LOCUS AY302110 2511 bp mRNA linear HUM 20-MAR-2006
DEFINITION Homo sapiens MDIG (MDIG) mRNA, complete cds; alternatively spliced.
ACCESSION AY302110
VERSION AY302110.3
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2511)
AUTHORS Zhang,Y., Lu,Y., Yuan,B.Z., Castranova,V., Shi,X., Stauffer,J.L.,
Demers,L.M. and Chen,F.
TITLE The Human mineral dust-induced gene, mdig, is a cell growth
regulating gene associated with lung cancer
JOURNAL Oncogene 24 (31), 4873-4882 (2005)
PUBMED 15897898
REFERENCE 2 (bases 1 to 2511)
AUTHORS Chen,F. and Demers,L.M.
TITLE Direct Submission
JOURNAL Submitted (17-MAY-2003) Pathology and Physiology, National
Institute for Occupational Safety and Health, 1095 Willowdale Road,
Morgantown, WV 26505, USA
REFERENCE 3 (bases 1 to 2511)
AUTHORS Chen,F.
TITLE Direct Submission
JOURNAL Submitted (10-AUG-2004) Pathology and Physiology Research Branch,
National Institute for Occupational Safety and Health, 1095
Willowdale Road, Morgantown, WV 26505, USA
REMARK Sequence update by submitter
REFERENCE 4 (bases 1 to 2511)
AUTHORS Chen,F.
TITLE Direct Submission
JOURNAL Submitted (20-MAR-2006) Pathology and Physiology Research Branch,
National Institute for Occupational Safety and Health, 1095
Willowdale Road, Morgantown, WV 26505, USA
REMARK Sequence update by submitter
COMMENT On Mar 20, 2006 this sequence version replaced AY302110.2.
FEATURES Location/Qualifiers
source 1..2511
/db_xref="H-InvDB:HIT000251520"
/organism="Homo sapiens"
/mol_type="mRNA"
/isolation_source="coal miners exposed to silica or other
mineral dusts for a number of years"
/db_xref="taxon:9606"
/chromosome="3"
/cell_type="alveolar macrophages"
/note="corresponds to EST BE441202"
gene 1..2511
/gene="MDIG"
CDS 281..1678
/gene="MDIG"
/note="mineral dust induced gene; lung fibrosis- and
cancer-associated; contains an extended exon 10"
/codon_start=1
/product="MDIG"
/protein_id="AAP59421.1"
/translation="MPKKAKPTGSGKEEGPAPCKQMKLEAAGGPSALNFDSPSSLFES
LISPIKTETFFKEFWEQKPLLIQRDDPALATYYGSLFKLTDLKSLCSRGMYYGRDVNV
CRCVNGKKKVLNKDGKAHFLQLRKDFDQKRATIQFHQPQRFKDELWRIQEKLECYFGS
LVGSNVYITPAGSQGLPPHYDDVEVFILQLEGEKHWRLYHPTVPLAREYSVEAEERIG
RPVHEFMLKPGDLLYFPRGTIHQADTPAGLAHSTHVTISTYQNNSWGDFLLDTISGLV
FDTAKEDVELRTGIPRQLLLQVESTTVATRRLSGFLRTLADRLEGTKELLSSDMKKDF
IMHRLPPYSAGDGAELSTPGGKLPRLDSVVRLQFKDHIVLTVLPDQDQSDEAQEKMVY
IYHSLKNSRETHMMGNEEETEFHGLRFPLSHLDALKQIWNSPAISVKDLKLTTDEEKE
SLVLSLWTECLIQVV"
misc_feature 395..1000
/gene="MDIG"
/note="COG2850; Region: uncharacterized conserved region"
BASE COUNT 756 a 509 c 612 g 634 t
ORIGIN
1 atctaggggt agggtcgcgg aagccttggt tacagagagt cgcacacgtg gcctgctaat
61 ggtcgcgaca ccggtgacga gcgcacggaa agtttggagg cttagcaagg agggtggtgc
121 cggcctccgc ccggtggtgg cagaactgcc tgtgcgagca cggcttccac gtgggctgcg
