LOCUS AY221963 4445 bp mRNA linear HUM 31-JAN-2005
DEFINITION Homo sapiens HECT and RCC1 containing protein 4 isoform 1 (HERC4)
mRNA, complete cds, alternatively spliced.
ACCESSION AY221963
VERSION AY221963.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4445)
AUTHORS Hochrainer,K., Mayer,H., Baranyi,U., Binder,B., Lipp,J. and
Kroismayr,R.
TITLE The human HERC family of ubiquitin ligases: novel members, genomic
organization, expression profiling, and evolutionary aspects
JOURNAL Genomics 85 (2), 153-164 (2005)
PUBMED 15676274
REFERENCE 2 (bases 1 to 4445)
AUTHORS Hochrainer,K., Mayer,H., Kroismayr,R., Baranyi,U., Binder,B.R. and
Lipp,J.
TITLE Direct Submission
JOURNAL Submitted (20-JAN-2003) Vascular Biology and Thrombosis Research,
University of Vienna, Brunnerstrasse 59, Vienna 1235, Austria
FEATURES Location/Qualifiers
source 1..4445
/db_xref="H-InvDB:HIT000251087"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q22.1"
gene 1..4445
/gene="HERC4"
CDS 249..3422
/gene="HERC4"
/note="contains HECT domain and RCC1-like repeats;
putative E3 ligase; alternatively spliced"
/codon_start=1
/product="HECT and RCC1 containing protein 4 isoform 1"
/protein_id="AAO65480.1"
/translation="MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLR
HTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDK
GQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFC
WGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNK
FGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGH
NSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSN
RKSPFTVKGNWYPYNGQCLPDIDSEEYFCVKRIFSGGDQSFSHYSSPQNCGPPDDFRC
PNPTKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGCLNGSFLAVSNDDHYR
TGTRFSGVDMNAARLLFHKLIQPDHPQISQQVAASLEKNLIPKLTSSLPDVEALRFYL
TLPECPLMSDSNNFTTIAIPFGTALVNLEKAPLKVLENWWSVLEPPLFLKIVELFKEV
VVHLLKLYKIGIPPSERRIFNSFLHTALKVLEILHRVNEKMGQIIQYDKFYIHEVQEL
IDIRNDYINWVQQQAYGMDVNHGLTELADIPVTICTYPFVFDAQAKTTLLQTDAVLQM
QMAIDQAHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRKTKNIDYKKPLKV
IFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDLFHLI
GVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQLLDYPEDDI
EETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFD
AFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIF
WEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGEEYLPVSHTCFNLLD
LPKYTEKETLRSKLIQAIDHNEGFSLI"
BASE COUNT 1354 a 763 c 937 g 1391 t
ORIGIN
1 agtctcttcc ccaactctcc ccacccctgg tgctctccgc cccgcttgcc tcccgttctt
61 ccccgcccgc tccatccggg tcgctgacgg ctgtctctgg actggacagc agtggcgtcc
121 gcttttctct aaggaacccg ataagaactc cattttctgt tgatgtggag acatagggta
181 cctccaactt tccggggttt cagaagagaa ttttttattg aaactggaag accaaaataa
241 ttacaagcat gttgtgctgg ggaaatgcat cctttgggca gctaggtttg ggtggaattg
301 atgaagaaat tgtactagag cccagaaaaa gtgacttctt tataaataaa agggtccgag
361 atgtaggatg tggactcaga catactgtgt ttgttctgga tgatggaaca gtgtacacat
421 gtggatgtaa tgatctagga cagctaggtc atgaaaaatc cagaaagaaa ccagagcagg
481 ttgttgccct ggatgcccaa aatattgtag ctgtttcatg tggagaagct catacgttag
541 cgctaaatga caaaggccag gtgtatgctt ggggtctcga ttctgatgga cagcttggcc
601 tggtaggatc agaggaatgc atcagagtac ccagaaatat taaaagtttg tcagatatcc
661 agattgtaca ggttgcttgt ggttactatc attcacttgc actttctaaa gcaagtgaag
721 tcttctgttg gggacagaat aaatatggcc aattgggttt aggtactgac tgtaaaaagc
781 aaacttcacc gcagctgctt aagtctttgc ttggaatccc tttcatgcaa gttgcagcag
841 gaggagccca tagttttgta ctcacccttt ctggagctat ctttggatgg ggacgcaaca
901 agtttggtca gctaggtctt aatgatgaaa atgataggta tgttcctaat ttactaaagt
961 cactaagatc tcagaaaata gtttatattt gttgtggaga agatcatact gctgctctaa
1021 ccaaggaagg tggagtgttt acttttggag ctggagggta tggtcagttg ggccataatt
1081 ctaccagtca tgaaataaac ccaaggaaag tttttgaact tatgggaagc attgtcactg
1141 agattgcttg tggacggcag cacacttctg cttttgttcc ttcatcagga cgaatttact
