LOCUS AY228368 1780 bp mRNA linear HUM 30-MAR-2003
DEFINITION Homo sapiens vaccinia related kinase 2 isoform 2 (VRK2) mRNA,
complete cds; alternatively spliced.
ACCESSION AY228368
VERSION AY228368.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1780)
AUTHORS Suriyapperuma,S.P. and Sarfarazi,M.
TITLE Identification of 6 Different Isoforms for Vaccinia-Related Kinase
2 (VRK2) Gene
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 1780)
AUTHORS Suriyapperuma,S.P. and Sarfarazi,M.
TITLE Direct Submission
JOURNAL Submitted (31-JAN-2003) Molecular Ophthalmic Genetics Laboratory,
University of Connecticut Health Center, 263 Farmington Ave,
Farmington, CT 06030-1110, USA
FEATURES Location/Qualifiers
source 1..1780
/db_xref="H-InvDB:HIT000085394"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2p16-p15"
/cell_type="fibroblast"
gene 1..1780
/gene="VRK2"
CDS 163..1689
/gene="VRK2"
/note="protein kinase; contains the first 47-bp of intron
1 added to the end of non-coding exon 1; resulting
insertion does not change the open reading frame;
alternatively spliced"
/codon_start=1
/product="vaccinia related kinase 2 isoform 2"
/protein_id="AAO73048.1"
/translation="MPPKRNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIY
LAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPL
FYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHEN
EYVHGDVKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTS
LDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVL
KWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINV
HTPNSQKVDSQKAATKQVNKAHNRLIEKKVHSERSAESCATWKVQKEEKLIGLMNNEA
AQESTRRRQKYQESQEPLNEVNSFPQEISYTQFPNSFYEPHQDFTSPDIFKKSRSPSW
YKYTSTVSTGITDLESSTGLWPTISQFTLSEETNADVYYYRIIIPVLLMLVFLALFFL
"
BASE COUNT 572 a 351 c 405 g 452 t
ORIGIN
1 gacgcagctg gagagaagtt aggcaggtcc tagggagggc aggctcgagt gctgggcccg
61 cctccccgcg ggactgtagg cccgggggct ccgcctcgtc gcagcggcag gtaggaggcg
121 gtgcgcgcgg cccggcgacg ggggatcctg aggcccgaag tgatgccacc aaaaagaaat
181 gaaaaataca aacttcctat tccatttcca gaaggcaagg ttctggatga tatggaaggc
241 aatcagtggg tactgggcaa gaagattggc tctggaggat ttggattgat atatttagct
301 ttccccacaa ataaaccaga gaaagatgca agacatgtag taaaagtgga atatcaagaa
361 aatggcccgt tattttcaga acttaaattt tatcagagag ttgcaaaaaa agactgtatc
421 aaaaagtgga tagaacgcaa acaacttgat tatttaggaa ttcctctgtt ttatggatct
481 ggtctgactg aattcaaggg aagaagttac agatttatgg taatggaaag actaggaata
541 gatttacaga agatctcagg ccagaatggt acctttaaaa agtcaactgt cctgcaatta
601 ggtatccgaa tgttggatgt actggagtat atacatgaaa atgaatatgt tcatggtgat
661 gtaaaagcag caaatctact tttgggttac aaaaatccag accaggttta tcttgcagat
721 tatggacttt cctacagata ttgtcccaat gggaaccaca aacagtatca ggaaaatcct
781 agaaaaggcc ataatgggac aatagagttt accagcttgg atgcccacaa gggagtagcc
841 ttgtccagac gaagtgacgt tgagatcctc ggctactgca tgctgcggtg gttgtgtggg
901 aaacttccct gggaacagaa cctgaaggac cctgtggctg tgcagactgc taaaacaaat
961 ctgttggacg agctccccca gtcagtgctt aaatgggctc cttctggaag cagttgctgt
1021 gaaatagccc aatttttggt atgtgctcat agtttagcat atgatgaaaa gccaaactat
1081 caagccctca agaaaatttt gaaccctcat ggaatacctt taggaccact ggacttttcc
1141 acaaaaggac agagtataaa tgtccatact ccaaacagtc aaaaagttga ttcacaaaag
1201 gctgcaacaa agcaagtcaa caaggcacac aataggttaa tcgaaaaaaa agtccacagt
1261 gagagaagcg ctgagtcctg tgcaacatgg aaagtgcaga aagaggagaa actgattgga
1321 ttgatgaaca atgaagcagc tcaggaaagc acaaggagaa gacagaaata tcaagagtct
1381 caagaacctt tgaatgaagt aaacagtttc ccacaagaaa tcagctatac acaattccca
1441 aactcatttt atgagcctca tcaagatttt accagtccag atatattcaa gaagtcaaga
1501 tctccatctt ggtataaata cacttccaca gtcagcacgg ggatcacaga cttagaaagt
1561 tcaactggac tttggcctac aatttcccag tttactctta gtgaagagac aaacgcagat
1621 gtttattatt atcgcatcat catacctgtc cttttgatgt tagtatttct tgctttattt
1681 tttctctgaa gatgatacca aaattccttt tgataatttt ttaagtttcc agctcttcac
1741 cgaaatgttg tattcttatt tcagtgtttc cttccagaca
//