181 ccgccgggcg tcatgtcggg cctaagagac acgctctaca gctgtgaaat ctgaagttca
241 ggtttgcatt tccttactgc tttgtcttga agacagaacg atgccaaaga aagcaaagcc
301 tacagggagt gggaaggaag aggggccggc tccctgtaag cagatgaagt tagaagcagc
361 tggggggcct tcagctttaa actttgacag tcccagtagt ctctttgaaa gtttaatctc
421 gcccatcaag acagagactt ttttcaagga attctgggag cagaagcccc ttctcattca
481 gagagatgac cctgcactgg ccacatacta tgggtccctg ttcaagctaa cagatctgaa
541 gagtctgtgc agccggggga tgtactatgg aagagatgtg aatgtctgcc ggtgtgtcaa
601 tgggaagaag aaggttttaa ataaagatgg caaagcacac tttcttcagc tgagaaaaga
661 ttttgatcag aaaagggcaa cgattcagtt tcaccaacct cagagattta aggatgagct
721 ttggaggatc caggagaagc tggaatgtta ctttggctcc ttggttggct cgaatgtgta
781 cataactccc gcaggatctc agggcctgcc gccccattat gatgatgtcg aggttttcat
841 cctgcagctg gagggagaga aacactggcg cctctaccac cccactgtgc ccctggcacg
901 agagtacagc gtggaggccg aggaaaggat cggcaggccg gtgcatgagt ttatgctgaa
961 gccgggtgat ttgttgtact ttcccagagg aaccattcat caagcggaca ctcctgcggg
1021 gctggcccac tctactcacg tgaccatcag cacctaccag aacaattcat ggggagattt
1081 ccttttggat accatctcgg ggcttgtatt tgatactgca aaggaagacg tggagttacg
1141 gaccggcata ccccggcagc tgctcctgca ggtggaatcc acaactgttg ctacaagacg
1201 attaagtggc ttcctgagga cacttgcaga ccggctggag ggcaccaaag aactgctttc
1261 ctcagacatg aagaaggatt ttattatgca cagactcccc ccttactctg cgggagatgg
1321 ggcagagctg tcaacaccag gtggaaagtt accgaggctg gacagtgtag tgagactgca
1381 gtttaaagac cacattgtcc tcacagtact gccggatcaa gatcaatctg atgaagctca
1441 agaaaagatg gtgtacatct atcattcctt aaagaatagt agagagacac acatgatggg
1501 aaatgaggag gaaacagagt ttcatggact tcgcttccct ttgtcacatt tggatgcact
1561 gaagcaaatt tggaatagtc cagctatttc tgtcaaggac ctgaaactta ctacagatga
1621 ggaaaaggaa agcctggtat tatccctctg gacagaatgt ttaattcaag tagtctagtg
1681 cctttgcaga atcaaatgcc tactatttta tatgcatata ttaaaagaaa agcaaagacc
1741 tgagccgagg agaggatgaa ttcaagtttc cttacctgcg tatctactaa caaacatgag
1801 acctccctgt tacaggtggt cagttggcca aatgtactaa cgggcacatg aaagaaagaa
1861 cagcaaatta ccaagtgtct cagaaaatga caaaaccata ttttgacaag tttatttaat
1921 ccagtgtggt agaaaaggca caattccaat gtatcattta gaattgaatg tcattaacct
1981 ggctttgttc tttggaagaa acaacttctt taaagagctt ctttggctct agaaaaattt
2041 caaacaatta aaataagaaa aaattttaaa ctggtttttt ataatgaaaa tatacatacc
2101 tttgtgtata gacaagccca tgcccattaa aataaagtta tcctgtaaca taaattttat
2161 taaataatac ttccccacag atgagaggca cgcaacacct atggacaaaa gggagttaca
2221 gaggctgctt aaaagatgga gaaaagcctg agattgaagg aggaaaaaaa cccagtattt
2281 aaagtctata aaaaatactc aaaatagtgg gtcttcgagt ttaaaatagt cattgttatt
2341 ttacattcta aagtgcatgt aggttgatat tttttaaaat atcattggag aatttaatct
2401 ttctttataa aaatagagca tttttctgct ttctggcaaa agttggggat aaaaggaaaa
2461 aaagttgtca aaatgtaatt ttcagtccaa ttcaccagga aaacatgctt g
//