LOCUS       AY258597                1002 bp    DNA     linear   HUM 29-APR-2003
DEFINITION  Homo sapiens PTC bitter taste receptor (PTC) gene, PTC-taster
            allele, complete cds.
ACCESSION   AY258597
VERSION     AY258597.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1002)
  AUTHORS   Kim,U.K., Jorgenson,E., Coon,H., Leppert,M., Risch,N. and Drayna,D.
  TITLE     Positional cloning of the human quantitative trait locus underlying
            taste sensitivity to phenylthiocarbamide
  JOURNAL   Science 299 (5610), 1221-1225 (2003)
   PUBMED   12595690
REFERENCE   2  (bases 1 to 1002)
  AUTHORS   Kim,U.-K. and Drayna,D.T.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-MAR-2003) NIDCD, NIH, 5 Research Court, Rockville, MD
            20850, USA
FEATURES             Location/Qualifiers
     source          1..1002
                     /db_xref="H-InvDB:HIT000385976"
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q35-q36"
     gene            <1..>1002
                     /gene="PTC"
                     /allele="taster"
     mRNA            <1..>1002
                     /gene="PTC"
                     /allele="taster"
                     /product="PTC bitter taste receptor"
     CDS             1..1002
                     /gene="PTC"
                     /allele="taster"
                     /note="7 transmembrane G protein coupled receptor"
                     /codon_start=1
                     /product="PTC bitter taste receptor"
                     /protein_id="AAP14666.1"
                     /translation="MLTLTRIRTVSYEVRSTFLFISVLEFAVGFLTNAFVFLVNFWDV
                     VKRQPLSNSDCVLLCLSISRLFLHGLLFLSAIQLTHFQKLSEPLNHSYQAIIMLWMIA
                     NQANLWLAACLSLLYCSKLIRFSHTFLICLASWVSRKISQMLLGIILCSCICTVLCVW
                     CFFSRPHFTVTTVLFMNNNTRLNWQIKDLNLFYSFLFCYLWSVPPFLLFLVSSGMLTV
                     SLGRHMRTMKVYTRNSRDPSLEAHIKALKSLVSFFCFFVISSCAAFISVPLLILWRDK
                     IGVMVCVGIMAACPSGHAAVLISGNAKLRRAVMTILLWAQSSLKVRADHKADSRTLC"
     variation       145
                     /gene="PTC"
                     /note="compared to TAS2R38 sequence found in GenBank
                     Accession Number AF494231; results in proline to alanine
                     amino acid change"
                     /replace="g"
     variation       557
                     /gene="PTC"
                     /note="compared to TAS2R38 sequence found in GenBank
                     Accession Number AF494231; results in isoleucine to
                     asparagine amino acid change"
                     /replace="a"
     variation       785
                     /gene="PTC"
                     /note="compared to TAS2R38 sequence found in GenBank
                     Accession Number AF494231; results in alanine to valine
                     amino acid change"
                     /replace="t"
     variation       886
                     /gene="PTC"
                     /note="compared to TAS2R38 sequence found in GenBank
                     Accession Number AF494231; results in valine to isoleucine
                     amino acid change"
                     /replace="a"
BASE COUNT          201 a          264 c          229 g          308 t
ORIGIN      
        1 atgttgactc taactcgcat ccgcactgtg tcctatgaag tcaggagtac atttctgttc
       61 atttcagtcc tggagtttgc agtggggttt ctgaccaatg ccttcgtttt cttggtgaat
      121 ttttgggatg tagtgaagag gcagccactg agcaacagtg attgtgtgct gctgtgtctc
      181 agcatcagcc ggcttttcct gcatggactg ctgttcctga gtgctatcca gcttacccac
      241 ttccagaagt tgagtgaacc actgaaccac agctaccaag ccatcatcat gctatggatg
      301 attgcaaacc aagccaacct ctggcttgct gcctgcctca gcctgcttta ctgctccaag
      361 ctcatccgtt tctctcacac cttcctgatc tgcttggcaa gctgggtctc caggaagatc
      421 tcccagatgc tcctgggtat tattctttgc tcctgcatct gcactgtcct ctgtgtttgg
      481 tgctttttta gcagacctca cttcacagtc acaactgtgc tattcatgaa taacaataca
      541 aggctcaact ggcagattaa agatctcaat ttattttatt cctttctctt ctgctatctg
      601 tggtctgtgc ctcctttcct attgtttctg gtttcttctg ggatgctgac tgtctccctg
      661 ggaaggcaca tgaggacaat gaaggtctat accagaaact ctcgtgaccc cagcctggag
      721 gcccacatta aagccctcaa gtctcttgtc tcctttttct gcttctttgt gatatcatcc
      781 tgtgctgcct tcatctctgt gcccctactg attctgtggc gcgacaaaat aggggtgatg
      841 gtttgtgttg ggataatggc agcttgtccc tctgggcatg cagccgtcct gatctcaggc
      901 aatgccaagt tgaggagagc tgtgatgacc attctgctct gggctcagag cagcctgaag
      961 gtaagagccg accacaaggc agattcccgg acactgtgct ga
//