaa tacataaagt tttcctcttc tgccttggat
841 atttataatg ggtatcggga agtctaaaat aaattcctgc cctctttctc tctcttgggg
901 taaaaggcac agtgtggata caagtccagg atatcatgag tcagattcca agaagtctga
961 agatctatcc ttgtgtaatg ttgctgagca cagcaataca acagaggggc caacaggaaa
1021 gcaggaggga gctcagagcg tggaagagat gtttgaagaa gaagctgaag aagaggtgtt
1081 cctcaaattt gtgatattgc atgcagaaga tgacacagat gaagccctca gagtccagaa
1141 tctgctacaa gatgactttg gtatcaaacc cggaataatc tttgctgaga tgccatgtgg
1201 cagacagcat ttacagaatt tagatgatgc tgtaaatggg tctgcatgga caatcttatt
1261 actgactgaa aactttttaa gagatacttg gtgtaatttc cagttctata cgtccctaat
1321 gaactccgtt aacaggcagc ataaatacaa ctctgttata cccatgcggc ccctgaacaa
1381 tccccttccc cgagaaagga ctccctttgc cctccaaacc atcaatgcct tagaggaaga
1441 aagtcgtgga tttcctacac aagtagaaag aatttttcag gagtctgtgt ataagacaca
1501 acaaactata tggaaagaga caagaaatat ggtacaaaga caatttattg cctgagatga
1561 aacatataac atgtggctgg ctcttgtttt gtaaaccaaa tgattaatct tcacttgaga
1621 aagcagtttc taggaaatgt ttaaataaaa gagagtcttc accttaaaga aacctatgga
1681 gcacaagaaa gataaatttc tgcaggacag cctataaaat tgtggtactt tttgatgttt
1741 cagtaaactt gacattgtca gagtttcaag gacttttctt tcacaatttt cctagttcat
1801 ggatatgaaa aaggaattct caatccatat tccttgtatt gaaccttgaa caaaaacttg
1861 tatgacagac atttttaaaa atgtgacaac acttttattc tctgaatttt gatctcaaag
1921 gacacagaaa aaaaatggcc ccaggagatc tgatcacact tcctcctgag gcacctctca
1981 tggatgttgc aataagcatt cgggtactat cacccagaaa tatgaattgc cagaatagaa
2041 catttagcat gttaagcgtt gatgcatata aaatcagaaa tagatgtgag aatggtggaa
2101 ctttttaaaa gaacccagtc aaatgtattt tctgctgaaa tctgcatatt tggaggcatt
2161 tcccaccacc gattcacagc ccatttgata gtgtggtagt tagggacttc gtggagtggt
2221 gttcagacgt cccctggggc ttaaatctct tcatattagt catcatttgt aactatggct
2281 ttatttgcag agcttctaaa aggcgtataa ctgtgtgagt ggccagatat tcacttttta
2341 aatcaaaaac ctctcttatg gaagctttaa aagtttccgt cacacacaat tctcttctca
2401 ggaagtattt ctcatttagg tcttcaaagt agcctgactg tgtgcatgtg tgtgtgtgat
2461 aggttattta taaagacttt ggatagaagg agatgtattt tattacctcc tattctagag
2521 ccccatgctc ctaacaagcc agagaggccc caaacaggat tgtttctttc ctccacagcc
2581 cttctgccca tctgagattg agggagcatc gtccacttga gatcagggat ggggtggaga
2641 atgggtcatg tcatgtaatg agaaaagccc tcttcgggat catgagactt ggttctagtc
2701 caatttctgc cactgaggat gaatgtaact gtgggcaaac tatttaccct cctttatctg
2761 tgaaatgaaa gggttgaatt gatggatctc taaaggcttt tgtcctctat gaggatgtga
2821 aaaactaggg accacaaaag ggaacaagca aaaaagtttg gattcgataa agtgatatgt
2881 aatagttgca gaaggcttta tatatgctta taatgaaaag atattttttg tatattgaca
2941 gcataattta tttttaatgc tgtcattaca cttaaagtca caggaaaaaa atatacatgc
3001 ttactcaggc tttcttaaaa ataaattttt atagagatcc ttgagtaaag acattttgct
3061 taatttcttt tttcttattc cccacttgta tatcccctac cagtaccggg atctgcacac
3121 atctttttgc agttacctct tcatagccat gaaccaaaac gttctatgag gagcatgcaa
3181 gtaagtcaag cctcctattc tgttagtact tattagagga ggagatggtt ttcattgcat
3241 agtgacattt tcttagcctt aacgttctga tagtagctta ctactcactt ctctttttca
3301 gttttcataa taagtattca tttttttgcc ataatgcttc ctgtaaagcc aattttatat
3361 actaataaaa catgaactgc ccactcttca tgcctgccaa acttggggca attgatgcta
3421 aatggtattt ttaaaataaa tgtttttatt ctt
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