1201 cttttgggct tggtggtaat gggcagctgg gaaccggttc aacaagcaac aggaaaagtc
1261 cctttactgt aaaaggaaat tggtacccct ataatgggca gtgtctacca gatattgatt
1321 ctgaagaata tttctgtgta aaaagaattt tctcaggggg agatcaaagc ttttcacatt
1381 actctagtcc ccagaactgt gggccaccag atgacttcag atgtcccaat ccgacaaagc
1441 agatctggac agtgaatgaa gctctaattc agaaatggct gagctatcct tctggaaggt
1501 ttcctgtgga gatagccaat gagatagatg gaacgttttc ttcctctggt tgcctaaatg
1561 gaagtttttt agctgttagc aatgatgatc actatagaac aggtaccaga ttttcagggg
1621 ttgatatgaa tgctgctagg cttttattcc acaaacttat acaacctgat catccgcaga
1681 tatctcagca ggtggcagct agtttggaaa agaatcttat tcctaaactg actagctcct
1741 tacctgatgt tgaagcattg aggttttatc ttactctacc agaatgtccc ctgatgagtg
1801 attccaacaa tttcacaaca atagcaattc cctttggtac agctcttgtg aacctagaaa
1861 aggcaccact gaaagtactt gaaaactggt ggtcagtact tgaacctcca ctattcctca
1921 agatagtaga actttttaag gaagttgtgg tacatctttt gaaactctac aagatcggta
1981 ttcccccttc tgaaagaaga attttcaaca gttttcttca tactgcatta aaggttttag
2041 aaatactaca tagggtaaat gagaaaatgg gacagattat acagtatgat aaattttata
2101 tacatgaagt acaagaattg atagacataa gaaatgatta tatcaactgg gtccaacagc
2161 aggcctatgg aatggatgtc aaccatggat taactgagtt ggcagatatc cctgttacaa
2221 tctgtacata tccatttgta tttgatgccc aagcaaaaac tactctgtta cagaccgatg
2281 cagtcttaca gatgcagatg gctattgatc aggcccacag gcagaatgtc tcctctcttt
2341 ttctcccagt gattgaatct gtgaatccct gcttaattct agtggtgcgt agagaaaata
2401 ttgtaggaga tgcaatggaa gtccttagga aaacaaagaa catagattac aagaagccac
2461 tcaaggttat atttgttgga gaagatgctg tggatgcagg aggggtgcgc aaagaatttt
2521 tcttgctcat catgagggaa ttattggatc ctaaatacgg catgtttagg tattatgaag
2581 attccaggct catttggttt tctgataaga catttgaaga cagtgatttg ttccatttga
2641 ttggtgttat ctgtggctta gcaatttata attgtaccat tgtggacctc cattttcctt
2701 tggctttata taagaaacta ctgaaaaaga agccatcctt ggatgatttg aaagaactaa
2761 tgcctgatgt tgggagaagc atgcaacagt tactggatta tccagaagat gacatagagg
2821 aaacattttg tcttaatttt acgatcacag ttgaaaactt tggtgcaaca gaagtgaaag
2881 agctggttct aaatggtgca gacacagctg ttaacaaaca aaatcggcaa gagtttgtcg
2941 atgcttatgt ggattacata ttcaataaat cagtggcttc cttatttgat gcttttcatg
3001 cgggctttca taaggtctgt ggaggaaaag tccttctgct ctttcagcct aatgaactac
3061 aagcaatggt cattggaaat acaaattatg attggaagga actggaaaag aatacagaat
3121 acaaagggga atattgggca gaacatccta cgataaaaat tttttgggaa gtatttcacg
3181 aattaccatt ggaaaagaag aaacagtttc tgttattttt gacaggtagt gatcgcattc
3241 ctattcttgg tatgaagagt ctgaaactag tcatccagtc cacaggaggt ggtgaggagt
3301 atctcccagt ttcccatact tgttttaatc ttctggatct tccaaaatat acagaaaaag
3361 aaactctacg ctctaaactg atccaagcta ttgatcacaa tgaaggcttc agtttaatat
3421 aactttggag ttataactat tcagtttagt gcaaaagcat taaactattt gtgtttttct
3481 tgtggtgatg aattcagcaa ggtgacagag gtactattat aattcttact tgcagaatgt
3541 tcaatctacg agtgttcatg gaagccaaaa aatattaaag gaaaatgaac aaactgttaa
3601 tattattgta cagaaccatg gatttttttt gaccatcttc taataaacat agcaagtatt
3661 atgaatacat taaagtttta ctaacatgaa ttttaagagt ttgcatattt cagaaatgat
3721 ctggtgtgag tgcatggaaa tattgcttaa tttttcttca atcattgagt gaaaaacctt
3781 taactttggc ctgcaatagt catttgatta ttttttcatt ttgtaaataa tgttaagttt
3841 tgtaataaaa tagttatgtt ctgataccag tacagtttct atggttgtaa ttgaacttga
3901 acagactttt aaaggttaaa aattatgatt taaatcttac tctgagactc tataaaaaga
3961 aaaaaaaggt agcatggtgg aaacactatc ttttcttttt tgctagaata agtgtctttg
4021 tgcaaaccta aatcacagat agggaatata ctacataacc tgcagttctt ttctttgtga
4081 atcctgacac actgatagat gggggattgt cgatcagaga acttattaat atttagtact
4141 ggaagaactc tgtctccaca gttgccagta ataaaaagaa acattggcta ctatgagcac
4201 caatcactgg gttatagctt tcaaaattat tgatgctgca gtgctttaga gctatttcct
4261 tgaatttaag aaacaaatct taacagtttt atggtgctga tgcttagttg tctcatgcca
4321 ttaaattgta aaagtgagtt gatgcaatac atgtgacttt ctgctataat gcaaatattt
4381 attttttaaa tttattttaa aatgccgtga aaactgttta ataaagattt attgttttaa
4441 tattt
//