LOCUS AY245866 2465 bp mRNA linear HUM 15-OCT-2003
DEFINITION Homo sapiens cAMP-specific phosphodiesterase variant PDE4D7 (PDE4D)
mRNA, complete cds; alternatively spliced.
ACCESSION AY245866
VERSION AY245866.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2465)
AUTHORS Gretarsdottir,S., Thorleifsson,G., Reynisdottir,S.T., Manolescu,A.,
Jonsdottir,S., Jonsdottir,T., Gudmundsdottir,T., Bjarnadottir,S.M.,
Einarsson,O.B., Gudjonsdottir,H.M., Hawkins,M., Gudmundsson,G.,
Gudmundsdottir,H., Andrason,H., Gudmundsdottir,A.S.,
Sigurdardottir,M., Chou,T.T., Nahmias,J., Goss,S.,
Sveinbjornsdottir,S., Valdimarsson,E.M., Jakobsson,F.,
Agnarsson,U., Gudnason,V., Thorgeirsson,G., Fingerle,J., Gurney,M.,
Gudbjartsson,D., Frigge,M.L., Kong,A., Stefansson,K. and
Gulcher,J.R.
TITLE The gene encoding phosphodiesterase 4D confers risk of ischemic
stroke
JOURNAL Nat. Genet. 35 (2), 131-138 (2003)
PUBMED 14517540
REMARK Erratum:[Nat Genet. 2005 May;37(5):555]
REFERENCE 2 (bases 1 to 2465)
AUTHORS Gretarsdottir,S., Sigurdardottir,M., Ronnenberg,J.A., Hemesath,T.
and Gulcher,J.R.
TITLE Direct Submission
JOURNAL Submitted (03-MAR-2003) deCODE Genetics, Sturlugata 8, Reykjavik
IS-101, Iceland
FEATURES Location/Qualifiers
source 1..2465
/db_xref="H-InvDB:HIT000251182"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="5"
/cell_line="SKNAS"
gene 1..2465
/gene="PDE4D"
5'UTR 1..211
/gene="PDE4D"
/note="alternatively spliced; PED4D7A"
CDS 212..2458
/gene="PDE4D"
/codon_start=1
/product="cAMP-specific phosphodiesterase variant PDE4D7"
/protein_id="AAP75760.1"
/translation="MKRNTCDLLSRSKSASEETLHSSNEEEDPFRGMEPYLVRRLSCR
NIQLPPLAFRQLEQADLKSESENIQRPTSLPLKILPLIAITSAESSGFDVDNGTSAGR
SPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDL
IVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASE
TLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTF
LDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLA
KELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLED
HYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSN
QFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDI
VLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKP
LQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWET
WADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEED
GESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACV
IDDRSPDT"
3'UTR 2459..2465
/gene="PDE4D"
BASE COUNT 724 a 566 c 553 g 622 t
ORIGIN
1 atagttggcg taccctgagg cctgccagtt cctgccttaa tgcatatgta gtcgtaattg
61 agttctgaca cggccttgga tgtttctgtc ctaaatagct gacattgcat cttcaagact
121 gtcattccag ttggcttttg agtggatacg tgcagtgaga tcattgacac tggaaacact
181 agttcccatt ttaattactt aaaacaccac gatgaaaaga aatacctgtg atttgctttc
241 tcggagcaaa agtgcctctg aggaaacact acattccagt aatgaagagg aagacccttt
301 ccgcggaatg gaaccctatc ttgtccggag actttcatgt cgcaatattc agcttccccc
361 tctcgccttc agacagttgg aacaagctga cttgaaaagt gaatcagaga acattcaacg
421 accaaccagc ctccccctga agattctgcc gctgattgct atcacttctg cagaatccag
481 tggttttgat gtggacaatg gcacatctgc gggacggagt cccttggatc ccatgaccag
541 cccaggatcc gggctaattc tccaagcaaa ttttgtccac agtcaacgac gggagtcctt
601 cctgtatcga tccgacagcg attatgacct ctctccaaag tctatgtccc ggaactcctc
661 cattgccagt gatatacacg gagatgactt gattgtgact ccatttgctc aggtcttggc
721 cagtctgcga actgtacgaa acaactttgc tgcattaact aatttgcaag atcgagcacc
781 tagcaaaaga tcacccatgt gcaaccaacc atccatcaac aaagccacca taacagagga
841 ggcctaccag aaactggcca gcgagaccct ggaggagctg gactggtgtc tggaccagct
901 agagacccta cagaccaggc actccgtcag tgagatggcc tccaacaagt ttaaaaggat
961 gcttaatcgg gagctcaccc atctctctga aatgagtcgg tctggaaatc aagtgtcaga
1021 gtttatatca aacacattct tagataagca acatgaagtg gaaattcctt ctccaactca
1081 gaaggaaaag gagaaaaaga aaagaccaat gtctcagatc agtggagtca agaaattgat
1141 gcacagctct agtctgacta attcaagtat cccaaggttt ggagttaaaa ctgaacaaga
1201 agatgtcctt gccaaggaac tagaagatgt gaacaaatgg ggtcttcatg ttttcagaat
1261 agcagagttg tctggtaacc ggcccttgac tgttatcatg cacaccattt ttcaggaacg
1321 ggatttatta aaaacattta aaattccagt agatacttta attacatatc ttatgactct
1381 cgaagaccat taccatgctg atgtggccta tcacaacaat atccatgctg cagatgttgt
1441 ccagtctact catgtgctat tatctacacc tgctttggag gctgtgttta cagatttgga
1501 gattcttgca gcaatttttg ccagtgcaat acatgatgta gatcatcctg gtgtgtccaa
1561 tcaatttctg atcaatacaa actctgaact tgccttgatg tacaatgatt cctcagtctt
1621 agagaaccat catttggctg tgggctttaa attgcttcag gaagaaaact gtgacatttt
1681 ccagaatttg accaaaaaac aaagacaatc tttaaggaaa atggtcattg acatcgtact
1741 tgcaacagat atgtcaaaac acatgaatct actggctgat ttgaagacta tggttgaaac
1801 taagaaagtg acaagctctg gagttcttct tcttgataat tattccgata ggattcaggt
1861 tcttcagaat atggtgcact gtgcagatct gagcaaccca acaaagcctc tccagctgta
1921 ccgccagtgg acggaccgga taatggagga gttcttccgc caaggagacc gagagaggga
1981 acgtggcatg gagataagcc ccatgtgtga caagcacaat gcttccgtgg aaaaatcaca
2041 ggtgggcttc atagactata ttgttcatcc cctctgggag acatgggcag acctcgtcca
2101 ccctgacgcc caggatattt tggacacttt ggaggacaat cgtgaatggt accagagcac
2161 aatccctcag agcccctctc ctgcacctga tgacccagag gagggccggc agggtcaaac
2221 tgagaaattc cagtttgaac taactttaga ggaagatggt gagtcagaca cggaaaagga
2281 cagtggcagt caagtggaag aagacactag ctgcagtgac tccaagactc tttgtactca
2341 agactcagag tctactgaaa ttccccttga tgaacaggtt gaagaggagg cagtagggga
2401 agaagaggaa agccagcctg aagcctgtgt catagatgat cgttctcctg acacgtaaca
2461 gtgca
//