LOCUS AY228371 1710 bp mRNA linear HUM 30-MAR-2003
DEFINITION Homo sapiens vaccinia related kinase 2 isoform 5 (VRK2) mRNA,
complete cds; alternatively spliced.
ACCESSION AY228371
VERSION AY228371.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1710)
AUTHORS Suriyapperuma,S.P. and Sarfarazi,M.
TITLE Identification of 6 Different Isoforms for Vaccinia-Related Kinase
2 (VRK2) Gene
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 1710)
AUTHORS Suriyapperuma,S.P. and Sarfarazi,M.
TITLE Direct Submission
JOURNAL Submitted (31-JAN-2003) Molecular Ophthalmic Genetics Laboratory,
University of Connecticut Health Center, 263 Farmington Ave,
Farmington, CT 06030-1110, USA
FEATURES Location/Qualifiers
source 1..1710
/db_xref="H-InvDB:HIT000085397"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2p16-p15"
/cell_type="fibroblast"
gene 1..1710
/gene="VRK2"
CDS 447..1619
/gene="VRK2"
/note="protein kinase; contains a 47-bp insertion after
exon 1 and a deletion of the entire of exon 4; results in
the removal of the first 118 amino acids of the wild type
protein encoded by exons 2-5; alternatively spliced"
/codon_start=1
/product="vaccinia related kinase 2 isoform 5"
/protein_id="AAO73051.1"
/translation="MVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEY
VHGDVKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLD
AHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKW
APSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHT
PNSQKVDSQKAATKQVNKAHNRLIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQ
ESTRRRQKYQESQEPLNEVNSFPQEISYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYK
YTSTVSTGITDLESSTGLWPTISQFTLSEETNADVYYYRIIIPVLLMLVFLALFFL"
BASE COUNT 544 a 342 c 392 g 432 t
ORIGIN
1 gacgcagctg gagagaagtt aggcaggtcc tagggagggc aggctcgagt gctgggcccg
61 cctccccgcg ggactgtagg cccgggggct ccgcctcgtc gcagcggcag gtaggaggcg
121 gtgcgcgcgg cccggcgacg ggggatcctg aggcccgaag tgatgccacc aaaaagaaat
181 gaaaaataca aacttcctat tccatttcca gaaggcaagg ttctggatga tatggaaggc
241 aatcagtggg tactgggcaa gaagattggc tctggaggat ttggattgat atatttagct
301 ttccccacaa ataaaccaga gaaagatgca agacatgtag taaaagtgtc aaaaagtgga
361 tagaacgcaa acaacttgat tatttaggaa ttcctctgtt ttatggatct ggtctgactg
421 aattcaaggg aagaagttac agatttatgg taatggaaag actaggaata gatttacaga
481 agatctcagg ccagaatggt acctttaaaa agtcaactgt cctgcaatta ggtatccgaa
541 tgttggatgt actggaatat atacatgaaa atgaatatgt tcatggtgat gtaaaagcag
601 caaatctact tttgggttac aaaaatccag accaggttta tcttgcagat tatggacttt
661 cctacagata ttgtcccaat gggaaccaca aacagtatca ggaaaatcct agaaaaggcc
721 ataatgggac aatagagttt accagcttgg atgcccacaa gggagtagcc ttgtccagac
781 gaagtgacgt tgagatcctc ggctactgca tgctgcggtg gttgtgtggg aaacttccct
841 gggaacagaa cctgaaggac cctgtggctg tgcagactgc taaaacaaat ctgttggacg
901 agctccccca gtcagtgctt aaatgggctc cttctggaag cagttgctgt gaaatagccc
961 aatttttggt atgtgctcat agtttagcat atgatgaaaa gccaaactat caagccctca
1021 agaaaatttt gaaccctcat ggaatacctt taggaccact ggacttttcc acaaaaggac
1081 agagtataaa tgtccatact ccaaacagtc aaaaagttga ttcacaaaag gctgcaacaa
1141 agcaagtcaa caaggcacac aataggttaa tcgaaaaaaa agtccacagt gagagaagcg
1201 ctgagtcctg tgcaacatgg aaagtgcaga aagaggagaa actgattgga ttgatgaaca
1261 atgaagcagc tcaggaaagc acaaggagaa gacagaaata tcaagagtct caagaacctt
1321 tgaatgaagt aaacagtttc ccacaagaaa tcagctatac acaattccca aactcatttt
1381 atgagcctca tcaagatttt accagtccag atatattcaa gaagtcaaga tctccatctt
1441 ggtataaata cacttccaca gtcagcacgg ggatcacaga cttagaaagt tcaactggac
1501 tttggcctac aatttcccag tttactctta gtgaagagac aaacgcagat gtttattatt
1561 atcgcatcat catacctgtc cttttgatgt tagtatttct tgctttattt tttctctgaa
1621 gatgatacca aaattccttt tgataatttt ttaagtttcc agctcttcac cgaaatgttg
1681 tattcttatt tcagtgtttc cttccagaca
//