LOCUS AY258597 1002 bp DNA linear HUM 29-APR-2003 DEFINITION Homo sapiens PTC bitter taste receptor (PTC) gene, PTC-taster allele, complete cds. ACCESSION AY258597 VERSION AY258597.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1002) AUTHORS Kim,U.K., Jorgenson,E., Coon,H., Leppert,M., Risch,N. and Drayna,D. TITLE Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide JOURNAL Science 299 (5610), 1221-1225 (2003) PUBMED 12595690 REFERENCE 2 (bases 1 to 1002) AUTHORS Kim,U.-K. and Drayna,D.T. TITLE Direct Submission JOURNAL Submitted (17-MAR-2003) NIDCD, NIH, 5 Research Court, Rockville, MD 20850, USA FEATURES Location/Qualifiers source 1..1002 /db_xref="H-InvDB:HIT000385976" /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /chromosome="7" /map="7q35-q36" gene <1..>1002 /gene="PTC" /allele="taster" mRNA <1..>1002 /gene="PTC" /allele="taster" /product="PTC bitter taste receptor" CDS 1..1002 /gene="PTC" /allele="taster" /note="7 transmembrane G protein coupled receptor" /codon_start=1 /product="PTC bitter taste receptor" /protein_id="AAP14666.1" /translation="MLTLTRIRTVSYEVRSTFLFISVLEFAVGFLTNAFVFLVNFWDV VKRQPLSNSDCVLLCLSISRLFLHGLLFLSAIQLTHFQKLSEPLNHSYQAIIMLWMIA NQANLWLAACLSLLYCSKLIRFSHTFLICLASWVSRKISQMLLGIILCSCICTVLCVW CFFSRPHFTVTTVLFMNNNTRLNWQIKDLNLFYSFLFCYLWSVPPFLLFLVSSGMLTV SLGRHMRTMKVYTRNSRDPSLEAHIKALKSLVSFFCFFVISSCAAFISVPLLILWRDK IGVMVCVGIMAACPSGHAAVLISGNAKLRRAVMTILLWAQSSLKVRADHKADSRTLC" variation 145 /gene="PTC" /note="compared to TAS2R38 sequence found in GenBank Accession Number AF494231; results in proline to alanine amino acid change" /replace="g" variation 557 /gene="PTC" /note="compared to TAS2R38 sequence found in GenBank Accession Number AF494231; results in isoleucine to asparagine amino acid change" /replace="a" variation 785 /gene="PTC" /note="compared to TAS2R38 sequence found in GenBank Accession Number AF494231; results in alanine to valine amino acid change" /replace="t" variation 886 /gene="PTC" /note="compared to TAS2R38 sequence found in GenBank Accession Number AF494231; results in valine to isoleucine amino acid change" /replace="a" BASE COUNT 201 a 264 c 229 g 308 t ORIGIN 1 atgttgactc taactcgcat ccgcactgtg tcctatgaag tcaggagtac atttctgttc 61 atttcagtcc tggagtttgc agtggggttt ctgaccaatg ccttcgtttt cttggtgaat 121 ttttgggatg tagtgaagag gcagccactg agcaacagtg attgtgtgct gctgtgtctc 181 agcatcagcc ggcttttcct gcatggactg ctgttcctga gtgctatcca gcttacccac 241 ttccagaagt tgagtgaacc actgaaccac agctaccaag ccatcatcat gctatggatg 301 attgcaaacc aagccaacct ctggcttgct gcctgcctca gcctgcttta ctgctccaag 361 ctcatccgtt tctctcacac cttcctgatc tgcttggcaa gctgggtctc caggaagatc 421 tcccagatgc tcctgggtat tattctttgc tcctgcatct gcactgtcct ctgtgtttgg 481 tgctttttta gcagacctca cttcacagtc acaactgtgc tattcatgaa taacaataca 541 aggctcaact ggcagattaa agatctcaat ttattttatt cctttctctt ctgctatctg 601 tggtctgtgc ctcctttcct attgtttctg gtttcttctg ggatgctgac tgtctccctg 661 ggaaggcaca tgaggacaat gaaggtctat accagaaact ctcgtgaccc cagcctggag 721 gcccacatta aagccctcaa gtctcttgtc tcctttttct gcttctttgt gatatcatcc 781 tgtgctgcct tcatctctgt gcccctactg attctgtggc gcgacaaaat aggggtgatg 841 gtttgtgttg ggataatggc agcttgtccc tctgggcatg cagccgtcct gatctcaggc 901 aatgccaagt tgaggagagc tgtgatgacc attctgctct gggctcagag cagcctgaag 961 gtaagagccg accacaaggc agattcccgg acactgtgct ga //