LOCUS AY228372 1782 bp mRNA linear HUM 30-MAR-2003
DEFINITION Homo sapiens vaccinia related kinase 2 isoform 6 (VRK2) mRNA,
complete cds; alternatively spliced.
ACCESSION AY228372
VERSION AY228372.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1782)
AUTHORS Suriyapperuma,S.P. and Sarfarazi,M.
TITLE Identification of 6 Different Isoforms for Vaccinia-Related Kinase
2 (VRK2) Gene
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 1782)
AUTHORS Suriyapperuma,S.P. and Sarfarazi,M.
TITLE Direct Submission
JOURNAL Submitted (31-JAN-2003) Molecular Ophthalmic Genetics Laboratory,
University of Connecticut Health Center, 263 Farmington Ave,
Farmington, CT 06030-1110, USA
FEATURES Location/Qualifiers
source 1..1782
/db_xref="H-InvDB:HIT000085398"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2p16-p15"
/cell_type="fibroblast"
gene 1..1782
/gene="VRK2"
CDS 116..1306
/gene="VRK2"
/note="protein kinase; contains a new 49-bp inserted
between exons 12 and 13; results in a newly created
premature stop codon in exon 13 and removes the last 112
amino acids of the wild type protein; alternatively
spliced"
/codon_start=1
/product="vaccinia related kinase 2 isoform 6"
/protein_id="AAO73052.1"
/translation="MPPKRNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIY
LAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPL
FYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHEN
EYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTS
LDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVL
KWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINV
HTPNSQKVDSQKAATKQVNKAHNRLIEKKVHSERSAESCATWKVQKEEKLIGLMNNEA
AQFR"
BASE COUNT 583 a 344 c 386 g 469 t
ORIGIN
1 gacgcagctg gagagaagtt aggcaggtcc tagggagggc aggctcgagt gctgggcccg
61 cctccccgcg ggactgtagg cccgggggct ccgcctcgtc gcagcggcag aagtgatgcc
121 accaaaaaga aatgaaaaat acaaacttcc tattccattt ccagaaggca aggttctgga
181 tgatatggaa ggcaatcagt gggtactggg caagaagatt ggctctggag gatttggatt
241 gatatattta gctttcccca caaataaacc agagaaagat gcaagacatg tagtaaaagt
301 ggaatatcaa gaaaatggcc cgttattttc agaacttaaa ttttatcaga gagttgcaaa
361 aaaagactgt atcaaaaagt ggatagaacg caaacaactt gattatttag gaattcctct
421 gttttatgga tctggtctga ctgaattcaa gggaagaagt tacagattta tggtaatgga
481 aagactagga atagatttac agaagatctc aggccagaat ggtaccttta aaaagtcaac
541 tgtcctgcaa ttaggtatcc gaatgttgga tgtactggaa tatatacatg aaaatgaata
601 tgttcatggt gatataaaag cagcaaatct acttttgggt tacaaaaatc cagaccaggt
661 ttatcttgca gattatggac tttcctacag atattgtccc aatgggaacc acaaacagta
721 tcaggaaaat cctagaaaag gccataatgg gacaatagag tttaccagct tggatgccca
781 caagggagta gccttgtcca gacgaagtga cgttgagatc ctcggctact gcatgctgcg
841 gtggttgtgt gggaaacttc cctgggaaca gaacctgaag gaccctgtgg ctgtgcagac
901 tgctaaaaca aatctgttgg acgagctccc ccagtcagtg cttaaatggg ctccttctgg
961 aagcagttgc tgtgaaatag cccaattttt ggtatgtgct catagtttag catatgatga
1021 aaagccaaac tatcaagccc tcaagaaaat tttgaaccct catggaatac ctttaggacc
1081 actggacttt tccacaaaag gacagagtat aaatgtccat actccaaaca gtcaaaaagt
1141 tgattcacaa aaggctgcaa caaagcaagt caacaaggca cacaataggt taatcgaaaa
1201 aaaagtccac agtgagagaa gcgctgagtc ctgtgcaaca tggaaagtgc agaaagagga
1261 gaaactgatt ggattgatga acaatgaagc agctcagttt aggtagaagc ttaggctatt
1321 gatttgaacc cactattttt tctaatgaaa gcacaaggag aagacagaaa tatcaagagt
1381 ctcaagaacc tttgaatgaa gtaaacagtt tcccacaaaa aatcagctat acacaattcc
1441 caaactcatt ttatgagcct catcaagatt ttaccagtcc agatatattc aagaagtcaa
1501 gatctccatc ttggtataaa tacacttcca cagtcagcac ggggatcaca gacttagaaa
1561 gttcaactgg actttggcct acaatttccc agtttactct tagtgaagag acaaacgcag
1621 atgtttatta ttatcgcatc atcatacctg tccttttgat gttagtattt cttgctttat
1681 tttttctctg aagatgatac caaaattcct tttgataatt ttttaagttt ccagctcttc
1741 accgaaatgt tgtattctta tttcagtgtt tccttccaga ca
//