LOCUS AY228367 1645 bp mRNA linear HUM 30-MAR-2003
DEFINITION Homo sapiens vaccinia related kinase 2 isoform 1 (VRK2) mRNA,
complete cds; alternatively spliced.
ACCESSION AY228367
VERSION AY228367.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1645)
AUTHORS Suriyapperuma,S.P. and Sarfarazi,M.
TITLE Identification of 6 Different Isoforms for Vaccinia-Related Kinase
2 (VRK2) Gene
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 1645)
AUTHORS Suriyapperuma,S.P. and Sarfarazi,M.
TITLE Direct Submission
JOURNAL Submitted (31-JAN-2003) Molecular Ophthalmic Genetics Laboratory,
University of Connecticut Health Center, 263 Farmington Ave,
Farmington, CT 06030-1110, USA
FEATURES Location/Qualifiers
source 1..1645
/db_xref="H-InvDB:HIT000085393"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2p16-p15"
/cell_type="fibroblast"
gene 1..1645
/gene="VRK2"
CDS 28..1554
/gene="VRK2"
/note="protein kinase; contains deletion of last 88-bp of
the first non-conding exon; resulting deletion does not
change the open reading frame; alternatively spliced"
/codon_start=1
/product="vaccinia related kinase 2 isoform 1"
/protein_id="AAO73047.1"
/translation="MPPKRNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIY
LAFPTNKPEKDARHVVEVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPL
FYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHEN
EYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTS
LDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVL
KWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINV
HTPNSQKVDSQKAATKQVNKAHNRLIEKKVHSERSAESCATWKVQKEEKLIGLMNNEA
AQESTRRRQKYQESQEPLNEVNSFPQKISYTQFPNSFYEPHQDFTSPDIFKKSRSPSW
YKYTSTVSTGITDLESSTGLWPTISQFTLSEETNADVYYYRIIIPVLLMLVFLALFFL
"
BASE COUNT 560 a 306 c 342 g 437 t
ORIGIN
1 gacgcagctg gagagaagtt agaagtgatg ccaccaaaaa gaaatgaaaa atacaaactt
61 cctattccat ttccagaagg caaggttctg gatgatatgg aaggcaatca gtgggtactg
121 ggcaagaaga ttggctctgg aggatttgga ttgatatatt tagctttccc cacaaataaa
181 ccagagaaag atgcaagaca tgtagtagaa gtggaatatc aagaaaatgg cccgttattt
241 tcagaactta aattttatca gagagttgca aaaaaagact gtatcaaaaa gtggatagaa
301 cgcaaacaac ttgattattt aggaattcct ctgttttatg gatctggtct gactgaattc
361 aagggaagaa gttacagatt tatggtaatg gaaagactag gaatagattt acagaagatc
421 tcaggccaga atggtacctt taaaaagtca actgtcctgc aattaggtat ccgaatgttg
481 gatgtactgg aatatataca tgaaaatgaa tatgttcatg gtgatataaa agcagcaaat
541 ctacttttgg gttacaaaaa tccagaccag gtttatcttg cagattatgg actttcctac
601 agatattgtc ccaatgggaa ccacaaacag tatcaggaaa atcctagaaa aggccataat
661 gggacaatag agtttaccag cttggatgcc cacaagggag tagccttgtc cagacgaagt
721 gacgttgaga tcctcggcta ctgcatgctg cggtggttgt gtgggaaact tccctgggaa
781 cagaacctga aggaccctgt ggctgtgcag actgctaaaa caaatctgtt ggacgagctc
841 ccccagtcag tgcttaaatg ggctccttct ggaagcagtt gctgtgaaat agcccaattt
901 ttggtatgtg ctcatagttt agcatatgat gaaaagccaa actatcaagc cctcaagaaa
961 attttgaacc ctcatggaat acctttagga ccactggact tttccacaaa aggacagagt
1021 ataaatgtcc atactccaaa cagtcaaaaa gttgattcac aaaaggctgc aacaaagcaa
1081 gtcaacaagg cacacaatag gttaatcgaa aaaaaagtcc acagtgagag aagcgctgag
1141 tcctgtgcaa catggaaagt gcagaaagag gagaaactga ttggattgat gaacaatgaa
1201 gcagctcagg aaagcacaag gagaagacag aaatatcaag agtctcaaga acctttgaat
1261 gaagtaaaca gtttcccaca aaaaatcagc tatacacaat tcccaaactc attttatgag
1321 cctcatcaag attttaccag tccagatata ttcaagaagt caagatctcc atcttggtat
1381 aaatacactt ccacagtcag cacggggatc acagacttag aaagttcaac tggactttgg
1441 cctacaattt cccagtttac tcttagtgaa gagacaaacg cagatgttta ttattatcgc
1501 atcatcatac ctgtcctttt gatgttagta tttcttgctt tattttttct ctgaagatga
1561 taccaaaatt ccttttgata attttttaag tttccagctc ttcaccgaaa tgttgtattc
1621 ttatttcagt gtttccttcc agaca
//