LOCUS AY228369 1678 bp mRNA linear HUM 30-MAR-2003
DEFINITION Homo sapiens vaccinia related kinase 2 isoform 3 (VRK2) mRNA,
complete cds; alternatively spliced.
ACCESSION AY228369
VERSION AY228369.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1678)
AUTHORS Suriyapperuma,S.P. and Sarfarazi,M.
TITLE Identification of 6 Different Isoforms for Vaccinia-Related Kinase
2 (VRK2) Gene
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 1678)
AUTHORS Suriyapperuma,S.P. and Sarfarazi,M.
TITLE Direct Submission
JOURNAL Submitted (31-JAN-2003) Molecular Ophthalmic Genetics Laboratory,
University of Connecticut Health Center, 263 Farmington Ave,
Farmington, CT 06030-1110, USA
FEATURES Location/Qualifiers
source 1..1678
/db_xref="H-InvDB:HIT000085395"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2p16-p15"
/cell_type="fibroblast"
gene 1..1678
/gene="VRK2"
CDS 130..1587
/gene="VRK2"
/note="protein kinase; contains a deletion of the first
54-bp of exon 2; results in the removal of the first 23
amino acids of the wild type protein; alternatively
spliced"
/codon_start=1
/product="vaccinia related kinase 2 isoform 3"
/protein_id="AAO73049.1"
/translation="MEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQEN
GPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLG
IDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDVKAANLLLGYKNPDQVY
LADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCML
RWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLA
YDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHN
RLIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNS
FPQEISYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPT
ISQFTLSEETNADVYYYRIIIPVLLMLVFLALFFL"
BASE COUNT 544 a 324 c 374 g 436 t
ORIGIN
1 gagcagctgg agagaagtta ggcaggtcct agggagggca ggctcgagtg ctgggcccgc
61 ctccccgcgg gactgtaggc ccgggggctc cgcctcgtcg cagcggcaga aggcaaggtt
121 ctggatgata tggaaggcaa tcagtgggta ctgggcaaga agattggctc tggaggattt
181 ggattgatat atttagcttt ccccacaaat aaaccagaga aagatgcaag acatgtagta
241 aaagtggaat atcaagaaaa tggcccgtta ttttcagaac ttaaatttta tcagagagtt
301 gcaaaaaaag actgtatcaa aaagtggata gaacgcaaac aacttgatta tttaggaatt
361 cctctgtttt atggatctgg tctgactgaa ttcaagggaa gaagttacag atttatggta
421 atggaaagac taggaataga tttacagaag atctcaggcc agaatggtac ctttaaaaag
481 tcaactgtcc tgcaattagg tatccgaatg ttggatgtac tggaatatat acatgaaaat
541 gaatatgttc atggtgatgt aaaagcagca aatctacttt tgggttacaa aaatccagac
601 caggtttatc ttgcagatta tggactttcc tacagatatt gtcccaatgg gaaccacaaa
661 cagtatcagg aaaatcctag aaaaggccat aatgggacaa tagagtttac cagcttggat
721 gcccacaagg gagtagcctt gtccagacga agtgacgttg agatcctcgg ctactgcatg
781 ctgcggtggt tgtgtgggaa acttccctgg gaacagaacc tgaaggaccc tgtggctgtg
841 cagactgcta aaacaaatct gttggacgag ctcccccagt cagtgcttaa atgggctcct
901 tctggaagca gttgctgtga aatagcccaa tttttggtat gtgctcatag tttagcatat
961 gatgaaaagc caaactatca agccctcaag aaaattttga accctcatgg aataccttta
1021 ggaccactgg acttttccac aaaaggacag agtataaatg tccatactcc aaacagtcaa
1081 aaagttgatt cacaaaaggc tgcaacaaag caagtcaaca aggcacacaa taggttaatc
1141 gaaaaaaaag tccacagtga gagaagcgct gagtcctgtg caacatggaa agtgcagaaa
1201 gaggagaaac tgattggatt gatgaacaat gaagcagctc aggaaagcac aaggagaaga
1261 cagaaatatc aagagtctca agaacctttg aatgaagtaa acagtttccc acaagaaatc
1321 agctatacac aattcccaaa ctcattttat gagcctcatc aagattttac cagtccagat
1381 atattcaaga agtcaagatc tccatcttgg tataaataca cttccacagt cagcacgggg
1441 atcacagact tagaaagttc aactggactt tggcctacaa tttcccagtt tactcttagt
1501 gaagagacaa acgcagatgt ttattattat cgcatcatca tacctgtcct tttgatgtta
1561 gtatttcttg ctttattttt tctctgaaga tgataccaaa attccttttg ataatttttt
1621 aagtttccag ctcttcaccg aaatgttgta ttcttatttc agtgtttcct tccagaca
//