LOCUS AY245867 2758 bp mRNA linear HUM 15-OCT-2003
DEFINITION Homo sapiens cAMP-specific phosphodiesterase variant PDE4D9 (PDE4D)
mRNA, complete cds; alternatively spliced.
ACCESSION AY245867
VERSION AY245867.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2758)
AUTHORS Gretarsdottir,S., Thorleifsson,G., Reynisdottir,S.T., Manolescu,A.,
Jonsdottir,S., Jonsdottir,T., Gudmundsdottir,T., Bjarnadottir,S.M.,
Einarsson,O.B., Gudjonsdottir,H.M., Hawkins,M., Gudmundsson,G.,
Gudmundsdottir,H., Andrason,H., Gudmundsdottir,A.S.,
Sigurdardottir,M., Chou,T.T., Nahmias,J., Goss,S.,
Sveinbjornsdottir,S., Valdimarsson,E.M., Jakobsson,F.,
Agnarsson,U., Gudnason,V., Thorgeirsson,G., Fingerle,J., Gurney,M.,
Gudbjartsson,D., Frigge,M.L., Kong,A., Stefansson,K. and
Gulcher,J.R.
TITLE The gene encoding phosphodiesterase 4D confers risk of ischemic
stroke
JOURNAL Nat. Genet. 35 (2), 131-138 (2003)
PUBMED 14517540
REMARK Erratum:[Nat Genet. 2005 May;37(5):555]
REFERENCE 2 (bases 1 to 2758)
AUTHORS Gretarsdottir,S., Sigurdardottir,M., Ronnenberg,J.A., Hemesath,T.
and Gulcher,J.R.
TITLE Direct Submission
JOURNAL Submitted (03-MAR-2003) deCODE Genetics, Sturlugata 8, Reykjavik
101, Iceland
FEATURES Location/Qualifiers
source 1..2758
/db_xref="H-InvDB:HIT000251183"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="5"
/cell_line="HeLa"
gene 1..2758
/gene="PDE4D"
CDS 718..2757
/gene="PDE4D"
/note="alternatively spliced"
/codon_start=1
/product="cAMP-specific phosphodiesterase variant PDE4D9"
/protein_id="AAP75761.1"
/translation="MSIIMKPRSRSTSSLRTAEAVCFDVDNGTSAGRSPLDPMTSPGS
GLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLAS
LRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQ
LETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPS
PTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGL
HVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNN
IHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELA
LMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMN
LLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRI
MEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQD
ILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGS
QVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT"
BASE COUNT 802 a 623 c 611 g 722 t
ORIGIN
1 ttctcactgc cctgcggtgt tttgaactgc cttcttacag acgtcataca gcccttgagg
61 aatagtttct gcctggtgag attgaatgat agttctcatt cacaaaaccc tggattctaa
121 gcagggacac acagaaatta ctttcgcagg taaatcagcc cacccagcca aagtgtggag
181 agatttgttc cttggctgac ttctttgctc cacggagagg agtgttttcc tgtgcttgcc
241 ctgaaatgga acttccttga cagctctccc gtgttacagt acctcccggt cattttcttt
301 ttctctctct ctacctgcgc tcttcgagtg tcagaaacct ttaaagctgt tactatggaa
361 ttgcaaaaaa gagatcaagt gactctttca ctatgctggt ttcccttgtg acccagatga
421 agaatcaatt cagaattcag ttcctccctt ggcattgcaa gacacagaag aaactgtcac
481 ttcctaacag cctagtactg gagtaaattc agtatgaagg aagaaagcgc tcctgcgtgt
541 tagaaccttg cccatgagct ggaccgagga caggagatgg actccaggaa aattggattt
601 cttcaagcag cctcccttgg aaatggaata tctttaaaat cttctttgca gaaagacagt
661 tagaatgtat taatcagaat agttgaagac ttattttcct ttttattttt tttcaaaatg
721 agcattatta tgaagccaag atcccgatct acaagttccc taaggactgc agaggcagtt
781 tgttttgatg tggacaatgg cacatctgcg ggacggagtc ccttggatcc catgaccagc
841 ccaggatccg ggctaattct ccaagcaaat tttgtccaca gtcaacgacg ggagtccttc
901 ctgtatcgat ccgacagcga ttatgacctc tctccaaagt ctatgtcccg gaactcctcc
961 attgccagtg atatacacgg agatgacttg attgtgactc catttgctca ggtcttggcc
1021 agtctgcgaa ctgtacgaaa caactttgct gcattaacta atttgcaaga tcgagcacct
1081 agcaaaagat cacccatgtg caaccaacca tccatcaaca aagccaccat aacagaggag
1141 gcctaccaga aactggccag cgagaccctg gaggagctgg actggtgtct ggaccagcta
1201 gagaccctac agaccaggca ctccgtcagt gagatggcct ccaacaagtt taaaaggatg
1261 cttaatcggg agctcaccca tctctctgaa atgagtcggt ctggaaatca agtgtcagag
1321 tttatatcaa acacattctt agataagcaa catgaagtgg aaattccttc tccaactcag
1381 aaggaaaagg agaaaaagaa aagaccaatg tctcagatca gtggagtcaa gaaattgatg
1441 cacagctcta gtctgactaa ttcaagtatc ccaaggtttg gagttaaaac tgaacaagaa
1501 gatgtccttg ccaaggaact agaagatgtg aacaaatggg gtcttcatgt tttcagaata
1561 gcagagttgt ctggtaaccg gcccttgact gttatcatgc acaccatttt tcaggaacgg
1621 gatttattaa aaacatttaa aattccagta gatactttaa ttacatatct tatgactctc
1681 gaagaccatt accatgctga tgtggcctat cacaacaata tccatgctgc agatgttgtc
1741 cagtctactc atgtgctatt atctacacct gctttggagg ctgtgtttac agatttggag
1801 attcttgcag caatttttgc cagtgcaata catgatgtag atcatcctgg tgtgtccaat
1861 caatttctga tcaatacaaa ctctgaactt gccttgatgt acaatgattc ctcagtctta
1921 gagaaccatc atttggctgt gggctttaaa ttgcttcagg aagaaaactg tgacattttc
1981 cagaatttga ccaaaaaaca aagacaatct ttaaggaaaa tggtcattga catcgtactt
2041 gcaacagata tgtcaaaaca catgaatcta ctggctgatt tgaagactat ggttgaaact
2101 aagaaagtga caagctctgg agttcttctt cttgataatt attccgatag gattcaggtt
2161 cttcagaata tggtgcactg tgcagatctg agcaacccaa caaagcctct ccagctgtac
2221 cgccagtgga cggaccggat aatggaggag ttcttccgcc aaggagaccg agagagggaa
2281 cgtggcatgg agataagccc catgtgtgac aagcacaatg cttccgtgga aaaatcacag
2341 gtgggcttca tagactatat tgttcatccc ctctgggaga catgggcaga cctcgtccac
2401 cctgacgccc aggatatttt ggacactttg gaggacaatc gtgaatggta ccagagcaca
2461 atccctcaga gcccctctcc tgcacctgat gacccagagg agggccggca gggtcaaact
2521 gagaaattcc agtttgaact aactttagag gaagatggtg agtcagacac ggaaaaggac
2581 agtggcagtc aagtggaaga agacactagc tgcagtgact ccaagactct ttgtactcaa
2641 gactcagagt ctactgaaat tccccttgat gaacaggttg aagaggaggc agtaggggaa
2701 gaagaggaaa gccagcctga agcctgtgtc atagatgatc gttctcctga cacgtaac
//